B B Fredholm

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine
    Maria Lindskog
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Nature 418:774-8. 2002
  2. ncbi request reprint Increased nociceptive response in mice lacking the adenosine A1 receptor
    Wei ping Wu
    Department of Neurotec, Division of Clinical Neurophysiology, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Pain 113:395-404. 2005
  3. ncbi request reprint Influence of the adenosine A1 receptor on blood pressure regulation and renin release
    Russell D Brown
    Dept of Medical Cell Biology, Division of Integrative Physiology, Uppsala Univ, S 751 23 Uppsala, Sweden
    Am J Physiol Regul Integr Comp Physiol 290:R1324-9. 2006
  4. doi request reprint Adenosine--a physiological or pathophysiological agent?
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 17177, Stockholm, Sweden
    J Mol Med (Berl) 92:201-6. 2014
  5. pmc Adenosine receptors as drug targets
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Cell Res 316:1284-8. 2010
  6. ncbi request reprint Notes on the history of caffeine use
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institute, Nanna Svartz vag 2, 171 77, Stockholm, Sweden
    Handb Exp Pharmacol 200:1-9. 2011
  7. pmc Fuels for transportation
    Bertil B Fredholm
    Karolinska Institutet, Stockholm, Sweden
    Ambio 39:31-5. 2010
  8. ncbi request reprint Aspects of the general biology of adenosine A2A signaling
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Prog Neurobiol 83:263-76. 2007
  9. ncbi request reprint G-protein-coupled receptors: an update
    B B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:3-7. 2007
  10. pmc International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Pharmacol Rev 63:1-34. 2011

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine
    Maria Lindskog
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Nature 418:774-8. 2002
    ..Together, these studies demonstrate the involvement of DARPP-32 and its phosphorylation/dephosphorylation in the stimulant action of caffeine...
  2. ncbi request reprint Increased nociceptive response in mice lacking the adenosine A1 receptor
    Wei ping Wu
    Department of Neurotec, Division of Clinical Neurophysiology, Karolinska Institutet, Karolinska University Hospital Huddinge, S 141 86 Stockholm, Sweden
    Pain 113:395-404. 2005
    ..A1 receptors also contribute to the antinociceptive effect of spinal morphine. Selective A1 receptor agonists may be tested clinically as analgesics, particularly under conditions of neuropathic pain...
  3. ncbi request reprint Influence of the adenosine A1 receptor on blood pressure regulation and renin release
    Russell D Brown
    Dept of Medical Cell Biology, Division of Integrative Physiology, Uppsala Univ, S 751 23 Uppsala, Sweden
    Am J Physiol Regul Integr Comp Physiol 290:R1324-9. 2006
    ..Our results confirm that adenosine, acting through the adenosine A1 receptor, plays an important role in regulating blood pressure, renin release, and sodium excretion...
  4. doi request reprint Adenosine--a physiological or pathophysiological agent?
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 17177, Stockholm, Sweden
    J Mol Med (Berl) 92:201-6. 2014
    ..The fact that drugs that target adenosine receptors in disease will also hit the physiological processes will make drug development more tricky. ..
  5. pmc Adenosine receptors as drug targets
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Cell Res 316:1284-8. 2010
    ..These pathophysiological roles of adenosine also offer some potential drug targets, but the fact that adenosine receptors are involved in so many processes does not simplify drug development...
  6. ncbi request reprint Notes on the history of caffeine use
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institute, Nanna Svartz vag 2, 171 77, Stockholm, Sweden
    Handb Exp Pharmacol 200:1-9. 2011
    ..It is interesting to note that before these drinks were commonly used on a daily basis they were used for medicinal purposes, indicating that their pharmacological actions had long been noted...
  7. pmc Fuels for transportation
    Bertil B Fredholm
    Karolinska Institutet, Stockholm, Sweden
    Ambio 39:31-5. 2010
    ..A key feature is the introduction of electric cars. This raises the third issue covered in this article: namely, how battery technology is going to meet the increasing needs posed by the transport sector...
  8. ncbi request reprint Aspects of the general biology of adenosine A2A signaling
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Prog Neurobiol 83:263-76. 2007
    ..The contributors to this part of the meeting have summarized some of the key questions below...
