Jenny Frånberg

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes
    Jenny Frånberg
    Karolinska Institutet Alzheimer s Disease Research Center KI ADRC, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 5:e9772. 2010
  2. doi request reprint Affinity pulldown of γ-secretase and associated proteins from human and rat brain
    Yasuhiro Teranishi
    The Karolinska Institutet KI Dainippon Sumitomo Pharma Alzheimer Center KASPAC, KI Alzheimer s Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Huddinge, Sweden
    J Cell Mol Med 14:2675-86. 2010
  3. doi request reprint Active gamma-secretase is localized to detergent-resistant membranes in human brain
    Ji Yeun Hur
    Karolinska Institutet KI Dainippon Sumitomo Pharma Alzheimer Center, KI Alzheimer s Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Huddinge, Sweden
    FEBS J 275:1174-87. 2008
  4. pmc The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing
    Johanna Wanngren
    Department of Neurobiology, Caring Sciences and Society, KI Alzheimer Disease Research Center, Karolinska Institutet, Novum, SE 141 86 Stockholm, Sweden
    J Biol Chem 285:8527-36. 2010
  5. pmc Synaptic and endosomal localization of active gamma-secretase in rat brain
    Susanne Frykman
    Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, Novum, Huddinge, Sweden
    PLoS ONE 5:e8948. 2010
  6. doi request reprint Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain
    Jenny Frånberg
    Karolinska Institutet Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Novum, SE 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 404:564-8. 2011
  7. ncbi request reprint Rat brain gamma-secretase activity is highly influenced by detergents
    Jenny Frånberg
    Karolinska Institutet Alzheimer s Disease Research Center KI ADRC, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Novum Plan 5, SE 141 57 Huddinge, Sweden
    Biochemistry 46:7647-54. 2007
  8. doi request reprint Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains
    Hedvig Welander
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Dainippon Sumitomo Pharma Alzheimer Center, Novum, Huddinge, Sweden
    J Neurochem 110:697-706. 2009

Collaborators

Detail Information

Publications8

  1. pmc gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes
    Jenny Frånberg
    Karolinska Institutet Alzheimer s Disease Research Center KI ADRC, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 5:e9772. 2010
    ..Prior to gamma-secretase cleavage, substrates are ectodomain shedded, producing membrane bound C-terminal fragments (CTFs)...
  2. doi request reprint Affinity pulldown of γ-secretase and associated proteins from human and rat brain
    Yasuhiro Teranishi
    The Karolinska Institutet KI Dainippon Sumitomo Pharma Alzheimer Center KASPAC, KI Alzheimer s Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Huddinge, Sweden
    J Cell Mol Med 14:2675-86. 2010
    ..Interestingly, TMP21 and the PS associated protein syntaxin1 were associated to γ-secretase in rat brain. We suggest that the present method can be used for further studies on the composition of the γ-secretase complex...
  3. doi request reprint Active gamma-secretase is localized to detergent-resistant membranes in human brain
    Ji Yeun Hur
    Karolinska Institutet KI Dainippon Sumitomo Pharma Alzheimer Center, KI Alzheimer s Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, Huddinge, Sweden
    FEBS J 275:1174-87. 2008
    ..Finally, confocal microscopy showed co-localization of gamma-secretase components and a lipid raft marker in thin sections of human brain. We conclude that the active gamma-secretase complex is localized to lipid rafts in human brain...
  4. pmc The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing
    Johanna Wanngren
    Department of Neurobiology, Caring Sciences and Society, KI Alzheimer Disease Research Center, Karolinska Institutet, Novum, SE 141 86 Stockholm, Sweden
    J Biol Chem 285:8527-36. 2010
    ....
  5. pmc Synaptic and endosomal localization of active gamma-secretase in rat brain
    Susanne Frykman
    Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Center, Novum, Huddinge, Sweden
    PLoS ONE 5:e8948. 2010
    ..However, no thorough studies have been performed to show the subcellular localization of the active gamma-secretase in the affected organ of AD, namely the brain...
  6. doi request reprint Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain
    Jenny Frånberg
    Karolinska Institutet Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Novum, SE 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 404:564-8. 2011
    ..In summary, this study shows that the contribution of PS2 on γ-secretase activity is of less importance, explaining the mild phenotype of PS2-deficient mice...
  7. ncbi request reprint Rat brain gamma-secretase activity is highly influenced by detergents
    Jenny Frånberg
    Karolinska Institutet Alzheimer s Disease Research Center KI ADRC, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Novum Plan 5, SE 141 57 Huddinge, Sweden
    Biochemistry 46:7647-54. 2007
    ..4% CHAPSO. Therefore, using 1% CHAPSO for solubilization and subsequently diluting the sample to 0.4% is an appropriate procedure for obtaining a soluble, highly active gamma-secretase from rat brain...
  8. doi request reprint Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains
    Hedvig Welander
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Dainippon Sumitomo Pharma Alzheimer Center, Novum, Huddinge, Sweden
    J Neurochem 110:697-706. 2009
    ..Immunohistochemistry was performed and was found to be in line with our findings. Abeta1-43 polymerizes rapidly and we suggest that this variant may be of importance for AD...