K Fuxe

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Volume transmission and its different forms in the central nervous system
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Chin J Integr Med 19:323-9. 2013
  2. doi request reprint On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1476:119-31. 2012
  3. ncbi request reprint GPCR heteromers and their allosteric receptor-receptor interactions
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Curr Med Chem 19:356-63. 2012
  4. pmc Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    J Neural Transm 116:923-39. 2009
  5. doi request reprint The discovery of central monoamine neurons gave volume transmission to the wired brain
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Prog Neurobiol 90:82-100. 2010
  6. doi request reprint Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Pharmacol 10:14-22. 2010
  7. doi request reprint The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Recept Signal Transduct Res 30:272-83. 2010
  8. ncbi request reprint Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function
    Kjell Fuxe
    Karolinska Institutet, Department of Neuroscience, Retzius vag 8, S 171 77 Stockholm, Sweden
    Physiol Behav 92:210-7. 2007
  9. doi request reprint Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    CNS Neurosci Ther 16:e18-42. 2010
  10. ncbi request reprint Adenosine A(2A) receptors, dopamine D(2) receptors and their interactions in Parkinson's disease
    Kjell Fuxe
    Division of Cellular and Molecular Neurochemistry, Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Mov Disord 22:1990-2017. 2007

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. doi request reprint Volume transmission and its different forms in the central nervous system
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Chin J Integr Med 19:323-9. 2013
    ..Short and long distance VT may take place in meridian channels via diffusion and flow in the interstitial fluid. Acupuncture can produce VT signals by releasing transmitters and modulators from nerve terminals and mast cells...
  2. doi request reprint On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1476:119-31. 2012
    ..This article is part of a Special Issue entitled: Brain Integration...
  3. ncbi request reprint GPCR heteromers and their allosteric receptor-receptor interactions
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Curr Med Chem 19:356-63. 2012
    ..Furthermore, novel therapeutic approaches could be possible based on the use of heteromers as targets for drug development based on their unique pharmacology...
  4. pmc Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    J Neural Transm 116:923-39. 2009
    ..In addition, a combined targeting of receptor mosaics in the ventral striatum and in the cerebral cortex should also be considered...
  5. doi request reprint The discovery of central monoamine neurons gave volume transmission to the wired brain
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Prog Neurobiol 90:82-100. 2010
    ..The impact of the technicolour approach to the connectome for the future characterization of the wired networks of the brain is emphasized...
  6. doi request reprint Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Pharmacol 10:14-22. 2010
    ..We discuss the possible relevance of some putative D(2) receptor heteromers in the treatment of Parkinson's disease and schizophrenia, respectively...
  7. doi request reprint The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Recept Signal Transduct Res 30:272-83. 2010
    ..GPCR homomers and GPCR assemblies are not isolated but also directly interact with other proteins to form horizontal molecular networks at the plasma membrane...
  8. ncbi request reprint Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function
    Kjell Fuxe
    Karolinska Institutet, Department of Neuroscience, Retzius vag 8, S 171 77 Stockholm, Sweden
    Physiol Behav 92:210-7. 2007
    ..Thus, A2A receptor antagonists and A2A receptor agonists, respectively, may offer novel treatments of Parkinson's disease (reduced D2 receptor signaling) and of schizophrenia and drug addiction (increased D2 receptor signaling)...
  9. doi request reprint Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    CNS Neurosci Ther 16:e18-42. 2010
    ..Thus, the integrative receptor-receptor interactions in these RM give novel aspects on the pathophysiology and treatment strategies, based on combined treatments, for PD, schizophrenia, and drug addiction...
  10. ncbi request reprint Adenosine A(2A) receptors, dopamine D(2) receptors and their interactions in Parkinson's disease
    Kjell Fuxe
    Division of Cellular and Molecular Neurochemistry, Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Mov Disord 22:1990-2017. 2007
    ..Their neuroprotective actions may involve an increase in the retrograde trophic signaling in the nigro-striatal DA system...
  11. ncbi request reprint From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring and volume transmission
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Brain Res Rev 55:17-54. 2007
    ..This will lead to the unified execution of information handling and trophism for optimal brain function and survival...
