Johan Frostegard

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Immunity, atherosclerosis and cardiovascular disease
    Johan Frostegard
    Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Nobels vag 13, Stockholm, Sweden
    BMC Med 11:117. 2013
  2. pmc Cardiovascular co-morbidity in patients with rheumatic diseases
    Johan Frostegard
    Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Karolinska Institutet, 171 77 Stockholm, Sweden
    Arthritis Res Ther 13:225. 2011
  3. doi request reprint Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
    Johan Frostegard
    Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Immunol 134:47-54. 2010
  4. doi request reprint Systemic lupus erythematosus and cardiovascular disease
    J Frostegard
    Department of Rheumatology, Karolinska University Hospital, Huddinge, Sweden
    Lupus 17:364-7. 2008
  5. pmc Low levels of IgM antibodies to oxidized cardiolipin increase and high levels decrease risk of cardiovascular disease among 60-year olds: a prospective study
    Jun Su
    Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Karolinska Institutet, 17177 Stockholm, Sweden
    BMC Cardiovasc Disord 13:1. 2013
  6. doi request reprint Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism
    Ulf de Faire
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Autoimmun 34:73-9. 2010
  7. doi request reprint Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden
    Hans Grönlund
    Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Eur J Cardiovasc Prev Rehabil 16:382-6. 2009
  8. doi request reprint Carotid atherosclerosis, disease measures, oxidized low-density lipoproteins, and atheroprotective natural antibodies for cardiovascular disease in early rheumatoid arthritis -- an inception cohort study
    Sofia Ajeganova
    Karolinska University Hospital, Stockholm, Sweden
    J Rheumatol 39:1146-54. 2012
  9. ncbi request reprint Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension
    Jun Su
    Center of Infectious Medicine and Unit of Rheumatology, F 59 Department of Medicine, Karolinska University Hospital, Huddinge, Stockholm 141 86, Sweden
    Atherosclerosis 188:160-6. 2006
  10. ncbi request reprint Platelet-activating factor-acetylhydrolase and other novel risk and protective factors for cardiovascular disease in systemic lupus erythematosus
    Anna Cederholm
    Karolinska University Hospital, Huddinge, Sweden
    Arthritis Rheum 50:2869-76. 2004

Detail Information

Publications57

  1. pmc Immunity, atherosclerosis and cardiovascular disease
    Johan Frostegard
    Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Nobels vag 13, Stockholm, Sweden
    BMC Med 11:117. 2013
    ..The potential causes of immune reactions and inflammation in atherosclerosis and how inflammation can be targeted therapeutically to provide novel treatments for CVD are reviewed...
  2. pmc Cardiovascular co-morbidity in patients with rheumatic diseases
    Johan Frostegard
    Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Karolinska Institutet, 171 77 Stockholm, Sweden
    Arthritis Res Ther 13:225. 2011
    ..Hopefully novel therapies can be developed that target the causes of the inflammation in atherosclerotic lesions both in rheumatic patients and in the general population...
  3. doi request reprint Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
    Johan Frostegard
    Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Immunol 134:47-54. 2010
    ..It is possible that anti-PC can be used as a novel diagnostic tool and therapy in atherosclerotic disease...
  4. doi request reprint Systemic lupus erythematosus and cardiovascular disease
    J Frostegard
    Department of Rheumatology, Karolinska University Hospital, Huddinge, Sweden
    Lupus 17:364-7. 2008
    ..Treatment of patients with SLE should include a close monitoring of traditional risk factors and also the above-mentioned non-traditional for CVD...
  5. pmc Low levels of IgM antibodies to oxidized cardiolipin increase and high levels decrease risk of cardiovascular disease among 60-year olds: a prospective study
    Jun Su
    Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Karolinska Institutet, 17177 Stockholm, Sweden
    BMC Cardiovasc Disord 13:1. 2013
    ..Antibodies against cardiolipin (aCL) are associated with increased risk of cardiovascular disease (CVD). We here determine the role of antibodies against oxidized CL (aOxCL)...
  6. doi request reprint Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism
    Ulf de Faire
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Autoimmun 34:73-9. 2010
    ..We here determine the role of IgM antibodies against phosphorylcholine (anti-PC) in prediction of cardiovascular disease (CVD) and on macrophage uptake of Oxidized LDL (OxLDL)...
  7. doi request reprint Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden
    Hans Grönlund
    Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden
    Eur J Cardiovasc Prev Rehabil 16:382-6. 2009
    ..IgM antibodies against PC (anti-PC) are present ubiquitously in the population as natural antibodies. We here determine the association between anti-PC and incidence of myocardial infarction (MI)...
