Nico P Dantuma

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin
    Nico P Dantuma
    Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers vag 3, S 17177 Stockholm, Sweden
    Trends Cell Biol 22:483-91. 2012
  2. doi request reprint The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation
    Nico P Dantuma
    Department of Cell and Molecular Biology, The Medical Nobel Institute, Karolinska Institutet, Von Eulers vag 3, S 17177 Stockholm, Sweden
    DNA Repair (Amst) 8:449-60. 2009
  3. pmc C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation
    Christian Heinen
    Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers vag 3, S 17177 Stockholm, Sweden
    Nat Commun 2:191. 2011
  4. doi request reprint Stressing the ubiquitin-proteasome system
    Nico P Dantuma
    Department of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3 S 17177, Stockholm, Sweden
    Cardiovasc Res 85:263-71. 2010
  5. ncbi request reprint The UBA2 domain functions as an intrinsic stabilization signal that protects Rad23 from proteasomal degradation
    Stijn Heessen
    Microbiology and Tumor Biology Center, Karolinska Institutet, Nobels vag 16, S 171 77 Stockholm, Sweden
    Mol Cell 18:225-35. 2005
  6. ncbi request reprint Inhibition of ubiquitin/proteasome-dependent proteolysis in Saccharomyces cerevisiae by a Gly-Ala repeat
    Stijn Heessen
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    FEBS Lett 555:397-404. 2003
  7. ncbi request reprint Aggregate formation inhibits proteasomal degradation of polyglutamine proteins
    Lisette G G C Verhoef
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    Hum Mol Genet 11:2689-700. 2002
  8. ncbi request reprint A transgenic mouse model of the ubiquitin/proteasome system
    Kristina Lindsten
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    Nat Biotechnol 21:897-902. 2003
  9. pmc Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress
    Florian A Salomons
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, Von Eulers vag 3, S 17177, Stockholm, Sweden
    Mol Cell Biol 29:1774-85. 2009
  10. ncbi request reprint Monitoring of ubiquitin-dependent proteolysis with green fluorescent protein substrates
    Victoria Menendez-Benito
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Methods Enzymol 399:490-511. 2005

Collaborators

Detail Information

Publications27

  1. doi request reprint Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin
    Nico P Dantuma
    Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers vag 3, S 17177 Stockholm, Sweden
    Trends Cell Biol 22:483-91. 2012
    ..Here, we discuss recent data that expand our current model of the role of Cdc48/p97 as a ubiquitin-selective segregase in the nuclear chromatin environment...
  2. doi request reprint The ubiquitin receptor Rad23: at the crossroads of nucleotide excision repair and proteasomal degradation
    Nico P Dantuma
    Department of Cell and Molecular Biology, The Medical Nobel Institute, Karolinska Institutet, Von Eulers vag 3, S 17177 Stockholm, Sweden
    DNA Repair (Amst) 8:449-60. 2009
    ..In this review, we discuss our present knowledge on the functions of Rad23 in protein degradation and DNA repair and speculate on the importance of the dual roles of Rad23 for the cell's ability to cope with stress conditions...
  3. pmc C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation
    Christian Heinen
    Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers vag 3, S 17177 Stockholm, Sweden
    Nat Commun 2:191. 2011
    ....
  4. doi request reprint Stressing the ubiquitin-proteasome system
    Nico P Dantuma
    Department of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3 S 17177, Stockholm, Sweden
    Cardiovasc Res 85:263-71. 2010
    ..In this review, we will summarize our current understanding of proteotoxic stress-induced dysfunction of the UPS and some of its implications for human pathologies...
  5. ncbi request reprint The UBA2 domain functions as an intrinsic stabilization signal that protects Rad23 from proteasomal degradation
    Stijn Heessen
    Microbiology and Tumor Biology Center, Karolinska Institutet, Nobels vag 16, S 171 77 Stockholm, Sweden
    Mol Cell 18:225-35. 2005
    ..Thus, the UBA2 domain of Rad23 is an evolutionarily conserved stabilization signal that allows Rad23 to interact with the proteasome without facing destruction...
  6. ncbi request reprint Inhibition of ubiquitin/proteasome-dependent proteolysis in Saccharomyces cerevisiae by a Gly-Ala repeat
    Stijn Heessen
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    FEBS Lett 555:397-404. 2003
    ..The conserved effect of the GA repeat in yeast opens the possibility for the use of genetic screens to unravel its mode of action...
  7. ncbi request reprint Aggregate formation inhibits proteasomal degradation of polyglutamine proteins
    Lisette G G C Verhoef
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    Hum Mol Genet 11:2689-700. 2002
    ..Introduction of a degradation signal in ataxin-1/Q92 reduced the incidence of nuclear inclusions and the cellular toxicity, conceivably by accelerating the clearance of the soluble substrate...
  8. ncbi request reprint A transgenic mouse model of the ubiquitin/proteasome system
    Kristina Lindsten
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 171 77 Stockholm, Sweden
    Nat Biotechnol 21:897-902. 2003
    ..These transgenic animals provide a tool for monitoring the status of the ubiquitin/proteasome system in physiologic or pathologic conditions...
  9. pmc Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress
    Florian A Salomons
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, Von Eulers vag 3, S 17177, Stockholm, Sweden
    Mol Cell Biol 29:1774-85. 2009
    ..Our data suggest that the failure of the UPS to clear aggregated proteins in the aftermath of proteotoxic stress episodes may contribute to the selective deposition of aggregation-prone proteins in conformational diseases...
  10. ncbi request reprint Monitoring of ubiquitin-dependent proteolysis with green fluorescent protein substrates
    Victoria Menendez-Benito
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Methods Enzymol 399:490-511. 2005
    ....
  11. ncbi request reprint Fluorescent reporters for the ubiquitin-proteasome system
    Florian A Salomons
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm S 17177, Sweden
    Essays Biochem 41:113-28. 2005
    ..Moreover, these reporters can aid the identification and development of novel anti-cancer and anti-inflammatory drugs based on UPS inhibition...
  12. doi request reprint Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates
    Lisette G G C Verhoef
    Department of Cell and Molecular Biology, The Medical Nobel Institute, Karolinska Institutet, Von Eulers vag 3, S 17177 Stockholm, Sweden
    FASEB J 23:123-33. 2009
    ..These observations provide an explanation for the accumulation of UBB(+1) in neurodegenerative disorders and offers new insights into the physical constraints determining proteasomal degradation...
  13. ncbi request reprint Endoplasmic reticulum stress compromises the ubiquitin-proteasome system
    Victoria Menendez-Benito
    Department of Cell and Molecular Biology, The Medical Nobel Institute, Karolinska Institutet, PO Box 285, Von Eulers vag 3, S 171 77 Stockholm, Sweden
    Hum Mol Genet 14:2787-99. 2005
    ..The compromised UPS during ER stress may explain the long-term gradual accumulation of misfolded proteins as well as the selective vulnerability of particular cell populations in conformational diseases...
  14. doi request reprint The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks
    Klara Acs
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Nat Struct Mol Biol 18:1345-50. 2011