  12. doi request reprint Brain receptor mosaics and their intramembrane receptor-receptor interactions: molecular integration in transmission and novel targets for drug development
    Kjell Fuxe
    Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, Stockholm, Sweden
    J Acupunct Meridian Stud 2:1-25. 2009
    ..The novel therapeutic aspects given by the RMs will be discussed in the frame of molecular neurology and psychiatry and combined drug therapy appears as the future way to go...
  13. ncbi request reprint Intramembrane receptor-receptor interactions: a novel principle in molecular medicine
    K Fuxe
    Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, Stockholm, Sweden
    J Neural Transm 114:49-75. 2007
    ..Finally, the impact of intramembrane receptor-receptor interactions in molecular medicine is discussed outside the brain with focus on the endocrine, the cardiovascular and the immune systems...
  14. doi request reprint Heterodimers and receptor mosaics of different types of G-protein-coupled receptors
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Physiology (Bethesda) 23:322-32. 2008
    ..This field has now become a major research area, and this review deals with their physiology being integrators of receptor signaling in the CNS and their use as targets for novel drug development based on their unique pharmacology...
  15. pmc Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes
    S Ferre
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 88:7238-41. 1991
    ..This A2a-D2 interaction may underlie the neuroleptic-like actions of adenosine agonists and the enhancing effects of adenosine antagonists, such as caffeine, on locomotor activity...
  16. ncbi request reprint Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptor interactions in the basal ganglia
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Brain Res Brain Res Rev 26:258-73. 1998
    ..These molecular circuits are biased and may therefore represent part of the molecular mechanism for the storage of memory traces (engrams) in the membranes...
  17. ncbi request reprint Involvement of D1 dopamine receptors in the nicotine-induced neuro-endocrine effects and depletion of diencephalic catecholamine stores in the male rat
    K Andersson
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Neuroendocrinology 48:188-200. 1988
    ..abstract truncated at 400 words)..
  18. ncbi request reprint Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum
    S Ferre
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuropharmacology 38:129-40. 1999
    ....
  19. ncbi request reprint Galanin/alpha2-receptor interactions in central cardiovascular control
    Z Diaz-Cabiale
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuropharmacology 39:1377-85. 2000
    ..These mechanisms could be mediated by a reciprocal galanin-alpha(2) receptor interaction within the NTS...
  20. ncbi request reprint Intraventricular injection of neurotensin reduces dopamine D2 agonist binding in rat forebrain and intermediate lobe of the pituitary gland. Relationship to serum hormone levels and nerve terminal coexistence
    G von Euler
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Brain Res 531:253-62. 1990
    ....
  21. ncbi request reprint Comparative localization of fibroblast growth factor receptor-1, -2, and -3 mRNAs in the rat brain: in situ hybridization analysis
    N Belluardo
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Comp Neurol 379:226-46. 1997
    ..Their apparent cellular specificity suggests that these receptor subtypes can have a differential trophic role in the brain, reflecting the various biological activities shown by the ligands of the FGF family...
  22. ncbi request reprint Evidence for a cardiovascular role of central galanin neurons: focus on interactions with alpha 2-adrenergic and neuropeptide Y mechanisms
    A Harfstrand
    Department of Histology, Karolinska Institutet, Stockholm, Sweden
    J Cardiovasc Pharmacol 10:S199-204. 1987
    ..abstract truncated at 250 words)..
  23. ncbi request reprint Systemic oxytocin treatment modulates alpha 2-adrenoceptors in telencephalic and diencephalic regions of the rat
    Z Diaz-Cabiale
    Department of Neuroscience BZ lab, Karolinska Institute, S 171 77 Stockholm, Sweden
    Brain Res 887:421-5. 2000
    ..These results suggest that long-term modulation of autonomic and neuroendocrine functions and emotional behaviours elicited by brain oxytocin may involve enhancement of central alpha 2-adrenoceptor function...