  8. doi request reprint Carotid atherosclerosis, disease measures, oxidized low-density lipoproteins, and atheroprotective natural antibodies for cardiovascular disease in early rheumatoid arthritis -- an inception cohort study
    Sofia Ajeganova
    Karolinska University Hospital, Stockholm, Sweden
    J Rheumatol 39:1146-54. 2012
    ..We studied whether carotid atherosclerosis, RA disease measures, or potential cardiovascular biomarkers influenced the incidence of CVD in an RA inception cohort...
  9. ncbi request reprint Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension
    Jun Su
    Center of Infectious Medicine and Unit of Rheumatology, F 59 Department of Medicine, Karolinska University Hospital, Huddinge, Stockholm 141 86, Sweden
    Atherosclerosis 188:160-6. 2006
    ..To determine the importance of antibodies against phosphorylcholine (PC) and oxidized low density lipoprotein (OxLDL) for development of atherosclerosis...
  10. ncbi request reprint Platelet-activating factor-acetylhydrolase and other novel risk and protective factors for cardiovascular disease in systemic lupus erythematosus
    Anna Cederholm
    Karolinska University Hospital, Huddinge, Sweden
    Arthritis Rheum 50:2869-76. 2004
    ..It is therefore interesting that the risk of CVD is high in inflammatory diseases such as systemic lupus erythematosus (SLE). In this study, we investigated nontraditional risk factors for the development of CVD in patients with SLE...
  11. ncbi request reprint Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
    Johan Frostegard
    Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Arthritis Rheum 52:192-200. 2005
    ..Autoantibodies to OxLDL are common in SLE and cross-react with anticardiolipin antibodies (aCL). We therefore hypothesized that lipid peroxidation is enhanced in patients with SLE in general...
  12. ncbi request reprint Effect of biological therapy on levels of atheroprotective antibodies against phosphorylcholine and apolipoproteins in rheumatoid arthritis - a one year study
    Sofia Ajeganova
    Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Exp Rheumatol 29:942-50. 2011
    ....
  13. doi request reprint Longitudinal levels of apolipoproteins and antibodies against phosphorylcholine are independently associated with carotid artery atherosclerosis 5 years after rheumatoid arthritis onset--a prospective cohort study
    Sofia Ajeganova
    Department of Rheumatology, R92, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Rheumatology (Oxford) 50:1785-93. 2011
    ..Here, we determined the associations of apolipoproteins and immunoglobulin M (IgM) antibodies against phosphorylcholine (anti-PC) with carotid artery atherosclerosis in a prospective cohort of patients with early RA...
  14. pmc Increased prevalence of vulnerable atherosclerotic plaques and low levels of natural IgM antibodies against phosphorylcholine in patients with systemic lupus erythematosus
    Cristina Anania
    Department of Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Arthritis Res Ther 12:R214. 2010
    ..The objective herein was to study atherosclerosis in SLE in detail and in relation to traditional and non-traditional risk factors...
  15. doi request reprint Genetic and environmental regulation of inflammatory CVD biomarkers Lp-PLA2 and IgM anti-PC
    Iffat Rahman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 17177 Stockholm, Sweden
    Atherosclerosis 218:117-22. 2011
    ..Their relationships and possible co-regulation with other established CVD biomarkers are also examined...
  16. ncbi request reprint Low levels of antibodies against oxidized but not nonoxidized cardiolipin and phosphatidylserine are associated with atherosclerotic plaques in systemic lupus erythematosus
    Jun Su
    From the Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Karolinska Institutet, Stockholm Department of Laboratory Medicine, Division of Clinical Physiology, and Department of Rheumatology, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Rheumatol 40:1856-64. 2013
    ..We here study antibodies against oxidized cardiolipin (anti-OxCL) and phosphatidylserine (anti-OxPS) in SLE and in relation to atherosclerosis measures...
  17. doi request reprint Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden
    Roland Fiskesund
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Stroke 41:607-12. 2010
    ..Here we determine the association between anti-PC and the incidence of stroke...
  18. ncbi request reprint Decreased binding of annexin v to endothelial cells: a potential mechanism in atherothrombosis of patients with systemic lupus erythematosus
    Anna Cederholm
    Department of Medicine, Center for Infectious Medicine, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:198-203. 2005
    ..The cause of the exceedingly high risk of atherothrombosis in systemic lupus erythematosus (SLE) is not clear but antiphospholipid antibodies (aPL) and potentially antithrombotic annexin V have been implicated...
