L Fratiglioni

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint An active and socially integrated lifestyle in late life might protect against dementia
    Laura Fratiglioni
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec Department, Karolinska Institute and Stockholm Gerontology Research Center, Stockholm, Sweden
    Lancet Neurol 3:343-53. 2004
  2. ncbi request reprint APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study
    Wenyong Huang
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm Gerontology Research Center, corrected Stockholm, Sweden
    Arch Neurol 61:1930-4. 2004
  3. ncbi request reprint [Variability of epidemiological measures in mild cognitive impairment and dementia]
    Laura Fratiglioni
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec Department, Karolinska Institutet, Box 6401, Olivecronasväg 4, SE 113 82 Stockholm, Sweden
    Ann Ist Super Sanita 41:81-6. 2005
  4. ncbi request reprint Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE
    Behnosh F Björk
    Karolinska Institutet, Department NVS, Division of KI Alzheimer Disease Research Center, SE 141 57 Huddinge, Sweden
    Neurobiol Aging 28:1374-80. 2007
  5. ncbi request reprint Predictors of progression from mild cognitive impairment to Alzheimer disease
    K Palmer
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neurology 68:1596-602. 2007
  6. ncbi request reprint Influence of social network on occurrence of dementia: a community-based longitudinal study
    L Fratiglioni
    Stockholm Gerontology Research Centre, and Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet 355:1315-9. 2000
  7. ncbi request reprint [Epidemiology of aging with focus on physical and mental functional ability]
    L Fratiglioni
    Sektionen för geriatrik epidemiologi, ARC, Karolinska Institutet, och Stiftelsen Stockholms läns äldrecentrum
    Lakartidningen 98:552-8. 2001
  8. ncbi request reprint Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies
    L Fratiglioni
    Stockholm Gerontology Research Center, Neurotec, Karolinska Institute, Huddinge University Hospital, Sweden
    Behav Brain Res 113:117-20. 2000
  9. doi request reprint Occurrence of cognitive impairment and dementia in the community: a 9-year-long prospective study
    B Caracciolo
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 70:1778-85. 2008
  10. doi request reprint The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
    B Caracciolo
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, Stockholm 113 30, Sweden
    J Neurol Neurosurg Psychiatry 82:788-93. 2011

Collaborators

Detail Information

Publications95

  1. ncbi request reprint An active and socially integrated lifestyle in late life might protect against dementia
    Laura Fratiglioni
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec Department, Karolinska Institute and Stockholm Gerontology Research Center, Stockholm, Sweden
    Lancet Neurol 3:343-53. 2004
    ..Further research is necessary to better define the mechanisms of these associations and better delineate preventive and therapeutic strategies...
  2. ncbi request reprint APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study
    Wenyong Huang
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm Gerontology Research Center, corrected Stockholm, Sweden
    Arch Neurol 61:1930-4. 2004
    ..Both family aggregation and apolipoprotein E (APOE) epsilon4 allele are well-known risk factors for dementia, but the relation between these two factors remains unclear...
  3. ncbi request reprint [Variability of epidemiological measures in mild cognitive impairment and dementia]
    Laura Fratiglioni
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec Department, Karolinska Institutet, Box 6401, Olivecronasväg 4, SE 113 82 Stockholm, Sweden
    Ann Ist Super Sanita 41:81-6. 2005
    ..Variability will decrease only when more precise criteria and aims of the concept "MCI" will be specified...
  4. ncbi request reprint Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE
    Behnosh F Björk
    Karolinska Institutet, Department NVS, Division of KI Alzheimer Disease Research Center, SE 141 57 Huddinge, Sweden
    Neurobiol Aging 28:1374-80. 2007
    ..These findings indicate a role for IDE in AD, and provide models that may improve chances of further independent replication...
  5. ncbi request reprint Predictors of progression from mild cognitive impairment to Alzheimer disease
    K Palmer
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neurology 68:1596-602. 2007
    ..To determine the occurrence of neuropsychiatric symptomatology and the relation to future development of Alzheimer disease (AD) in persons with and without mild cognitive impairment (MCI)...
  6. ncbi request reprint Influence of social network on occurrence of dementia: a community-based longitudinal study
    L Fratiglioni
    Stockholm Gerontology Research Centre, and Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Lancet 355:1315-9. 2000
    ..Few data are available on the effect of social ties on dementia development. This study explored whether single social network components and different degrees of the social connections affect dementia incidence...