  24. ncbi request reprint Subchronic toluene exposure in low concentrations produces signs of reduced dysfunction in the 6-hydroxydopamine lesioned nigrostriatal dopaminergic system of the rat
    A Cintra
    Department of Neuroscience, Karolinska Institutet, Solna, Sweden
    Neurosci Lett 274:5-8. 1999
    ..In conclusion, a subchronic exposure to low doses of toluene (80 ppm) leads to signs of reduced dysfunction of the nigrostriatal dopaminergic system after the neurotoxic treatment...
  25. ncbi request reprint Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease
    K Fuxe
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neurology 61:S19-23. 2003
    ....
  26. ncbi request reprint Internalization of intracerebrally administered porcine galanin (1-29) by a discrete nerve cell population in the hippocampus of the rat
    A Jansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, S 171 77, Sweden
    Exp Neurol 161:153-66. 2000
    ....
  27. ncbi request reprint Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum
    Z Diaz-Cabiale
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroreport 12:1831-4. 2001
    ..The A2AR agonist CGS 21680 was found to significantly increase IC50 values of competitive inhibition curves of the D2R/D3R antagonist [125I]iodosulpiride vs dopamine both in rat striatal and human striatal brain sections...
  28. ncbi request reprint Mapping and computer assisted morphometry and microdensitometry of glucocorticoid receptor immunoreactive neurons and glial cells in the rat central nervous system
    A Cintra
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroscience 62:843-97. 1994
    ..Overall, our results emphasize that glucocorticoids may appropriately tune networks of different areas to obtain optimal integration and in this way improve survival of the animal under challenging conditions...
  29. ncbi request reprint Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat
    A C Hansson
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden Max Delbrück Center for Molecular Medicine MDC, 13125 Berlin Buch, Germany
    Eur J Neurosci 12:2918-34. 2000
    ..Thus, the present findings suggest that the adrenal cortical system through GR and MR participate in the control of neurotrophic factor signalling in a highly subregion- and cellular-dependent manner...
  30. ncbi request reprint Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2A receptors in dopamine D2 receptor regulation in the rat dopamine-denervated striatum
    I Stromberg
    Department of Neuroscience, Karolinska Institute, Stockholm, S 17177 Sweden
    Eur J Neurosci 12:4033-7. 2000
    ..This mechanism gives a therapeutic potential to A2A antagonists in the treatment of PD by enhancing D2 receptor function...
  31. ncbi request reprint Relationships of 5-hydroxytryptamine immunoreactive terminal-like varicosities to 5-hydroxytryptamine-2A receptor-immunoreactive neuronal processes in the rat forebrain
    A Jansson
    Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, Retzius vag 8, S 171 77 Stockholm, Sweden
    J Chem Neuroanat 22:185-203. 2001
    ..This observation suggests that 5-HT2A receptor mediated 5-HT transmission in the rat forebrain is mainly a volume transmission process mediated via short distance diffusion in the extra-cellular space...
  32. ncbi request reprint Oxytocin/alpha(2)-Adrenoceptor interactions in feeding responses
    Z Diaz-Cabiale
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroendocrinology 71:209-18. 2000
    ....
  33. ncbi request reprint Antagonistic oxytocin/alpha2-adrenoreceptor interactions in the nucleus tractus solitarii: relevance for central cardiovascular control
    Z Diaz-Cabiale
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neuroendocrinol 12:1167-73. 2000
    ....
  34. doi request reprint Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Brain Res Rev 58:415-52. 2008
    ..Ultimately receptor-receptor interactions within RM that modify dopaminergic and serotonergic signaling may give new strategies for treatment of a wide range of diseases associated with altered dopaminergic and serotonergic signaling...
  35. ncbi request reprint The dopamine D2 antagonist remoxipride acts in vivo on a subpopulation of dopamine D2 receptors
    S O Ogren
    Karolinska Institute, Department of Neuroscience, Stockholm, Sweden
    Neuroscience 61:269-83. 1994
    ..The results support earlier suggestions that remoxipride in vivo may act on a subpopulation of dopamine D2 receptors...
