Research Topics
Genomes and Genes
| Yihai CaoSummaryAffiliation: Karolinska Institutet Country: Sweden Publications
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Detail Information
Publications
Forty-year journey of angiogenesis translational researchYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Sci Transl Med 3:114rv3. 2011..Today, antiangiogenic drugs are used to treat human cancers and retinal vascular diseases. Here, we guide readers through 40 years of angiogenesis research and discuss challenges of antiangiogenic therapy...- Erythropoietin in cancer: a dilemma in risk therapyYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden Department of Medicine and Health Sciences, Linkoping University, 581 83 Linkoping, Sweden Electronic address
Trends Endocrinol Metab 24:190-9. 2013..Understanding the multifarious functions of EPO and its reciprocal relation with other signaling pathways is crucial for developing more effective agents for cancer therapy and for minimizing risks for cancer patients... 
Tumor-derived VEGF modulates hematopoiesisYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute 171 77 Stockholm, Sweden
J Angiogenes Res 1:9. 2009..Stimulation of extramedullary hematopoiesis sheds new light on complex biological functions of VEGF and significantly increases our understanding of molecular mechanisms underlying VEGF-induced tumor growth...
Therapeutic angiogenesis for ischemic disorders: what is missing for clinical benefits?Yihai Cao
Department of Microbiology and Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Discov Med 9:179-84. 2010....- Angiogenesis: What can it offer for future medicine?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Exp Cell Res 316:1304-8. 2010..In this mini-review, I discuss current available antiangiogenic drugs and future therapeutic options based on the angiogenesis principle... - Why and how do tumors stimulate lymphangiogenesis?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177 Stockholm, Sweden
Lymphat Res Biol 6:145-8. 2008.... - Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseasesYihai Cao
Yihai Cao is at the Department of Microbiology, Tumour and Cell Biology, Karolinska Institute, 171 77 Stockholm
Nat Rev Drug Discov 9:107-15. 2010..This Perspective discusses recent progress in understanding the molecular mechanisms that control adipose tissue angiogenesis and in defining potential new vascular targets and approaches for the treatment of this group of diseases... - R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathwaysYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77, Stockholm, Sweden
J Mol Med (Berl) 86:785-9. 2008..Thus, therapeutic development of antiangiogenic agents for the treatment of cancer should be aimed to block multiple angiogenic signaling pathways and their interactive loops... - Monotherapy versus combination therapy of angiogenic and arteriogenic factors for the treatment of ischemic disordersY Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Curr Mol Med 9:967-72. 2009.... - Positive and negative modulation of angiogenesis by VEGFR1 ligandsYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Sci Signal 2:re1. 2009..This Review discusses the distinctive roles of VEGFR1 and its ligands PlGF and VEGF-B in the mediation of angiogenic signaling and considers the therapeutic potential of targeting these particular vascular factors... - Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistanceYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Semin Cancer Biol 19:338-43. 2009.... - Tumor angiogenesis and molecular targets for therapyYihai Cao
Laboratory of Angiogenesis Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Front Biosci 14:3962-73. 2009.... - Optimizing the delivery of cancer drugs that block angiogenesisYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Sci Transl Med 2:15ps3. 2010..In this Perspective, we discuss these drug-related issues and propose ways to optimize antiangiogenic therapy by the development of new drug delivery systems... - Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Int J Dev Biol 55:557-62. 2011.... - Off-tumor target--beneficial site for antiangiogenic cancer therapy?Yihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobelsvag 16, Solna Campus, Box 280, 171 77 Stockholm, Sweden
Nat Rev Clin Oncol 7:604-8. 2010..This new concept has been validated in preclinical tumor models, and responses in patients have positively correlated with clinical benefits... - A review of Judah Folkman's remarkable achievements in biomedicineYihai Cao
Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:13203-5. 2008 - Angiogenesis modulates adipogenesis and obesityYihai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
J Clin Invest 117:2362-8. 2007..Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders... - VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathyRenhai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 107:856-61. 2010..Our findings link VEGF and PlGF to cancer-associated retinopathy, reveal the molecular mechanisms of VEGFR1 ligand-mediated retinopathy, and define VEGFR1 as an important target of antiangiogenic therapy for treatment of retinopathy... - Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasisRenhai Cao
Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, Stockholm, Sweden
Proc Natl Acad Sci U S A 109:15894-9. 2012..Thus, intervention and targeting of the FGF-2- and VEGF-C-induced angiogenic and lymphangiogenic synergism could be potentially important approaches for cancer therapy and prevention of metastasis... - Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesisNiina Veitonmaki
