Johan Frostegard

Summary

Affiliation: Karolinska Hospital
Country: Sweden

Publications

  1. ncbi request reprint Circulating oxidized low-density lipoprotein is increased in hypertension
    Johan Frostegard
    Unit of Rheumatology, Department of Medicine, Centre for Molecular Medicine, Karolinska Hospital, 17671 Stockholm, Sweden
    Clin Sci (Lond) 105:615-20. 2003
  2. ncbi request reprint [Organ donation and utilitarianism: medical ethics more important than medical efficiency]
    Johan Frostegard
    Karolinska institutet och Karolinska Universitetssjukhuset
    Lakartidningen 101:229. 2004
  3. ncbi request reprint Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion
    J Frostegard
    Department of Rheumatology, Karolinska Hospital Stockholm, Sweden
    Am J Obstet Gynecol 189:568-73. 2003
  4. ncbi request reprint Autoimmunity, oxidized LDL and cardiovascular disease
    Johan Frostegard
    Department of Rheumatology and Centre for Molecular Medicine, Karolinska Hospital, Karolinska Institute, P O Box 30, 17176 Stockholm, Sweden
    Autoimmun Rev 1:233-7. 2002
  5. doi request reprint Longitudinal levels of apolipoproteins and antibodies against phosphorylcholine are independently associated with carotid artery atherosclerosis 5 years after rheumatoid arthritis onset--a prospective cohort study
    Sofia Ajeganova
    Department of Rheumatology, R92, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Rheumatology (Oxford) 50:1785-93. 2011
  6. pmc Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus
    Cristina Anania
    Department of Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Arthritis Res Ther 12:R214. 2010
  7. ncbi request reprint Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
    Johan Frostegard
    Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Arthritis Rheum 52:192-200. 2005
  8. ncbi request reprint Oxidised LDL modulates immune-activation by an IL-12 dependent mechanism
    Guo Zhong Fei
    Department of Medicine, Karolinska Hospital, Karolinska Institute, S 17176 Stockholm, Sweden
    Atherosclerosis 169:77-85. 2003
  9. doi request reprint Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
    Johan Frostegard
    Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Immunol 134:47-54. 2010
  10. doi request reprint Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden
    Roland Fiskesund
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Stroke 41:607-12. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Circulating oxidized low-density lipoprotein is increased in hypertension
    Johan Frostegard
    Unit of Rheumatology, Department of Medicine, Centre for Molecular Medicine, Karolinska Hospital, 17671 Stockholm, Sweden
    Clin Sci (Lond) 105:615-20. 2003
    ..In contrast, aOxLDL levels were unchanged and the role of aOxLDL may depend on disease stage and/or type...
  2. ncbi request reprint [Organ donation and utilitarianism: medical ethics more important than medical efficiency]
    Johan Frostegard
    Karolinska institutet och Karolinska Universitetssjukhuset
    Lakartidningen 101:229. 2004
  3. ncbi request reprint Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion
    J Frostegard
    Department of Rheumatology, Karolinska Hospital Stockholm, Sweden
    Am J Obstet Gynecol 189:568-73. 2003
    ..The purpose of this study was to determine the antibody levels against platelet-activating factor (PAF), PAF-like lipids lysophosphatidylcholine (LPC), cardiolipin (CL), and oxidized low-density lipoprotein (LDL) in recurrent abortion...
  4. ncbi request reprint Autoimmunity, oxidized LDL and cardiovascular disease
    Johan Frostegard
    Department of Rheumatology and Centre for Molecular Medicine, Karolinska Hospital, Karolinska Institute, P O Box 30, 17176 Stockholm, Sweden
    Autoimmun Rev 1:233-7. 2002
    ..If confirmed prospectively, non-traditional risk factors like OxLDL in the circulation, autoantibodies against OxLDL and phospholipids and inflammation could lead to new therapeutic strategies and insight into disease mechanisms...
  5. doi request reprint Longitudinal levels of apolipoproteins and antibodies against phosphorylcholine are independently associated with carotid artery atherosclerosis 5 years after rheumatoid arthritis onset--a prospective cohort study
    Sofia Ajeganova
    Department of Rheumatology, R92, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Rheumatology (Oxford) 50:1785-93. 2011
    ..Here, we determined the associations of apolipoproteins and immunoglobulin M (IgM) antibodies against phosphorylcholine (anti-PC) with carotid artery atherosclerosis in a prospective cohort of patients with early RA...
  6. pmc Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus
    Cristina Anania
    Department of Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Arthritis Res Ther 12:R214. 2010
    ..The objective herein was to study atherosclerosis in SLE in detail and in relation to traditional and non-traditional risk factors...
  7. ncbi request reprint Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
    Johan Frostegard
    Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Arthritis Rheum 52:192-200. 2005
    ..Autoantibodies to OxLDL are common in SLE and cross-react with anticardiolipin antibodies (aCL). We therefore hypothesized that lipid peroxidation is enhanced in patients with SLE in general...
  8. ncbi request reprint Oxidised LDL modulates immune-activation by an IL-12 dependent mechanism
    Guo Zhong Fei
    Department of Medicine, Karolinska Hospital, Karolinska Institute, S 17176 Stockholm, Sweden
    Atherosclerosis 169:77-85. 2003
    ..This suggests that a specific T cell epitope in oxLDL is not necessary for oxLDL-induced T cell activation...