  36. ncbi request reprint Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat
    K Fuxe
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Neurosci Lett 101:337-41. 1989
    ..These results suggest that G-proteins mediate the central cardiovascular actions of neuropeptide Y and clonidine...
  37. ncbi request reprint Intracerebral infusion of H-dopamine and H-mannitol in the striatum of halothane-anaesthetized male rats. A dual-probe microdialysis study of long-distance diffusion
    M Höistad
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 12:2505-14. 2000
    ..In conclusion, the dual-probe microdialysis approach proved to be a valid method to study in vivo diffusion and migration in the brain, and the intracerebral spread of compounds highly depends on the nature of the compound infused...
  38. doi request reprint Intercalated and paracapsular cell islands of the adult rat amygdala: a combined rapid-Golgi, ultrastructural, and immunohistochemical account
    D Marcellino
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Neuroscience 226:324-47. 2012
    ....
  39. ncbi request reprint Dynamics of volume transmission in the brain. Focus on catecholamine and opioid peptide communication and the role of uncoupling protein 2
    K Fuxe
    Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institute, Stockholm, Sweden
    J Neural Transm 112:65-76. 2005
    ....
  40. ncbi request reprint Increased diffusion of prolactin-like material into the brain neuropil from homologous adenohypophyseal transplants in the rat neostriatum after a 6-OH-dopamine induced degeneration of the mesostriatal dopamine neurons
    B Bjelke
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Neurosci Lett 107:33-8. 1989
    ..These results indicate that the loss of neostriatal dopamine leads to an increase in prolactin release from the adenohypophyseal striatal transplant giving further evidence for the existence of volume transmission in brain...
  41. ncbi request reprint Interactions among adenosine deaminase, adenosine A(1) receptors and dopamine D(1) receptors in stably cotransfected fibroblast cells and neurons
    M Torvinen
    Department of Neuroscience, Karolinska Institute, 171 77, Stockholm, Sweden
    Neuroscience 113:709-19. 2002
    ....
  42. ncbi request reprint Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    Joelle Hillion
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    J Biol Chem 277:18091-7. 2002
    ..These results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D(2)R are involved...
  43. ncbi request reprint Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors
    Zaida Diaz-Cabiale
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    Neurosci Lett 324:154-8. 2002
    ..These results demonstrate that mGlu5R/A2AR/D2R interactions play an important modulatory role in the function of the ventral striopallidal GABA pathway, which might have implications for the treatment of schizophrenia and drug addiction...
  44. ncbi request reprint Prominent expression of acidic fibroblast growth factor in motor and sensory neurons
    R Elde
    Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden
    Neuron 7:349-64. 1991
    ..Confocal and electron microscopic analysis suggested that a large portion of aFGF immunoreactivity was associated with the cytoplasmic face of neuronal membranes, consistent with the hypothesis that aFGF is a sequestered growth factor...
  45. ncbi request reprint Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat
    K Fuxe
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Exp Brain Res 88:131-9. 1992
    ..Also a significant reduction of DOPAC and HVA was observed. These neurochemical changes were all prevented by treatment with dihydralazine.(ABSTRACT TRUNCATED AT 250 WORDS)..
  46. pmc Functional coupling between A1 adenosine receptors and G-proteins in rat hippocampal membranes assessed by high-affinity GTPase activity
    Y Odagaki
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Br J Pharmacol 116:2691-7. 1995
    ....
  47. ncbi request reprint Trafficking of adenosine A2A and dopamine D2 receptors
    Maria Torvinen
    Department of Neuroscience, Karolinska Institute, 17 177 Stockholm, Sweden
    J Mol Neurosci 25:191-200. 2005
    ..Taken together, an activation of either A2A and D2 receptor or blockade of D2 receptors will cause long-lasting changes in A2A and D2 receptor trafficking...
  48. ncbi request reprint Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons
    Luigi F Agnati
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Pharmacol Rev 55:509-50. 2003
    ....