  9. ncbi request reprint G-protein-coupled receptors: an update
    B B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:3-7. 2007
    ..Thus there are many challenges for the basic scientist and the drug industry...
  10. pmc International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Pharmacol Rev 63:1-34. 2011
    ..There are also developments hinting at the usefulness of allosteric modulators. Many drugs targeting adenosine receptors are in clinical trials, but the established therapeutic use is still very limited...
  11. ncbi request reprint Adenosine, an endogenous distress signal, modulates tissue damage and repair
    B B Fredholm
    Department of Physiology and Pharmacology, Karolinska Insitutet, Stockholm, Sweden
    Cell Death Differ 14:1315-23. 2007
    ..This review will briefly summarize what is known and what is not in this regard. It is argued that drugs targeting adenosine receptors might be useful adjuncts in many therapeutic approaches...
  12. doi request reprint Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice
    L Li
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Neuroscience 170:923-8. 2010
    ..The results indicate that activation of peripheral adenosine A(2A) receptors during inflammation is associated with mechanical hyperalgesia, and that this effect is more prominent in females than in males...
  13. pmc Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranes
    S Ferre
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Proc Natl Acad Sci U S A 88:7238-41. 1991
    ..This A2a-D2 interaction may underlie the neuroleptic-like actions of adenosine agonists and the enhancing effects of adenosine antagonists, such as caffeine, on locomotor activity...
  14. ncbi request reprint Dopamine D(1) receptor-induced gene transcription is modulated by DARPP-32
    P Svenningsson
    Departments of Physiology and Pharmacology Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 75:248-57. 2000
    ..These results demonstrate an important involvement of DARPP-32 in dopamine receptor-mediated regulation of gene expression both in striatal neurons, which are enriched in DARPP-32, and in pallidal neurons, which do not contain DARPP-32...
  15. ncbi request reprint Alpha 2-adrenoceptor agonist-mediated inhibition of [3H]noradrenaline release from rat hippocampus is reduced by 4-aminopyridine, but that caused by an adenosine analogue or omega-conotoxin is not
    P S Hu
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol Scand 136:347-53. 1989
    ..Furthermore, the results indicate that pre-synaptic A1-receptors on hippocampal NA neurons do not primarily regulate 4-AP-dependent potassium channels, but they might act directly on a Ca2+ conductance...
  16. ncbi request reprint Adaptive changes in adenosine receptors following long-term treatment with the adenosine receptor agonist R-phenylisopropyl adenosine
    M Fernandez
    Department of Physiology and Pharmacology, Divison of Molecular Neuropharmacology, Karolinska Institutet, Stockholm, Sweden
    Life Sci 58:769-76. 1996
    ....
  17. ncbi request reprint Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2
    G Schulte
    Karolinska Institutet, Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Stockholm, Sweden
    Mol Pharmacol 58:477-82. 2000
    ..In conclusion, this study shows that all the human adenosine receptors transfected into CHO cells are able to activate ERK1/2 at physiologically relevant concentrations of the endogenous agonist...
  18. ncbi request reprint Caffeine mimics the effect of a dopamine D2/3 receptor agonist on the expression of immediate early genes in globus pallidus
    P Svenningsson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Neuropharmacology 36:1309-17. 1997
    ..The fact that pallidal c-fos mRNA expression decreased upon repeated administration of caffeine may be related to the development of tolerance to locomotion stimulation that occurs following chronic caffeine ingestion...
  19. ncbi request reprint Evidence that prejunctional adenosine receptors regulating acetylcholine release from rat hippocampal slices are linked to an N-ethylmaleimide-sensitive G-protein, but not to adenylate cyclase or dihydropyridine-sensitive Ca2+-channels
    M Dunér-Engström
    Department of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Acta Physiol Scand 134:119-26. 1988
    ..Our results suggest that the presynaptic inhibitory effects of A1-receptor agonists on [3H]ACh release are exerted via a nucleotide-binding protein that can be inhibited by NEM.(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi request reprint GTP differentially affects antagonist radioligand binding to adenosine A(1) and A(2A) receptors in human brain
    B Kull
    Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Neuropharmacology 39:2374-80. 2000
    ..However, the relative abundance of the receptors differs between species, and this may be related to the differences observed in the potency of the endogenous agonist...
