Henrik Falhammar

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi Maternal and neonatal outcomes in the Torres Strait Islands with a sixfold increase in type 2 diabetes in pregnancy over six years
    Henrik Falhammar
    Cairns Diabetes Centre, Cairns Base Hospital, Cairns, Queensland, Australia
    Aust N Z J Obstet Gynaecol 50:120-6. 2010
  2. doi Biochemical and genetic diagnosis of 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, D2 04, 171 76, Stockholm, Sweden
    Endocrine 50:306-14. 2015
  3. doi Nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency: clinical presentation, diagnosis, treatment, and outcome
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D2 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 50:32-50. 2015
  4. doi Non-functioning adrenal incidentalomas caused by 21-hydroxylase deficiency or carrier status?
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 47:308-14. 2014
  5. doi Quality of life, social situation, and sexual satisfaction, in adult males with congenital adrenal hyperplasia
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 47:299-307. 2014
  6. doi Bone mineral density, bone markers, and fractures in adult males with congenital adrenal hyperplasia
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 168:331-41. 2013
  7. doi Thyrotoxic periodic paralysis: clinical and molecular aspects
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D2 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 43:274-84. 2013
  8. doi Clinical outcomes in the management of congenital adrenal hyperplasia
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, D2 04, 17176 Stockholm, Sweden
    Endocrine 41:355-73. 2012
  9. pmc Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia
    Henrik Falhammar
    Departments of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska Institute, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 166:441-9. 2012
  10. doi Cardiovascular risk, metabolic profile, and body composition in adult males with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes Department of Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 164:285-93. 2011

Collaborators

Detail Information

Publications36

  1. doi Maternal and neonatal outcomes in the Torres Strait Islands with a sixfold increase in type 2 diabetes in pregnancy over six years
    Henrik Falhammar
    Cairns Diabetes Centre, Cairns Base Hospital, Cairns, Queensland, Australia
    Aust N Z J Obstet Gynaecol 50:120-6. 2010
    ..Torres Strait Islander population has a high prevalence of type 2 diabetes (T2DM)...
  2. doi Biochemical and genetic diagnosis of 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, D2 04, 171 76, Stockholm, Sweden
    Endocrine 50:306-14. 2015
    ..Neonatal screening misses some patients with milder classic CAH and most NCCAH cases. In conclusion, diagnosing classic CAH is life-saving, but diagnosing NCCAH is also important to prevent unnecessary suffering. ..
  3. doi Nonclassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency: clinical presentation, diagnosis, treatment, and outcome
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D2 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 50:32-50. 2015
    ..Different risk factors and negative consequences should be monitored regularly in an attempt to improve the clinical outcome. More research is needed in this relatively common disorder...
  4. doi Non-functioning adrenal incidentalomas caused by 21-hydroxylase deficiency or carrier status?
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 47:308-14. 2014
    ..Patient presented with multiple AIs with hyperandrogenism or a Middle East origin screening for CAH or carrier status may be indicated...
  5. doi Quality of life, social situation, and sexual satisfaction, in adult males with congenital adrenal hyperplasia
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 47:299-307. 2014
    ..Optimizing glucocorticoid therapy might further improve QoL. Some disadvantages found in patients diagnosed late will hopefully not be seen in patients diagnosed by neonatal screening, but this has yet to be studied...
  6. doi Bone mineral density, bone markers, and fractures in adult males with congenital adrenal hyperplasia
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 168:331-41. 2013
    ..BMD measured by dual energy X-ray absorptiometry and markers of bone metabolism and androgens/17-hydroxyprogesterone levels were investigated...
  7. doi Thyrotoxic periodic paralysis: clinical and molecular aspects
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, D2 04, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Endocrine 43:274-84. 2013
    ..Definitive treatment is cure of the hyperthyroidism. The underlying mechanisms of TPP remain, however, incompletely understood awaiting further studies...
  8. doi Clinical outcomes in the management of congenital adrenal hyperplasia
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, D2 04, 17176 Stockholm, Sweden
    Endocrine 41:355-73. 2012
    ..The introduction of neonatal CAH screening may enhance long-term results. Monitoring of different risk factors and negative consequences should be done regularly in an attempt to improve clinical outcomes further...
  9. pmc Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia
    Henrik Falhammar
    Departments of Endocrinology, Metabolism and Diabetes, D02 04, Karolinska Institute, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 166:441-9. 2012
    ..Fertility in males with congenital adrenal hyperplasia (CAH) is reported from normal to severely impaired. Therefore, we investigated fertility/fecundity, social/sexual situation, and pituitary-gonadal function in CAH males...