  49. ncbi request reprint Galanin/alpha2-adrenoceptor interactions in telencephalic and diencephalic regions of the rat
    Z Diaz-Cabiale
    Department of Neuroscience BZ lab, Karolinska Institute, Stockholm, Sweden
    Neuroreport 12:151-5. 2001
    ..These findings suggest the existence of an antagonistic galanin/alpha2 adrenoceptor interaction in the medial hypothalamus and amygdala that may be of relevance for alpha2-adrenoceptor-regulated neuroendocrine functions and food intake...
  50. ncbi request reprint The dopamine D1 receptor-rich main and paracapsular intercalated nerve cell groups of the rat amygdala: relationship to the dopamine innervation
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, A2 4, 171 77, Stockholm, Sweden
    Neuroscience 119:733-46. 2003
    ....
  51. ncbi request reprint Induction of hippocampal glial cells expressing basic fibroblast growth factor RNA by corticosterone
    A C Hansson
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroreport 12:141-5. 2001
    ..These data suggest that in a subpopulation of hippocampal glial cells corticosterone regulates bFGF gene expression transcriptionally in an on/off manner...
  52. doi request reprint Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neuropharmacology 54:815-23. 2008
    ..Taken together, these results give evidence for the existence of antagonistic CB(1)/D(2) receptor-receptor interactions within CB(1)/D(2) heteromers in which A(2A) receptors may also participate...
  53. pmc Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institute, Stockholm 17177, Sweden
    J Biol Chem 283:26016-25. 2008
    ..The present study shows that a main functional significance of the D(3) receptor is to obtain a stronger dopaminergic response in the striatal neurons that co-express the two receptors...
  54. ncbi request reprint Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: counteraction by a NTR1-like receptor antagonist
    Zaida Diaz-Cabiale
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Neuroreport 13:763-6. 2002
    ..These data indicate that there exists in the striatum at the prejunctional level an intramembrane antagonistic NT receptor/DA D2 receptor-receptor interaction where NTR1 like receptor activation reduces the DA D2 autoreceptor function...
  55. ncbi request reprint Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes
    Maria Torvinen
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    Mol Pharmacol 67:400-7. 2005
    ..D(3) receptor is one of the therapeutic targets for treatment of schizophrenia, and therefore, the A(2A)/D(3) receptor interactions could provide an alternative antischizophrenic treatment...
  56. ncbi request reprint Long-term modulation by postnatal oxytocin of the alpha 2-adrenoceptor agonist binding sites in central autonomic regions and the role of prenatal stress
    Z Diaz-Cabiale
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neuroendocrinol 16:183-90. 2004
    ....
  57. doi request reprint A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 394:222-7. 2010
    ..All together these results indicate that by targeting A(2A)R serine 374 it will be possible to allosterically modulate A(2A)R-D(2)R function, thus representing a new approach for therapeutically modulate D(2)R function...
  58. doi request reprint Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade of binding of multiple proteins to its third intracellular loop
    Dasiel O Borroto-Escuela
    Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
    Cell Physiol Biochem 25:397-408. 2010
    ....
  59. doi request reprint On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Neural Transm 117:681-7. 2010
    ..However, this was not associated with a reduction of DA cell loss. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease and warrants further future investigation...
  60. doi request reprint Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet Retzius väg 8, 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 393:767-72. 2010
    ....
  61. doi request reprint Voltage-sensitivity at the human dopamine D2S receptor is agonist-specific
    Kristoffer Sahlholm
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biochem Biophys Res Commun 377:1216-21. 2008
    ..This is the first demonstration of voltage-sensitive and voltage-insensitive behaviour of different agonists acting via the same receptor...
  62. ncbi request reprint Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Brain Res 1143:208-20. 2007
    ..A(2A) agonists may therefore represent cocaine antagonist drugs to be used in treatment of cocaine addiction acting inter alia by antagonizing signaling in accumbens A(2A)/D(2) and A(2A)/D(3) heteromers...
  63. doi request reprint Differential voltage-sensitivity of D2-like dopamine receptors
    Kristoffer Sahlholm
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Biochem Biophys Res Commun 374:496-501. 2008
    ..Our findings provide new insight into the functional differences of these closely related receptors...