  9. doi request reprint Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
    Johan Frostegard
    Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Immunol 134:47-54. 2010
    ..It is possible that anti-PC can be used as a novel diagnostic tool and therapy in atherosclerotic disease...
  10. doi request reprint Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden
    Roland Fiskesund
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Stroke 41:607-12. 2010
    ..Here we determine the association between anti-PC and the incidence of stroke...
  11. ncbi request reprint Decreased binding of annexin v to endothelial cells: a potential mechanism in atherothrombosis of patients with systemic lupus erythematosus
    Anna Cederholm
    Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:198-203. 2005
    ..The cause of the exceedingly high risk of atherothrombosis in systemic lupus erythematosus (SLE) is not clear but antiphospholipid antibodies (aPL) and potentially antithrombotic annexin V have been implicated...
  12. pmc Low level of physical activity in women with rheumatoid arthritis is associated with cardiovascular risk factors but not with body fat mass--a cross sectional study
    Ann Charlotte Elkan
    Department of Rheumatology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    BMC Musculoskelet Disord 12:13. 2011
    ....
  13. ncbi request reprint Annexin A5 as a novel player in prevention of atherothrombosis in SLE and in the general population
    Anna Cederholm
    Department of Medicine, Karolinska University Hospital, Huddinge, Sweden
    Ann N Y Acad Sci 1108:96-103. 2007
    ..It may be hypothesized that ANXA5 can be effective as a treatment to prevent plaque rupture and atherothrombosis not only in SLE, but also in a general population prone to CVD...
  14. doi request reprint Carotid atherosclerosis, disease measures, oxidized low-density lipoproteins, and atheroprotective natural antibodies for cardiovascular disease in early rheumatoid arthritis -- an inception cohort study
    Sofia Ajeganova
    Karolinska University Hospital, Stockholm, Sweden
    J Rheumatol 39:1146-54. 2012
    ..We studied whether carotid atherosclerosis, RA disease measures, or potential cardiovascular biomarkers influenced the incidence of CVD in an RA inception cohort...
  15. ncbi request reprint Annexin A5 multitasking: a potentially novel antiatherothrombotic agent?
    Anna Cederholm
    Center for Infectious Medicine and Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Huddinge and Karolinska Institutet, Stockholm, Sweden
    Drug News Perspect 20:321-6. 2007
    ..Antiatherothrombotic potential of ANXA5 deserves further attention and careful studies in order to determine its true physiological impact as well as its possible therapeutic applications...
  16. ncbi request reprint Effect of biological therapy on levels of atheroprotective antibodies against phosphorylcholine and apolipoproteins in rheumatoid arthritis - a one year study
    Sofia Ajeganova
    Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Exp Rheumatol 29:942-50. 2011
    ....
  17. pmc Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study
    Ann Charlotte Elkan
    Department of Rheumatology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Arthritis Res Ther 11:R37. 2009
    ..The aim of this study was to analyze the associations between diet, body composition, lipids and atheroprotective natural antibodies against phosphorylcholine (anti-PC) in patients with RA...
  18. ncbi request reprint Annexin A5 in cardiovascular disease and systemic lupus erythematosus
    Anna Cederholm
    Center for Infectious Medicine and Unit of Rheumatology, F59, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Immunobiology 210:761-8. 2005
    ..This review will focus on potential involvement of ANXA5 in pathogenesis of CVD, particularly caused by underlying atherosclerosis and atherothrombosis...
  19. ncbi request reprint Effects of low-dose prednisolone on endothelial function, atherosclerosis, and traditional risk factors for atherosclerosis in patients with rheumatoid arthritis--a randomized study
    Ingiäld Hafström
    Department of Rheumatology, Department of Cardiology, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Rheumatol 34:1810-6. 2007
    ..To determine the influence of low-dose prednisolone on atherosclerosis, endothelial function, and risk factors for atherosclerosis in patients with early rheumatoid arthritis (RA)...
  20. doi request reprint Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men
    Beatrice G Sjöberg
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 203:528-32. 2009
    ..Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC and incidence of cardiovascular disease (CVD)...
  21. ncbi request reprint Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction
    Kristina Edfeldt
    Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Eur Heart J 25:1447-53. 2004
    ..Recent studies imply that TLR4 polymorphisms might affect atherogenesis. In this study we investigated the impact of LPS-hypo-responsive TLR4 variants on the risk of myocardial infarction (MI)...
  22. ncbi request reprint Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction
    Anna M Bennet
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, P O Box 210, S 171 77, Stockholm, Sweden
    Atherosclerosis 171:359-67. 2003
    ..Interleukin-6 (IL-6) is a key pro-inflammatory and immune-stimulatory cytokine of presumed importance for CVD and the metabolic syndrome...
  23. ncbi request reprint Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus
    Elisabet Svenungsson
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 48:2533-40. 2003
    ....