  7. ncbi request reprint [Epidemiology of aging with focus on physical and mental functional ability]
    L Fratiglioni
    Sektionen för geriatrik epidemiologi, ARC, Karolinska Institutet, och Stiftelsen Stockholms läns äldrecentrum
    Lakartidningen 98:552-8. 2001
    ..The natural history of the dementias have been sufficiently outlined for allocating medical and social resources, and for counseling patients and relatives...
  8. ncbi request reprint Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies
    L Fratiglioni
    Stockholm Gerontology Research Center, Neurotec, Karolinska Institute, Huddinge University Hospital, Sweden
    Behav Brain Res 113:117-20. 2000
    ..A review of all studies that either support or refute this hypothesis is presented separately for PD and AD...
  9. doi request reprint Occurrence of cognitive impairment and dementia in the community: a 9-year-long prospective study
    B Caracciolo
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 70:1778-85. 2008
    ....
  10. doi request reprint The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
    B Caracciolo
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, Stockholm 113 30, Sweden
    J Neurol Neurosurg Psychiatry 82:788-93. 2011
    ..To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: (i) MCI severity, (ii) time of assessment and (iii) interaction with other factors...
  11. ncbi request reprint Association of stroke with dementia, cognitive impairment, and functional disability in the very old: a population-based study
    L Zhu
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Stroke 29:2094-9. 1998
    ..BACKGROUND and..
  12. ncbi request reprint The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen Project
    C Qiu
    Stockholm Gerontology Research Center, Box 6401 Olivecronas väg 4, S 113 82 Stockholm, Sweden
    Arch Neurol 58:2034-9. 2001
    ..The relationship between education and Alzheimer disease (AD) or dementia has been widely examined and the evidence obtained is mixed. Several hypotheses have been proposed to explain the observed association between them...
  13. ncbi request reprint Institutionalization in the elderly: the role of chronic diseases and dementia. Cross-sectional and longitudinal data from a population-based study
    H Aguero-Torres
    Stockholm Gerontology Research Center, Neurotec, Karolinska Institutet, Stockholm, Sweden
    J Clin Epidemiol 54:795-801. 2001
    ..This study confirms that dementia and cognitive impairment are the main contributors to institutionalization in the elderly, independently of their sociodemographic status, social network, or functional status...
  14. doi request reprint Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study
    W L Xu
    Department of Neurobiology, Aging Research Center, Care Sciences and Society, Stockholm Gerontology Research Center, Karolinska Institutet, Stockholm, Sweden
    Diabetologia 52:1031-9. 2009
    ..We aimed to clarify the association of diabetes with different dementing disorders taking into account glycaemic control, and to explore the link between glucose dysregulation and neurodegeneration...
  15. doi request reprint Medial temporal lobe is vulnerable to vascular risk factors in men: a population-based study
    C Qiu
    Department of Neurobiology, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Eur J Neurol 19:876-83. 2012
    ..We investigate whether an aggregation of VRFs is associated with volume of hippocampus and entorhinal cortex in elderly people living in the community...
  16. doi request reprint Personality and lifestyle in relation to dementia incidence
    H X Wang
    Aging Research Center, Dept Neurobiology, Care Sciences and Society, Karolinska Institutet, Gavlegatan 16, 113 30 Stockholm, Sweden
    Neurology 72:253-9. 2009
    ..The aim of the current study was to explore the separate and combined effects of neuroticism and extraversion on the risk of dementia, and to examine whether lifestyle factors may modify this association...
  17. ncbi request reprint Incidence of dementia in relation to stroke and the apolipoprotein E epsilon4 allele in the very old. Findings from a population-based longitudinal study
    L Zhu
    Stockholm Gerontology Research Center, Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Stroke 31:53-60. 2000
    ..Both stroke and the apolipoprotein E (APOE) epsilon4 allele increase the risk of dementia. However, the interaction between stroke and APOE on dementia is still unclear. We addressed this topic by using a longitudinal design...
  18. ncbi request reprint Aging and the occurrence of dementia: findings from a population-based cohort with a large sample of nonagenarians
    E von Strauss
    Stockholm Gerontology Research Center, Division of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Arch Neurol 56:587-92. 1999
    ..This question is relevant both for understanding the pathogenetic mechanism of the dementias and for the public health prospective because of the increasing number of 85-year-old or older persons in our population...