  64. ncbi request reprint Biochemical identification of the dopamine D2 receptor domains interacting with the adenosine A2A receptor
    Maria Torvinen
    Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
    J Mol Neurosci 24:173-80. 2004
    ....
  65. doi request reprint Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm 17177, Sweden
    Biochem Biophys Res Commun 394:988-92. 2010
    ....
  66. doi request reprint Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 402:801-7. 2010
    ....
  67. doi request reprint Muscarinic receptor family interacting proteins: role in receptor function
    Dasiel O Borroto-Escuela
    Centre de Biotecnologia Molecular, Department d Enginyeria Quimica, Universitat Politecnica de Catalunya, Colom 1, 08222 Terrassa, Barcelona, Spain
    J Neurosci Methods 195:161-9. 2011
    ....
  68. ncbi request reprint Prolonged effects of intraventricular galanin on a 5-hydroxytryptamine(1A) receptor mediated function in the rat
    H Razani
    Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Neurosci Lett 299:145-9. 2001
    ....
  69. ncbi request reprint Stimulation of D2 receptors in the prefrontal cortex reduces PCP-induced hyperactivity, acetylcholine release and dopamine metabolism in the nucleus accumbens
    A Del Arco
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neural Transm 114:185-93. 2007
    ..These results suggest that the stimulation of prefrontal D2 receptors plays an inhibitory role in regulating spontaneous and PCP-induced motor activity and also in the neurochemical changes produced by PCP in the nucleus accumbens...
  70. ncbi request reprint Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function
    Kjell Fuxe
    Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, Stockholm, Sweden
    J Mol Neurosci 26:209-20. 2005
    ..Finally, recent evidence for the existence of antagonistic A2A-D3 heteromeric receptor complexes in cotransfected cell lines has been summarized...
  71. doi request reprint Voltage-dependence of the human dopamine D2 receptor
    Kristoffer Sahlholm
    Department of Neuroscience, Karolinska Institutet, SE 117 77 Stockholm, Sweden
    Synapse 62:476-80. 2008
    ..Our results are likely to bear relevance to the function of the D2 receptor in gating synaptic input and in regulating plasticity...
  72. doi request reprint Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytes
    Kristoffer Sahlholm
    Department of Neuroscience, Karolinska Institutet, SE 117 77 Stockholm, Sweden
    Eur J Pharmacol 591:52-8. 2008
    ..GIRK channels represent a novel effector system for histamine H(4) receptor modulation, which may be of physiological relevance and prove useful in the development of compounds targeting this receptor...
  73. ncbi request reprint Regulation of DARPP-32 phosphorylation by Delta9-tetrahydrocannabinol
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neuropharmacology 54:31-5. 2008
    ..These results indicate that, in the striatum, THC promotes PKA-dependent phosphorylation of DARPP-32 in striatal medium spiny neurons expressing dopamine D1 and adenosine A2A receptors...
  74. doi request reprint Dopamine D2 and 5-hydroxytryptamine 5-HT(₂A) receptors assemble into functionally interacting heteromers
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 401:605-10. 2010
    ..Possible novel therapeutic strategies for treatment of schizophrenia should be explored by targeting this heteromer...
  75. ncbi request reprint The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes
    Kristoffer Sahlholm
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Eur J Pharmacol 567:206-10. 2007
    ....
  76. doi request reprint The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization
    Dasiel O Borroto-Escuela
    Centre de Biotecnologia Molecular, Department d Enginyeria Quimica, Universitat Politecnica de Catalunya, Terrassa, 08222 Barcelona, Spain Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
    Biochim Biophys Acta 1803:813-25. 2010
    ....
  77. ncbi request reprint Hyperactivity to novelty induced by social isolation is not correlated with changes in D2 receptor function and binding in striatum
    Alberto Del Arco
    Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden
    Psychopharmacology (Berl) 171:148-55. 2004
    ..While these behavioral changes have been partly related to a dysregulation of dopaminergic activity in striatum (dorsal and ventral), the involvement of changes in the function of dopamine receptors is still a matter of controversy...
