C Gotherstrom

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Fetal and adult multipotent mesenchymal stromal cells are killed by different pathways
    Cecilia Gotherstrom
    Division of Clinical Immunology and Transfusion Medicine, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cytotherapy 13:269-78. 2011
  2. doi request reprint Identification of candidate surface antigens for non-invasive prenatal diagnosis by comparative global gene expression on human fetal mesenchymal stem cells
    C Gotherstrom
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Mol Hum Reprod 16:472-80. 2010
  3. ncbi request reprint Immunomodulation by multipotent mesenchymal stromal cells
    Cecilia Gotherstrom
    Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Transplantation 84:S35-7. 2007
  4. ncbi request reprint No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
    Mikael Sundin
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Haematologica 92:1208-15. 2007
  5. ncbi request reprint Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    Katarina Le Blanc
    Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Lancet 363:1439-41. 2004
  6. ncbi request reprint Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells
    C Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 32:265-72. 2003
  7. ncbi request reprint Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse
    Jerry Chan
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London, United Kingdom
    Stem Cells 25:875-84. 2007
  8. ncbi request reprint Functional studies of mesenchymal stem cells derived from adult human adipose tissue
    Andrea Dicker
    Department of Medicine, M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Exp Cell Res 308:283-90. 2005
  9. ncbi request reprint Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression
    Garth Cronwright
    Department of Oncology and Pathology, Karolinska Institutet, Sweden
    Cancer Res 65:2207-15. 2005
  10. ncbi request reprint Immunologic properties of human fetal mesenchymal stem cells
    Cecilia Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Am J Obstet Gynecol 190:239-45. 2004

Collaborators

Detail Information

Publications15

  1. doi request reprint Fetal and adult multipotent mesenchymal stromal cells are killed by different pathways
    Cecilia Gotherstrom
    Division of Clinical Immunology and Transfusion Medicine, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden
    Cytotherapy 13:269-78. 2011
    ..Recently, there has been considerable interest in MSC because they have features favorable for transplantation, namely their multipotency and non-immunogenic properties...
  2. doi request reprint Identification of candidate surface antigens for non-invasive prenatal diagnosis by comparative global gene expression on human fetal mesenchymal stem cells
    C Gotherstrom
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Mol Hum Reprod 16:472-80. 2010
    ..Identification of novel surface antigens on circulating human fMSC and not maternal PBL facilitates positive selection strategies for isolating fMSC for non-invasive prenatal diagnosis...
  3. ncbi request reprint Immunomodulation by multipotent mesenchymal stromal cells
    Cecilia Gotherstrom
    Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Transplantation 84:S35-7. 2007
    ..The unique properties of MSC suggest emerging roles for them in cell therapy and in the treatment of immunomediated diseases...
  4. ncbi request reprint No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients
    Mikael Sundin
    Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Haematologica 92:1208-15. 2007
    ..The objective of this study was to investigate whether antibodies against MSC were present after hematopoietic stem cell transplantation (HSCT) including treatment with matched or mismatched allogeneic MSC...
  5. ncbi request reprint Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    Katarina Le Blanc
    Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Lancet 363:1439-41. 2004
    ..Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo...
  6. ncbi request reprint Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells
    C Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Bone Marrow Transplant 32:265-72. 2003
    ..fMSC inhibit lymphocyte proliferation induced by mitogens, but not alloreactivity as measured by MLC...
  7. ncbi request reprint Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse
    Jerry Chan
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London, United Kingdom
    Stem Cells 25:875-84. 2007
    ..Although the low-level of chimerism achieved is not curative for DMD, this approach may be useful in other severe mesenchymal or enzyme deficiency syndromes, where low-level protein expression may ameliorate disease pathology...
  8. ncbi request reprint Functional studies of mesenchymal stem cells derived from adult human adipose tissue
    Andrea Dicker
    Department of Medicine, M63, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Exp Cell Res 308:283-90. 2005
    ..Human adipose-tissue-derived MSCs could therefore constitute an efficient and easily obtainable renewable cellular source for studies of adipocyte biology...
  9. ncbi request reprint Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression
    Garth Cronwright
    Department of Oncology and Pathology, Karolinska Institutet, Sweden
    Cancer Res 65:2207-15. 2005
    ..In addition, E-cadherin expression increases, mimicking a mesenchymal epithelial transition. These results afford SSX a functional role in normal stem cell migration and suggest a potentially similar function in cancer cell metastases...
  10. ncbi request reprint Immunologic properties of human fetal mesenchymal stem cells
    Cecilia Gotherstrom
    Division of Clinical Immunology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Am J Obstet Gynecol 190:239-45. 2004
    ..Mesenchymal stem cells (MSCs) can be isolated from adult bone marrow and fetal liver. We investigated the immunologic properties of undifferentiated and differentiated human fetal MSCs...
  11. ncbi request reprint Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes
    K Le Blanc
    Division of Clinical Immunology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Scand J Immunol 60:307-15. 2004
    ..In summary, human MSC suppress proliferation of both CD4+ and CD8+ lymphocyte and decrease the expression of activation markers...
  12. ncbi request reprint Human first-trimester fetal MSC express pluripotency markers and grow faster and have longer telomeres than adult MSC
    Pascale V Guillot
    Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, U K
    Stem Cells 25:646-54. 2007
    ..01). Compared with adult MSC, first-trimester fetal tissues constitute a source of MSC with characteristics that appear advantageous for cell therapy...
  13. ncbi request reprint Difference in gene expression between human fetal liver and adult bone marrow mesenchymal stem cells
    Cecilia Gotherstrom
    Division of Clinical Immunology, F79, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Haematologica 90:1017-26. 2005
    ..Fetal and adult MSC have similar morphology but differ in proliferative, differentiating and immunosuppressive properties. Further exploring their differences could help in choosing the right source for cellular therapy...
  14. ncbi request reprint Functional characterization of human mesenchymal stem cell-derived adipocytes
    Mikael Ryden
    Department of Medicine, Center of Metabolism and Endocrinology, Karolinska Institute, Huddinge University Hospital, 141 86, Stockholm, Sweden
    Biochem Biophys Res Commun 311:391-7. 2003
    ..These systems could be of great value in adipocyte research as a renewable source of adipocytes...
  15. ncbi request reprint Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta
    Katarina Le Blanc
    Center for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Transplantation 79:1607-14. 2005
    ..Adult human leukocyte antigen (HLA)-matched MSC have been used in cellular therapies of bone disorders such as osteogenesis imperfecta, with promising results...