  21. ncbi request reprint Signaling via A2A adenosine receptor in four PC12 cell clones
    G Arslan
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 359:28-32. 1999
    ..A large difference in receptor number resulted in differences in potency of an agonist...
  22. ncbi request reprint Propentofylline and a hydroxy metabolite augment A2-receptor mediated cyclic AMP accumulation and attenuate A1-receptor mediated inhibition of acetylcholine release in the rat hippocampus
    B B Fredholm
    Department of Pharmacology, Karolinska Institut, Stockholm, Sweden
    Pharmacol Toxicol 65:347-51. 1989
    ..This selectivity in action can only partly be explained by receptor subtype selectivity, and effects at sites other than the adenosine receptor are of major importance...
  23. ncbi request reprint Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors
    B B Fredholm
    Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 380:197-202. 1999
    ..Thus, only a few of the antagonists show such high selectivity that it is not offset by differences in drug distribution and levels of receptor subtype expression...
  24. ncbi request reprint Differences in the effect of chronic and acute caffeine on self-administration of cocaine in mice
    A Kuzmin
    Pavlov Medical University, St Petersburg, Russia Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Eur J Neurosci 12:3026-32. 2000
    ....
  25. pmc Adenosine A(3) receptors regulate heart rate, motor activity and body temperature
    J N Yang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 199:221-30. 2010
    ..To examine the phenotype of mice that lack the adenosine A(3) receptor (A(3)R)...
  26. doi request reprint Adenosine A(1) receptors and vascular reactivity
    Y Wang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 199:211-20. 2010
    ..Blood pressure is higher in A(1) receptor knock-out (A(1)R-/-) mice than in wild type litter mates (A(1)R+/+) and we have examined if this could be related to altered vascular functions...
  27. ncbi request reprint Stimulatory and inhibitory effects of adenosine A(2A) receptors on nerve growth factor-induced phosphorylation of extracellular regulated kinases 1/2 in PC12 cells
    G Arslan
    Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institute, S 171 77, Stockholm, Sweden
    Neurosci Lett 292:183-6. 2000
    ..These results may be explained by the fact that NGF action is mediated via different pathways at early and late time points...
  28. ncbi request reprint Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors
    J N Yang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:63-75. 2007
    ..To examine cardiac function, body temperature and locomotor behaviour in the awake adenosine A(1) receptor knock out mouse of both sexes...
  29. ncbi request reprint Interaction of dihydropyridine calcium channel agonists and antagonists with adenosine receptors
    P S Hu
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Pharmacol Toxicol 61:121-5. 1987
    ..The potency of the compounds for this effect is much lower than their potency as calcium channel agonists or antagonists. The results may therefore be of more experimental than clinical significance...
  30. pmc Perinatal caffeine, acting on maternal adenosine A(1) receptors, causes long-lasting behavioral changes in mouse offspring
    Olga Björklund
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e3977. 2008
    ..There are lingering concerns about caffeine consumption during pregnancy or the early postnatal period, partly because there may be long-lasting behavioral changes after caffeine exposure early in life...
  31. ncbi request reprint Regional differences in the ability of caffeine to affect haloperidol-induced striatal c-fos mRNA expression in the rat
    P Svenningsson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Neuropharmacology 37:331-7. 1998
    ..It is suggested that this could depend upon a different action of caffeine on the cortical inputs to these two parts of the striatum...
  32. ncbi request reprint Adenosine A(1) receptor agonism in the immature rat brain and heart
    U Aden
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Eur J Pharmacol 426:185-92. 2001
    ..Thus, the lack of a neuroprotective effect of ADAC may be explained by the fact that adenosine A(1) receptors are not part of a functional unit in the 7-day-old rat brain...
  33. ncbi request reprint Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors
    W P Wu
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Huddinge University Hospital, Karolinska Institutet, S 141 86 Huddinge, Sweden
    Neuroscience 114:523-7. 2002
    ..However, no evidence for a role of A(3)AR in nociception and the antinociceptive effect of R-PIA was found...