  10. doi Cardiovascular risk, metabolic profile, and body composition in adult males with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes Department of Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 164:285-93. 2011
    ..We therefore investigated cardiovascular and metabolic risk profiles in adult CAH males...
  11. ncbi Non-classic congenital adrenal hyperplasia due to 21-hydoxylase deficiency as a cause of infertility and miscarriages
    Henrik Falhammar
    Department of Endocrinology, Cairns Base Hospital, PO Box 902, Cairns, QLD 4870, Australia
    N Z Med J 123:77-80. 2010
    ..After diagnosing NCAH due to 21-hydroxylase deficiency and initiating glucocorticoid treatment,conception occurred within 3 months and uneventful pregnancies and deliveries ensued...
  12. ncbi Increased liver enzymes in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
    Endocr J 56:601-8. 2009
    ..These women might have increased frequency of NAFLD. The finding of higher LFT also in non-obese patients suggests that not only central obesity but also glucocorticoids per se may influence...
  13. ncbi Temporary elevated insulin-like growth factor I during lactation
    H Falhammar
    Department of Endocrinology, Cairns Base Hospital, PO Box 902, Cairns, Queensland 4870, Australia
    Singapore Med J 50:e295-7. 2009
    ..In conclusion, this unique case suggests an association between the frequency of lactation and IGF-I levels, and demonstrates the difficulties encountered when measuring hormones during breastfeeding...
  14. ncbi Cyclic ectopic Cushing's syndrome and somatostatin analogue treatment
    Henrik Falhammar
    Department of Endocrinology, Cairns Base Hospital, PO Box 902, Cairns, QLD 4870, Australia
    N Z Med J 122:92-5. 2009
    ..A case of cyclic Cushing's syndrome due to a bronchial carcinoid with brain metastasis is presented which responded very well to long-term somatostatin analogue treatment...
  15. ncbi Fractures and bone mineral density in adult women with 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 92:4643-9. 2007
    ..Patients with classical congenital adrenal hyperplasia (CAH) receive lifelong, often supraphysiological, glucocorticoid therapy. Pharmacological doses of glucocorticoids are an established risk factor for osteoporosis...
  16. doi Sexual function and surgical outcome in women with congenital adrenal hyperplasia due to CYP21A2 deficiency: clinical perspective and the patients' perception
    Anna Nordenstrom
    Department of Pediatrics, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 95:3633-40. 2010
    ..Little is known about how these women feel that the disease has affected their lives regarding surgery and psychosexual adaptation...
  17. ncbi Distribution of neuropeptide Y Leu7Pro polymorphism in patients with type 1 diabetes and diabetic nephropathy among Swedish and American populations
    Jun Ma
    Department of Molecular Medicine and Surgery, L6 B2, Karolinska Institutet, Rolf Luft Center for Diabetes Research, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur J Endocrinol 157:641-5. 2007
    ..The present study aims to evaluate the susceptibility of this polymorphism to the development of DN in two different populations...
  18. ncbi Metabolic profile and body composition in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism, and Diabetes, D2 04, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 92:110-6. 2007
    ..The chronic, often supraphysiological glucocorticoid doses used in congenital adrenal hyperplasia (CAH) might increase morbidity in cardiovascular disease and diabetes...
  19. ncbi Type of mutation and surgical procedure affect long-term quality of life for women with congenital adrenal hyperplasia
    Agneta Nordenskjold
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 93:380-6. 2008
    ..In congenital adrenal hyperplasia (CAH) caused by different mutations, feminizing surgery is mostly performed in childhood, and many patients are lost to follow-up...
  20. doi Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: A total population study
    Hedvig Engberg
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Child and Adolescent Psychiatry Research Center, Stockholm, Sweden Electronic address
    Psychoneuroendocrinology 60:195-205. 2015
    ..Prenatal androgen exposure and deficient endogenous cortisol and/or adrenaline production may provide explanations for these findings, but other factors related to CAH cannot be excluded...
  21. doi Increased Cardiovascular and Metabolic Morbidity in Patients With 21-Hydroxylase Deficiency: A Swedish Population-Based National Cohort Study
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes H F, Karolinska University Hospital, SE 171 76 Stockholm, Sweden Department of Molecular Medicine and Surgery, SE 171 76 Karolinska Institutet H F, Stockholm, Sweden Department of Clinical Neuroscience L F, Karolinska Institutet, SE 171 77 Stockholm, Sweden Child and Adolescent Psychiatry Research Center L F, SE 113 30 Stockholm, Sweden Department of Obstetrics and Gynaecology A L H, Karolinska University Hospital, SE 171 76 Stockholm, Sweden Department of Women s and Children s Health A L H, Ag N, An N, SE 171 76 Karolinska Institutet, Stockholm, Sweden Department of Medical Epidemiology and Biostatistics C N, C A, Karolinska Institutet, SE 171 77 Stockholm, Sweden Lung and Allergy Unit C A, Astrid Lindgren Children s Hospital, Karolinska University Hospital, SE 171 64 Stockholm, Sweden Center for Molecular Medicine Ag N, Karolinska Institutet, SE 171 76 Stockholm, Sweden and Paediatric Surgery Ag N and Department of Paediatric Endocrinology An N, Astrid Lindgren Children s Hospital, Karolinska University Hospital, SE 171 64 Stockholm, Sweden
    J Clin Endocrinol Metab 100:3520-8. 2015
    ..Congenital adrenal hyperplasia (CAH) is lethal in its most severe forms if not treated with glucocorticoids. However, glucocorticoids may increase the risk of cardiovascular and metabolic morbidity...
  22. doi A threefold increase in gestational diabetes over two years: review of screening practices and pregnancy outcomes in Indigenous women of Cape York, Australia
    Bronwyn Davis
    Cairns Diabetes Centre, Cairns Base Hospital, Cairns, Queensland, Australia
    Aust N Z J Obstet Gynaecol 53:363-8. 2013
    ..Australian Aboriginal women have a high prevalence of type 2 diabetes (T2DM) in pregnancy and gestational diabetes (GDM)...
  23. doi Voice problems due to virilization in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Ulrika Nygren
    Division of Speech Language Pathology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden Department of Speech and Language Pathology, Karolinska University Hospital, Stockholm, Sweden
    Clin Endocrinol (Oxf) 79:859-66. 2013
    ..High levels of androgens in women may cause virilization of the larynx and a masculine voice. The purpose of the present study was to investigate subjective voice problems due to virilization in women with CAH...
  24. doi IGF2BP2 and IGF2 genetic effects in diabetes and diabetic nephropathy
    Tianwei Gu
    Department of Molecular Medicine and Surgery, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    J Diabetes Complications 26:393-8. 2012
    ..Its protein functionally binds to 5'-UTR of the imprinting IGF2 gene. The present study aims to evaluate the IGF2BP2-IGF2 genetic effects in diabetes and DN...
  25. doi Voice characteristics in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Ulrika Nygren
    Department of Clinical Science, Intervention and Technology, Division of Logopedics and Phoniatrics, Astrid Lindgren Children Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Endocrinol (Oxf) 70:18-25. 2009
    ..Raised levels of androgens can lead to increased mass in the laryngeal tissues, which may lower the fundamental frequency (F0) of the voice...
  26. doi Maternal and neonatal outcomes following diabetes in pregnancy in Far North Queensland, Australia
    Bronwyn Davis
    Cairns Diabetes Centre, Cairns, Queensland, Australia
    Aust N Z J Obstet Gynaecol 49:393-9. 2009
    ..Diabetes in pregnancy (DIP) is increasing and is associated with a number of adverse consequences for both the mother and the child...
  27. doi Increased psychiatric morbidity in men with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism, and Diabetes H F, Karolinska University Hospital, SE 171 76 Stockholm, Sweden Departments of Molecular Medicine and Surgery H F, An N, and Medical Epidemiology and Biostatistics A B, M L, P L, Karolinska Institutet, SE 171 77 Stockholm, Sweden Department of Child Psychiatry A B, Medical University of Warsaw, 02 091 Warsaw, Poland Institute of Neuroscience and Physiology M L, University of Gothenburg, SE 405 30 Gothenburg, Sweden Department of Women s and Children s Health and Center for Molecular Medicine Ag N, Karolinska Institutet, SE 171 77 Stockholm, Sweden Departments of Pediatric Surgery Ag N, and Pediatric Endocrinology An N, Astrid Lindgren Children Hospital, Karolinska University Hospital, SE 171 76 Stockholm, Sweden Department of Clinical Neuroscience L F, Karolinska Institutet, SE 171 77 Stockholm, Sweden and Child and Adolescent Psychiatry Research Center L F, SE 11330 Stockholm, Sweden
    J Clin Endocrinol Metab 99:E554-60. 2014
    ..Reports on psychiatric morbidity in males with congenital adrenal hyperplasia (CAH) are lacking...