  19. doi request reprint The influence of vascular disease on cognitive performance in the preclinical and early phases of Alzheimer's disease
    E J Laukka
    Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 29:498-503. 2010
    ..Alzheimer's disease (AD) is one of the most important causes of old-age cognitive impairment. We aimed to examine the influence of history of vascular disease on cognition in preclinical and early AD...
  20. ncbi request reprint Detection of mild dementia in community surveys. Is it possible to increase the accuracy of our diagnostic instruments?
    A Herlitz
    Stockholm Gerontology Research Center, Karolinska Institute, Stockholm, Sweden
    Arch Neurol 54:319-24. 1997
    ..To investigate the accuracy of cognitive tests and clinical dementia diagnosis in distinguishing between mildly demented and nondemented subjects...
  21. ncbi request reprint Vitamin B(12) and folate in relation to the development of Alzheimer's disease
    H X Wang
    Stockholm Gerontology Research Center and Division of Geriatric Medicine, Neurotec, Karolinska Institutet, Stockholm
    Neurology 56:1188-94. 2001
    ..To explore the associations of low serum levels of vitamin B(12) and folate with AD occurrence...
  22. ncbi request reprint Incidence of stroke in relation to cognitive function and dementia in the Kungsholmen Project
    L Zhu
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neurology 54:2103-7. 2000
    ..To investigate whether cognitive function is related to incidence of stroke...
  23. ncbi request reprint Mild cognitive impairment in the population and physical health: data on 1,435 individuals aged 75 to 95
    G B Frisoni
    Stockholm Gerontology Research Center, Division of Geriatric Medicine, Neurotec, Karolinska Institute, Sweden
    J Gerontol A Biol Sci Med Sci 55:M322-8. 2000
    ..The physical health correlates of mild cognitive impairment (MCI) in the older individual are poorly known. The aim of this study was to investigate the relationship between physical health and MCI with population data...
  24. pmc Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex
    C Qiu
    Ageing Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Centre, Stockholm, Sweden
    J Neurol Neurosurg Psychiatry 75:828-33. 2004
    ..The risk effect of APOE epsilon 4 allele for Alzheimer's disease is acknowledged, whereas the putative protective effect of epsilon 2 allele remains in debate...
  25. ncbi request reprint Lead concentrations in elderly urban people related to blood pressure and mental performance: results from a population-based study
    M Nordberg
    Institute of Environmental Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Am J Ind Med 38:290-4. 2000
    ..The Kungsholmen project is a longitudinal study of ageing and dementia conducted in Stockholm in 1987. In a 1994-96 follow-up, 804 subjects had their blood samples analyzed for lead...
  26. ncbi request reprint Cognitive predictors of incident Alzheimer's disease: a prospective longitudinal study
    B J Small
    Stockholm Gerontology Research Center, Sweden
    Neuropsychology 11:413-20. 1997
    ..Further, supportive episodic memory tasks may be more salient predictors of incident AD than tasks that offer less supportive encoding or retrieval conditions...
  27. ncbi request reprint Natural history of Alzheimer's disease and other dementias: review of the literature in the light of the findings from the Kungsholmen Project
    H Aguero-Torres
    Stockholm Gerontology Research Center, Sweden
    Int J Geriatr Psychiatry 13:755-66. 1998
    ..However, thanks to longitudinal research, which has only recently begun to proliferate, not only is better comprehension of the continuity of the cognitive decline possible, but also the identification of some prognostic factors...
  28. ncbi request reprint Cognitive support at episodic encoding and retrieval: similar patterns of utilization in community-based samples of Alzheimer's disease and vascular dementia patients
    O Almkvist
    Stockholm Gerontology Research Center, Sweden
    J Clin Exp Neuropsychol 21:816-30. 1999
    ..The results suggests a similarity between AD and VaD patients with regard to the nature of the episodic memory impairment, despite etiologic differences between the diseases...
  29. ncbi request reprint Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study
    W L Xu
    Aging Research Center, Neurotec, Karolinska Institutet, Sweden
    Neurology 63:1181-6. 2004
    ..The authors investigated the relationship between diabetes mellitus and risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD)...