  34. ncbi request reprint Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes in the antilipolytic actions of PGE2 and nicotinic acid
    S M Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 190:87-96. 2007
    ..We examined whether compensatory changes after adenosine A(1) receptor knockout [A(1)R (-/-)] eliminate the antilipolytic actions mediated by this receptor...
  35. ncbi request reprint Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum
    P Svenningsson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 9:2135-41. 1997
    ..The findings illustrate the utility of blockade of gene expression with antisense oligonucleotides for in vivo studies of drug actions...
  36. ncbi request reprint Down-regulation of adenosine A2A receptors upon NGF-induced differentiation of PC12 cells
    G Arslan
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Neuropharmacology 36:1319-26. 1997
    ..This might be a way for PC12 cells to counteract an inhibitory effect of A2A receptor activation on some aspects of neurotrophin signalling...
  37. ncbi request reprint Glucocorticoid receptor activation leads to up-regulation of adenosine A1 receptors and down-regulation of adenosine A2 responses in DDT1 MF-2 smooth muscle cells
    P Gerwins
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Mol Pharmacol 40:149-55. 1991
    ..In summary, we have shown that A1 and A2 receptors on the same cell are differentially regulated by glucocorticoids and that this has functional importance in the regulation of cAMP accumulation...
  38. ncbi request reprint Genetic evidence that cocaine and caffeine stimulate locomotion in mice via different mechanisms
    A Kuzmin
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Life Sci 66:PL113-8. 2000
    ..Thus, differences in the sensitivity to caffeine and cocaine between mouse strains provide genetic evidence that these two stimulants probably produce locomotor stimulation via somewhat different mechanisms...
  39. ncbi request reprint Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia
    G Schulte
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Acta Physiol Scand 182:133-43. 2004
    ..We studied whether the adenosine A1 receptor (A1R) was important for remote, delayed adaptation to ischaemia using a mouse with targeted deletion of the A1R gene...
  40. ncbi request reprint Distribution of adenosine receptors in the postmortem human brain: an extended autoradiographic study
    P Svenningsson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Synapse 27:322-35. 1997
    ..The adenosine A2A receptor antagonist radioligand [3H]SCH 58261 was also found to label these extrastriatal structures. Thus, adenosine A2A receptors seem to be more widely distributed in the human brain than previously recognized...
  41. ncbi request reprint Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells
    B B Fredholm
    Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Biochem Pharmacol 61:443-8. 2001
    ....
  42. ncbi request reprint P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells
    G Arslan
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Neuropharmacology 39:482-96. 2000
    ..ATP also caused a small increase in cyclic AMP, but this was abolished in the presence of indomethacin. Thus, after NGF treatment ATP acts partially via a P2Y receptor, possibly the P2Y2 subtype...
  43. ncbi request reprint Signalling from adenosine receptors to mitogen-activated protein kinases
    Gunnar Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Cell Signal 15:813-27. 2003
    ..Although each of the adenosine receptors can activate one or more of the MAPKs, the mechanisms appear to differ substantially, both between receptor subtypes in the same cell type and between the same receptor in different cell types...
  44. ncbi request reprint Aggravated brain damage after hypoxic ischemia in immature adenosine A2A knockout mice
    Ulrika Aden
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Stroke 34:739-44. 2003
    ..However, the roles of the different adenosine receptors are unclear, particularly in young animals. We examined the role of adenosine A2A receptors (A2AR) using 7-day-old A2A knockout (A2AR(-/-)) mice in a model of HI...
  45. ncbi request reprint The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration
    Olga Björklund
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Toxicology 241:119-33. 2007
    ..Thus, the consequences of MeHg toxicity during gestation and lactation can be reduced by adenosine A(1) and A(2A) receptor inactivation, either via their genetic deletion or by treatment with their antagonist caffeine...
  46. ncbi request reprint The adenosine A1 receptor contributes to the stimulatory, but not the inhibitory effect of caffeine on locomotion: a study in mice lacking adenosine A1 and/or A2A receptors
    Linda Halldner
    Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Neuropharmacology 46:1008-17. 2004
    ..Furthermore, these results suggest that the inhibitory effect of high doses of caffeine is due neither to blockade of the A1R, nor of the A2AR, and an effect independent of these adenosine receptors is likely...