    ..1 or CDC-48.2, or cofactors UFD-1 or NPL-4, are highly sensitive to ionizing radiation. Our data suggest that human RNF8 and RNF168 promote VCP-mediated displacement of L3MBTL1 to unmask 53BP1 chromatin binding sites...
  15. pmc A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure
    Martijn S Luijsterburg
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    EMBO J 31:2511-27. 2012
    ....
  16. pmc The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
    Giuseppe Coppotelli
    Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Nucleic Acids Res 41:2950-62. 2013
    ..Thus, by regulating chromatin compaction, EBNA1 may reset cellular transcription during infection and prime the infected cells for malignant transformation...
  17. pmc DDB2 promotes chromatin decondensation at UV-induced DNA damage
    Martijn S Luijsterburg
    Department of Cell and Molecular Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
    J Cell Biol 197:267-81. 2012
    ..Finally, we show that lesion recognition by XPC, but not DDB2, was strongly reduced in ATP-depleted cells and was regulated by the steady-state levels of poly(ADP-ribose) chains...
  18. pmc Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment
    Christa J Maynard
    Department of Cell and Molecular Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:13986-91. 2009
    ..Together our data show that polyubiquitylated proteins accumulate in R6/2 brain despite a largely operative UPS, and suggest that neurons are able to avoid or compensate for the inhibitory effects of N-mutHtt...
  19. doi request reprint Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals
    Christian Heinen
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 584:1585-90. 2010
    ..These data suggest that the protective effect of UBA domains depends on their structural integrity rather than ubiquitin binding capabilities...
  20. ncbi request reprint Stabilization signals: a novel regulatory mechanism in the ubiquitin/proteasome system
    Nico P Dantuma
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 171 77, Stockholm, Sweden
    FEBS Lett 529:22-6. 2002
    ..In this review, we discuss a new type of regulatory domain: the stabilization signal. A model is proposed according to which protein half-lives are determined by the interplay of counteracting degradation and stabilization signals...
  21. ncbi request reprint Biogenesis and processing of the amyloid precursor protein in the early secretory pathway
    Alexandra Selivanova
    Department of Neurobiology, Caring Sciences and Society NVS, KI Alzheimer Disease Research Center, Karolinska Institutet, Novum 5th floor, S 141 57 Stockholm, Sweden
    Biochem Biophys Res Commun 357:1034-9. 2007
    ..Our in vitro study suggests that newly synthesized APP is subject to amyloidogenic processing during the initial phases of the secretory pathway...
  22. ncbi request reprint The ubiquitin/proteasome system in Epstein-Barr virus latency and associated malignancies
    Nico P Dantuma
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, S 17177 Stockholm, Sweden
    Semin Cancer Biol 13:69-76. 2003
    ..Knowledge of these multiple strategies of interference with regulated proteolysis may provide new clues for the treatment of EBV-associated malignancies...
  23. doi request reprint Illuminating the ubiquitin/proteasome system
    Florian A Salomons
    Department of Cell and Molecular Biology, Karolinska Institutet, S 17177 Stockholm, Sweden
    Exp Cell Res 316:1289-95. 2010
    ..In this review, we will summarize studies that have implemented this approach to examine the UPS and discuss novel insights in the dynamic organization of the UPS...
  24. pmc Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
    Kristina Lindsten
    Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Cell Biol 157:417-27. 2002
    ..Our findings suggest that the inhibitory activity of UBB(+1) may be an important determinant of neurotoxicity and contribute to an environment that favors the accumulation of misfolded proteins...
  25. ncbi request reprint Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice
    Farasat Zaman
    Department of Woman and Child Health, Pediatric Endocrinology Unit, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Cancer Res 67:10078-86. 2007
    ..These findings could have important implications for the use of proteasome inhibitors in the treatment of childhood cancer...
  26. pmc A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling
    Nico P Dantuma
    Department of Cell and Molecular Biology, The Medical Nobel Institute, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Cell Biol 173:19-26. 2006
    ..Thus, the ubiquitin cycle couples various ubiquitin-dependent processes because of a rate-limiting pool of free ubiquitin. We propose that this ubiquitin equilibrium may allow cells to sense proteotoxic stress in a genome-wide fashion...
  27. ncbi request reprint COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein
    Alexandra Selivanova
    Department of Neurobiology, Caring Sciences and Society NVS, KI Alzheimer Disease Research Center, Karolinska Institutet, Novum 5th floor, S 141 57 Stockholm, Sweden
    Biochem Biophys Res Commun 350:220-6. 2006
    ..These results suggest that COPI-dependent retrograde transport is important for APP processing and influences production of beta-amyloid peptide...