  19. doi request reprint Low levels of IgM antibodies against phosphorylcholine-A potential risk marker for ischemic stroke in men
    Beatrice G Sjöberg
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 203:528-32. 2009
    ..Natural antibodies specific for phosphorylcholine (anti-PC) have been implicated as protective factors in atherosclerosis. We herein determined the relationship between IgM anti-PC and incidence of cardiovascular disease (CVD)...
  20. doi request reprint Low levels of antibodies against phosphorylcholine in Alzheimer's disease
    Ulrika K Eriksson
    Deparment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden
    J Alzheimers Dis 21:577-84. 2010
    ..Further attention is merited to elucidate the role of anti-PC in AD development and the usefulness of anti-PC as a part of risk prediction, prognosis, diagnosis, or treatment...
  21. ncbi request reprint Risk factors for cardiovascular disease in systemic lupus erythematosus
    E Svenungsson
    Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Circulation 104:1887-93. 2001
    ..We determined the prevalence of traditional and nontraditional risk factors for CVD in SLE patients with and without CVD compared with controls...
  22. ncbi request reprint Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine
    Helena Domeij
    Department of Dental Medicine, Division of Pediatric Dentistry, Karolinska Institutet, Stockholm, Sweden Institute of Environmental Medicine, Unit of Immunology and Chronic Disease, Karolinska Institutet, Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 106:72-8. 2013
    ..Annexin A5 (ANXA5) is an antithrombotic and atheroprotective plasma protein. Here, we demonstrate novel pro-inflammatory and atherogenic properties of LPC, and inhibitory effects of ANXA5...
  23. ncbi request reprint Oxidised LDL modulates immune-activation by an IL-12 dependent mechanism
    Guo Zhong Fei
    Department of Medicine, Karolinska Hospital, Karolinska Institute, S 17176 Stockholm, Sweden
    Atherosclerosis 169:77-85. 2003
    ..This suggests that a specific T cell epitope in oxLDL is not necessary for oxLDL-induced T cell activation...
  24. ncbi request reprint Risk factors for cardiovascular disease in patients with periodontitis
    Kåre Buhlin
    Department of Periodontology, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden
    Eur Heart J 24:2099-107. 2003
    ..This study compared plasma levels of established risk markers for atherosclerosis and indices of inflammation in 50 patients with severe periodontitis to those in 46 healthy cases...
  25. doi request reprint Natural antibodies against phosphorylcholine in cardiovascular disease
    Ulf de Faire
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Ann N Y Acad Sci 1173:292-300. 2009
    ..Animal experiments indicate that both active immunization with PC and passive immunization with anti-PC ameliorate atherosclerosis development. The possibility that anti-PC could be used therapeutically in humans deserves further study...
  26. ncbi request reprint Low levels of IgM antibodies against phosphorylcholine-A increase mortality risk in patients undergoing haemodialysis
    Juan Jesus Carrero
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nephrol Dial Transplant 24:3454-60. 2009
    ..We here study the association between IgM antibodies against phosphorylcholine-A (anti-PC) and risk of death in patients undergoing haemodialysis (HD)...
  27. ncbi request reprint Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction
    Kristina Edfeldt
    Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Eur Heart J 25:1447-53. 2004
    ..Recent studies imply that TLR4 polymorphisms might affect atherogenesis. In this study we investigated the impact of LPS-hypo-responsive TLR4 variants on the risk of myocardial infarction (MI)...
  28. doi request reprint IgM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes
    Kenneth Caidahl
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Int J Cardiol 167:464-9. 2013
    ..We sought to determine whether low levels of immunoglobulin-M (IgM) autoantibodies against PC add prognostic information in acute coronary syndromes (ACS)...
  29. ncbi request reprint The A-1087IL-10 allele is associated with cardiovascular disease in SLE
    Guo Zhong Fei
    Rheumatology Unit, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 177:409-14. 2004
    ..Furthermore, the IL-10 AA genotype is associated with reduced ratio of atheroprotective to atherogenic cytokines in SLE patients with CVD...
  30. pmc Low level of physical activity in women with rheumatoid arthritis is associated with cardiovascular risk factors but not with body fat mass--a cross sectional study
    Ann Charlotte Elkan
    Department of Rheumatology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    BMC Musculoskelet Disord 12:13. 2011
    ....
  31. ncbi request reprint Annexin A5 as a novel player in prevention of atherothrombosis in SLE and in the general population
    Anna Cederholm
    Department of Medicine, Karolinska University Hospital, Huddinge, Sweden
    Ann N Y Acad Sci 1108:96-103. 2007
    ..It may be hypothesized that ANXA5 can be effective as a treatment to prevent plaque rupture and atherothrombosis not only in SLE, but also in a general population prone to CVD...