  47. doi request reprint Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors
    J Yang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol (Oxf) 210:590-9. 2014
    ..To investigate whether adenosine influences NFκB activation in vascular smooth muscle cells (VSMCs) and, if so, to examine the role of its receptors...
  48. pmc Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors
    P Svenningsson
    Department of Physiology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 97:1856-60. 2000
    ..The results also underscore the fact that the adenosine system plays a role in the generation of responses to dopamine D(2) antagonists in vivo...
  49. ncbi request reprint Age-dependent changes in adenosine receptors are not modified by life-long intermittent alcohol administration
    B B Fredholm
    Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Brain Res 791:177-85. 1998
    ....
  50. pmc Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor
    B Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:9407-12. 2001
    ..However, under pathophysiological conditions, including noxious stimulation and oxygen deficiency, they are important...
  51. ncbi request reprint Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat
    K Fuxe
    Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden
    Neurosci Lett 101:337-41. 1989
    ..These results suggest that G-proteins mediate the central cardiovascular actions of neuropeptide Y and clonidine...
  52. ncbi request reprint Differential sensitivity to blockade by 4-aminopyridine of presynaptic receptors regulating [3H]acetylcholine release from rat hippocampus
    B B Fredholm
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 54:1386-90. 1990
    ..Furthermore, the results indicate that presynaptic A1 receptors on hippocampal cholinergic neurons do not primarily regulate 4-AP-dependent potassium channels, but that they might act directly on a Ca2+ conductance...
  53. ncbi request reprint Adenosine-dopamine interactions revealed in knockout mice
    Peter Salmi
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 17177 Stockholm, Sweden
    J Mol Neurosci 26:239-44. 2005
    ..Many A1 receptors are located presynaptically, where they regulate transmitter release. In A1 knockout mice, glutamatergic and dopaminergic transmission is therefore modified...
  54. ncbi request reprint Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice
    Alexander Kuzmin
    Department of Neuroscience, Karolinska Institutet, Sweden
    Eur Neuropsychopharmacol 16:129-36. 2006
    ..It is hypothesised that the stimulatory effect of low doses of caffeine in C57BL/6J mice is due to concomitant blockade of both A(1) and A(2A) adenosine receptors...
  55. ncbi request reprint Anoxia redistributes adenosine A(2A) receptors in PC12 cells and increases receptor-mediated formation of cAMP
    Giulia Arslan
    Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 365:150-7. 2002
    ....
  56. ncbi request reprint Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors
    R Nergårdh
    Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Pharmacol Biochem Behav 82:495-505. 2005
    ..We suggest that the balance between signaling via dopamine D1 and D5 receptors determines the functional effects of agonists at D1/D5 receptors...
  57. ncbi request reprint In vivo biodistribution of [N-11C-methyl]KF 17837 using 3-D-PET: evaluation as a ligand for the study of adenosine A2A receptors
    S Stone-Elander
    Karolinska Pharmacy, Stockholm, Sweden
    Nucl Med Biol 24:187-91. 1997
    ..This fact and the apparently high nonspecific binding in vivo of [N-11C-methyl]KF 17837 in regions with low receptor densities limits its usefulness as a ligand for quantification of the adenosine A2A receptors in the primate brain...
  58. ncbi request reprint Structure and function of adenosine receptors and their genes
    B B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 362:364-74. 2000
    ..Following the activation of G proteins several cellular effector pathways can be affected. Signaling via adenosine receptors is also known to interact in functionally important ways with signaling initiated via other receptors...
  59. doi request reprint Decreased behavioral activation following caffeine, amphetamine and darkness in A3 adenosine receptor knock-out mice
    Olga Björklund
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Physiol Behav 95:668-76. 2008
    ..The possibility that this is due to a role of A3 receptors in development is discussed...
