Linda Björkhem-Bergman

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study
    Linda Björkhem-Bergman
    Karolinska Institutet, Department of Laboratory Medicine, Divisions of Clinical Pharmacology, Stockholm, Sweden
    Drug Metab Dispos 41:704-8. 2013
  2. ncbi Review: Exploring anticarcinogenic agents in a rat hepatocarcinogenesis model--focus on selenium and statins
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology C1 68, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Karolinska Institute, 141 86, Stockholm, Sweden
    In Vivo 26:527-35. 2012
  3. ncbi Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology C1 68, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Anticancer Res 30:1105-12. 2010
  4. pmc Statin treatment and mortality in bacterial infections--a systematic review and meta-analysis
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e10702. 2010
  5. ncbi Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase
    Tomas Nordman
    Department of Laboratory Medicine, F 46, Karolinska Institutet, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Biofactors 18:45-50. 2003
  6. ncbi Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase
    Linda Björkhem-Bergman
    Division of Pathology, Department of Microbiology, Pathology and Immunology, Karolinska Institutet, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Biochem Pharmacol 63:1875-84. 2002
  7. doi Atorvastatin treatment induces uptake and efflux transporters in human liver
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology, Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Drug Metab Dispos 41:1610-5. 2013
  8. ncbi The role of thioredoxin reductase activity in selenium-induced cytotoxicity
    Zbigniew Madeja
    Department of Laboratory Medicine, Division of Pathology, F46, Karolinska Institutet, Karolinska University Hospital in Huddinge, SE 141 86 Stockholm, Sweden
    Biochem Pharmacol 69:1765-72. 2005
  9. doi Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology C1 68, Karolinska University Hospital, Huddinge, Karolinska Institutet, SE 141 86, Stockholm, Sweden
    Drug Metab Dispos 41:1488-93. 2013
  10. ncbi Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide
    Linda Björkhem-Bergman
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, S 14186 Stockholm, Sweden
    Peptides 25:1849-55. 2004