  78. ncbi request reprint Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression
    Patricia A Jiménez-Vasquez
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur Neuropsychopharmacol 17:298-308. 2007
    ..ECS decreased FSL immobility in the Porsolt swim test. These findings suggest that NPY is involved in depressive disorder and that antidepressant effects of ECS may in part be mediated through NPY...
  79. ncbi request reprint Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter
    A C Hansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neuroendocrinol 18:104-14. 2006
    ..The results could be confirmed with real-time PCR in the dentate gyrus. It appears as if the exon IV promoter is the major target for corticosterone-mediated transcriptional regulation of BDNF in the hippocampus...
  80. ncbi request reprint Detection of beta-endorphin in the cerebrospinal fluid after intrastriatal microinjection into the rat brain
    Malin Höistad
    Department of Neuroscience, Karolinska Institutet, Retziusv 8, 17177 Stockholm, Sweden
    Brain Res 1041:167-80. 2005
    ..This may be of relevance when interpreting studies based on intracerebral injections of peptides, and advances our knowledge regarding the migration of compounds within the brain...
  81. ncbi request reprint Quantitative dual-probe microdialysis: evaluation of [3H]mannitol diffusion in agar and rat striatum
    Malin Höistad
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 81:80-93. 2002
    ..Quantitative dual-probe microdialysis will be valuable in characterizing interstitial diffusion and the clearance processes underpinning volume transmission in the brain...
  82. ncbi request reprint Acute intermittent nicotine treatment produces a reduction in the total number of FGF-2 immunoreactive astroglial cells in the substantia nigra of the rat: a stereological analysis
    Fang Ling Liu
    Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Neurosci Lett 355:181-4. 2004
    ..The results may be explained by an inhibition of FGF-2 synthesis in a subpopulation of nigral astroglia by nicotinic receptor activation, favouring a reduction of astroglial neurotrophism in the substantia nigra...
  83. ncbi request reprint Determination of histamine in microdialysis samples from rat brain by microbore column liquid chromatography following intramolecular excimer-forming derivatization with pyrene-labeling reagent
    Takashi Yoshitake
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
    J Neurosci Methods 127:11-7. 2003
    ....
  84. pmc Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge
    Anita C Hansson
    Department of Neuroscience, Karolinska Institutet, 10401 Stockholm, Sweden
    Brain Res 1215:1-10. 2008
    ..8 h. The early reduction in c-fos family and junB transcripts may contribute to the GR/MR-dependent changes on hippocampal plasticity and may be dependent on rapid corticosteroid signaling...
  85. doi request reprint Wiring and volume transmission in rat amygdala. Implications for fear and anxiety
    Miguel Pérez de la Mora
    Department of Biophysics, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 253, Mexico, DF, 04510, Mexico
    Neurochem Res 33:1618-33. 2008
    ....
  86. ncbi request reprint Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders
    Sergi Ferre
    National Institute on Drug Abuse, IRP, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Parkinsonism Relat Disord 10:265-71. 2004
    ..Finding out the mechanisms involved in this dynamic regulation can have important implications for the treatment of basal ganglia disorders, schizophrenia and drug addiction...
  87. ncbi request reprint Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
    Meritxell Canals
    Department of Biochemistry and Molecular Biology, University of Barcelona, Martí y Franquès 1, E 08028 Barcelona, Spain
    J Biol Chem 278:46741-9. 2003
    ..In the most probable one, helix 5 and/or helix 6 and the N-terminal portion of I3 from D2R approached helix 4 and the C-terminal portion of the C-tail from the A2AR, respectively...
  88. ncbi request reprint Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration
    Marzena Karcz-Kubicha
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, NIDA, NIH, IRP, Department of Health and Human Services, Baltimore, MD, USA
    Neuropsychopharmacology 28:1281-91. 2003
    ....
  89. pmc Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, U SA
    Proc Natl Acad Sci U S A 99:11940-5. 2002
    ..The results suggest that a functional mGluR5/A2AR interaction is required to overcome the well-known strong tonic inhibitory effect of dopamine on striatal adenosine A2AR function...