  60. ncbi request reprint Modulation of glial cell functions by adenosine receptors
    Elisabetta Daré
    Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Nanna Svartz vag 2, S 171 77 Stockholm, Sweden
    Physiol Behav 92:15-20. 2007
    ..Microglial cells appear to be important in regulating adenosine formation from ATP and adenosine can affect many microglial signaling pathways. Adenosine receptors on oligodendrocytes regulate white matter development...
  61. pmc Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine
    Jiang Ning Yang
    Karolinska Institutet, Nanna Svartz vag 2, Stockholm S 171 77 Sweden
    Am J Physiol Heart Circ Physiol 296:H1141-9. 2009
    ..The A(2A)R plays an important role in the modulation of O(2)C and LA by acute and chronic caffeine administration. There is also evidence for effects of higher doses of caffeine being independent of both A(1)R and A(2A)R...
  62. ncbi request reprint A1 receptor deficiency causes increased insulin and glucagon secretion in mice
    Stina M Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochem Pharmacol 74:1628-35. 2007
    ..In conclusion, the A(1)R minimally affects muscle glucose uptake, but is important in regulating pancreatic islet function...
  63. doi request reprint Adenosine, through the A1 receptor, inhibits vesicular MHC class I cross-presentation by resting DC
    Liying Chen
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institute, 171 77 Stockholm, Sweden
    Mol Immunol 45:2247-54. 2008
    ..It is concluded that 2-Cl-Ado, by acting on A(1) receptor, can suppress vesicular MHC class I cross-presentation in rDC...
  64. doi request reprint Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage
    Olga Björklund
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 596:6-13. 2008
    ..It also reduced apoptosis in human astroglioma D384 cells after oxygen deprivation. In conclusion, the data point to a cytoprotective role of adenosine mediated by both A(1) and A(3) receptors in primary mouse astrocytes...
  65. doi request reprint Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin
    Stina M Johansson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 597:92-101. 2008
    ....
  66. pmc Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine
    Jiang Ning Yang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Appl Physiol (1985) 106:631-9. 2009
    ..Thus at least some aspects of long-term caffeine use can be mimicked by genetic manipulation of the A(1)R and A(2A)R...
  67. ncbi request reprint Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations
    G Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Neuroscience 121:907-16. 2003
    ..Many adenosine A1 receptor positive structures are in close contact with isolectin B4 positive C-fiber primary afferents and/or postsynaptic structures containing components of importance for the modulation of nociceptive information...
  68. ncbi request reprint Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon
    N Altiok
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol Scand 144:55-63. 1992
    ..Thus, D384 cells possess both A1 and A2 adenosine receptors influencing cyclic AMP in opposite directions.(ABSTRACT TRUNCATED AT 250 WORDS)..
  69. ncbi request reprint Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Neurology 61:S5-9. 2003
    ..There are issues of efficacy and potential side effects that need to be resolved, but the future looks bright...
  70. ncbi request reprint Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus
    Linda Halldner
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, 17177 Stockholm, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 370:270-8. 2004
    ..Thus, most of the [(3)H]CGS 21680 binding in hippocampus is dependent on the presence of adenosine A(1) receptors, but not on A(2A) receptors, indicating a novel binding site or novel binding mode...
  71. ncbi request reprint Evidence for functional adenosine A3 receptors in microglia cells
    Christian Hammarberg
    Karolinska Institutet, Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Stockholm, Sweden
    J Neurochem 86:1051-4. 2003
    ..The involvement of the A3R in Cl-IB-MECA-induced ERK1/2 phosphorylation was confirmed by demonstrating that those effects are absent in primary mouse microglia cells isolated from mice lacking the gene for the A3R...
  72. ncbi request reprint Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Section of Molecular Neuropharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Cell Mol Neurobiol 23:379-400. 2003
    ..Since adenosine is rapidly formed by breakdown of extracellular ATP, such interactions may be biologically important...
  73. ncbi request reprint Distribution, biochemistry and function of striatal adenosine A2A receptors
    P Svenningsson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Prog Neurobiol 59:355-96. 1999
    ..In the present review, current knowledge on the distribution, biochemistry and function of striatal A2A receptors is summarized...
  74. pmc Effect of an intracellular calcium chelator on the regulation of electrically evoked [3H]-noradrenaline release from rat hippocampal slices
    B B Fredholm
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Br J Pharmacol 108:126-31. 1993
    ....
  75. ncbi request reprint NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice
    Sietske M Schotanus
    The Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Neurophysiology, Von Eulers Vag 8, 171 77 Stockholm, Sweden
    Neuropharmacology 51:272-82. 2006
    ..Our results demonstrate that NMDA depresses synaptic transmission in a concentration- and temperature-dependent manner via release of adenosine and activation of adenosine A1 receptors...
  76. ncbi request reprint Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha
    Olga Karovic
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochem Pharmacol 73:694-708. 2007
    ..This points to cobalt and hypoxia not only inducing HIF-1alpha regulated genes but also affecting similarly other cellular functions, including metabolism...
  77. ncbi request reprint Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor
    Stina Johansson
    Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochem Pharmacol 70:598-605. 2005
    ..64 microM) but not by adenosine or 2-chloroadenosine. We conclude that adenosine and analogues do not act as agonists or partial agonists at the GHSR1a and that cross-talk between the GHSR1a and A(2B) receptors is limited...
  78. pmc Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC
    Frank Brand
    Karolinska Institutet, Department of Physiology and Pharmacology, Sect Receptor Biology and Signaling, S 171 77 Stockholm, Sweden
    Eur J Pharmacol 590:36-42. 2008
    ..The basic characterization of Alexa488-APEC described here showed that it provides a useful tool for tracing adenosine A(2A) receptors in vitro...
  79. ncbi request reprint Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 17177 Stockholm, Sweden
    Annu Rev Pharmacol Toxicol 45:385-412. 2005
    ..The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted...
  80. ncbi request reprint Pharmacology of adenosine A2A receptors and therapeutic applications
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Curr Top Med Chem 3:413-26. 2003
    ..Efforts to develop new therapies based on A(2A) receptors have focused on these topics. However, A(2A) receptors are found on many other cell types and on them as well agonists can exert effect...
  81. ncbi request reprint Exciting news about A2A receptors
    Per Svenningsson
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Neurology 61:S10-1. 2003
  82. ncbi request reprint [Connection between caffeine, adenosine receptors and dopamine. Coffee reduces the risk of Parkinson disease]
    Bertil B Fredholm
    Institutionen för fysiologi och farmakologi, Karolinska Institutet, Stockholm
    Lakartidningen 101:2552-5. 2004
  83. ncbi request reprint Intake inhibition by NPY and CCK-8: A challenge of the notion of NPY as an "Orexigen"
    A A Ammar
    Karolinska Institutet, Section of Applied Neuroendocrinology, Novum, S 14157 Huddinge, Sweden
    Behav Brain Res 161:82-7. 2005
    ..These results strengthen the hypothesis that NPY, like CCK-8, is an inhibitor of consummatory ingestive behavior and suggest that this inhibition is mediated via the NTS...
  84. ncbi request reprint MRI evaluation and functional assessment of brain injury after hypoxic ischemia in neonatal mice
    Ulrika Aden
    Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Stroke 33:1405-10. 2002
    ..We examined early events after hypoxic ischemia (HI) in the 7-day-old mouse brain by MRI and related them to long-term functional effects and histopathology in the same animals at 4 to 5 weeks of age...
  85. ncbi request reprint The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38
    Gunnar Schulte
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Exp Cell Res 290:168-76. 2003
    ..ERK1/2 activation was dependent on PI3K but not on PKA. p38 activation by NECA was instead independent of PI3K but required cAMP and PKA. The potent activation of both MAPKs suggests a physiological role...
  86. ncbi request reprint Adenosine and brain function
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet Stockholm, Sweden
    Int Rev Neurobiol 63:191-270. 2005
  87. ncbi request reprint Effect of acute and chronic administration of caffeine on pain-like behaviors in rats with partial sciatic nerve injury
    Wei ping Wu
    Section of Clinical Neurophysiology, Karolinska University Hospital Huddinge, Karolinska Institutet, S 141 86 Stockholm, Sweden
    Neurosci Lett 402:164-6. 2006
    ..The potential hyperalgesic effect of chronic A1 adenosine receptor blockade may have been compensated for by an antinociceptive effect of caffeine through antagonism of A2A receptors and tolerance development...