Collaborators

Detail Information

Publications24

  1. doi Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study
    Linda Björkhem-Bergman
    Karolinska Institutet, Department of Laboratory Medicine, Divisions of Clinical Pharmacology, Stockholm, Sweden
    Drug Metab Dispos 41:704-8. 2013
    ....
  2. ncbi Review: Exploring anticarcinogenic agents in a rat hepatocarcinogenesis model--focus on selenium and statins
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology C1 68, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Karolinska Institute, 141 86, Stockholm, Sweden
    In Vivo 26:527-35. 2012
    ..Interestingly, also in the case of selenium the inhibited carcinogenesis was associated with reduced TrxR activity, indicating an important role for this enzyme in carcinogenesis...
  3. ncbi Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology C1 68, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Anticancer Res 30:1105-12. 2010
    ..This study tests the hypothesis that statins (HMGCoA reductase inhibitors) inhibit carcinogenesis and that this effect may be mediated by the statin-induced inhibition of ubiquinone synthesis...
  4. pmc Statin treatment and mortality in bacterial infections--a systematic review and meta-analysis
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 5:e10702. 2010
    ..The aim of this study was to evaluate the effect of statin-treatment on mortality in patients with bacterial infections, by means of a systematic review and a meta-analysis...
  5. ncbi Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase
    Tomas Nordman
    Department of Laboratory Medicine, F 46, Karolinska Institutet, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Biofactors 18:45-50. 2003
    ..The reduction of ubiquinone by the three enzymes offers a multifunctional system for extramitochondrial regeneration of an important antioxidant...
  6. ncbi Drug-resistant human lung cancer cells are more sensitive to selenium cytotoxicity. Effects on thioredoxin reductase and glutathione reductase
    Linda Björkhem-Bergman
    Division of Pathology, Department of Microbiology, Pathology and Immunology, Karolinska Institutet, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Biochem Pharmacol 63:1875-84. 2002
    ..Different responses in the activity of the key enzymes in selenium metabolism are one possible mechanism explaining the differential cytotoxicity of selenium in these cells...
  7. doi Atorvastatin treatment induces uptake and efflux transporters in human liver
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology, Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Drug Metab Dispos 41:1610-5. 2013
    ....
  8. ncbi The role of thioredoxin reductase activity in selenium-induced cytotoxicity
    Zbigniew Madeja
    Department of Laboratory Medicine, Division of Pathology, F46, Karolinska Institutet, Karolinska University Hospital in Huddinge, SE 141 86 Stockholm, Sweden
    Biochem Pharmacol 69:1765-72. 2005
    ..These data strongly suggest that TrxR1 may be a crucial enzyme responsible for cell resistance against selenium cytotoxicity...
  9. doi Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology C1 68, Karolinska University Hospital, Huddinge, Karolinska Institutet, SE 141 86, Stockholm, Sweden
    Drug Metab Dispos 41:1488-93. 2013
    ..In conclusion, the 4β-hydroxycholesterol ratio is comparable to midazolam clearance as a marker of CYP3A4 induction, and each may be used to evaluate CYP3A4 induction in clinical trials evaluating drug-drug interactions for new drugs. ..
  10. ncbi Mammalian thioredoxin reductase alters cytolytic activity of an antibacterial peptide
    Linda Björkhem-Bergman
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, S 14186 Stockholm, Sweden
    Peptides 25:1849-55. 2004
    ..The levels of TrxR are enhanced in many cancer cells, including SCLC, and it is possible that cytolytic activity of cytolytic cells on SCLC may in part be mediated by granulysin and modulated by TrxR...
  11. doi Influence of simvastatin on the thromboxane and prostacyclin pathways, in vitro and in vivo
    Cristine Skogastierna
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    J Cardiovasc Pharmacol 61:1-7. 2013
    ..This may have pathophysiological implications by promoting a prothrombotic state in the blood vessels...
  12. doi The anti-carcinogenic effect of statins in a rat model correlates with levels and synthesis of ubiquinone
    Jure Acimovic
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 425:348-52. 2012
    ..The ratio between the different Q-isoforms might be used as a more sensitive marker of statin-induced inhibition of Q than measuring total Q levels...
  13. ncbi Selenium prevents tumor development in a rat model for chemical carcinogenesis
    Linda Björkhem-Bergman
    Department of Laboratory Medicine, Division of Pathology, F46, Karolinska Institutet, Karolinska University Hospital in Huddinge, SE 141 86 Stockholm, Sweden
    Carcinogenesis 26:125-31. 2005
    ..Taken together our data indicate that the carcinogenetic process may be prevented by selenium supplementation both during the promotion and the progression phase...
  14. doi Statins inhibit expression of thioredoxin reductase 1 in rat and human liver and reduce tumour development
    Cristine Skogastierna
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Biochem Biophys Res Commun 417:1046-51. 2012
    ..The aim of the present study was to investigate if statin treatment is associated with alterations in the hepatic expression of TrxR...
  15. doi Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells
    Lena Ekström
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 430:90-4. 2013
    ..Thus, our results reveal a simvastatin-specific reduction of cellular TrxR1 levels that at least in part involves direct inhibitory effects on the basal activity of the core promoter guiding TrxR1 expression...
  16. doi Vitamin D and drug-metabolising enzymes
    Jonatan D Lindh
    Karolinska Institutet, Department of Laboratory Medicine, Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Photochem Photobiol Sci 11:1797-801. 2012
    ..Taken together, vitamin D status might contribute to inter- and intraindividual differences in drug metabolism, but the therapeutic impact of these findings remains to be established...
  17. doi Seasonal variation in blood drug concentrations and a potential relationship to vitamin D
    Jonatan D Lindh
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Drug Metab Dispos 39:933-7. 2011
    ..Even though a causal relationship remains to be established, it is suggested that individual differences in vitamin D may contribute to variability in drug metabolism and disposition...
  18. pmc Possible drug-drug interaction between quetiapine and lamotrigine--evidence from a Swedish TDM database
    Marine L Andersson
    Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden
    Br J Clin Pharmacol 72:153-6. 2011
    ..The aim of the present study was to investigate a previously proposed interaction between quetiapine and lamotrigine resulting in reduced serum quetiapine concentrations...
  19. ncbi Is there a role for statins in fungal infections?
    Peter W Bergman
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska University Hospital, Huddinge, Karolinska Institutet, 141 86, Stockholm, Sweden
    Expert Rev Anti Infect Ther 11:1391-400. 2013
    ..Given the limited evidence for a beneficial effect of statins in fungal infection, randomized and controlled trials are highly warranted in this field...
  20. pmc The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo
    Marjan Shafaati
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, Huddinge, Sweden
    J Lipid Res 51:318-23. 2010
    ..One of the side-effects of voriconazole is visual disturbances. Because CYP46A1 is also expressed in the neural retina, we discuss the possibility that the inhibition of CYP46A1 by voriconazole contributes to these visual disturbances...
  21. ncbi Selenite-induced apoptosis in doxorubicin-resistant cells and effects on the thioredoxin system
    Kerstin Jönsson-Videsäter
    Division of Hematology and Oncology, Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm SE 141 86, Sweden
    Biochem Pharmacol 67:513-22. 2004
    ..Our results demonstrate pronounced selective selenium-mediated apoptosis in therapy-resistant cells and suggest that redox regulation through the thioredoxin system is an important target for cancer therapy...
  22. pmc Studies on the antibacterial effects of statins--in vitro and in vivo
    Peter Bergman
    Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 6:e24394. 2011
    ..Statin treatment has been associated with a beneficial outcome on respiratory tract infections. In addition, previous in vitro and in vivo experiments have indicated favorable effects of statins in bacterial infections...
  23. doi Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis
    Linda Björkhem-Bergman
    Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden
    J Psychopharmacol 25:299-305. 2011
    ..However, metformin is not approved for use in non-diabetic patients and it is still not generally advisable to recommend metformin to counteract antipsychotic-induced weight gain...
  24. ncbi The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress
    Ling Xia
    Department of Microbiology, Pathology, and Immunology, Division of Pathology, F46, Karolinska Institutet, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    J Biol Chem 278:2141-6. 2003
    ..These data demonstrate that the selenoenzyme thioredoxin reductase is an important selenium-dependent ubiquinone reductase and can explain how selenium and ubiquinone, by a combined action, may protect the cell from oxidative damage...