  32. doi request reprint Anti-apoA-1 IgG and oxidized LDL are raised in rheumatoid arthritis (RA): potential associations with cardiovascular disease and RA disease activity
    N Vuilleumier
    Department of Rheumatology, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Scand J Rheumatol 39:447-53. 2010
    ....
  33. ncbi request reprint Naturally occurring human phosphorylcholine antibodies are predominantly products of affinity-matured B cells in the adult
    Roland Fiskesund
    Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Immunol 192:4551-9. 2014
    ..These results provide novel insights into the cellular and molecular ontogeny of atheroprotective PC Abs, thereby offering new opportunities for Ab-based therapeutic interventions. ..
  34. pmc Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study
    Ann Charlotte Elkan
    Rheumatology Unit, Karolinska Institutet at Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
    Arthritis Res Ther 10:R34. 2008
    ....
  35. ncbi request reprint Annexin A5 multitasking: a potentially novel antiatherothrombotic agent?
    Anna Cederholm
    Center for Infectious Medicine and Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Huddinge and Karolinska Institutet, Stockholm, Sweden
    Drug News Perspect 20:321-6. 2007
    ..Antiatherothrombotic potential of ANXA5 deserves further attention and careful studies in order to determine its true physiological impact as well as its possible therapeutic applications...
  36. ncbi request reprint Annexin A5 in cardiovascular disease and systemic lupus erythematosus
    Anna Cederholm
    Center for Infectious Medicine and Unit of Rheumatology, F59, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Immunobiology 210:761-8. 2005
    ..This review will focus on potential involvement of ANXA5 in pathogenesis of CVD, particularly caused by underlying atherosclerosis and atherothrombosis...
  37. doi request reprint Endothelial function and markers of endothelial activation in relation to cardiovascular disease in systemic lupus erythematosus
    E Svenungsson
    Department of Medicine, Unit of Rheumatology, The Karolinska Institute, Karolinska University Hospital, Solna
    Scand J Rheumatol 37:352-9. 2008
    ..Our objective was to evaluate endothelial function and markers of endothelial activation in relation to CVD in SLE...
  38. doi request reprint Natural antibodies against phosphorylcholine as potential protective factors in SLE
    J Su
    Rheumatology Unit, Karolinska University Hospital, Huddinge, Karolinska Institutet corrected Stockholm, Sweden
    Rheumatology (Oxford) 47:1144-50. 2008
    ..We have recently reported that natural antibodies against phosphorylcholine (anti-PC) have atheroprotective properties. Here we compare anti-PC with other autoantibodies in SLE patients with and without cardiovascular disease (CVD)...
  39. doi request reprint Dyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular disease
    X Hua
    Department of Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Scand J Rheumatol 38:184-9. 2009
    ..This study focused on lipoprotein composition and properties in systemic lupus erythematosus (SLE)...
  40. ncbi request reprint Association of TNF-alpha serum levels and TNFA promoter polymorphisms with risk of myocardial infarction
    A M Bennet
    Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Box 210, S 171 77 Stockholm, Sweden
    Atherosclerosis 187:408-14. 2006
    ..Obese subjects with elevated TNF-a levels, and carriers of polymorphisms in or near TNFA are particularly susceptible to the hazards of smoking, results which may have implications for cardiovascular preventive measures...
  41. ncbi request reprint Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction
    Anna M Bennet
    Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, P O Box 210, S 171 77, Stockholm, Sweden
    Atherosclerosis 171:359-67. 2003
    ..Interleukin-6 (IL-6) is a key pro-inflammatory and immune-stimulatory cytokine of presumed importance for CVD and the metabolic syndrome...
  42. pmc Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study
    Ann Charlotte Elkan
    Department of Rheumatology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Arthritis Res Ther 11:R37. 2009
    ..The aim of this study was to analyze the associations between diet, body composition, lipids and atheroprotective natural antibodies against phosphorylcholine (anti-PC) in patients with RA...
  43. ncbi request reprint Effects of low-dose prednisolone on endothelial function, atherosclerosis, and traditional risk factors for atherosclerosis in patients with rheumatoid arthritis--a randomized study
    Ingiäld Hafström
    Department of Rheumatology, Department of Cardiology, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Rheumatol 34:1810-6. 2007
    ..To determine the influence of low-dose prednisolone on atherosclerosis, endothelial function, and risk factors for atherosclerosis in patients with early rheumatoid arthritis (RA)...
  44. ncbi request reprint SLE, atherosclerosis and cardiovascular disease
    J Frostegard
    Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 257:485-95. 2005
    ..Hopefully novel therapeutic principles will be developed that target the causes of the inflammation and immune reactions present in atherosclerotic lesions...
  45. doi request reprint Effects of anti-cardiolipin antibodies and IVIg on annexin A5 binding to endothelial cells: implications for cardiovascular disease
    A G Frostegård
    Department of Medicine, Karolinska University Hospital, Huddinge and Karolinska Institutet, Stockholm, Sweden
    Scand J Rheumatol 39:77-83. 2010
    ..APS may be primary but is also common in patients with systemic lupus erythematosus (SLE). The anti-coagulant protein annexin A5 (ANXA5) is implicated in CVD by interfering with phospholipids and aPL...
  46. doi request reprint Disease factors in early rheumatoid arthritis are associated with differential risks for cardiovascular events and mortality depending on age at onset: a 10-year observational cohort study
    Sofia Ajeganova
    From the Unit of Rheumatology, Department of Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm R and D Centre, Spenshult Hospital for Rheumatic Diseases, Oskarström and Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institute, Stockholm Unit of Rheumatology, Department of Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Rheumatol 40:1958-66. 2013
    ..To investigate, within the first 2 years of diagnosis with rheumatoid arthritis (RA), associations between disease-related measures and cardiovascular disease (CVD) and mortality in patients with RA onset before and after 65 years of age...
  47. ncbi request reprint Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism
    J Frostegard
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 17:963-8. 1997
    ..Our findings suggest that the PAF receptor plays an important role in the inflammatory component of atherosclerosis...
  48. ncbi request reprint Cardiac valvular abnormalities are frequent in systemic lupus erythematosus patients with manifest arterial disease
    K Jensen-Urstad
    Cardiovascular Laboratory, Department of Medicine, Karolinska Institute at Karolinska Hospital, Stockholm, Sweden
    Lupus 11:744-52. 2002
    ..In conclusion, valvular abnormalities are strongly associated with CVD in SLE. Raised levels of homocysteine and triglycerides characterize patients with cardiac valve abnormalities...
  49. ncbi request reprint Treatment with combined oral contraceptives induces a rise in serum C-reactive protein in the absence of a general inflammatory response
    M van Rooijen
    Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Thromb Haemost 4:77-82. 2006
    ..C-reactive protein (CRP) is the strongest independent predictor of myocardial infarction and stroke in women. Recent studies have indicated that CRP levels are raised during use of combined oral contraceptives (COCs)...
  50. ncbi request reprint Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion
    J Frostegard
    Department of Rheumatology, Karolinska Hospital Stockholm, Sweden
    Am J Obstet Gynecol 189:568-73. 2003
    ..The purpose of this study was to determine the antibody levels against platelet-activating factor (PAF), PAF-like lipids lysophosphatidylcholine (LPC), cardiolipin (CL), and oxidized low-density lipoprotein (LDL) in recurrent abortion...
  51. ncbi request reprint Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus
    Elisabet Svenungsson
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 48:2533-40. 2003
    ....
  52. ncbi request reprint Circulating oxidized low-density lipoprotein is increased in hypertension
    Johan Frostegard
    Unit of Rheumatology, Department of Medicine, Centre for Molecular Medicine, Karolinska Hospital, 17671 Stockholm, Sweden
    Clin Sci (Lond) 105:615-20. 2003
    ..In contrast, aOxLDL levels were unchanged and the role of aOxLDL may depend on disease stage and/or type...
  53. ncbi request reprint Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein
    J Frostegard
    Department of Medicine, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 121:93-103. 1996
    ..It is thus possible that the chronic inflammatory process characterizing atherosclerosis is perpetuated by autoreactive T cells, which recognize hsp60 expressed by monocytes, induced by oxidized LDL...
  54. ncbi request reprint Association of serum antibodies to heat-shock protein 65 with borderline hypertension
    J Frostegard
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Hypertension 29:40-4. 1997
    ..041). In conclusion, we demonstrate that serum antibody titers to HSP65 are enhanced in individuals with borderline hypertension, which may indicate an ongoing immune reaction in the artery wall...
  55. ncbi request reprint Induction of early atherosclerosis in CBA/J mice by combination of Trypanosoma cruzi infection and a high cholesterol diet
    D Sunnemark
    Microbiology and Tumorbiology Center MTC, Karolinska Institutet, Stockholm, Sweden
    Atherosclerosis 153:273-82. 2000
    ..Finally, we suggest that CBA/J mice infected with T. cruzi parasites and given a fatty diet could serve as a useful experimental model in the continued analysis of factors contributing to the induction of atherosclerosis...