Sven Erik Dahlen

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
  2. ncbi Treatment of asthma with antileukotrienes: first line or last resort therapy?
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Eur J Pharmacol 533:40-56. 2006
  3. ncbi Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib
    Pär Gyllfors
    Division of Respiratory Medicine, Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 111:1116-21. 2003
  4. ncbi Influence of zafirlukast and loratadine on exercise-induced bronchoconstriction
    Barbro Dahlen
    Division of Respiratory Medicine, Department of Medicine at Karolinska Hospital and Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 109:789-93. 2002
  5. ncbi [TNF-blockade--new strategy in difficult-to-treat asthma]
    Sven Erik Dahlen
    Centrum för allergiforskning, Karolinska Institutet, Stockholm
    Lakartidningen 105:1946-8. 2008
  6. ncbi Mast cell engraftment of the peripheral lung enhances airway hyperresponsiveness in a mouse asthma model
    Barbara Fuchs
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Lung Cell Mol Physiol 303:L1027-36. 2012
  7. ncbi [Wrong to discard antileukotrienes in the treatment of asthma]
    Sven Erik Dahlen
    Institutet för miljömedicin, Karolinska Institutet, Stockholm
    Lakartidningen 104:3901. 2007
  8. ncbi Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung
    Ewa Sundström
    Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Pharmacol Exp Ther 307:408-18. 2003
  9. ncbi Inhibition of nitric-oxide synthase enhances antigen-induced contractions and increases release of cysteinyl-leukotrienes in guinea pig lung parenchyma: nitric oxide as a protective factor
    Anna Karin Larsson
    Experimental Asthma and Allergy Research, Division of Physiology, The Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 17177 Stockholm, Sweden
    J Pharmacol Exp Ther 315:458-65. 2005
  10. ncbi Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant
    Linda Swedin
    The National Institute of Environmental Medicine, Division of Physiology, Karolinska Institutet, Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 92:44-53. 2010

Collaborators

Detail Information

Publications16

  1. ncbi Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
    ..Addition of a leukotriene receptor antagonist such as montelukast improves asthma in aspirin-intolerant patients over and above what can be achieved by glucocorticosteroids...
  2. ncbi Treatment of asthma with antileukotrienes: first line or last resort therapy?
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Eur J Pharmacol 533:40-56. 2006
    ..Further research needs and new areas for leukotriene involvement in respiratory diseases are also discussed...
  3. ncbi Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib
    Pär Gyllfors
    Division of Respiratory Medicine, Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 111:1116-21. 2003
    ..Recently, 2 isotypes of COX have been identified, and COX-2-selective NSAIDs have been developed for treatment of inflammatory disorders...
  4. ncbi Influence of zafirlukast and loratadine on exercise-induced bronchoconstriction
    Barbro Dahlen
    Division of Respiratory Medicine, Department of Medicine at Karolinska Hospital and Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 109:789-93. 2002
    ..There is thus a need for additional therapies for optimal control of exercise-induced bronchoconstriction (EIB)...
  5. ncbi [TNF-blockade--new strategy in difficult-to-treat asthma]
    Sven Erik Dahlen
    Centrum för allergiforskning, Karolinska Institutet, Stockholm
    Lakartidningen 105:1946-8. 2008
  6. ncbi Mast cell engraftment of the peripheral lung enhances airway hyperresponsiveness in a mouse asthma model
    Barbara Fuchs
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Lung Cell Mol Physiol 303:L1027-36. 2012
    ..Moreover, the spatial distribution and number of pulmonary mast cells determine severity and localization of the AHR...
  7. ncbi [Wrong to discard antileukotrienes in the treatment of asthma]
    Sven Erik Dahlen
    Institutet för miljömedicin, Karolinska Institutet, Stockholm
    Lakartidningen 104:3901. 2007
  8. ncbi Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung
    Ewa Sundström
    Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Pharmacol Exp Ther 307:408-18. 2003
    ..The findings resemble and extend recent observations in clinical studies of patients with asthma and support the usefulness of this particular model in airway pharmacology...
  9. ncbi Inhibition of nitric-oxide synthase enhances antigen-induced contractions and increases release of cysteinyl-leukotrienes in guinea pig lung parenchyma: nitric oxide as a protective factor
    Anna Karin Larsson
    Experimental Asthma and Allergy Research, Division of Physiology, The Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 17177 Stockholm, Sweden
    J Pharmacol Exp Ther 315:458-65. 2005
    ..The findings support the belief that endogenous NO has a protective anti-inflammatory effect in the airways...
  10. ncbi Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant
    Linda Swedin
    The National Institute of Environmental Medicine, Division of Physiology, Karolinska Institutet, Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 92:44-53. 2010
    ..This study further supports that AHR on the one hand, and the inflammatory response and generation of prostanoids on the other, are dissociated and, at least in part, uncoupled events...
  11. ncbi The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea
    Ville Pulkkinen
    The Unit for Asthma and Allergy Research, the National Institute of Environmental Medicine and the Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Lung Cell Mol Physiol 303:L956-66. 2012
    ..The findings reinforce the hypothesis that TAS2Rs are potential targets for the development of a new class of more efficacious agonists for bronchodilation...
  12. ncbi The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release
    Magnus Bäck
    National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Adv Exp Med Biol 507:315-9. 2002
  13. ncbi Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites
    Ewa Selg
    The National Institute of Environmental Medicine, Division of Physiology and Centre for Allergy Research, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 88:101-10. 2009
    ..Whereas bronchoconstriction induced by LTD(4) was amplified predominantly by secondarily released TXA(2), that induced by PGD(2) was attenuated by bronchoprotective PGE(2) and PGI(2), presumably tonically produced in the airways...
  14. ncbi Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung
    Ewa Selg
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Division of Physiology, Centre for Allergy Research, Karolinska Institutet, Box 287, SE 171 77 Stockholm, Sweden
    Prostaglandins Leukot Essent Fatty Acids 78:89-97. 2008
    ....
  15. ncbi Challenge of isolated sputum cells supports in vivo origin of intolerance reaction to aspirin/non-steroidal anti-inflammatory drugs in asthma
    Ai Higashi
    Unit of Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Stockholm, Sweden
    Int Arch Allergy Immunol 158:299-306. 2012
    ..The aim of this study was to test if challenge with aspirin of sputum cells from subjects with AIA triggers the release of cysteinyl leukotrienes (CysLTs), known to be mediators of bronchoconstriction in AIA...
  16. ncbi Comparison of aerosol and intranasal challenge in a mouse model of allergic airway inflammation and hyperresponsiveness
    Linda Swedin
    The National Institute of Environmental Medicine, Division of Physiology, and The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Int Arch Allergy Immunol 153:249-58. 2010
    ..Comparisons were made between mice challenged with OVA either as an aerosol or intranasally. The protocol that induced maximal AHR in BALB/c mice was thereafter tested in C57BL/6 mice...