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Cancer Res 64:3679-86. 2004..Thus, our findings provide a mechanistic insight with respect to the angiostatic action and signaling pathway of K1-5 and angiostatin... - Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in miceEbba Brakenhielm
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Circ Res 94:1579-88. 2004..Our findings suggest that similarly to growth and organogenesis in other tissues, adipose tissue growth is dependent on angiogenesis. Our observations may have conceptual implications for the prevention of obesity and related disorders... - Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeabilityAnna Eriksson
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Circulation 107:1532-8. 2003..This may have conceptual implications for applying Rac antagonists in treatment and prevention of VEGF-induced vascular leakage and edema in connection with ischemic disorders... - Blockage of VEGF-induced angiogenesis by preventing VEGF secretionMeit Bjorndahl
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Circ Res 94:1443-50. 2004..Gene transfer of a hVEGF-KDEL construct into tumor cells likewise produced a dramatic antitumor effect. Thus, our study provides a novel antiangiogenic approach by preventing the secretion of VEGF... - Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasisYihai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Adv Cancer Res 97:203-24. 2007..Understanding the roles of individual and combined angiogenic factors in promoting tumor angiogenesis is crucial for defining therapeutic targets and antiangiogenic drug development for the treatment of cancer... - PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasisRenhai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Cancer Cell 6:333-45. 2004..These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis... - Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeabilityRenhai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Circ Res 94:664-70. 2004..Such information is important to consider in development of novel therapeutic strategies using these angiogenic factors... - Zebrafish models to study hypoxia-induced pathological angiogenesis in malignant and nonmalignant diseasesLasse Dahl Jensen
Deparment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Birth Defects Res C Embryo Today 93:182-93. 2011..These zebrafish disease models offer exciting opportunities to understand the mechanisms of disease development, progression, and development of more effective drugs for therapeutic intervention... - Hypoxia-induced metastasis model in embryonic zebrafishPegah Rouhi
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Nat Protoc 5:1911-8. 2010..The average experimental time for this model is 7 d. Our protocol offers a remarkable opportunity to study molecular mechanisms of hypoxia-induced cancer metastasis... - Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugsEva Maria Eleonora Hedlund
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 110:654-9. 2013..These findings demonstrate that tumor-derived PlGF negatively modulates tumor angiogenesis and tumor growth and may potentially serve as a predictive marker of anti-VEGF cancer therapy... - Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor modelSamantha Lin Chiou Lee
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:19485-90. 2009..Our findings also shed light on molecular mechanisms of beneficial effects of clinically available anti-VEGF drugs for cancer therapy... - Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stabilityJunhang Zhang
Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 17176, Stockholm, Sweden
FASEB J 23:153-63. 2009..A combination of PDGF-AB and FGF-2 would be optimal proangiogenic agents for the treatment of ischemic diseases... - Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculatureEva Maria Hedlund
Department of Microbiology and Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:17505-10. 2009..Our findings shed light on functions of PlGF as a vascular remodeling factor that normalizes the tumor vasculature and thus may have conceptual implications of cancer therapy... - Tumor-derived lymphangiogenic factors and lymphatic metastasisYihai Cao
Laboratory of Angiogenesis Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
Biomed Pharmacother 61:534-9. 2007..Understanding regulatory mechanisms of lymphangiogenesis is pivotal for development of lymphangiogenesis antagonists that might therapeutically be used for intervention of lymphatic metastasis... - Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of actionRenhai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Blood 107:3531-6. 2006..Our findings indicate that HGF may play a critical role in lymphangiogenesis and potentially contribute to lymphatic metastasis... - PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cellsYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Nat Med 18:100-10. 2012.... - Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasisLars Johan Nissen
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
J Clin Invest 117:2766-77. 2007..Our data suggest that intervention of this non-VEGF reciprocal interaction loop for the tumor vasculature could be an important therapeutic target for the treatment of cancer and metastasis... - Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosisEbba Brakenhielm
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 101:2476-81. 2004..Adiponectin, as a direct endogenous angiogenesis inhibitor, may have therapeutic implications in the treatment of angiogenesis-dependent diseases... - Opposing effects of circadian clock genes bmal1 and period2 in regulation of VEGF-dependent angiogenesis in developing zebrafishLasse Dahl Jensen
