Cecilia Gotherstrom

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Immunologic properties of human fetal mesenchymal stem cells
    Cecilia Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Am J Obstet Gynecol 190:239-45. 2004
  2. ncbi Functional studies of mesenchymal stem cells derived from adult human adipose tissue
    Andrea Dicker
    Department of Medicine, M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Exp Cell Res 308:283-90. 2005
  3. ncbi No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
    Mikael Sundin
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Haematologica 92:1208-15. 2007
  4. ncbi Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Transplantation 79:1607-14. 2005
  5. ncbi Difference in gene expression between human fetal liver and adult bone marrow mesenchymal stem cells
    Cecilia Gotherstrom
    Division of Clinical Immunology, F79, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Haematologica 90:1017-26. 2005
  6. pmc A research study of the association between maternal microchimerism and systemic lupus erythematosus in adults: a comparison between patients and healthy controls based on single-nucleotide polymorphism using quantitative real-time PCR
    Anna Maria Jonsson Kanold
    Department of Obstetrics and Gynecology, Center for Fetal Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e74534. 2013
  7. ncbi Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression
    Garth Cronwright
    Department of Oncology and Pathology, Karolinska Institutet, Sweden
    Cancer Res 65:2207-15. 2005
  8. doi Human neural stem/progenitor cells derived from embryonic stem cells and fetal nervous system present differences in immunogenicity and immunomodulatory potentials in vitro
    Jia Liu
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm, Sweden
    Stem Cell Res 10:325-37. 2013
  9. ncbi Identification of maternal hematopoietic cells in a 2nd-trimester fetus
    Cecilia Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Stockholm, Sweden
    Fetal Diagn Ther 20:355-8. 2005
  10. ncbi Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    Katarina Le Blanc
    Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Lancet 363:1439-41. 2004

Collaborators

Detail Information

Publications14

  1. ncbi Immunologic properties of human fetal mesenchymal stem cells
    Cecilia Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Am J Obstet Gynecol 190:239-45. 2004
    ..Mesenchymal stem cells (MSCs) can be isolated from adult bone marrow and fetal liver. We investigated the immunologic properties of undifferentiated and differentiated human fetal MSCs...
  2. ncbi Functional studies of mesenchymal stem cells derived from adult human adipose tissue
    Andrea Dicker
    Department of Medicine, M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Exp Cell Res 308:283-90. 2005
    ..Human adipose-tissue-derived MSCs could therefore constitute an efficient and easily obtainable renewable cellular source for studies of adipocyte biology...
  3. ncbi No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
    Mikael Sundin
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Haematologica 92:1208-15. 2007
    ..The objective of this study was to investigate whether antibodies against MSC were present after hematopoietic stem cell transplantation (HSCT) including treatment with matched or mismatched allogeneic MSC...
  4. ncbi Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Transplantation 79:1607-14. 2005
    ..Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results...
  5. ncbi Difference in gene expression between human fetal liver and adult bone marrow mesenchymal stem cells
    Cecilia Gotherstrom
    Division of Clinical Immunology, F79, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Haematologica 90:1017-26. 2005
    ..Fetal and adult MSC have similar morphology but differ in proliferative, differentiating and immunosuppressive properties. Further exploring their differences could help in choosing the right source for cellular therapy...
  6. pmc A research study of the association between maternal microchimerism and systemic lupus erythematosus in adults: a comparison between patients and healthy controls based on single-nucleotide polymorphism using quantitative real-time PCR
    Anna Maria Jonsson Kanold
    Department of Obstetrics and Gynecology, Center for Fetal Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e74534. 2013
    ..Systemic Lupus erythematosus (SLE) is an autoimmune disorder with a resemblance to graft-versus-host disease. The aim of this study was to investigate the association between maternal microchimerism in the blood and SLE...
  7. ncbi Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression
    Garth Cronwright
    Department of Oncology and Pathology, Karolinska Institutet, Sweden
    Cancer Res 65:2207-15. 2005
    ..In addition, E-cadherin expression increases, mimicking a mesenchymal epithelial transition. These results afford SSX a functional role in normal stem cell migration and suggest a potentially similar function in cancer cell metastases...
  8. doi Human neural stem/progenitor cells derived from embryonic stem cells and fetal nervous system present differences in immunogenicity and immunomodulatory potentials in vitro
    Jia Liu
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Stockholm, Sweden
    Stem Cell Res 10:325-37. 2013
    ..To conclude, hESC-NPCs and hfNPCs displayed similarities but also significant differences in their immunocompetence and interaction with allogeneic PBMCs, differences may be crucial for the outcome of cell therapy...
  9. ncbi Identification of maternal hematopoietic cells in a 2nd-trimester fetus
    Cecilia Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Stockholm, Sweden
    Fetal Diagn Ther 20:355-8. 2005
    ..To study the subset of maternal cells in fetal tissue in a 2nd-trimester fetus with malformations...
  10. ncbi Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    Katarina Le Blanc
    Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Lancet 363:1439-41. 2004
    ..Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo...
  11. doi Fetal and adult multipotent mesenchymal stromal cells are killed by different pathways
    Cecilia Gotherstrom
    Division of Clinical Immunology and Transfusion Medicine, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cytotherapy 13:269-78. 2011
    ..Recently, there has been considerable interest in MSC because they have features favorable for transplantation, namely their multipotency and non-immunogenic properties...
  12. ncbi Functional characterization of human mesenchymal stem cell-derived adipocytes
    Mikael Ryden
    Department of Medicine, Center of Metabolism and Endocrinology, Karolinska Institute, Huddinge University Hospital, 141 86, Stockholm, Sweden
    Biochem Biophys Res Commun 311:391-7. 2003
    ..These systems could be of great value in adipocyte research as a renewable source of adipocytes...
  13. ncbi Defined serum-free media for in vitro expansion of adipose-derived mesenchymal stem cells
    Shahla Hamza Al-Saqi
    Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden Electronic address
    Cytotherapy 16:915-26. 2014
    ..The aim of this study was to evaluate a defined serum-free medium for in vitro expansion of MSCs as a prerequisite for their clinical use...
  14. ncbi Immunomodulation by multipotent mesenchymal stromal cells
    Cecilia Gotherstrom
    Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Transplantation 84:S35-7. 2007
    ..The unique properties of MSC suggest emerging roles for them in cell therapy and in the treatment of immunomediated diseases...