Genomes and Genes
Affiliation: Karolinska Institutet
- TLR activation induces TNF-alpha production from adult neural stem/progenitor cellsRuxandra Covacu
Department of Clinical Neurosciences, Division of Neuroimmunology, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden
J Immunol 182:6889-95. 2009..Additionally, activation of these receptors can induce production of proinflammatory cytokines. These findings suggest that NSCs may be primed to participate in cytokine production during neuroinflammatory or traumatic conditions...
- Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosisAsa Andersson
Department of Clinical Neurosciences, Neuroimmunology Unit, Karolinska University Hospital at Solna, Karolinska Institutet, Stockholm, Sweden
J Leukoc Biol 84:1248-55. 2008..Significant expression of HMGB1 and its receptors on accumulating activated macrophages and resident microglia may thus provide a positive feedback loop that amplifies the inflammatory response during MS and EAE pathogenesis...
- Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesisRuxandra Covacu
Department of Clinical Neuroscience, Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden
Stem Cells 24:2792-800. 2006..Our findings reveal a new role for NO during neuroinflammatory conditions, whereby its proastroglial fate-determining effect on neural stem cells might directly influence the neuroregenerative process...
- Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in ratsMilena Z Adzemovic
Neuroimmunology Unit, Department of Clinical Neuroscience, Center of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 7:e39794. 2012..In addition, the congenic strain showed a reduced antigen specific response and a predominant anti-inflammatory Th2 phenotype. These results indicate novel mechanisms in the genetic regulation of neuroinflammation...
- The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxideAlexander Espinosa
Rheumatology Unit, Department of Medicine, CMM L8 04, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Exp Cell Res 314:3605-13. 2008..This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus...