Affiliation: Karolinska Institutet
- Blunted response to cocaine in the Flinders hypercholinergic animal model of depressionP Fagergren
Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
Neuroscience 132:1159-71. 2005..In conclusion, the FSL animal model of depression demonstrates marked blunting of the locomotor and dynorphin neuroadaptative responses to cocaine in accordance with its enhanced cholinergic sensitivity...
- Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administrationP Fagergren
Karolinska Institute, Department of Clinical Neuroscience, Karolinska Hospital, S 171 76 Stockholm, Sweden
Eur J Neurosci 17:2212-8. 2003..In addition, the temporal nature of the changes in PDYN gene expression within the striatal compartments could reflect a change in drug responsivity that occurs during the transition to drug dependence...
- Human cocaine- and amphetamine-regulated transcript (CART) mRNA is highly expressed in limbic- and sensory-related brain regionsY L Hurd
Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S 171 76 Stockholm, Sweden
J Comp Neurol 425:583-98. 2000..Rat brain specimens were also studied and many similarities to the human CART mRNA expression were evident. However, the most marked species difference was the virtual absence of the CART mRNA in the rat thalamus...