  88. ncbi request reprint Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2
    Gunnar Schulte
    Section of Molecular Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Mol Pharmacol 62:1137-46. 2002
    ..In conclusion, the adenosine A(3) receptor recruits a pathway that involves betagamma release from G(i/o), PI3K, Ras, and MEK to induce ERK1/2 phosphorylation and activation, whereas signaling is independent of Ca(2+), PKC, and c-Src...
  89. ncbi request reprint Adenosine receptors as targets for drug development
    Bertil B Fredholm
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Drug News Perspect 16:283-9. 2003
    ..Among some of the conditions for which adenosine receptor-based therapy might be used are Parkinson's disease, hypoxia/ischemia, epilepsy, kidney disease and asthma...
  90. ncbi request reprint Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons
    Mikael Andersson
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Neurosci 25:8432-8. 2005
    ....
  91. ncbi request reprint Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists
    Gunnar Schulte
    Section of Molecular Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cell Signal 14:109-13. 2002
    ....
  92. ncbi request reprint [The passion concerning behavior of human beings. The intensive sociology debate and some lessons learned from it]
    Bertil B Fredholm
    Institutionen för fysiologi och farmakologi, Karolinska Institutet, Stockholm
    Lakartidningen 99:1604-8. 2002
  93. ncbi request reprint Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase
    Christian Hammarberg
    Department of Physiology and Pharmacology, Section of Molecular Pharmacology, Karolinska Institutet, S 171 77, Stockholm, Sweden
    Biochem Pharmacol 67:129-34. 2004
    ....
  94. ncbi request reprint Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells
    Jan Lynge
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, August Krogh Institute, Copenhagen University, Universitetsparken 13, Copenhagen Ø, DK 2100, Denmark
    Biochem Biophys Res Commun 307:180-7. 2003
    ....
  95. pmc Adenosine receptor antagonists alter the stability of human epileptic GABAA receptors
    Cristina Roseti
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza di Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I 00185 Rome, Italy
    Proc Natl Acad Sci U S A 105:15118-23. 2008
    ..Our findings strongly suggest that cortical A2-A3 receptors alter the stability of GABA(A) receptors, which could offer therapeutic opportunities...
  96. ncbi request reprint Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor
    Dag Stenberg
    Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    J Sleep Res 12:283-90. 2003
    ..We conclude that constitutional lack of adenosine A1R does not prevent the homeostatic regulation of sleep...
  97. pmc A1 adenosine receptors mediate hypoxia-induced ventriculomegaly
    Christopher P Turner
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:11718-22. 2003
    ..Thus, adenosine acting on A1ARs appears to mediate hypoxia-induced brain injury ventriculomegaly during early postnatal development...
  98. pmc Modulation of hippocampal glutamatergic transmission by ATP is dependent on adenosine a(1) receptors
    Susan A Masino
    Department of Pharmacology and Program in Neuroscience, University of Colorado Health Sciences Center, Denver 80262, USA
    J Pharmacol Exp Ther 303:356-63. 2002
    ....
  99. ncbi request reprint Mice lacking the adenosine A1 receptor are anxious and aggressive, but are normal learners with reduced muscle strength and survival rate
    Lydia Gimenez-Llort
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Eur J Neurosci 16:547-50. 2002
    ..These results confirm the involvement of adenosine in motor activity, exploratory behaviour, anxiety and aggressiveness. A1Rs also appear to play a critical role in ageing-related deterioration...
  100. ncbi request reprint Adenosine A1 receptors are crucial in keeping an epileptic focus localized
    Denise E Fedele
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    Exp Neurol 200:184-90. 2006
    ..These results open up a new dimension of the A1 receptor's role in controlling excitotoxic cell death and further demonstrate its importance in preventing the progression of status epilepticus to lethal consequences...
  101. ncbi request reprint Involvement of A1 adenosine receptors in the acquisition of fertilizing capacity
    Alba Minelli
    Dipartimento di Scienze Biochimiche e Biotecnologie Molecolari, Sezione Biochimica Cellulare, Perugia, Italy
    J Androl 25:286-92. 2004
    ....