  28. doi Gender role behavior, sexuality, and psychosocial adaptation in women with congenital adrenal hyperplasia due to CYP21A2 deficiency
    Louise Frisén
    Department of Psychiatry, Danderyd Hospital, SE 18287 Stockholm, Sweden
    J Clin Endocrinol Metab 94:3432-9. 2009
    ..Gender-atypical behavior has been described in young girls as well as in women with congenital adrenal hyperplasia (CAH) due to a CYP21A2 deficiency...
  29. doi Increased mortality in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Henrik Falhammar
    Department of Endocrinology, Metabolism and Diabetes H F, Department of Obstetrics and Gynecology A L H, Karolinska University Hospital, 171 76 Stockholm, Sweden Department of Molecular Medicine and Surgery H F, Department of Clinical Neuroscience L F, Department of Medical Epidemiology and Biostatistics C N, C A, Department of Women s and Children s Health A L H, Ag N, An N, Karolinska Institutet, 171 76 Stockholm, Sweden Child and Adolescent Psychiatry Research Center L F, Stockholm, SE 11330, Sweden and Lung and Allergy Unit, C A, Department of Paediatric Surgery Ag N, Department of Paediatric Endocrinology An N, Astrid Lindgren Children s Hospital, Karolinska Institutet, 171 76 Solna, Sweden
    J Clin Endocrinol Metab 99:E2715-21. 2014
    ..Reports on mortality in patients with congenital adrenal hyperplasia (CAH) are lacking...
  30. doi Ileal neuroendocrine tumors and heart: not only valvular consequences
    Jan Calissendorff
    Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institute, Stockholm, Sweden
    Endocrine 48:743-55. 2015
    ..This treatment is also indicated when heart metastases are detected, with the addition of diuretics and fluid restriction in cases of heart failure. Myocardial metastases are rarely treated by surgical resection...
  31. doi One hundred years of congenital adrenal hyperplasia in Sweden: a retrospective, population-based cohort study
    Sebastian Gidlöf
    Department of Molecular Medicine and Surgery, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Department of Obstetrics and Gynaecology, Karolinska University Hospital Huddinge, Stockholm, Sweden Electronic address
    Lancet Diabetes Endocrinol 1:35-42. 2013
    ..We aimed to assess the effect of historical medical improvements in the care of patients with this disorder over time and to assess the effects of neonatal screening in Sweden...
  32. pmc Limited value of long-term biochemical follow-up in patients with adrenal incidentalomas-a retrospective cohort study
    Hannah Yeomans
    Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, SE 118 82, Stockholm, Sweden
    BMC Endocr Disord 15:6. 2015
    ..We hypothesized that 24-month biochemical follow-up in patients with an initial normal screening would fail to increase the sensitivity in finding hormone producing tumours...
  33. doi ⁶⁸Ga-DOTA-TOC-PET/CT detects heart metastases from ileal neuroendocrine tumors
    Jan Calissendorff
    Endocrine Section, VO Internmedicin, Department of Clinical Science and Education, Karolinska Institutet, Sodersjukhuset, Sjukhusbacken 10, 118 83, Stockholm, Sweden
    Endocrine 47:169-76. 2014
    ..Prospective studies are needed to confirm the true clinical value of (68)Ga-DOTA-TOC-PET/CT in detecting cardiac metastases in both ileal and non-ileal NETs...
  34. ncbi Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy
    Jun Ma
    Rolf Luft Center for Diabetes Research, Department of Molecular Medicine and Surgery, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Diabetes Complications 21:28-33. 2007
    ..However, the genetic influence of the ACDC gene in T1D and diabetic microvascular complications is still unclear. The present study aims to evaluate the association of the ACDC genetic variation in T1D and diabetic nephropathy (DN)...
  35. pmc Adult case of partial trisomy 9q
    Keith Tiong
    School of Medicine, James Cook University, Queensland, Australia
    BMC Med Genet 11:26. 2010
    ..This is the first reported case of an extensive endocrinology investigation of short stature in trisomy 9q and the outcome of growth hormone treatment...
  36. doi Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection
    Santosh K Chaubey
    Department of Medicine, Cairns Base Hospital, PO Box 902, Cairns, QLD 4870, Australia
    Sex Health 6:254-7. 2009
    ..These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals...