Stefan Brene

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Running is rewarding and antidepressive
    Stefan Brene
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Physiol Behav 92:136-40. 2007
  2. ncbi request reprint The antidepressant effect of running is associated with increased hippocampal cell proliferation
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Int J Neuropsychopharmacol 8:357-68. 2005
  3. ncbi request reprint Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 31:256-64. 2006
  4. ncbi request reprint Neuronal activity-induced regulation of Lingo-1
    Alexandra Trifunovski
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Neuroreport 15:2397-400. 2004
  5. ncbi request reprint Social isolation increases number of newly proliferated cells in hippocampus in female flinders sensitive line rats
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Hippocampus 17:1193-200. 2007
  6. pmc Nogo receptor 1 regulates formation of lasting memories
    Alexandra Karlén
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:20476-81. 2009
  7. pmc Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain
    Tobias E Karlsson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e60892. 2013
  8. ncbi request reprint Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling
    Toshiki Endo
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain 130:2951-61. 2007
  9. ncbi request reprint Selective decline of Nogo mRNA in the aging brain
    Alexandra Trifunovski
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroreport 17:913-6. 2006
  10. ncbi request reprint Running increases ethanol preference
    Martin Werme
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Behav Brain Res 133:301-8. 2002

Collaborators

Detail Information

Publications21

  1. pmc Running is rewarding and antidepressive
    Stefan Brene
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Physiol Behav 92:136-40. 2007
    ..Here we discuss and compare neurochemical and functional changes in the brain after addictive drugs and exercise with a focus on brain reward pathways and hippocampus...
  2. ncbi request reprint The antidepressant effect of running is associated with increased hippocampal cell proliferation
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Int J Neuropsychopharmacol 8:357-68. 2005
    ..Thus, suppression of cell proliferation in the hippocampus could constitute one of the mechanisms that underlie depression, and physical activity might be an efficient antidepressant...
  3. ncbi request reprint Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 31:256-64. 2006
    ..In addition, we also show that the increased NPY after running is correlated to increased cell proliferation, which is associated with an antidepressive-like effect...
  4. ncbi request reprint Neuronal activity-induced regulation of Lingo-1
    Alexandra Trifunovski
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    Neuroreport 15:2397-400. 2004
    ..Our data demonstrate inverse regulation of NgR and Lingo-1 in these situations, suggesting that Lingo-1 up-regulation is one characteristic of activity-induced neural plasticity responses...
  5. ncbi request reprint Social isolation increases number of newly proliferated cells in hippocampus in female flinders sensitive line rats
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Hippocampus 17:1193-200. 2007
    ..We demonstrate strain and gender specific responses to stress induced regulation of factors important for hippocampal plasticity...
  6. pmc Nogo receptor 1 regulates formation of lasting memories
    Alexandra Karlén
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 106:20476-81. 2009
    ..Understanding the molecular underpinnings of synaptic rearrangements that carry lasting memories may facilitate development of treatments for memory dysfunction...
  7. pmc Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain
    Tobias E Karlsson
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e60892. 2013
    ....
  8. ncbi request reprint Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling
    Toshiki Endo
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain 130:2951-61. 2007
    ..In such situations, methods to control cortical plasticity, possibly by targeting Nogo signalling, may become helpful...
  9. ncbi request reprint Selective decline of Nogo mRNA in the aging brain
    Alexandra Trifunovski
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroreport 17:913-6. 2006
    ..Nogo mRNA, however, was significantly decreased in hippocampal subregions of aged animals. The specific decrease of Nogo mRNA levels in hippocampus and possibly cortex cerebri may relate to age-dependent decline of brain plasticity...
  10. ncbi request reprint Running increases ethanol preference
    Martin Werme
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Behav Brain Res 133:301-8. 2002
    ..Our results describe a behavioral interaction where running increases ethanol consumption...
  11. doi request reprint Housing conditions modulate escitalopram effects on antidepressive-like behaviour and brain neurochemistry
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Int J Neuropsychopharmacol 11:1135-47. 2008
    ..Different patterns of mRNA changes in hippocampus and brain reward pathways and responses in the PST by running and escitalopram suggest that antidepressant-like responses by running and escitalopram are achieved by different mechanisms...
  12. pmc Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Nature 501:412-5. 2013
    ..Our findings suggest that maternally transmitted mtDNA mutations may have a similar role in aggravating aspects of normal human ageing. ..
  13. doi request reprint Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus
    Elin Aberg
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Hippocampus 18:785-92. 2008
    ..Thus, our data suggest that the effects of exercise on neurogenesis and other plasticity changes in the hippocampal formation are mediated by mechanisms that do not involve retinoid receptor activation...
  14. ncbi request reprint Behavioral assessment of intermittent wheel running and individual housing in mice in the laboratory
    Therese M Pham
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Appl Anim Welf Sci 8:157-73. 2005
    ..Intermittent withdrawal of individual housing affects the animals more than other commodities. Wheel running normalizes some effects of intermittent separation from the enriched, social home cage...
  15. ncbi request reprint Neurotrophin levels and behaviour in BALB/c mice: impact of intermittent exposure to individual housing and wheel running
    Shun Wei Zhu
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska University Hospital, Karolinska Institute, Stockholm 141 86, Sweden
    Behav Brain Res 167:1-8. 2006
    ..Our results also suggest that some changes in neurotrophin levels induced by intermittent individual housing are not similar to those caused by continuous individual housing...
  16. ncbi request reprint Decreased ethanol preference and wheel running in Nurr1-deficient mice
    Martin Werme
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Eur J Neurosci 17:2418-24. 2003
    ..Together, our data thus imply involvement of Nurr1 in the transition to a state of high ethanol consumption as well as in the development of a high amount of wheel running in mice...
  17. ncbi request reprint Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuroreport 18:1039-43. 2007
    ..Our findings of decreased dopamine D2 receptor levels in socially isolated Flinders Sensitive Line rats suggest that low D2 receptor expression may play a role in pathophysiology of depression...
  18. pmc Orchestrated regulation of Nogo receptors, LOTUS, AMPA receptors and BDNF in an ECT model suggests opening and closure of a window of synaptic plasticity
    Max Nordgren
    Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 8:e78778. 2013
    ..Our data provide correlations between ECS treatment and molecular events compatible with the hypothesis that both effects and side effects of ECT may be caused by structural synaptic rearrangements. ..
  19. doi request reprint Lrrk2 and alpha-synuclein are co-regulated in rodent striatum
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, Retzius väg 8 B2 4, S 17177 Stockholm, Sweden
    Mol Cell Neurosci 39:586-91. 2008
    ..Because striatal Lrrk2 and alpha-synuclein levels were not changed by dopamine depletion, we conclude that Lrrk2 and alpha-synuclein mRNA levels are possibly co-regulated, but they are not influenced by striatal dopamine levels...
  20. pmc High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio
    Jaime M Ross
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 107:20087-92. 2010
    ..The mtDNA mutator mouse allows us to conclude that the increased LDH-A/LDH-B ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes...
  21. ncbi request reprint Activity-induced and developmental downregulation of the Nogo receptor
    Anna Josephson
    Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
    Cell Tissue Res 311:333-42. 2003
    ..Strong, rapid and transient downregulation of NgR mRNA in response to kainic acid and after wheel running in cortex and hippocampus suggests a role for NgR and Nogo-A in plasticity, learning and memory...