Lasse Folkersen

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Prediction of ischemic events on the basis of transcriptomic and genomic profiling in patients undergoing carotid endarterectomy
    Lasse Folkersen
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Mol Med 18:669-75. 2012
  2. pmc GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome
    Lasse Folkersen
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Bioinformatics 25:1978-9. 2009
  3. pmc Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants
    Lasse Folkersen
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 4:e7677. 2009
  4. pmc Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study
    Lasse Folkersen
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Med 17:1365-73. 2011
  5. pmc Diverging alternative splicing fingerprints in the transforming growth factor-β signaling pathway identified in thoracic aortic aneurysms
    Sanela Kurtovic
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Med 17:665-75. 2011
  6. doi Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis
    Ljubica Perisic
    From the Department of Molecular Medicine and Surgery L P, E H, A R, M L, C O, U H, and Department of Medicine G P B, J O, Karolinska Institute, Stockholm, Sweden Department of Molecular Genetics, Novo Nordisk, Copenhagen, Denmark L F Department of Surgery, Sodersjukhuset, Stockholm, Sweden P G Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden F P and Department of Proteomics, Royal Institute of Technology, Stockholm, Sweden J O
    Arterioscler Thromb Vasc Biol 33:2432-43. 2013
  7. pmc Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve
    Shohreh Maleki
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 91:129-39. 2013
  8. doi High plasma adiponectin concentration is associated with all-cause mortality in patients with carotid atherosclerosis
    Jonas Persson
    Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Sweden
    Atherosclerosis 225:491-6. 2012
  9. doi Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease
    Lasse Folkersen
    Atherosclerosis Research Unit, Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Circ Cardiovasc Genet 3:365-73. 2010
  10. doi Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve
    Valentina Paloschi
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 31:691-7. 2011

Detail Information

Publications26

  1. pmc Prediction of ischemic events on the basis of transcriptomic and genomic profiling in patients undergoing carotid endarterectomy
    Lasse Folkersen
    Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Mol Med 18:669-75. 2012
    ..The method may be developed to identify subjects at very high risk of ischemic events...
  2. pmc GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome
    Lasse Folkersen
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Bioinformatics 25:1978-9. 2009
    ..It also features functions to fit a linear regression based on several genetic models that enables study of the relationship between gene expression and genotype...
  3. pmc Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants
    Lasse Folkersen
    Department of Medicine, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 4:e7677. 2009
    ..We investigated five different expression microarray datasets in order to determine if the genotype had effect on expression of any gene transcript in aorta, mammary artery, carotid plaque and lymphoblastoid cells...
  4. pmc Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study
    Lasse Folkersen
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Med 17:1365-73. 2011
    ..Conversely, genes were identified that were only differentially expressed with dilation in BAV patients. The result has bearing on future clinical studies in which separate analysis of BAV and TAV patients is recommended...
  5. pmc Diverging alternative splicing fingerprints in the transforming growth factor-β signaling pathway identified in thoracic aortic aneurysms
    Sanela Kurtovic
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Med 17:665-75. 2011
    ..In summary, alternative splicing is a common feature of TAA formation. Our results suggest that dilatation in TAV and BAV patients has different alternative splicing fingerprints in the TGFβ pathway...
  6. doi Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis
    Ljubica Perisic
    From the Department of Molecular Medicine and Surgery L P, E H, A R, M L, C O, U H, and Department of Medicine G P B, J O, Karolinska Institute, Stockholm, Sweden Department of Molecular Genetics, Novo Nordisk, Copenhagen, Denmark L F Department of Surgery, Sodersjukhuset, Stockholm, Sweden P G Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden F P and Department of Proteomics, Royal Institute of Technology, Stockholm, Sweden J O
    Arterioscler Thromb Vasc Biol 33:2432-43. 2013
    ....
  7. pmc Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve
    Shohreh Maleki
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 91:129-39. 2013
    ..Implementing a new strategy, we have demonstrated an angiostatic gene expression signature in patients with BAV, indicating impaired wound healing in these patients, potentially involved in BAV-associated aortopathy...
  8. doi High plasma adiponectin concentration is associated with all-cause mortality in patients with carotid atherosclerosis
    Jonas Persson
    Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Sweden
    Atherosclerosis 225:491-6. 2012
    ..The role of adiponectin as a risk factor for mortality and recurrent ischemic cardiovascular events in patients with carotid artery disease is unknown...
  9. doi Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease
    Lasse Folkersen
    Atherosclerosis Research Unit, Experimental Cardiovascular Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Circ Cardiovasc Genet 3:365-73. 2010
    ..Genes in close proximity to these risk-SNPs are often thought to be pathogenetically important based on their location alone. However, the actual connections between SNPs and disease mechanisms remain largely unknown...
  10. doi Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve
    Valentina Paloschi
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 31:691-7. 2011
    ..Here we analyze the expression of FN spliceforms in dilated and nondilated ascending aorta of tricuspid aortic valve (TAV) and BAV patients...
  11. doi Tissue factor pathway inhibitor-2 is induced by fluid shear stress in vascular smooth muscle cells and affects cell proliferation and survival
    Johan Ekstrand
    Section of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Vasc Surg 52:167-75. 2010
    ..Here, we investigated the effect of FSS on SMC gene expression and function...
  12. doi The expression of IGFs and IGF binding proteins in human carotid atherosclerosis, and the possible role of IGF binding protein-1 in the regulation of smooth muscle cell proliferation
    Jing Wang
    Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden
    Atherosclerosis 220:102-9. 2012
    ....
  13. doi Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms
    Veronica Jackson
    Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    J Thorac Cardiovasc Surg 144:459-66. 2012
    ..Here, we analyzed the occurrence of MMPs and MMP inhibitors in ascending aortic aneurysms in patients with bicuspid and tricuspid aortic valves...
  14. pmc Endogenous control genes in complex vascular tissue samples
    Lasse Folkersen
    Cardiovasular Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    BMC Genomics 10:516. 2009
    ..We here present an analysis of the differences in expression results obtained with microarray and real-time PCR, dependent on different choices of endogenous control genes...
  15. pmc Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease
    Maria Sabater-Lleal
    Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 9:e104082. 2014
    ..The present results should help elucidate the molecular underpinnings of the co-morbidity observed across COPD and CAD...
  16. pmc Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response
    Maria Jesus Iglesias
    Atherosclerosis Research Unit, Department of Medicine, Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 7:e32306. 2012
    ..The regulation of the inflammatory response appears to occur in a very specific manner at the chromatin level for specific genes and this study highlights the level of fine-tuning that occurs in the immune response...
  17. doi 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms
    Karl Gertow
    Department of Medicine, Center for Molecular Medicine, Unit of Experimental Cardiovascular Research, Karolinska Institutet, Stockholm SE 17176, Sweden
    Atherosclerosis 215:411-6. 2011
    ..These findings suggest a link between ALOX15B and atherothrombotic events that merits further investigation...
  18. pmc Human genetic evidence for involvement of CD137 in atherosclerosis
    Leif A Söderström
    Experimental Cardiovascular Research Group, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Department of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Mol Med 20:456-65. 2014
    ....
  19. doi PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk
    Montse Guardiola
    From the Center for Cardiovascular Genetics, Institute of Cardiovascular Science M G, H J E, J P, K W L, J A C, S E H, P J T, and Genetic Epidemiology Group, Department of Epidemiology and Public Health M V H, University College London, London, UK Unitat de Recerca en Lípids i Arteriosclerosi, Universitat Rovira i Virgili, CIBERDEM, IISPV, Reus, Spain M G Genomics and Pathophysiology of Cardiovascular Diseases Team, iCAN, Sorbonne Universités, UPMC University Paris 06, INSERM UMR_S 1166, Paris, France C P, E N Molecular Genetics Department, Novo Nordisk A S, Copenhagen, Denmark L F Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden L F, F V H, P E, G P B Atherosclerosis Research Unit, Department of Medicine Solna F v H
    Circ Cardiovasc Genet 8:356-62. 2015
    ..The aim of this study was to use genetic variants of PLA2G10, encoding sPLA2-X, to investigate the contribution of sPLA2-X to the measure of sPLA2 activity and coronary heart disease (CHD) risk traits and outcome...
  20. doi A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness)
    Rona J Strawbridge
    Atherosclerosis Research Unit, Centre for Molecular Medicine, Building L8 03, Karolinska University Hospital Solna, 17176, Stockholm, Sweden
    Diabetologia 57:1159-72. 2014
    ..The present study employed a Mendelian randomisation approach and carotid artery intima-media thickness (cIMT), a surrogate marker of coronary artery disease, to address this question...
  21. doi Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk
    Karl Gertow
    Atherosclerosis Research Unit, Karolinska University Hospital Solna, Center for Molecular Medicine, Stockholm, Sweden
    Circ Cardiovasc Genet 5:656-65. 2012
    ..Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse...
  22. doi α7 Nicotinic acetylcholine receptor is expressed in human atherosclerosis and inhibits disease in mice--brief report
    Maria E Johansson
    From the Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden M E J, A M L, L Folkersen, Z Q Y, G K H and Department of Physiology, Institute of Neuroscience and Physiology M E J, M A U, Department of Rheumatology and Inflammation Research, Institute of Medicine A B, A A, U I, and Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine L Fogelstrand, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Arterioscler Thromb Vasc Biol 34:2632-6. 2014
    ..We have analyzed the expression of the α7 nicotinic acetylcholine receptor (α7nAChR) in human atherosclerotic plaques and studied its effects on the development of atherosclerosis in the hypercholesterolemic Ldlr(-/-) mouse model...
  23. doi Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion
    Anders Gabrielsen
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 88:795-806. 2010
    ..The findings suggest that intraplaque TXA(2) generation may contribute to the development of atherosclerosis and its thrombotic complications in humans...
  24. doi Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice
    Maria E Johansson
    Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Eur J Immunol 44:3081-92. 2014
    ..Altogether, this study suggests that NOD2 contributes to the expansion of the lipid-rich necrotic core and promotes vascular inflammation in atherosclerosis. ..
  25. pmc AllelicImbalance: an R/bioconductor package for detecting, managing, and visualizing allele expression imbalance data from RNA sequencing
    Jesper R Gådin
    Atherosclerosis Research Unit, Karolinska University Hospital Solna, Center for Molecular Medicine, Bldg L8 03, S 171 76, Stockholm, Sweden
    BMC Bioinformatics 16:194. 2015
    ..Flexible bioinformatics tools are needed to ease the workflow while retaining as much RNA sequencing information as possible throughout the analysis to detect and address the possible biases...
  26. doi A genome-wide association study identifies KNG1 as a genetic determinant of plasma factor XI Level and activated partial thromboplastin time
    Maria Sabater-Lleal
    Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 32:2008-16. 2012
    ....