Sven Erik Dahlen

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
  2. ncbi request reprint Treatment of asthma with antileukotrienes: first line or last resort therapy?
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Eur J Pharmacol 533:40-56. 2006
  3. ncbi request reprint Phenotypic predictors of response to oral glucocorticosteroids in severe asthma
    Maciej Kupczyk
    Karolinska Institutet, Stockholm, Sweden Medical University of Lodz, Poland Electronic address
    Respir Med 107:1521-30. 2013
  4. ncbi request reprint Antagonising EP1 and EP2 receptors reveal that the TP receptor mediates a component of antigen-induced contraction of the guinea pig trachea
    Jesper Säfholm
    Unit for Experimental Asthma and Allergy Research, Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 718:277-82. 2013
  5. ncbi request reprint The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma
    Jon R Konradsen
    Astrid Lindgren Children s Hospital, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 132:328-35.e5. 2013
  6. ncbi request reprint The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma
    Anna James
    The Centre for Allergy Research, Stockholm, Sweden
    Int Arch Allergy Immunol 162:135-42. 2013
  7. ncbi request reprint Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib
    Pär Gyllfors
    Division of Respiratory Medicine, Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 111:1116-21. 2003
  8. ncbi request reprint Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma
    Kameran Daham
    Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden Electronic address
    J Allergy Clin Immunol 134:306-13. 2014
  9. ncbi request reprint Toll-like receptor (TLR) 7 decreases and TLR9 increases the airway responses in mice with established allergic inflammation
    Mikael Adner
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden Electronic address
    Eur J Pharmacol 718:544-51. 2013
  10. doi request reprint Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects
    David Balgoma
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Anal Chem 85:7866-74. 2013

Detail Information

Publications35

  1. ncbi request reprint Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
    ..Addition of a leukotriene receptor antagonist such as montelukast improves asthma in aspirin-intolerant patients over and above what can be achieved by glucocorticosteroids...
  2. ncbi request reprint Treatment of asthma with antileukotrienes: first line or last resort therapy?
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Eur J Pharmacol 533:40-56. 2006
    ..Further research needs and new areas for leukotriene involvement in respiratory diseases are also discussed...
  3. ncbi request reprint Phenotypic predictors of response to oral glucocorticosteroids in severe asthma
    Maciej Kupczyk
    Karolinska Institutet, Stockholm, Sweden Medical University of Lodz, Poland Electronic address
    Respir Med 107:1521-30. 2013
    ..Our goal was to assess the usefulness of medical history, physiological variables and biomarkers as predictors of response to oral steroids...
  4. ncbi request reprint Antagonising EP1 and EP2 receptors reveal that the TP receptor mediates a component of antigen-induced contraction of the guinea pig trachea
    Jesper Säfholm
    Unit for Experimental Asthma and Allergy Research, Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 718:277-82. 2013
    ..PGE2 primarily regulate the basal tone via EP1 and EP2, whereas prostanoids, such as TXA2 and PGD2, contribute as mediator of the antigen-response by activation of the TP receptor...
  5. ncbi request reprint The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma
    Jon R Konradsen
    Astrid Lindgren Children s Hospital, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 132:328-35.e5. 2013
    ..The specific mechanisms involved are unknown, and novel biomarkers are required to facilitate treatment and diagnosis of therapy-resistant asthma. The chitinase-like protein YKL-40 has been related to asthma and airway remodeling...
  6. ncbi request reprint The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma
    Anna James
    The Centre for Allergy Research, Stockholm, Sweden
    Int Arch Allergy Immunol 162:135-42. 2013
    ..The effect of aspirin on the release of key arachidonic acid metabolites in activated eosinophils from subjects with aspirin-intolerant asthma (AIA) has not been investigated previously, despite the characteristic eosinophilia in AIA...
  7. ncbi request reprint Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib
    Pär Gyllfors
    Division of Respiratory Medicine, Department of Medicine at Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 111:1116-21. 2003
    ..Recently, 2 isotypes of COX have been identified, and COX-2-selective NSAIDs have been developed for treatment of inflammatory disorders...
  8. ncbi request reprint Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma
    Kameran Daham
    Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden Electronic address
    J Allergy Clin Immunol 134:306-13. 2014
    ..Prostaglandins that constrict and relax airways are synthesized in reactions catalyzed by either COX-1 or COX-2. It is not known whether selective inhibition of COX-2 makes asthmatic responses better or worse...
  9. ncbi request reprint Toll-like receptor (TLR) 7 decreases and TLR9 increases the airway responses in mice with established allergic inflammation
    Mikael Adner
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden Electronic address
    Eur J Pharmacol 718:544-51. 2013
    ....
  10. doi request reprint Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects
    David Balgoma
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Anal Chem 85:7866-74. 2013
    ..This method presents a functional and reproducible approach to addressing urine-specific matrix effects that can be readily formatted for quantifying large numbers of samples. ..
  11. doi request reprint Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics
    Christina Orsmark-Pietras
    Dept of Biosciences and Nutrition at NOVUM, Karolinska Institute, Stockholm, Sweden
    Eur Respir J 42:65-78. 2013
    ..In conclusion, specific gene expression patterns were observed in children with severe, therapy-resistant asthma. The increased expression of bronchodilatory TAS2Rs suggests a new target for the treatment of asthma. ..
  12. ncbi request reprint Influence of zafirlukast and loratadine on exercise-induced bronchoconstriction
    Barbro Dahlen
    Division of Respiratory Medicine, Department of Medicine at Karolinska Hospital and Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 109:789-93. 2002
    ..There is thus a need for additional therapies for optimal control of exercise-induced bronchoconstriction (EIB)...
  13. doi request reprint The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea
    Ville Pulkkinen
    The Unit for Asthma and Allergy Research, the National Institute of Environmental Medicine and the Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Lung Cell Mol Physiol 303:L956-66. 2012
    ..The findings reinforce the hypothesis that TAS2Rs are potential targets for the development of a new class of more efficacious agonists for bronchodilation...
  14. doi request reprint Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study
    Maciej Kupczyk
    Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Thorax 68:611-8. 2013
    ..The aim was to determine the sensitivity and specificity of electronic diary data to detect severe exacerbations (SEs) of asthma. A secondary aim was to identify phenotypic variables associated with a higher risk of exacerbation...
  15. doi request reprint Application of 'omics technologies to biomarker discovery in inflammatory lung diseases
    Craig E Wheelock
    Division of Physiological Chemistry II, Karolinska Institutet, Stockholm
    Eur Respir J 42:802-25. 2013
    ....
  16. ncbi request reprint Effects of 5-lipoxygenase inhibitor zileuton on airway responses to inhaled swine house dust in healthy subjects
    Britt Marie Larsson
    Lung and Allergy Research, Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 171 77 Stockholm, Sweden
    Respir Med 100:226-37. 2006
    ..Inhalation of swine house dust induces acute airway inflammation and increased bronchial responsiveness in healthy subjects...
  17. pmc The contractile action of leukotriene B4 in the guinea-pig lung involves a vascular component
    Kiyoto Sakata
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Br J Pharmacol 141:449-56. 2004
    ..British Journal of Pharmacology (2004) 141, 449-456. doi:10.1038/sj.bjp.0705641..
  18. ncbi request reprint [TNF-blockade--new strategy in difficult-to-treat asthma]
    Sven Erik Dahlen
    Centrum för allergiforskning, Karolinska Institutet, Stockholm
    Lakartidningen 105:1946-8. 2008
  19. ncbi request reprint Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung
    Ewa Sundström
    Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Pharmacol Exp Ther 307:408-18. 2003
    ..The findings resemble and extend recent observations in clinical studies of patients with asthma and support the usefulness of this particular model in airway pharmacology...
  20. doi request reprint Mast cell engraftment of the peripheral lung enhances airway hyperresponsiveness in a mouse asthma model
    Barbara Fuchs
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Lung Cell Mol Physiol 303:L1027-36. 2012
    ..Moreover, the spatial distribution and number of pulmonary mast cells determine severity and localization of the AHR...
  21. ncbi request reprint Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant
    Linda Swedin
    The National Institute of Environmental Medicine, Division of Physiology, Karolinska Institutet, Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 92:44-53. 2010
    ..This study further supports that AHR on the one hand, and the inflammatory response and generation of prostanoids on the other, are dissociated and, at least in part, uncoupled events...
  22. ncbi request reprint Inhibition of nitric-oxide synthase enhances antigen-induced contractions and increases release of cysteinyl-leukotrienes in guinea pig lung parenchyma: nitric oxide as a protective factor
    Anna Karin Larsson
    Experimental Asthma and Allergy Research, Division of Physiology, The Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 17177 Stockholm, Sweden
    J Pharmacol Exp Ther 315:458-65. 2005
    ..The findings support the belief that endogenous NO has a protective anti-inflammatory effect in the airways...
