Gilberto Fisone

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia
    Incarnation Aubert
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5541, Bordeaux Cedex, France
    Ann Neurol 57:17-26. 2005
  2. ncbi request reprint Signaling in the basal ganglia: postsynaptic and presynaptic mechanisms
    Gilberto Fisone
    Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden
    Physiol Behav 92:8-14. 2007
  3. doi request reprint L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 108:621-33. 2009
  4. pmc Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Biol Chem 287:27806-12. 2012
  5. ncbi request reprint Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Neurosci 27:6995-7005. 2007
  6. ncbi request reprint Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 20:1108-12. 2004
  7. doi request reprint Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Neuropharmacology 55:230-7. 2008
  8. ncbi request reprint Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons
    Mikael Andersson
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Neurosci 25:8432-8. 2005
  9. doi request reprint Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neuropharmacology 54:815-23. 2008
  10. ncbi request reprint Activation of the cAMP/PKA/DARPP-32 signaling pathway is required for morphine psychomotor stimulation but not for morphine reward
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neuropsychopharmacology 32:1995-2003. 2007

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia
    Incarnation Aubert
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5541, Bordeaux Cedex, France
    Ann Neurol 57:17-26. 2005
    ..Our data suggest that levodopa-induced dyskinesia results from increased dopamine D(1) receptor-mediated transmission at the level of the direct pathway...
  2. ncbi request reprint Signaling in the basal ganglia: postsynaptic and presynaptic mechanisms
    Gilberto Fisone
    Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden
    Physiol Behav 92:8-14. 2007
    ..The present review focuses on studies performed in our laboratory, which provide a molecular framework to understand the effects on motor activity of adenosine and caffeine...
  3. doi request reprint L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 108:621-33. 2009
    ..Our results demonstrate that in the dopamine-depleted striatum, L-DOPA activates ERK signaling specifically in striatonigral MSNs. This regulation may result in ERK-dependent changes in striatal plasticity leading to dyskinesia...
  4. pmc Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Biol Chem 287:27806-12. 2012
    ..These studies demonstrate that, in D1R-expressing MSNs, l-DOPA-induced activation of ERK and mTORC1 requires DARPP-32 and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia...
  5. ncbi request reprint Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Neurosci 27:6995-7005. 2007
    ....
  6. ncbi request reprint Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 20:1108-12. 2004
    ..These studies also show that lower levels of phosphorylated TH are associated with chronic neuroleptic treatment and may be related to depressed dopaminergic transmission in nigrostriatal neurons...
  7. doi request reprint Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Neuropharmacology 55:230-7. 2008
    ..This activation is associated to enhanced psychomotor sensitization and may be implicated in context-elicited drug seeking induced by repeated exposure to drugs of abuse...
  8. ncbi request reprint Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons
    Mikael Andersson
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    J Neurosci 25:8432-8. 2005
    ....
  9. doi request reprint Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis
    Daniel Marcellino
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neuropharmacology 54:815-23. 2008
    ..Taken together, these results give evidence for the existence of antagonistic CB(1)/D(2) receptor-receptor interactions within CB(1)/D(2) heteromers in which A(2A) receptors may also participate...
  10. ncbi request reprint Activation of the cAMP/PKA/DARPP-32 signaling pathway is required for morphine psychomotor stimulation but not for morphine reward
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neuropsychopharmacology 32:1995-2003. 2007
    ..These results demonstrate that dopamine D1 receptor-mediated activation of the cAMP/DARPP-32 cascade in striatal medium spiny neurons is involved in the psychomotor action, but not in the rewarding properties, of morphine...
  11. ncbi request reprint Regulation of DARPP-32 phosphorylation by Delta9-tetrahydrocannabinol
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neuropharmacology 54:31-5. 2008
    ..These results indicate that, in the striatum, THC promotes PKA-dependent phosphorylation of DARPP-32 in striatal medium spiny neurons expressing dopamine D1 and adenosine A2A receptors...
  12. doi request reprint Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Sci Signal 2:ra36. 2009
    ..Thus, the mTORC1 signaling cascade represents a promising target for the design of anti-Parkinsonian therapies...
  13. ncbi request reprint Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 96:482-8. 2006
    ..These results demonstrate that dopamine D2 antagonists increase GluR1 phosphorylation at Ser845 by removing the inhibitory tone exerted by dopamine D2 receptors on the PKA/DARPP-32 cascade...
  14. ncbi request reprint Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum
    Laura Pozzi
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Neurochem 86:451-9. 2003
    ..The results provide a novel biochemical paradigm elucidating the molecular mechanisms underlying the distinct therapeutic actions of typical and atypical anti-psychotic agents...
  15. ncbi request reprint DARPP-32 and modulation of cAMP signaling: involvement in motor control and levodopa-induced dyskinesia
    Kerstin Hakansson
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
    Parkinsonism Relat Disord 10:281-6. 2004
    ..The involvement of DARPP-32 in dopamine and adenosine transmission and the possible role played by abnormal regulation of DARPP-32 phosphorylation in levodopa-induced dyskinesia are discussed...
  16. doi request reprint Lrrk2 and alpha-synuclein are co-regulated in rodent striatum
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, Retzius väg 8 B2 4, S 17177 Stockholm, Sweden
    Mol Cell Neurosci 39:586-91. 2008
    ..Because striatal Lrrk2 and alpha-synuclein levels were not changed by dopamine depletion, we conclude that Lrrk2 and alpha-synuclein mRNA levels are possibly co-regulated, but they are not influenced by striatal dopamine levels...
  17. pmc Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e12322. 2010
    ..However, very little is known, in non-human primates, about the regulation of these signalling cascades and their association with the induction, manifestation and/or maintenance of dyskinesia...
  18. ncbi request reprint mTORC1 signaling in Parkinson's disease and L-DOPA-induced dyskinesia: A sensitized matter
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Cell Cycle 9:2713-8. 2010
    ..This finding is discussed with respect to underlying mechanisms and potential significance for the development of future therapeutic interventions...
  19. doi request reprint Molecular mechanisms of l-DOPA-induced dyskinesia
    Gilberto Fisone
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Int Rev Neurobiol 98:95-122. 2011
    ..Recent evidence pointing to pre-synaptic dysregulation is also discussed...
  20. ncbi request reprint Psychoactive drugs and regulation of the cAMP/PKA/DARPP-32 cascade in striatal medium spiny neurons
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Neurosci Biobehav Rev 31:79-88. 2007
    ..This review discusses the regulation of DARPP-32 exerted by psychoactive substances in specific populations of striatal projection neurons and its involvement in short- and long-term motor responses...
  21. pmc Convulsant doses of a dopamine D1 receptor agonist result in Erk-dependent increases in Zif268 and Arc/Arg3.1 expression in mouse dentate gyrus
    Giuseppe Gangarossa
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e19415. 2011
    ..These changes may be involved in forms of activity-dependent plasticity linked to the manifestation of seizures and to the ability of dopamine to affect learning and memory...
  22. pmc Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32
    Emmanuel Valjent
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 36:2561-70. 2011
    ..These results identify PKA as a major rpS6 kinase in neuronal cells and suggest that regulation of protein synthesis through rpS6 may be a potential target of antipsychotic drugs...
  23. ncbi request reprint Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice
    Anders Borgkvist
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm, Sweden
    Mol Cell Neurosci 31:293-302. 2006
    ..Therefore, we suggest that the En1(cre/+); Otx2(flox/flox) mutant mouse model represents a genetic tool for investigating molecular and behavioural consequences of developmental neuronal dysfunction in the DAergic system...
  24. doi request reprint Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1
    Alessandra Bonito-Oliva
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Neuropharmacology 72:197-203. 2013
    ..They also indicate that this effect is exerted by suppressing dephosphorylation at Ser240/244, through PKA-dependent activation of DARPP-32 and inhibition of PP-1...
  25. pmc Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites
    Niklas Lindgren
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:4305-9. 2003
    ..These results demonstrate that D2S and D2L receptors participate in presynaptic and postsynaptic dopaminergic transmission, respectively...
  26. doi request reprint mGlu5R promotes glutamate AMPA receptor phosphorylation via activation of PKA/DARPP-32 signaling in striatopallidal medium spiny neurons
    Maria Teresa Dell'anno
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Neuropharmacology 66:179-86. 2013
    ..This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  27. ncbi request reprint Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight
    Maria Collin
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, B3, 5th Floor, Room 514, SE 171 77 Stockholm, Sweden
    Eur J Neurosci 18:1265-78. 2003
    ....
  28. doi request reprint Parkinson's disease: levodopa-induced dyskinesia and signal transduction
    Emanuela Santini
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    FEBS J 275:1392-9. 2008
    ..The role of this pathological adaptation and of the consequent changes in signaling in the development and expression of LID are discussed...
