Research Topics
Genomes and Genes | Gilberto FisoneSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Publications
Increased D1 dopamine receptor signaling in levodopa-induced dyskinesiaIncarnation Aubert
Centre National de la Recherche Scientifique Unite Mixte de Recherche 5541, Bordeaux Cedex, France
Ann Neurol 57:17-26. 2005..Our data suggest that levodopa-induced dyskinesia results from increased dopamine D(1) receptor-mediated transmission at the level of the direct pathway...- Signaling in the basal ganglia: postsynaptic and presynaptic mechanismsGilberto Fisone
Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden
Physiol Behav 92:8-14. 2007..The present review focuses on studies performed in our laboratory, which provide a molecular framework to understand the effects on motor activity of adenosine and caffeine... 
L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian miceEmanuela Santini
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Neurochem 108:621-33. 2009..Our results demonstrate that in the dopamine-depleted striatum, L-DOPA activates ERK signaling specifically in striatonigral MSNs. This regulation may result in ERK-dependent changes in striatal plasticity leading to dyskinesia...
Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonismEmanuela Santini
Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
J Biol Chem 287:27806-12. 2012..These studies demonstrate that, in D1R-expressing MSNs, l-DOPA-induced activation of ERK and mTORC1 requires DARPP-32 and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia...- Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesiaEmanuela Santini
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
J Neurosci 27:6995-7005. 2007.... - Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidolKerstin Hakansson
Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
Eur J Neurosci 20:1108-12. 2004..These studies also show that lower levels of phosphorylated TH are associated with chronic neuroleptic treatment and may be related to depressed dopaminergic transmission in nigrostriatal neurons... - Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized miceAnders Borgkvist
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
Neuropharmacology 55:230-7. 2008..This activation is associated to enhanced psychomotor sensitization and may be implicated in context-elicited drug seeking induced by repeated exposure to drugs of abuse... - Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neuronsMikael Andersson
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
J Neurosci 25:8432-8. 2005.... - Activation of the cAMP/PKA/DARPP-32 signaling pathway is required for morphine psychomotor stimulation but not for morphine rewardAnders Borgkvist
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
Neuropsychopharmacology 32:1995-2003. 2007..These results demonstrate that dopamine D1 receptor-mediated activation of the cAMP/DARPP-32 cascade in striatal medium spiny neurons is involved in the psychomotor action, but not in the rewarding properties, of morphine... - Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysisDaniel Marcellino
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
Neuropharmacology 54:815-23. 2008..Taken together, these results give evidence for the existence of antagonistic CB(1)/D(2) receptor-receptor interactions within CB(1)/D(2) heteromers in which A(2A) receptors may also participate... - Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatumLaura Pozzi
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Neurochem 86:451-9. 2003..The results provide a novel biochemical paradigm elucidating the molecular mechanisms underlying the distinct therapeutic actions of typical and atypical anti-psychotic agents... - Regulation of DARPP-32 phosphorylation by Delta9-tetrahydrocannabinolAnders Borgkvist
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
Neuropharmacology 54:31-5. 2008..These results indicate that, in the striatum, THC promotes PKA-dependent phosphorylation of DARPP-32 in striatal medium spiny neurons expressing dopamine D1 and adenosine A2A receptors... - Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptorsKerstin Hakansson
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Neurochem 96:482-8. 2006..These results demonstrate that dopamine D2 antagonists increase GluR1 phosphorylation at Ser845 by removing the inhibitory tone exerted by dopamine D2 receptors on the PKA/DARPP-32 cascade... - Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesiaEmanuela Santini
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
Sci Signal 2:ra36. 2009..Thus, the mTORC1 signaling cascade represents a promising target for the design of anti-Parkinsonian therapies... - DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesiaKerstin Hakansson
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
Parkinsonism Relat Disord 10:281-6. 2004..The involvement of DARPP-32 in dopamine and adenosine transmission and the possible role played by abnormal regulation of DARPP-32 phosphorylation in levodopa-induced dyskinesia are discussed... - Lrrk2 and alpha-synuclein are co-regulated in rodent striatumMarie Westerlund
Department of Neuroscience, Karolinska Institutet, Retzius väg 8 B2 4, S 17177 Stockholm, Sweden
Mol Cell Neurosci 39:586-91. 2008..Because striatal Lrrk2 and alpha-synuclein levels were not changed by dopamine depletion, we conclude that Lrrk2 and alpha-synuclein mRNA levels are possibly co-regulated, but they are not influenced by striatal dopamine levels... - Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesiaEmanuela Santini
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 5:e12322. 2010..However, very little is known, in non-human primates, about the regulation of these signalling cascades and their association with the induction, manifestation and/or maintenance of dyskinesia... - mTORC1 signaling in Parkinson's disease and L-DOPA-induced dyskinesia: A sensitized matterEmanuela Santini
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Cell Cycle 9:2713-8. 2010..This finding is discussed with respect to underlying mechanisms and potential significance for the development of future therapeutic interventions... - Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrusGiuseppe Gangarossa
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e19415. 2011..These changes may be involved in forms of activity-dependent plasticity linked to the manifestation of seizures and to the ability of dopamine to affect learning and memory... - Psychoactive drugs and regulation of the cAMP/PKA/DARPP-32 cascade in striatal medium spiny neuronsAnders Borgkvist
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
Neurosci Biobehav Rev 31:79-88. 2007..This review discusses the regulation of DARPP-32 exerted by psychoactive substances in specific populations of striatal projection neurons and its involvement in short- and long-term motor responses... - Molecular mechanisms of l-DOPA-induced dyskinesiaGilberto Fisone
Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
Int Rev Neurobiol 98:95-122. 2011..Recent evidence pointing to pre-synaptic dysregulation is also discussed... - Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32Emmanuel Valjent
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Neuropsychopharmacology 36:2561-70. 2011..These results identify PKA as a major rpS6 kinase in neuronal cells and suggest that regulation of protein synthesis through rpS6 may be a potential target of antipsychotic drugs... - Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant miceAnders Borgkvist
Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
Mol Cell Neurosci 31:293-302. 2006..Therefore, we suggest that the En1(cre/+); Otx2(flox/flox) mutant mouse model represents a genetic tool for investigating molecular and behavioural consequences of developmental neuronal dysfunction in the DAergic system... - Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sitesNiklas Lindgren
Department of Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 100:4305-9. 2003..These results demonstrate that D2S and D2L receptors participate in presynaptic and postsynaptic dopaminergic transmission, respectively... - Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weightMaria Collin
Department of Neuroscience, Karolinska Institutet, , B3, 5th Floor, Room 514, SE-171 77 Stockholm, Sweden
Eur J Neurosci 18:1265-78. 2003.... - Parkinson's disease: levodopa-induced dyskinesia and signal transductionEmanuela Santini
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
FEBS J 275:1392-9. 2008..The role of this pathological adaptation and of the consequent changes in signaling in the development and expression of LID are discussed... - Looking BAC at striatal signaling: cell-specific analysis in new transgenic miceEmmanuel Valjent
INSERM, UMR S 839, 75005 Paris, France
Trends Neurosci 32:538-47. 2009..Thus, BAC transgenic mice are changing the way to conceive experiments and provide an opportunity to fill the gaps between molecular and systems neurosciences... - Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brainNiklas Lindgren
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Eur J Neurosci 15:769-73. 2002.... - L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated TransmissionMichael Feyder
Department of Neuroscience, Karolinska Institutet Stockholm, Sweden
Front Behav Neurosci 5:71. 2011..This review focuses on the abnormalities in signaling affecting the D1R-expressing MSNs and on their potential relevance for the design of novel anti-dyskinetic therapies... - Deciphering the Actions of Antiparkinsonian and Antipsychotic Drugs on cAMP/DARPP-32 SignalingAlessandra Bonito-Oliva
Department of Neuroscience, Karolinska Institutet Stockholm, Sweden
Front Neuroanat 5:38. 2011.... - Involvement of DARPP-32 phosphorylation in the stimulant action of caffeineMaria Lindskog
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
Nature 418:774-8. 2002..Together, these studies demonstrate the involvement of DARPP-32 and its phosphorylation/dephosphorylation in the stimulant action of caffeine... - Opposing effects of ERK and p38-JNK MAP kinase pathways on formation of prions in GT1-1 cellsElin Nordström
Department of Neuroscience, Retzius vag 8, Karolinska Institutet, Stockholm, SE 171 77 Sweden
FASEB J 23:613-22. 2009..Thus, the ERK and the p38-JNK MAP kinase pathways appear to exert opposing effects on rPrP(Sc) formation, suggesting that balances between these intracellular signaling cascades may regulate replication of prions... - Some aspects on the anatomy and function of central cholecystokinin systemsTomas Hokfelt
Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Pharmacol Toxicol 91:382-6. 2002..These effects may be related to the cortico-striatal CCK/glutamatergic pathway. Moreover, these studies provide evidence for endogenous release of a neuropeptide with behavioural consequences... - Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptorsC Guigoni
Basal Gang, Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, , France
Parkinsonism Relat Disord 11:S25-9. 2005..We also report the possible role of arrestin and G protein-coupled receptor kinases... - Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesiaBarbara Picconi
Clinica Neurologica, Dipartimento di Neuroscienze, , Via Montpellier 1, 00133 Rome, Italy
Nat Neurosci 6:501-6. 2003..These results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA-induced dyskinesia... - D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801Francesco Errico
Laboratory of Behavioural Neuroscience, Centro Ingegneria Genetica Biotecnologie Avanzate, 80145 Naples, Italy
J Neurosci 28:10404-14. 2008.... - The role of DARPP-32 in the actions of drugs of abuseAngus C Nairn
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Neuropharmacology 47:14-23. 2004..This review focuses on the critical role that DARPP-32 plays in mediating the actions of a broad range of drugs of abuse... - DARPP-32: an integrator of neurotransmissionPer Svenningsson
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Annu Rev Pharmacol Toxicol 44:269-96. 2004.... - The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neuronsFrancesco Errico
CEINGE Biotecnologie Avanzate, Naples, Italy
Mol Cell Neurosci 37:335-45. 2008..Altogether, our results indicate that Rhes is an important modulator of dopaminergic transmission in the striatum...