  23. pmc Toll-like receptor ligands LPS and poly (I:C) exacerbate airway hyperresponsiveness in a model of airway allergy in mice, independently of inflammation
    Magnus Starkhammar
    Divison of ENT Diseases, CLINTEC, Karolinska Institutet, Stockholm, Sweden Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 9:e104114. 2014
    ..These results may parallel clinical signs of microbial asthma exacerbation, including an extended duration of illness and increased respiratory symptoms. ..
  24. ncbi request reprint Refractoriness to exercise challenge: a review of the mechanisms old and new
    Johan Larsson
    Lung and Allergy Research, Division of Respiratory Medicine and Allergy, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, M53, 14186 Stockholm, Sweden
    Immunol Allergy Clin North Am 33:329-45, viii. 2013
    ....
  25. ncbi request reprint The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release
    Magnus Bäck
    National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Adv Exp Med Biol 507:315-9. 2002
  26. ncbi request reprint [Wrong to discard antileukotrienes in the treatment of asthma]
    Sven Erik Dahlen
    Institutet för miljömedicin, Karolinska Institutet, Stockholm
    Lakartidningen 104:3901. 2007
  27. doi request reprint Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma
    Barbro Dahlen
    Lung and Allergy Clinic, Department of Medicine at Karolinska University Hospital Huddinge and The Centre for Allergy Research, Karolinska Institutet, 141 86, Stockholm, Sweden
    Eur J Clin Pharmacol 68:1375-83. 2012
    ..The aim of the study was to compare, for the first time, the influence of the bronchodilators salbutamol (400 μg) and ipratropium (80 μg) on lung function changes induced by inhaled LTD(4)...
  28. doi request reprint Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung
    Ewa Selg
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Division of Physiology, Centre for Allergy Research, Karolinska Institutet, Box 287, SE 171 77 Stockholm, Sweden
    Prostaglandins Leukot Essent Fatty Acids 78:89-97. 2008
    ....
  29. doi request reprint Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites
    Ewa Selg
    The National Institute of Environmental Medicine, Division of Physiology and Centre for Allergy Research, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 88:101-10. 2009
    ..Whereas bronchoconstriction induced by LTD(4) was amplified predominantly by secondarily released TXA(2), that induced by PGD(2) was attenuated by bronchoprotective PGE(2) and PGI(2), presumably tonically produced in the airways...
  30. pmc Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids
    Susanna L Lundström
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden
    Mol Nutr Food Res 57:1378-89. 2013
    ..In contrast to well-characterized PUFA levels in serum, little is known regarding their downstream metabolic products. However, many of these compounds are lipid mediators with prominent roles during pro- and antiinflammatory processes...
  31. ncbi request reprint Challenge of isolated sputum cells supports in vivo origin of intolerance reaction to aspirin/non-steroidal anti-inflammatory drugs in asthma
    Ai Higashi
    Unit of Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Stockholm, Sweden
    Int Arch Allergy Immunol 158:299-306. 2012
    ..The aim of this study was to test if challenge with aspirin of sputum cells from subjects with AIA triggers the release of cysteinyl leukotrienes (CysLTs), known to be mediators of bronchoconstriction in AIA...
  32. pmc Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
    Magnus Bäck
    Nomenclature Subcommittee for Leukotriene Receptors, International Union of Basic and Clinical Pharmacology, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Br J Pharmacol 171:3551-74. 2014
    ..In conclusion, the receptors for the lipoxygenase products make up a sophisticated and tightly controlled system of endogenous pro- and anti-inflammatory signalling in physiology and pathology. ..
  33. ncbi request reprint [Costs of asthma and allergies to society unknown. Cost studies can give better planning of health care and research]
    Sven Arne Jansson
    Centrum för allergiforskning, Institutet för miljö medicin, Karolinska Institutet, Stockholm
    Lakartidningen 104:2792-6. 2007
  34. doi request reprint Application of metabolomics approaches to the study of respiratory diseases
    Stuart Snowden
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden
    Bioanalysis 4:2265-90. 2012
    ..Particular challenges in the field are presented and placed within the context of the future of the applications of metabolomics approaches to the study of respiratory diseases...
  35. doi request reprint Comparison of aerosol and intranasal challenge in a mouse model of allergic airway inflammation and hyperresponsiveness
    Linda Swedin
    The National Institute of Environmental Medicine, Division of Physiology, and The Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
    Int Arch Allergy Immunol 153:249-58. 2010
    ..Comparisons were made between mice challenged with OVA either as an aerosol or intranasally. The protocol that induced maximal AHR in BALB/c mice was thereafter tested in C57BL/6 mice...