  30. ncbi request reprint Worldwide prevalence and incidence of dementia
    L Fratiglioni
    Stockholm Gerontology Research Center, Sweden
    Drugs Aging 15:365-75. 1999
    ....
  31. doi request reprint The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study
    A Marengoni
    NVS Department, Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 265:288-95. 2009
    ..We aimed to disentangle the effect of chronic multimorbidity and disability on 3-year functional decline and survival in the elderly...
  32. doi request reprint Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study
    M Kivipelto
    Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Eur J Neurol 16:808-13. 2009
    ..Another marker of vitamin B12 deficiency, holo-transcobalamin (holo-TC), has not been studied in a prospective setting...
  33. ncbi request reprint Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: variation by use of antihypertensive medication?
    Z Guo
    Stockholm Gerontology Research Center and Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Epidemiol 153:225-31. 2001
    ..Further studies are needed to clarify whether use of antihypertensive medication, especially diuretics, modifies the effect of the allele...
  34. pmc Midlife overweight and obesity increase late-life dementia risk: a population-based twin study
    W L Xu
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 113 30 Stockholm, Sweden
    Neurology 76:1568-74. 2011
    ....
  35. ncbi request reprint Stability of the preclinical episodic memory deficit in Alzheimer's disease
    L Backman
    Department of Psychology, Uppsala University, Uppsala, Sweden
    Brain 124:96-102. 2001
    ..This may reflect the fact that those biological events that eventually result in clinically diagnosed Alzheimer's disease e.g. the appearance of amyloid plaques and neurofibrillary tangles) accumulate at a relatively slow rate...
  36. doi request reprint Undertreatment of osteoporosis in persons with dementia? A population-based study
    Y Haasum
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Gavlegatan 16, 113 30 Stockholm, Sweden
    Osteoporos Int 23:1061-8. 2012
    ..Thus, our results indicate an undertreatment of osteoporosis in dementia...
  37. ncbi request reprint Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  38. ncbi request reprint Heterogeneity in risk factors for cognitive impairment, no dementia: population-based longitudinal study from the Kungsholmen Project
    Roberto Monastero
    Aging Research Center, Division of Geriatric Epidemiology, Department for Neurobiology, Health Care Sciences, and Society, Karolinska Institutet, Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Geriatr Psychiatry 15:60-9. 2007
    ....
  39. ncbi request reprint The effect of borderline diabetes on the risk of dementia and Alzheimer's disease
    Weili Xu
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Diabetes 56:211-6. 2007
    ..Borderline diabetes may interact with severe systolic hypertension to multiply the risk of Alzheimer's disease...
  40. ncbi request reprint Personality and risk of cognitive impairment 25 years later
    Michael Crowe
    Department of Psychology, University of Alabama, 35294 2100, USA
    Psychol Aging 21:573-80. 2006
    ..Findings are discussed in the context of theories related to personality, psychological distress, arousal, and cognitive function...
  41. ncbi request reprint Cerebrovascular disease, APOE epsilon4 allele and cognitive decline in a cognitively normal population
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurol Res 28:650-6. 2006
    ..To investigate whether cerebrovascular disease (CVD) and apolipoprotein E (APOE) epsilon4 allele were associated with cognitive decline and whether the relationship between CVD and cognitive decline varied by APOE epsilon4 status...
  42. ncbi request reprint Heart failure and risk of dementia and Alzheimer disease: a population-based cohort study
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Olivecronas vag 4, S 113 82 Stockholm, Sweden
    Arch Intern Med 166:1003-8. 2006
    ..We sought to examine the hypothesis that heart failure is a risk factor for dementia and Alzheimer disease...
  43. ncbi request reprint Heritability of an age-dependent categorical phenotype: cognitive dysfunction
    Chandra A Reynolds
    Department of Psychology, University of California at Riverside, 92521, USA
    Twin Res Hum Genet 9:17-23. 2006
    ..The findings emphasize the extent to which research is needed to uncover nonfamilial environmental influences on cognitive dysfunction in later life...
  44. ncbi request reprint Role of genes and environments for explaining Alzheimer disease
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    Arch Gen Psychiatry 63:168-74. 2006
    ..Twin studies using selected samples have shown high heritability for Alzheimer disease (AD)...
  45. ncbi request reprint Mental, physical and social components in leisure activities equally contribute to decrease dementia risk
    Anita Karp
    Aging Research Center, Division of Geriatric Epidemiology, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 21:65-73. 2006
    ..Since many activities contain more than one component, we aimed to verify the effect of all three major components on the dementia risk, as well as their combined effect...
  46. ncbi request reprint Longitudinal models of growth and survival applied to the early detection of Alzheimer's disease
    John J McArdle
    Department of Psychology, University of Southern California, Los Angeles 90089, USA
    J Geriatr Psychiatry Neurol 18:234-41. 2005
    ..The accuracy and reliability of this approach is considered for a better understanding of the developmental course of AD in these data, including the potential removal of biases due to subject selection...
  47. ncbi request reprint Performance on neurocognitive tests by co-twins to dementia cases compared to normal control twins
    Margaret Gatz
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, USA
    J Geriatr Psychiatry Neurol 18:202-7. 2005
    ..These findings show that being at greater genetic risk for dementia is reflected in cognitive performance even in the absence of a diagnosis of dementia...
  48. doi request reprint Rehabilitation and nursing home admission after hospitalization in acute geriatric patients
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Am Med Dir Assoc 9:265-70. 2008
    ..This study explored the effect of multimorbidity, cognitive and physical impairment, and sociodemographic factors on the choice of allocation of geriatric patients at hospital discharge...
  49. ncbi request reprint The epidemiology of the dementias: an update
    Chengxuan Qiu
    Aging Research Center, Department of Neurobiology, Caring Sciences and Society NVS, Karolinska Institutet and the Stockholm Gerontology Research Center, Stockholm, Sweden
    Curr Opin Psychiatry 20:380-5. 2007
    ..The epidemiology of dementia is one of the priority fields in aging research. This review aims to highlight the most relevant findings over last years concerning occurrence, risk factors, and prevention of dementia and its major subtypes...
  50. doi request reprint Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease
    Katie Palmer
    Aging Research Center, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Geriatr Psychiatry 16:603-11. 2008
    ....
  51. pmc Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden
    Alessandra Marengoni
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Am J Public Health 98:1198-200. 2008
    ..Multimorbidity is the most common clinical picture of the elderly and may be increased by unhealthy behaviors linked to education...
  52. ncbi request reprint [A simple three-step model for detection of preclinical dementia among the elderly]
    Katie Palmer
    sektionen för geriatrik, Neurotec, Karolinska Institutet, Stockholm
    Lakartidningen 100:2606-8. 2003
  53. doi request reprint Early symptoms and signs of cognitive deficits might not always be detectable in persons who develop Alzheimer's disease
    Katie Palmer
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Int Psychogeriatr 20:252-8. 2008
    ..This study aims to determine how many individuals with AD show detectable symptoms or clinical signs of cognitive deficits three years before diagnosis...
  54. ncbi request reprint Physical exercise at midlife and risk of dementia three decades later: a population-based study of Swedish twins
    Ross Andel
    School of Aging Studies, University of South Florida, Tampa, Florida 33620, USA
    J Gerontol A Biol Sci Med Sci 63:62-6. 2008
    ..We explored the association between physical exercise at midlife and subsequent risk of dementia among members of the HARMONY study...
  55. ncbi request reprint Asthma, eczema, rhinitis and the risk for dementia
    Ulrika K Eriksson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 25:148-56. 2008
    ..Inflammation is associated with Alzheimer's disease (AD) and dementia. In light of the chronic inflammatory properties of the atopic disorders asthma, eczema and rhinitis, we hypothesized an association with dementia...
  56. ncbi request reprint Late-life body mass index and dementia incidence: nine-year follow-up data from the Kungsholmen Project
    Anna Rita Atti
    Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Am Geriatr Soc 56:111-6. 2008
    ..To describe the association between late-life body mass index (BMI) and dementia development with a time perspective and to investigate the effect of weight changes on dementia incidence...
  57. ncbi request reprint Brain reserve hypothesis in dementia
    Laura Fratiglioni
    Aging Research Center, Department NVS, Karolinska Institute, and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Alzheimers Dis 12:11-22. 2007
    ..Delaying dementia onset by five years would halve dementia prevalence and substantially decrease the number of dementia cases in the community...