  29. doi request reprint Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice
    Emmanuel Valjent
    INSERM, UMR S 839, 75005 Paris, France
    Trends Neurosci 32:538-47. 2009
    ..Thus, BAC transgenic mice are changing the way to conceive experiments and provide an opportunity to fill the gaps between molecular and systems neurosciences...
  30. doi request reprint Activation of Metabotropic Glutamate 4 Receptors Decreases L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease
    Sebastien Lopez
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Parkinsons Dis 1:339-46. 2011
    ..These results indicate that co-administration of LSP1-2111 may improve the efficacy of standard L-DOPA therapy by attenuating its liability for dyskinesia. ..
  31. ncbi request reprint Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain
    Niklas Lindgren
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 15:769-73. 2002
    ....
  32. pmc L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission
    Michael Feyder
    Department of Neuroscience, Karolinska Institutet Stockholm, Sweden
    Front Behav Neurosci 5:71. 2011
    ..This review focuses on the abnormalities in signaling affecting the D1R-expressing MSNs and on their potential relevance for the design of novel anti-dyskinetic therapies...
  33. doi request reprint Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1
    Elin K Allard
    Department of Neuroscience, Retzius vag 8, Karolinska Institutet, Stockholm SE 171 77, Sweden
    Neurobiol Dis 58:116-22. 2013
    ....
  34. doi request reprint Opposing effects of ERK and p38-JNK MAP kinase pathways on formation of prions in GT1-1 cells
    Elin Nordström
    Department of Neuroscience, Retzius vag 8, Karolinska Institutet, Stockholm, SE 171 77 Sweden
    FASEB J 23:613-22. 2009
    ..Thus, the ERK and the p38-JNK MAP kinase pathways appear to exert opposing effects on rPrP(Sc) formation, suggesting that balances between these intracellular signaling cascades may regulate replication of prions...
  35. ncbi request reprint Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine
    Maria Lindskog
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Nature 418:774-8. 2002
    ..Together, these studies demonstrate the involvement of DARPP-32 and its phosphorylation/dephosphorylation in the stimulant action of caffeine...
  36. pmc Deciphering the Actions of Antiparkinsonian and Antipsychotic Drugs on cAMP/DARPP-32 Signaling
    Alessandra Bonito-Oliva
    Department of Neuroscience, Karolinska Institutet Stockholm, Sweden
    Front Neuroanat 5:38. 2011
    ....
  37. ncbi request reprint Some aspects on the anatomy and function of central cholecystokinin systems
    Tomas Hokfelt
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Pharmacol Toxicol 91:382-6. 2002
    ..These effects may be related to the cortico-striatal CCK/glutamatergic pathway. Moreover, these studies provide evidence for endogenous release of a neuropeptide with behavioural consequences...
  38. ncbi request reprint Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Nat Neurosci 6:501-6. 2003
    ..These results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA-induced dyskinesia...
  39. ncbi request reprint Pathogenesis of levodopa-induced dyskinesia: focus on D1 and D3 dopamine receptors
    C Guigoni
    Basal Gang, Laboratoire de Physiologie et Physiopathologie de la Signalisation Cellulaire, CNRS UMR 5543, Universite Victor Segalen Bordeaux 2, France
    Parkinsonism Relat Disord 11:S25-9. 2005
    ..We also report the possible role of arrestin and G protein-coupled receptor kinases...
  40. ncbi request reprint DARPP-32: an integrator of neurotransmission
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Annu Rev Pharmacol Toxicol 44:269-96. 2004
    ....
  41. ncbi request reprint The role of DARPP-32 in the actions of drugs of abuse
    Angus C Nairn
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Neuropharmacology 47:14-23. 2004
    ..This review focuses on the critical role that DARPP-32 plays in mediating the actions of a broad range of drugs of abuse...
  42. ncbi request reprint The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons
    Francesco Errico
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Mol Cell Neurosci 37:335-45. 2008
    ..Altogether, our results indicate that Rhes is an important modulator of dopaminergic transmission in the striatum...
  43. doi request reprint D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801
    Francesco Errico
    Laboratory of Behavioural Neuroscience, Centro Ingegneria Genetica Biotecnologie Avanzate, 80145 Naples, Italy
    J Neurosci 28:10404-14. 2008
    ....