Karin Dahlman-Wright

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint International Union of Pharmacology. LXIV. Estrogen receptors
    Karin Dahlman-Wright
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Pharmacol Rev 58:773-81. 2006
  2. ncbi request reprint Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity
    Ingrid Dahlman
    Department of Medicine, Karolinska Institute, Huddinge, Stockholm, Sweden
    Pharmacogenet Genomics 16:881-9. 2006
  3. pmc Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study
    Maria Nilsson
    Departments of Biosciences and Nutrition, Karolinska Institutet, S 141 57 Huddinge, Sweden
    BMC Med Genet 8:73. 2007
  4. ncbi request reprint Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Cancer Res 70:5174-83. 2010
  5. doi request reprint Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose
    Ingrid Dahlman
    Department of Medicine, Karolinska Institutet, Huddinge, Stockholm
    Pharmacogenet Genomics 18:967-75. 2008
  6. doi request reprint RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1
    Nina Gustafsson
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 141 57 Huddinge, Sweden
    Cancer Res 70:1265-74. 2010
  7. ncbi request reprint Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver
    Hui Gao
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Mol Endocrinol 22:10-22. 2008
  8. ncbi request reprint Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 62:1299-305. 2002
  9. ncbi request reprint Identification of target genes involved in the antiproliferative effect of glucocorticoids reveals a role for nuclear factor-(kappa)B repression
    Lars Göran Bladh
    Department of Medical Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Novum, SE 141 86 Huddinge, Sweden
    Mol Endocrinol 19:632-43. 2005
  10. doi request reprint Microarray analysis of altered gene expression in ERbeta-overexpressing HEK293 cells
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 57, Huddinge, Sweden
    Endocrine 36:224-32. 2009

Detail Information

Publications61

  1. ncbi request reprint International Union of Pharmacology. LXIV. Estrogen receptors
    Karin Dahlman-Wright
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Pharmacol Rev 58:773-81. 2006
  2. ncbi request reprint Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity
    Ingrid Dahlman
    Department of Medicine, Karolinska Institute, Huddinge, Stockholm, Sweden
    Pharmacogenet Genomics 16:881-9. 2006
    ..LXRA and LXRB genes regulate adiposity, energy dissipation, as well as glucose and lipid homeostasis in mice. We investigated the LXR genes in human obesity...
  3. pmc Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study
    Maria Nilsson
    Departments of Biosciences and Nutrition, Karolinska Institutet, S 141 57 Huddinge, Sweden
    BMC Med Genet 8:73. 2007
    ..In this report we analyse ESR1 and ESR2 gene single nucleotide polymorphisms (SNPs) for association with obesity. We also relate adipose tissue ESR1 mRNA levels and ESR1 SNPs to adipocyte lipolysis and lipogenesis phenotypes...
  4. ncbi request reprint Genome-wide mapping of estrogen receptor-beta-binding regions reveals extensive cross-talk with transcription factor activator protein-1
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Cancer Res 70:5174-83. 2010
    ..Together, our results broaden insights into ERbeta DNA-binding at the genomic level by revealing crosstalk with the AP-1 transcription factor...
  5. doi request reprint Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose
    Ingrid Dahlman
    Department of Medicine, Karolinska Institutet, Huddinge, Stockholm
    Pharmacogenet Genomics 18:967-75. 2008
    ..The aim of this study was to investigate the association between ESR1 polymorphisms and T2D as well as quantitative phenotypes related to glucose homeostasis in French and Swedish Caucasians...
  6. doi request reprint RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1
    Nina Gustafsson
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 141 57 Huddinge, Sweden
    Cancer Res 70:1265-74. 2010
    ..Our findings suggest that RBCK1 regulates cell cycle progression and proliferation of ERalpha-positive breast cancer cells by supporting transcription of ERalpha and cyclin B1...
  7. ncbi request reprint Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver
    Hui Gao
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Mol Endocrinol 22:10-22. 2008
    ..These results extend our previous studies using gene expression profiling to characterize estrogen signaling in mouse liver, by characterizing the first step in this signaling cascade, the binding of ERalpha to DNA in intact chromatin...
  8. ncbi request reprint Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
    Thomas M Stulnig
    Department of Medical Nutrition and Biosciences, Karolinska Institutet, Huddinge, Sweden
    Mol Pharmacol 62:1299-305. 2002
    ....
  9. ncbi request reprint Identification of target genes involved in the antiproliferative effect of glucocorticoids reveals a role for nuclear factor-(kappa)B repression
    Lars Göran Bladh
    Department of Medical Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Novum, SE 141 86 Huddinge, Sweden
    Mol Endocrinol 19:632-43. 2005
    ..These results demonstrate that GC-mediated inhibition of NF-(kappa)B is an important mechanism in the antiproliferative response to GCs...
  10. doi request reprint Microarray analysis of altered gene expression in ERbeta-overexpressing HEK293 cells
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, 141 57, Huddinge, Sweden
    Endocrine 36:224-32. 2009
    ..The results of Gene Ontology analysis and proliferation assays are consistent with an antiproliferative role of ERbeta independent of ERalpha...
  11. ncbi request reprint Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3
    Hui Gao
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S 14157 Huddinge, Sweden
    Mol Endocrinol 20:1287-99. 2006
    ..We propose that this may be mediated, at least partially, via estrogen stimulation of the hepatic expression of Stat3, leading to decreased expression of hepatic lipogenic genes, and thereby to antidiabetic effects...
  12. ncbi request reprint Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation
    Chunyan Zhao
    Department of Biosciences at Novum, Karolinska Institutet, S 14157 Huddinge, Sweden
    Oncogene 22:7600-6. 2003
    ..Our results suggest that a decreased level of ERbeta mRNA may be associated with breast tumorigenesis, and that DNA methylation is an important mechanism for ERbeta gene silencing in breast cancer...
  13. ncbi request reprint Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively
    Knut R Steffensen
    Department of Biosciences, Karolinska Institutet at NOVUM, Huddinge, Sweden
    Biochem Biophys Res Commun 310:589-93. 2003
    ..These results indicate a role of LXR in early developmental stages of adipose tissue...
  14. doi request reprint The diversity of sex steroid action: regulation of metabolism by estrogen signaling
    Malin Hedengran Faulds
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 83 Huddinge, Sweden
    J Endocrinol 212:3-12. 2012
    ..The impact on metabolic processes of impaired estrogen signaling and knock out of each ER subtype will also be discussed...
  15. ncbi request reprint Mouse estrogen receptor beta isoforms exhibit differences in ligand selectivity and coactivator recruitment
    Chunyan Zhao
    Department of Biosciences at Novum, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    Biochemistry 44:7936-44. 2005
    ..Taken together, these results suggest that ligand selectivity and coactivator recruitment of the ERbeta isoforms constitute additional levels of specificity that influence the transcriptional response in estrogen target cells...
  16. ncbi request reprint Polymorphisms in the estrogen receptor beta gene and risk of breast cancer: no association
    Asta Forsti
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res Treat 79:409-13. 2003
    ..No difference in the allele distribution of the six studied polymorphisms was found between the breast cancer and control groups...
  17. pmc Effects of two common polymorphisms in the 3' untranslated regions of estrogen receptor beta on mRNA stability and translatability
    Milica Putnik
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    BMC Genet 10:55. 2009
    ..These two ERbeta SNPs have been investigated for association with disease in a large number of reports...
  18. ncbi request reprint Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Cancer Res 67:3955-62. 2007
    ..Our data suggest that ERbeta2 could influence ERalpha-mediated effects relevant for breast cancer development, including hormone responsiveness...
  19. doi request reprint Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity
    Hong Jiao
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 57 Stockholm, Sweden
    J Clin Endocrinol Metab 96:E962-6. 2011
    ..Previous studies suggest a role for fibroblast growth factor receptor 1 (FGFR1) in the regulation of energy balance...
  20. doi request reprint Global identification of genes regulated by estrogen signaling and demethylation in MCF-7 breast cancer cells
    Milica Putnik
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge S 14183, Sweden
    Biochem Biophys Res Commun 426:26-32. 2012
    ..However, our data does not support a direct molecular interplay of mediators of estrogen and epigenetic signaling at promoters of regulated genes...
  21. doi request reprint Interplay between AP-1 and estrogen receptor α in regulating gene expression and proliferation networks in breast cancer cells
    Karin Dahlman-Wright
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 83 Huddinge, Sweden
    Carcinogenesis 33:1684-91. 2012
    ..Knockdown of PKIB results in robust growth suppression of breast cancer cells. Collectively, our findings support c-Fos as a critical factor that governs estrogen-dependent gene expression and breast cancer proliferation programs...
  22. pmc aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra
    Per Antonson
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    PLoS ONE 9:e85581. 2014
    ..We propose that in aP2-Cre/ERα(flox/flox) mice, increased serum estrogen levels cause over-stimulation in the uterus and genital tracts resulting in hydrometra and vaginal obstruction. ..
  23. pmc Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter
    Maria Nilsson
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, S 14157 Huddinge, Sweden
    Nucleic Acids Res 35:4858-68. 2007
    ..Our results indicate that the human LXRB gene is controlled by glucose, thereby providing a novel mechanism by which glucose regulates cellular functions via LXRbeta...
  24. ncbi request reprint Functional characterization of a novel variant of estrogen receptor beta identified in screening of DNA derived from African Americans
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institute, S 141 57 Huddinge, Sweden
    Pharmacogenet Genomics 16:379-83. 2006
    ..Information on single nucleotide polymorphisms in the estrogen receptor beta (ERbeta) gene is lacking for the African American population...
  25. doi request reprint Estrogen receptor-α, RBCK1, and protein kinase C β 1 cooperate to regulate estrogen receptor-α gene expression
    Nina Gustafsson Sheppard
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, S 14183 Huddinge, Stockholm, Sweden
    J Mol Endocrinol 49:277-87. 2012
    ..The ligand-binding function of ERα does not influence the interaction with RBCK1. In summary, our data provide insight into the molecular mechanism by which ERα expression is modulated in breast cancer cells...
  26. doi request reprint Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: target genes include glutathione peroxidase 3 and cell death-inducing DNA fragmentation factor, alpha-subunit-like effector A
    Lovisa Lundholm
    Department of Biosciences and Nutrition at Novum, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    J Endocrinol 196:547-57. 2008
    ..We conclude that estrogen has large effects on gene expression in white adipose tissue and hypothesize that GPX3 and CIDEA could be important mediators of the effects of estrogen on fat mass...
  27. doi request reprint The gene regulatory networks controlled by estrogens
    Hui Gao
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, S141 83, Huddinge, Stockholm, Sweden
    Mol Cell Endocrinol 334:83-90. 2011
    ..This paper reviews the current knowledge of estrogen regulation of gene expression and subsequent gene regulatory networks with focus on studies using human cell lines and mouse models...
  28. pmc Estrogen signaling via estrogen receptor {beta}
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 57 Huddinge, Sweden
    J Biol Chem 285:39575-9. 2010
    ..We also highlight the recent work establishing new roles of ERβ signaling, including protective functions in the epithelial-mesenchymal transition and in atherosclerosis, as well as regulation of cell proliferation in the colon...
  29. pmc Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action
    Marko Matic
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 8:e57458. 2013
    ..Collectively, our findings indicate that hepatic ERα action may not be the responsible factor for the previously identified hepatic insulin resistance in ERαKO mice...
  30. pmc The genome landscape of ERalpha- and ERbeta-binding DNA regions
    Yawen Liu
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 105:2604-9. 2008
    ..Differences in the properties of ER bound regions might explain some of the differences in gene expression programs and physiological effects shown by the respective estrogen receptors...
  31. pmc Estrogen receptor beta: an overview and update
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Nucl Recept Signal 6:e003. 2008
    ..ERbeta agonists are being explored and validated as drugs for a growing number of indications. Hopefully, some ERbeta targeted drugs will prove to be efficient in enhancing human health...
  32. pmc Genome wide association study identifies KCNMA1 contributing to human obesity
    Hong Jiao
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    BMC Med Genomics 4:51. 2011
    ..Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity...
  33. ncbi request reprint Effects of testosterone and estrogen treatment on lipolysis signaling pathways in subcutaneous adipose tissue of postmenopausal women
    Hong Zang
    Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden
    Fertil Steril 88:100-6. 2007
    ....
  34. ncbi request reprint Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling
    Xiaojuan Sun
    Department of Laboratory Medicine, Division of Pathology, Huddinge University Hospital, F 46, Karolinska Institutet, S 141 86 Stockholm, Sweden
    J Pathol 207:91-101. 2005
    ..These differences in the molecular phenotype may give a better basis for diagnosis and for designing novel therapies...
  35. pmc Expression of activator protein-1 (AP-1) family members in breast cancer
    Amirhossein Kharman-Biz
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, S 14183, Huddinge, Sweden
    BMC Cancer 13:441. 2013
    ..We aimed to assess the potential role of AP-1 family members as novel biomarkers in breast cancer...
  36. pmc Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study
    Ingrid Dahlman
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    BMC Med Genet 10:27. 2009
    ..This project aimed to determine whether common genetic variations in LXRA and LXRB associate with type 2 diabetes (T2D) and quantitative measures of glucose homeostasis, and, if so, reveal the underlying mechanisms...
  37. doi request reprint Metabolic diseases and cancer risk
    Malin H Faulds
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Curr Opin Oncol 24:58-61. 2012
    ..This review focuses on the potential increased relative risk for the development of cancer in a population with a rapidly increasing incidence of metabolic disturbances...
  38. pmc Reduced levels of oestrogen receptor beta mRNA in Swedish patients with chronic fatigue syndrome
    Hanna Gräns
    Department of Laboratory Medicine, Division of Clinical Bacteriology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Clin Pathol 60:195-8. 2007
    ..Furthermore, an immunomediated pathogenesis has been suggested for CFS, providing an additional connection to oestrogen, which displays immunomodular functions...
  39. ncbi request reprint Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-kappaB and activator protein-1 repression
    Lars Göran Bladh
    Department of Medical Nutrition, Karolinska Institutet, Karolinska University Hospital in Huddinge, Novum, SE 141 86 Huddinge, Sweden
    Mol Pharmacol 67:815-26. 2005
    ..The genes differentially regulated by GRR488Q mutant versus the wild-type GR after 2 h of treatment seem mainly to be involved in control of transcription and cell growth. At 8 h, no such distinction could be seen...
  40. doi request reprint Liver X receptor in cholesterol metabolism
    Chunyan Zhao
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    J Endocrinol 204:233-40. 2010
    ..The overlapping and distinct roles of the LXRalpha and LXRbeta isoforms, and the potential use of LXRs as attractive targets for treatment of cardiovascular disease are also discussed...
  41. ncbi request reprint Specific regulation of lipocalin-type prostaglandin D synthase in mouse heart by estrogen receptor beta
    Michio Otsuki
    Department of Biosciences at Novum, Karolinska Institutet Huddinge SE 14157, Sweden
    Mol Endocrinol 17:1844-55. 2003
    ..We demonstrate that a one-nucleotide change (A to C) in the L-PGDS estrogen-responsive element affects receptor selectivity...
  42. ncbi request reprint Purification of functional full-length liver X receptor beta produced in Escherichia coli
    Gudrun Toresson
    Department of Biosciences, Novum, Karolinska Institute, Huddinge SE 14157, Sweden
    Protein Expr Purif 35:190-8. 2004
    ..The purified LXRbeta constitutes an important tool for further functional and structural studies...
  43. doi request reprint Binding of estrogen receptor alpha/beta heterodimers to chromatin in MCF-7 cells
    Zoi Papoutsi
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden
    J Mol Endocrinol 43:65-72. 2009
    ..Our results confirmed the recruitment of ERalpha/beta heterodimers to all these regions. This study represents the first demonstration of binding of ERalpha/beta heterodimers to various DNA-binding regions in intact chromatin...
  44. doi request reprint Key lipogenic gene expression can be decreased by estrogen in human adipose tissue
    Lovisa Lundholm
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Fertil Steril 90:44-8. 2008
    ..To characterize the molecular mechanisms by which estrogens reduce adipose tissue mass, with particular focus on genes involved in lipogenesis...
  45. doi request reprint Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases
    Malin Hedengran Faulds
    Department of Biosciences and Nutrition, Novum, Karolinska Institutet, S 141 83 Huddinge, Sweden
    Curr Opin Pharmacol 10:692-7. 2010
    ..Other strategies to explore the beneficial aspects of LXR activation include targeting co-factors or pathways that are modifying LXR activity...
  46. ncbi request reprint Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue
    Hui Gao
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, SE 141 86, Sweden
    Cell Metab 19:981-92. 2014
    ..We conclude that EBF1 is an important regulator of adipose morphology and fat cell lipolysis and may constitute a link between WAT inflammation, altered lipid metabolism, adipose hypertrophy, and insulin resistance. ..
  47. doi request reprint Estrogen receptor beta in breast cancer
    Lars Arne Haldosén
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden Electronic address
    Mol Cell Endocrinol 382:665-72. 2014
    ....
  48. ncbi request reprint Nuclear receptors in disease: the oestrogen receptors
    Maria Nilsson
    Departments of Biosciences and Medical Nutrition, Karolinska Institutet, Novum, SE 141 57 Huddinge, Sweden
    Essays Biochem 40:157-67. 2004
    ..Refined SERMs will, in the future, provide improved therapeutic strategies for existing and novel indications...
  49. ncbi request reprint Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice
    Marie K Lindberg
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Gothenburg, Sweden
    Mol Endocrinol 17:203-8. 2003
    ..In conclusion, our in vivo data indicate that an important physiological role of ERbeta is to modulate ERalpha-mediated gene transcription supporting a "Ying Yang" relationship between ERalpha and ERbeta in mice...
  50. ncbi request reprint Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in vitro
    Gary M Leong
    Pituitary Research Unit, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia
    Endocrinology 145:5525-31. 2004
    ..In summary, estrogen, via ERalpha, up-regulated hepatic expression of SOCS-2 and -3, probably through transcriptional activation. This indicates a novel mechanism of estrogen regulation of cytokine action...
  51. pmc Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice
    Galyna Bryzgalova
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 295:E904-12. 2008
    ..Decreased plasma levels of resistin probably also play an important role in this context...
  52. ncbi request reprint Estrogen increases coagulation factor V mRNA levels via both estrogen receptor-alpha and -beta in murine bone marrow/bone
    Sofia Moverare
    Division of Endocrinology, Department of Internal Medicine, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    Eur J Endocrinol 151:259-63. 2004
    ..The aim of this study was to identify estrogen-responsive target genes involved in the pathogenesis of estrogen-induced venous thromboembolism...
  53. ncbi request reprint Difference in skeletal muscle function in males vs. females: role of estrogen receptor-beta
    Birgitta Glenmark
    Department of Hand Surgery, Stockholm Soder Hospital, SE 118 83 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 287:E1125-31. 2004
    ..Improved contractile performance of male ERbeta(-/-) mouse muscles was associated with increased expression of mRNAs encoding important muscle proteins...
  54. ncbi request reprint Identification of estrogen-regulated genes of potential importance for the regulation of trabecular bone mineral density
    Marie K Lindberg
    Center for Bone Research at the Sahlgrenska Academy, Division of Endocrinology, Department of Internal Medicine, Göteborgs Universitet Göteborg, Sweden
    J Bone Miner Res 17:2183-95. 2002
    ..In conclusion, by using the microarray technique, we have identified four previously known and three novel estrogen-regulated genes of potential importance for the trabecular bone-sparing effect of estrogen...
  55. ncbi request reprint Identification of a functional variant of estrogen receptor beta in an African population
    Chunyan Zhao
    Karolinska Institute, Department of Biosciences at Novum, S 141 57 Huddinge, Sweden
    Carcinogenesis 25:2067-73. 2004
    ..To our knowledge, this represents the first identification of a functional polymorphism in the ERbeta gene. This novel polymorphism provides a tool for human genetic studies of diseases in the African population...
  56. ncbi request reprint Radiation-induced DNA-damage and gene expression profiles in human lung cancer cells with different radiosensitivity
    Bjorn Hellman
    Department of Pharmaceutical Biosciences, Division of Toxicology, Box 594, BMC, Uppsala University, SE 751 24 Uppsala, Sweden
    Exp Oncol 27:102-7. 2005
    ..Measurements of DNA double strand breaks and their subsequent repair after in vitro irradiation has been suggested to be an alternative way of monitoring radiotherapeutic response...
  57. ncbi request reprint Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production
    Wendy L Hall
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 83:592-600. 2006
    ..However, beneficial effects of isolated isoflavones on lipid biomarkers of cardiovascular disease risk have not yet been shown...
  58. ncbi request reprint Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production
    Wendy L Hall
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
    Am J Clin Nutr 82:1260-8; quiz 1365-6. 2005
    ..The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by which premenopausal women are protected against cardiovascular disease...
  59. ncbi request reprint Transgenic mouse models support HCR as an effector gene in the PSORS1 locus
    Outi Elomaa
    Department of Medical Genetics, University of Helsinki, Helsinki University Central Hospital, Finland
    Hum Mol Genet 13:1551-61. 2004
    ..These observations are also compatible with a model that a susceptibility gene for psoriasis induces changes that are contributory but not sufficient by itself to produce the clinical phenotype...
  60. ncbi request reprint Human estrogen receptor beta 548 is not a common variant in three distinct populations
    Li Xu
    Karolinska Institute, Department of Biosciences at Novum, SE 14157 Huddinge, Sweden
    Endocrinology 144:3541-6. 2003
    ..We did not detect any alleles that correspond to hERbeta548 in these samples or in additional samples of heterogeneous origin. It is concluded that hERbeta548 is not a common variant in Africans, Caucasians, or Asians...
  61. ncbi request reprint Estrogen receptor beta polymorphism is associated with prostate cancer risk
    Camilla Thellenberg-Karlsson
    Department of Radiation Sciences Oncology, University of Umea, Umea, Sweden
    Clin Cancer Res 12:1936-41. 2006
    ..ERbeta is thought to exert an antiproliferative and proapoptotic effect. We examined whether sequence variants in the ERbeta gene are associated with prostate cancer risk...