  58. ncbi request reprint The combined effect of age, education, and stroke on dementia and cognitive impairment no dementia in the elderly
    Diana De Ronchi
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 24:266-73. 2007
    ..This study aims to detect the impact of stroke on the occurrence of dementia and cognitive impairment/no dementia (CIND) in different age, sex, and education groups...
  59. pmc Accounting for the relationship between low education and dementia: a twin study
    Margaret Gatz
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
    Physiol Behav 92:232-7. 2007
    ..Low education is confirmed as a risk factor for dementia. Findings from three different analytic approaches showed that genetic influences did not explain this association...
  60. ncbi request reprint Prevention of Alzheimer's disease and dementia. Major findings from the Kungsholmen Project
    Laura Fratiglioni
    Karolinska Institutet, Aging Research Center, Division of Geriatric Epidemiology, NVS, and Stockholm Gerontology Research Center, Gavlegatan 16, S 113 30 Stockholm, Sweden
    Physiol Behav 92:98-104. 2007
    ..At the moment it is also possible to delineate some preventative strategies for dementia...
  61. ncbi request reprint Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
    Miia Kivipelto
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:1556-60. 2005
    ..Vascular risk factors play a role in the development of dementia, including Alzheimer disease (AD). However, little is known about the effect of body mass index and clustering of vascular risk factors on the development of dementia...
  62. ncbi request reprint Epidemiology of cerebrovascular disease related cognitive decline
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Karolinska Institute, Stockholm, Sweden
    Int Psychogeriatr 15:105-10. 2003
    ..Early treatment and prevention of cerebrovascular disease may be the major measures for preventing and postponing the progression of the vascular disease related cognitive decline...
  63. ncbi request reprint Influences of preclinical dementia and impending death on the magnitude of age-related cognitive deficits
    Lars Backman
    Department of Psychology, Uppsala University, Sweden
    Psychol Aging 17:435-42. 2002
    ..This pattern of findings suggests that the biological aging process exerts negative influences on cognitive functioning beyond those resulting from disease and mortality...
  64. ncbi request reprint Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease
    Anita Karp
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Am J Epidemiol 159:175-83. 2004
    ..In conclusion, the association between low education and increased AD risk was not mediated by adult SES or socioeconomic mobility. This suggests that early life factors may be relevant...
  65. ncbi request reprint Poor mental and physical health differentially contributes to disability in hospitalized geriatric patients of different ages
    Alessandra Marengoni
    Division of Internal Medicine I Geriatric Unit, Spedali Civili OP Richiedei, Department of Medical and Surgery Sciences, University of Brescia, Italy
    Int J Geriatr Psychiatry 19:27-34. 2004
    ..To evaluate the relationship between depressive symptoms, cognition and somatic diseases on functional status of geriatric patients at hospital discharge...
  66. ncbi request reprint Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 61:655-60. 2003
    ..To study the hypotheses that APOE-epsilon4 allele may interact with blood pressure to affect Alzheimer's disease (AD) occurrence and that antihypertensive therapy could modify such an effect...
  67. ncbi request reprint Women are more disabled in basic activities of daily living than men only in very advanced ages: a study on disability, morbidity, and mortality from the Kungsholmen Project
    Eva von Strauss
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    J Clin Epidemiol 56:669-77. 2003
    ..We explored the effect of morbidity, mortality, and occurrence of new disability on gender differences in activities of daily living (ADL) functioning in different age groups in the elderly population...
  68. ncbi request reprint Rate of cognitive decline in preclinical Alzheimer's disease: the role of comorbidity
    Lars Backman
    Aging Research Center at the Karolinska Institute and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 58:P228-36. 2003
    ..A possible exception to this pattern is that an increasing number of concomitant health conditions may exacerbate the rate of cognitive decline during the final portion of the preclinical phase in AD...
  69. ncbi request reprint Terminal decline and cognitive performance in very old age: does cause of death matter?
    Brent J Small
    Department of Gerontology, University of South Florida, Tampa 33620, USA
    Psychol Aging 18:193-202. 2003
    ..Cause of death failed to modify the magnitude of the cross-sectional and longitudinal deficits. The pattern of results point to the general nature of this phenomenon...
  70. ncbi request reprint Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 34:594-9. 2003
    ..Elevated blood pressure has been found to increase the risk of dementia, including Alzheimer disease. We sought to investigate whether pulse pressure was predictive of Alzheimer disease and dementia...