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Cell Rep 2:231-41. 2012..These results shed mechanistic insight on the role of the circadian clock in regulation of developmental angiogenesis, and our findings may be reasonably extended to other types of physiological or pathological angiogenesis... - Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivoMeit Bjorndahl
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 102:15593-8. 2005..Because members of the IGF ligand and receptor families are widely expressed in various types of solid tumors, our findings suggest that these factors are likely to contribute to lymphatic metastasis... - Hypoxia-independent angiogenesis in adipose tissues during cold acclimationYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Cell Metab 9:99-109. 2009..Our findings have conceptual implications concerning application of angiogenesis modulators for treatment of obesity and metabolic disorders... - Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndromeYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:18513-8. 2008..These findings define novel therapeutic targets of anti-VEGF agents and provide mechanistic insights into the action of this new class of clinically available anti-VEGF cancer drugs... - FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissueYuan Xue
Department of Microbiology, Laboratory of Angiogenesis Research, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Proc Natl Acad Sci U S A 105:10167-72. 2008..Thus, the FOXC2-Ang-2 signaling system is crucial for controlling adipose vascular function, which is part of an adaptation to increased adipose tissue metabolism... - Pathological angiogenesis facilitates tumor cell dissemination and metastasisPegah Rouhi
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Cell Cycle 9:913-7. 2010.... - Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vesselsPiotr Religa
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Nobelsvag 16, 171 77 Stockholm, Sweden
Blood 106:4184-90. 2005..EGFP+/CEPCs were also present in peritumoral lymphatic vessels of a fibrosarcoma. These data suggest that BM-derived CEPCs may play a role in "lymphvasculogenesis.".. - Mouse corneal lymphangiogenesis modelRenhai Cao
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Nat Protoc 6:817-26. 2011..This protocol offers a unique opportunity to study the mechanisms underlying lymphatic vessel formation, remodeling and function... - Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasisYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Cell Cycle 4:228-30. 2005..In this review, multiple roles of PDGFs in control of tumor growth and metastasis are discussed... - Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2Renhai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Nat Med 9:604-13. 2003..Our data show that a specific combination of angiogenic factors establishes functional and stable vascular networks, and provides guidance for the ongoing clinical trials of angiogenic factors for the treatment of ischemic diseases... - Cold-induced activation of brown adipose tissue and adipose angiogenesis in miceSharon Lim
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Nat Protoc 7:606-15. 2012..BAT and the increased metabolic rate result in a lean phenotype. This protocol provides an outstanding opportunity to study the molecular mechanisms that control adipose mass... - Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfishLasse Dahl Ejby Jensen
Department of Microbiology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 106:18408-13. 2009..Our results might also imply that the hypoxia-induced NO pathway contributes to development of progression of pathologies, including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system... - Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicityDanfang Zhang
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 108:4117-22. 2011.... - Molecular mechanisms and therapeutic development of angiogenesis inhibitorsYihai Cao
Laboratory of Angiogenesis Research, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Adv Cancer Res 100:113-31. 2008..Thus, deeper understanding the mechanisms of tumor angiogenesis and actions of these therapeutic molecules is crucial for designing more potent anticancer drugs... - Hypoxia-induced retinopathy model in adult zebrafishZiquan Cao
Institute of Medicine and Health, Linkoping University, Linkoping, Sweden
Nat Protoc 5:1903-10. 2010..This model provides a unique opportunity to study kinetically the development of retinopathy in adult animals using noninvasive protocols and to assess therapeutic efficacy of orally active antiangiogenic drugs... - Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivoYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Nat Protoc 5:912-20. 2010.... - Cancer-associated retinopathy: a new mechanistic insight on vascular remodelingRenhai Cao
Department of Microbiology, Karolinska Institute, Stockholm, Sweden
Cell Cycle 9:1882-5. 2010..These results demonstrate that tumor-derived angiogenic factors significantly confer the development of CAR and anti-VEGF agents might be potentially used for the treatment of CAR... - Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathyRenhai Cao
Department of Microbiology, Tumor and Cell Biology, The Karolinska Institute, Stockholm, Sweden
PLoS ONE 3:e2748. 2008.... - Antiangiogenic cancer therapyYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm S 171 77, Sweden
Semin Cancer Biol 14:139-45. 2004.... - Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalizationXiaowei Zheng
Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
Mol Cell Biol 26:4628-41. 2006.... - Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimersAnna Eriksson
Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77, Stockholm, Sweden
Cancer Cell 1:99-108. 2002..The underlying mechanism is due to the formation of functionally inactive heterodimers... - Update on therapeutic neovascularizationYihai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
Cardiovasc Res 65:639-48. 2005..With the increasing complexity of therapeutic strategies, it remains imperative that these approaches are rationally based on fundamental and preclinical data... - AngiostatinYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Semin Thromb Hemost 30:83-93. 2004..We hope that the information will be useful for further development of angiostatin and its related inhibitors as therapeutic agents... - Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasisYihai Cao
Laboratory of Angiogenesis Research, Microbiology and Tumour Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden
Nat Rev Cancer 5:735-43. 2005..Understanding the underlying mechanisms by which tumours induce lymphangiogenesis might provide important information for the therapeutic intervention of metastatic spread... - Kringle structures and antiangiogenesisYihai Cao
Microbiology and Tumor Biology Center, Karolinska Institute, S 171 77 Stockholm, Sweden
Curr Med Chem Anticancer Agents 2:667-81. 2002..This review will focus on the structural and functional relationships of kringle domains in regulation of angiogenesis and tumor growth... - Clock controls angiogenesisLasse Dahl Jensen
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Cell Cycle 12:405-8. 2013..Thus, our findings, for the first time, shed new light on mechanisms that underlie circadian clock-regulated angiogenesis... - Deletion of the laminin alpha4 chain leads to impaired microvessel maturationJill Thyboll
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17 177 Stockholm, Sweden
Mol Cell Biol 22:1194-202. 2002..The results demonstrate a central role for the laminin alpha4 chain in microvessel growth and, in the absence of other laminin alpha chains, in the composition of endothelial basement membranes... - A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasisSteven Clasper
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
Cancer Res 68:7293-303. 2008..These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis... - Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigsHuixia Lu
Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Public Health, Qi Lu Hospital, Shandong University, Jinan 250012, Shandong Province, People s Republic of China
Proc Natl Acad Sci U S A 104:12140-5. 2007..Our findings provide conceptual guidelines for the clinical development of proangiogenic/arteriogenic factors for the treatment of ischemic heart disease... - Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cellsRobert Pawliuk
Division of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts 02139, USA
Mol Ther 5:345-51. 2002..Resolution of this paradox may come from human trials of endostatin now underway... - Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinomaTakuji Torimura
Liver Cancer Division, Research Center for Innovative Cancer Therapy, and Center of the 21st Century COE Program for Medical Science, Second Department of Medicine, Fukuoka, Japan
Gastroenterology 130:1301-10. 2006..CONCLUSIONS: Antiangiogenic gene therapy with kringle 1-5 complementary DNA is a promising safe and effective strategy for suppression of growth of hepatocellular carcinoma... - IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbsKaterina Tritsaris
Department of Cellular and Molecular Medicine, Panum Institute, University of Copenhagen, Copenhagen 2200N, Denmark
Proc Natl Acad Sci U S A 104:15364-9. 2007..Our findings provide mechanistic insights on vascular functions of IL-20 and define therapeutic implication of this cytokine for the treatment of ischemic disorders... - Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient miceZhongjun Zhou
Department of Biochemistry, Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong, ROC
Cancer Res 64:4699-702. 2004..In the mouse corneal angiogenesis model, FGF-2-induced neovascularization was significantly impaired in Hspg2(Delta3/Delta3) mutant mice. Our results suggest that HS in perlecan positively regulates the angiogenesis in vivo... - Deletion of laminin-8 results in increased tumor neovascularization and metastasis in miceZhongjun Zhou
Department of Biochemistry, Faculty of Medicine, University of Hong Kong, People s Republic of China
Cancer Res 64:4059-63. 2004..Depletion of laminin alpha 4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis... - Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasisMeit A Björndahl
Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
Cancer Res 65:9261-8. 2005..Our data show that VEGF-A contributes to lymphatic mestastasis. Thus, blockage of VEGF-A-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis... - Filamin B deficiency in mice results in skeletal malformations and impaired microvascular developmentXianghua Zhou
Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Goteborg University, SE 413 45 Goteborg, Sweden
Proc Natl Acad Sci U S A 104:3919-24. 2007..These mice died or had to be euthanized before 4 weeks of age. Thus, the phenotypes of Flnb-deficient mice closely resemble those of human skeletal disorders with mutations in FLNB... - The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritisPercy F Sumariwalla
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
Arthritis Res Ther 5:R32-9. 2003..These data suggest that antiangiogenic therapies, which block formation of new blood vessels and hence reduce synovial expansion, might be effective in treating rheumatoid arthritis...