Dasiel O Borroto-Escuela

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden Electronic address
    Biochem Biophys Res Commun 443:278-84. 2014
  2. doi request reprint Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden Electronic address
    Biochem Biophys Res Commun 441:387-92. 2013
  3. doi request reprint Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 435:140-6. 2013
  4. doi request reprint Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet Retzius väg 8, 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 393:767-72. 2010
  5. doi request reprint Muscarinic receptor family interacting proteins: role in receptor function
    Dasiel O Borroto-Escuela
    Centre de Biotecnologia Molecular, Department d Enginyeria Quimica, Universitat Politecnica de Catalunya, Colom 1, 08222 Terrassa, Barcelona, Spain
    J Neurosci Methods 195:161-9. 2011
  6. doi request reprint Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 402:801-7. 2010
  7. doi request reprint A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 394:222-7. 2010
  8. doi request reprint Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade of binding of multiple proteins to its third intracellular loop
    Dasiel O Borroto-Escuela
    Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
    Cell Physiol Biochem 25:397-408. 2010
  9. doi request reprint Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm, Sweden
    Biol Psychiatry 71:84-91. 2012
  10. doi request reprint Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation
    Dasiel O Borroto-Escuela
    Centre de Biotecnologia Molecular, Department d Enginyeria Quémica, Universitat Politecnica de Catalunya, Terrassa, Spain
    Cell Physiol Biochem 28:1009-22. 2011

Detail Information

Publications28

  1. doi request reprint Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden Electronic address
    Biochem Biophys Res Commun 443:278-84. 2014
    ..This mechanism may contribute to the psychotic actions of LSD and DOI and the D2-5-HT2A heteroreceptor complex may thus be a target for the psychotic actions of hallunicogenic 5-HT2A agonists. ..
  2. doi request reprint Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden Electronic address
    Biochem Biophys Res Commun 441:387-92. 2013
    ..Taken together, the participation of 5-HT1A and FGFR1 homodimers and recruitment of β-arrestin2 was demonstrated in the FGFR1-5-HT1A heteroreceptor complexes upon agonist treatments. ..
  3. doi request reprint Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 435:140-6. 2013
    ....
  4. doi request reprint Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet Retzius väg 8, 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 393:767-72. 2010
    ....
  5. doi request reprint Muscarinic receptor family interacting proteins: role in receptor function
    Dasiel O Borroto-Escuela
    Centre de Biotecnologia Molecular, Department d Enginyeria Quimica, Universitat Politecnica de Catalunya, Colom 1, 08222 Terrassa, Barcelona, Spain
    J Neurosci Methods 195:161-9. 2011
    ....
  6. doi request reprint Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 402:801-7. 2010
    ....
  7. doi request reprint A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 394:222-7. 2010
    ..All together these results indicate that by targeting A(2A)R serine 374 it will be possible to allosterically modulate A(2A)R-D(2)R function, thus representing a new approach for therapeutically modulate D(2)R function...
  8. doi request reprint Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade of binding of multiple proteins to its third intracellular loop
    Dasiel O Borroto-Escuela
    Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
    Cell Physiol Biochem 25:397-408. 2010
    ....
  9. doi request reprint Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, Stockholm, Sweden
    Biol Psychiatry 71:84-91. 2012
    ..The hippocampus and its 5-hydroxytryptamine transmission plays an important role in depression related to its involvement in limbic circuit plasticity...
  10. doi request reprint Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation
    Dasiel O Borroto-Escuela
    Centre de Biotecnologia Molecular, Department d Enginyeria Quémica, Universitat Politecnica de Catalunya, Terrassa, Spain
    Cell Physiol Biochem 28:1009-22. 2011
    ..Overall, these results indicate that the NPxxY motif of the M(3) muscarinic acetylcholine receptor acts as key conformational switch for receptor signaling and multiprotein complex formation...
  11. doi request reprint The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Neurosci 32:6295-303. 2012
    ....
  12. doi request reprint G protein-coupled receptor heterodimerization in the brain
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Methods Enzymol 521:281-94. 2013
    ..We describe here how the assay is performed and discuss advantages and disadvantages of this method compared with other available techniques...
  13. doi request reprint Dopamine D2 and 5-hydroxytryptamine 5-HT(₂A) receptors assemble into functionally interacting heteromers
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 401:605-10. 2010
    ..Possible novel therapeutic strategies for treatment of schizophrenia should be explored by targeting this heteromer...
  14. doi request reprint On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 17177 Stockholm, Sweden
    J Mol Biol 406:687-99. 2011
    ..Thus, β-arrestin2 action becomes more rapid and short-lasting and, in this way, mimics G-protein-mediated signaling...
  15. pmc Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet Stockholm, Sweden
    Front Physiol 3:136. 2012
    ....
  16. doi request reprint Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 404:928-34. 2011
    ..The bioinformatic predictions suggest the existence of a basic set of common triplets (ALQ and LRA) in the two participating receptors that may contribute to the receptor-receptor interaction interfaces...
  17. pmc Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R
    Víctor Fernández-Dueñas
    Unitat de Farmacologia, Facultat de Medicina, Departament de Patologia i Terapèutica Experimental, Universitat de Barcelona, L Hospitalet de Llobregat, Barcelona, Spain
    J Neurochem 123:373-84. 2012
    ..Overall, these results provide structural insights to better understand the functioning of the A(2A)R/D(2)R oligomer in living cells...
  18. doi request reprint Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family
    Wilber Romero-Fernandez
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 409:764-8. 2011
    ..Thus, the evolutionary relationship within this gene family appears to have a distinct functional relevance...
  19. pmc Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the g protein-coupled receptor field
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 39:131-55. 2014
    ..The GPCR heteroreceptor complexes in the CNS have become exciting new targets for neurotherapeutics in Parkinson's disease, schizophrenia, drug addiction, and anxiety and depression opening a new field in neuropsychopharmacology. ..
  20. doi request reprint On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain Res 1476:119-31. 2012
    ..This article is part of a Special Issue entitled: Brain Integration...
  21. pmc On the existence and function of galanin receptor heteromers in the central nervous system
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet Stockholm, Sweden
    Front Endocrinol (Lausanne) 3:127. 2012
    ..Finally, putative GalR-α2-adrenoreceptor heteromers with antagonistic receptor-receptor interactions may be a widespread mechanism in the CNS for integration of galanin and noradrenaline signals also of likely relevance for depression...
  22. doi request reprint Moonlighting characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    IUBMB Life 63:463-72. 2011
    ....
  23. doi request reprint The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization
    Dasiel O Borroto-Escuela
    Centre de Biotecnologia Molecular, Department d Enginyeria Quimica, Universitat Politecnica de Catalunya, Terrassa, 08222 Barcelona, Spain Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
    Biochim Biophys Acta 1803:813-25. 2010
    ....
  24. doi request reprint Altered trafficking and unfolded protein response induction as a result of M3 muscarinic receptor impaired N-glycosylation
    Wilber Romero-Fernandez
    Department d Enginyeria Quimica, Centre de Biotecnologia Molecular, Universitat Politecnica de Catalunya, Edifici GAIA, Rbla San Nebridi s n, Terrassa, 08222 Barcelona, Spain
    Glycobiology 21:1663-72. 2011
    ..Collectively, our data provide experimental evidence of the critical role that N-glycan chains play in determining muscarinic receptor distribution, localization, as well as cell integrity...
  25. doi request reprint Bioluminescence resonance energy transfer methods to study G protein-coupled receptor-receptor tyrosine kinase heteroreceptor complexes
    Dasiel O Borroto-Escuela
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Methods Cell Biol 117:141-64. 2013
    ..Various experimental designs for optimization of these experiments are also described. ..
  26. doi request reprint Volume transmission and its different forms in the central nervous system
    Kjell Fuxe
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Chin J Integr Med 19:323-9. 2013
    ..Short and long distance VT may take place in meridian channels via diffusion and flow in the interstitial fluid. Acupuncture can produce VT signals by releasing transmitters and modulators from nerve terminals and mast cells...
  27. doi request reprint Differential expression of muscarinic acetylcholine receptor subtypes in Jurkat cells and their signaling
    Mileidys Perez Alea
    Centre for Molecular Biotechnology, Department of Chemical Engineering, Technical University of Catalonia, Barcelona, Spain
    J Neuroimmunol 237:13-22. 2011
    ..Our data clarifies the functional role of AChR subtypes in Jurkat cells and pave the way to future studies on the potential cross-talk among these subpopulations and their regulation of T lymphocytes immune function...
  28. doi request reprint Overproduction of human M₃ muscarinic acetylcholine receptor: an approach toward structural studies
    Wilber Romero-Fernandez
    Centre de Biotecnologia Molecular, Dept d Enginyeria Quimica, Universitat Politecnica de Catalunya, Terrassa 08222, Spain
    Biotechnol Prog 27:838-45. 2011
    ..Taking together several of the strategies used can help increasing M3R expression, not only to start purification efforts but also for secondary structural analysis trial and functional analyses...