  71. ncbi request reprint Psychiatric symptoms/syndromes in elderly persons with mild cognitive impairment. Data from a cross-sectional study
    Yvonne Forsell
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Acta Neurol Scand Suppl 179:25-8. 2003
    ..This study examined the prevalence of psychiatric syndromes and symptoms in elderly persons with mild cognitive impairment (MCI)...
  72. ncbi request reprint What is mild cognitive impairment? Variations in definitions and evolution of nondemented persons with cognitive impairment
    Katie Palmer
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Acta Neurol Scand Suppl 179:14-20. 2003
    ....
  73. ncbi request reprint Low blood pressure and risk of dementia in the Kungsholmen project: a 6-year follow-up study
    Chengxuan Qiu
    Aging Research Center, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 60:223-8. 2003
    ..Previous studies have reported a higher prevalence of dementia in persons with low blood pressure...
  74. pmc Detection of Alzheimer's disease and dementia in the preclinical phase: population based cohort study
    Katie Palmer
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institute, and Stockholm Gerontology Research Center, Box 6401, 11382, Stockholm, Sweden
    BMJ 326:245. 2003
    ..To evaluate a simple three step procedure to identify people in the general population who are in the preclinical phase of Alzheimer's disease and dementia...
  75. ncbi request reprint Lifetime principal occupation and risk of Alzheimer's disease in the Kungsholmen project
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and the Stockholm Gerontology Research Center, Sweden
    Am J Ind Med 43:204-11. 2003
    ..Some studies suggest that manual work is associated with dementia. This study is aimed at identifying the specific occupational categories that may be related to dementia...
  76. ncbi request reprint Dementing disorders in the elderly: evolution of disease severity over 7 years
    Hedda Aguero-Torres
    Division of Geriatric Epidemiology, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Gerontology Research Center, Sweden
    Alzheimer Dis Assoc Disord 16:221-7. 2002
    ..Long-term survivors in dementia are not rare, and as the absolute number of demented people is increasing, expanding our knowledge of these persons is of high public health importance...
  77. ncbi request reprint The impact of somatic and cognitive disorders on the functional status of the elderly
    Hedda Aguero-Torres
    The Kungsholmen Project, Stockholm Gerontology Research Center and Division of Geriatric Epidemiology, Box 6401, S 11382 Stockholm, Sweden
    J Clin Epidemiol 55:1007-12. 2002
    ..Attention to illnesses among cognitively impaired and demented people may shed light on remediable factors crucial to their daily functioning...
  78. ncbi request reprint Similar patterns of cognitive deficits in the preclinical phases of vascular dementia and Alzheimer's disease
    Erika Jonsson Laukka
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Int Neuropsychol Soc 10:382-91. 2004
    ..These results extend previous findings of similar patterns of cognitive deficits in the early clinical phases of AD and VaD to the preclinical phases of these diseases...
  79. ncbi request reprint Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project
    Hui Xin Wang
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Epidemiol 155:1081-7. 2002
    ....
  80. ncbi request reprint Cognitive functioning in preclinical vascular dementia: a 6-year follow-up
    Erika Jonsson Laukka
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 35:1805-9. 2004
    ....
  81. ncbi request reprint Cognitive impairment is the major risk factor for development of geriatric syndromes during hospitalization: results from the GIFA study
    Patrizia Mecocci
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce Padiglione E, Via Brunamonti 51, IT 06122 Perugia, Italy
    Dement Geriatr Cogn Disord 20:262-9. 2005
    ..To detect the main factors associated with the occurrence of specific geriatric syndromes (namely pressure sores, fecal incontinence, urinary incontinence and falls) in elderly patients during hospitalization...
  82. ncbi request reprint Alzheimer's disease and depression: preclinical comorbidity effects on cognitive functioning
    Anna Karin Berger
    Aging Research Center ARC, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Stockholm
    Cortex 41:603-12. 2005
    ..Thus, although depressive symptoms may result in slight cognitive deficits in preclinical AD, at the time of the dementia diagnosis these effects may be absorbed by the neurodegenerative process...
  83. ncbi request reprint Differential evolution of cognitive impairment in nondemented older persons: results from the Kungsholmen Project
    Katie Palmer
    Stockholm Gerontology Research Center and Division of Geriatric Epidemiology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Uppsala University, Sweden
    Am J Psychiatry 159:436-42. 2002
    ..This study was a prospective, population-based examination of the evolution of cognitive impairment, no dementia (CIND)...
  84. ncbi request reprint The age-dependent relation of blood pressure to cognitive function and dementia
    Chengxuan Qiu
    Aging Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and Stockholm Gerontology Research Centre, Stockholm, Sweden
    Lancet Neurol 4:487-99. 2005
    ....
  85. ncbi request reprint Anaemia increases the risk of dementia in cognitively intact elderly
    Anna Rita Atti
    Aging Research Centre, Division of Geriatric Epidemiology, Department of Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurobiol Aging 27:278-84. 2006
    ..The HR was increased even when different haemoglobin cut offs for anaemia definition were used. Thus, anaemia is suggested to be a new potential modifiable risk factor for dementia...
  86. ncbi request reprint Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
    Margaret Gatz
    Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
    Neurobiol Aging 26:439-47. 2005
    ..Among monozygotic twins where both twins had Alzheimer's disease, the within pair difference in age of onset ranged from both becoming demented in the same year to 7 years difference in onset...
  87. ncbi request reprint Occurrence of cognitive impairment and dementia after the age of 60: a population-based study from Northern Italy
    Diana De Ronchi
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Dement Geriatr Cogn Disord 19:97-105. 2005
    ..To evaluate the age, gender and education distribution of both cognitive impairment and dementia in the whole old age range of the elderly (from 61 years of age and over)...
  88. ncbi request reprint Apolipoprotein E and cognitive performance: a meta-analysis
    Brent J Small
    School of Aging Studies, University of South Florida, Tampa, FL 33620, USA
    Psychol Aging 19:592-600. 2004
    ..The meta-analysis results suggest that APOE-epsilon4 genotype does affect cognitive performance in healthy aging, although the influence is relatively small and specific to certain domains of cognitive performance...
  89. ncbi request reprint Occupational exposure to electromagnetic fields and risk of Alzheimer's disease
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, S 113 82 Stockholm, Sweden
    Epidemiology 15:687-94. 2004
    ..Extremely-low-frequency magnetic field (ELF-MF) exposure is suspected to increase the risk of Alzheimer's disease. Such fields are present in the vicinity of electrical motors and other electric appliances containing coils...
  90. ncbi request reprint Risk factors for cognitive impairment in HIV-1-infected persons with different risk behaviors
    Diana De Ronchi
    Institute of Psychiatry, University of Bologna, Italy
    Arch Neurol 59:812-8. 2002
    ....
  91. pmc Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study
    Tiia Anttila
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Box 6401, 11382 Stockholm, Sweden
    BMJ 329:539. 2004
    ..To evaluate the relation between midlife alcohol consumption and mild cognitive impairment and dementia in old age, and the possible modification of this relation by apolipoprotein E...
  92. ncbi request reprint A preclinical phase in vascular dementia: cognitive impairment three years before diagnosis
    Sari Jones
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Dement Geriatr Cogn Disord 18:233-9. 2004
    ..This observation suggests that circulatory disturbance is associated with cognitive problems several years before the actual VaD diagnosis...
  93. ncbi request reprint Decline in blood pressure over time and risk of dementia: a longitudinal study from the Kungsholmen project
    Chengxuan Qiu
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 35:1810-5. 2004
    ..Low blood pressure has been related to an increased risk of dementia. We sought to verify blood pressure variations before and after a dementia diagnosis and to relate blood pressure decline to subsequent Alzheimer disease and dementia...
  94. ncbi request reprint A longitudinal study integrating population, care and social services data. The Swedish National study on Aging and Care (SNAC)
    Marten Lagergren
    Stockholm Gerontology Research Center, Stockholm, Sweden
    Aging Clin Exp Res 16:158-68. 2004
    ..A large, national, long-term, longitudinal, multi-purpose study has been launched in Sweden--the Swedish National study on Aging and Care (SNAC). The study involves four research centers collecting data in four different areas of Sweden...
  95. ncbi request reprint Alcohol consumption and incidence of dementia in a community sample aged 75 years and older
    Wenyong Huang
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institutet and the Stockholm Gerontology Research Center, Olivecronas vag 4, Box 6401, S 113 82 Stockholm, Sweden
    J Clin Epidemiol 55:959-64. 2002
    ....