  90. ncbi request reprint Reversible and irreversible components of [(3)H]-N-propylnorapomorphine interaction with rat striatal membranes
    Martin Lepiku
    Institute of Organic and Bioorganic Chemistry, University of Tartu, Jakobi Str 2, EE 51014, Tartu, Estonia
    Neurosci Lett 325:111-4. 2002
    ..The irreversible component was heterogeneous and seems to be related to oxidative degradation of the radioligand, as the rate of this process was substantially reduced by antioxidants like ascorbic acid and dithiothreitol...
  91. ncbi request reprint Adenosine receptor heteromers and their integrative role in striatal function
    Sergi Ferre
    National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
    ScientificWorldJournal 7:74-85. 2007
    ..For instance, the adenosine A2A-dopamine D2 receptor heteromers work as integrators of two different neurotransmitters in the striatal spine module...
  92. ncbi request reprint Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias
    Tiziana Antonelli
    Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    J Neurol Sci 248:16-22. 2006
    ..This may lead to stabilization of abnormal receptor mosaics (high order hetero-oligomers) leading to formation of abnormal motor programs contributing to dyskinesia development...
  93. ncbi request reprint Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine
    Małgorzata Filip
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Brain Res 1077:67-80. 2006
    ..The results suggest an antagonistic role of A2ARs in D2R-mediated cocaine actions based at least in part on the existence of A2A/D2 heteromeric receptor complexes...
  94. ncbi request reprint Subchronic haloperidol increases CB(1) receptor binding and G protein coupling in discrete regions of the basal ganglia
    Mikael Andersson
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    J Neurosci Res 82:264-72. 2005
    ..The results help to elucidate the underlying biochemical mechanism of CB(1) receptor supersensitivity after haloperidol treatment...
  95. ncbi request reprint Targeting adenosine A2A receptors in Parkinson's disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02129, USA
    Trends Neurosci 29:647-54. 2006
    ..Thus, we review here a prime example of translational neuroscience, through which antagonism of A2A receptors has now entered the arena of clinical trials with realistic prospects for advancing PD therapeutics...
  96. ncbi request reprint Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases
    Luigi Francesco Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Neuromolecular Med 7:61-78. 2005
    ....
  97. ncbi request reprint One century of progress in neuroscience founded on Golgi and Cajal's outstanding experimental and theoretical contributions
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Brain Res Rev 55:167-89. 2007
    ..In fact, it has been proposed that a network of fibrils enmeshes the entire CNS forming a global molecular network (GMN) superimposed on the cellular networks...
  98. ncbi request reprint Dimer-based model for heptaspanning membrane receptors
    Rafael Franco
    Department Bioquímica i Biologia Molecular, Universitat de Barcelona, A Diagonal, 645 08028 Barcelona, Spain
    Trends Biochem Sci 30:360-6. 2005
    ..This model can aid our understanding of the operation of heptaspanning receptors and receptor channels, and, potentially, be important for improving the treatment of cardiovascular, neurological and neuropsychyatric diseases...
  99. ncbi request reprint Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors
    Ain Uustare
    Institute of Organic and Bioorganic Chemistry, University of Tartu, Jakobi Str 2, EE 51014 Tartu, Estonia
    Life Sci 76:1513-26. 2005
    ....
  100. ncbi request reprint How receptor mosaics decode transmitter signals. Possible relevance of cooperativity
    Luigi F Agnati
    Department of Biomedical Sciences, 41100 Modena, Italy
    Trends Biochem Sci 30:188-93. 2005
    ..Thus, the binding of the ligand at one receptor alters the likelihood of the same ligand binding at the next site, in the case of RMs, formed by identical receptors and/or by iso-receptors (receptors that bind the same ligand)...
  101. ncbi request reprint On the molecular basis of the receptor mosaic hypothesis of the engram
    Luigi F Agnati
    Department of Biomedical Sciences, University of Modena, Modena, Italy
    Cell Mol Neurobiol 24:501-16. 2004
    ..Hence, this mechanism may play a role in learning processes where the input to a neuron is likely to remain constant for a while...