Magnus Bjorkholm

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi Long-term treatment of invasive sinus, tracheobroncheal, pulmonary and intracerebral aspergillosis in acute lymphoblastic leukaemia
    M Bjorkholm
    Division of Hematology, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Infection 40:81-5. 2012
  2. pmc Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer
    Wenjuan Li
    Department of Microbiology Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine and School of Life Sciences, Shandong University, Jinan, PR China
    Mol Cancer 9:132. 2010
  3. pmc Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms
    Magnus Bjorkholm
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
    J Clin Oncol 29:2410-5. 2011
  4. pmc Success story of targeted therapy in chronic myeloid leukemia: a population-based study of patients diagnosed in Sweden from 1973 to 2008
    Magnus Bjorkholm
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Clin Oncol 29:2514-20. 2011
  5. doi How we treat elderly patients with Hodgkin lymphoma
    Magnus Bjorkholm
    Division of Hematology, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Oncol 23:421-8. 2011
  6. doi CNOP (mitoxantrone) chemotherapy is inferior to CHOP (doxorubicin) in the treatment of patients with aggressive non-Hodgkin lymphoma (meta-analysis)
    Magnus Bjorkholm
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Eur J Haematol 80:477-82. 2008
  7. ncbi Central nervous system occurrence in elderly patients with aggressive lymphoma and a long-term follow-up
    M Bjorkholm
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Oncol 18:1085-9. 2007
  8. pmc Immune-related and inflammatory conditions and risk of lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia
    Sigurdur Y Kristinsson
    Department of Medicine, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Natl Cancer Inst 102:557-67. 2010
  9. ncbi High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma
    Erik Björck
    Department of Molecular Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Blood 105:2908-15. 2005
  10. ncbi Intensive chemotherapy in patients with chronic myelogenous leukaemia (CML) in accelerated or blastic phase--a report from the Swedish CML Group
    Ulla Axdorph
    Division of Haematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Br J Haematol 118:1048-54. 2002

Detail Information

Publications90

  1. doi Long-term treatment of invasive sinus, tracheobroncheal, pulmonary and intracerebral aspergillosis in acute lymphoblastic leukaemia
    M Bjorkholm
    Division of Hematology, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Infection 40:81-5. 2012
    ..At the time of writing, 3.5 years after the initial diagnosis, the patient is working half-time and suffers from a possible voriconazole-induced polyneuropathy...
  2. pmc Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer
    Wenjuan Li
    Department of Microbiology Key Laboratory for Experimental Teratology of Chinese Ministry of Education, School of Medicine and School of Life Sciences, Shandong University, Jinan, PR China
    Mol Cancer 9:132. 2010
    ....
  3. pmc Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms
    Magnus Bjorkholm
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
    J Clin Oncol 29:2410-5. 2011
    ..Using population-based data from Sweden, we assessed the role of MPN treatment and subsequent AML/MDS risk with special focus on the leukemogenic potential of hydroxyurea (HU)...
  4. pmc Success story of targeted therapy in chronic myeloid leukemia: a population-based study of patients diagnosed in Sweden from 1973 to 2008
    Magnus Bjorkholm
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Clin Oncol 29:2514-20. 2011
    ..In Sweden, the drug was approved in November 2001. We report relative survival (RS) of patients with CML diagnosed during a 36-year period...
  5. doi How we treat elderly patients with Hodgkin lymphoma
    Magnus Bjorkholm
    Division of Hematology, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Curr Opin Oncol 23:421-8. 2011
    ..To review Hodgkin lymphoma in older adults with regard to epidemiology, disease characteristics, prognosis, treatment, and future developments...
  6. doi CNOP (mitoxantrone) chemotherapy is inferior to CHOP (doxorubicin) in the treatment of patients with aggressive non-Hodgkin lymphoma (meta-analysis)
    Magnus Bjorkholm
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Eur J Haematol 80:477-82. 2008
    ..CHOP chemotherapy is more efficacious than CNOP at equitoxic (myelosuppression) doses. CHOP is, however, associated with more alopecia and gastrointestinal toxicity...
  7. ncbi Central nervous system occurrence in elderly patients with aggressive lymphoma and a long-term follow-up
    M Bjorkholm
    Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Oncol 18:1085-9. 2007
    ..The incidence and risk factors for CNS manifestation were studied in a large cohort of elderly (>60 years) patients with aggressive lymphoma...
  8. pmc Immune-related and inflammatory conditions and risk of lymphoplasmacytic lymphoma or Waldenstrom macroglobulinemia
    Sigurdur Y Kristinsson
    Department of Medicine, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Natl Cancer Inst 102:557-67. 2010
    ..We conducted, to our knowledge, the most comprehensive study to date to evaluate associations between a personal or family history of many immune-related and/or inflammatory disorders and the subsequent risk of LPL-WM...
  9. ncbi High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma
    Erik Björck
    Department of Molecular Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Blood 105:2908-15. 2005
    ..CCNB1 expression had an independent prognostic value when included in a multivariate analysis together with the 5 parameters of the follicular lymphoma international prognostic index...
  10. ncbi Intensive chemotherapy in patients with chronic myelogenous leukaemia (CML) in accelerated or blastic phase--a report from the Swedish CML Group
    Ulla Axdorph
    Division of Haematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Br J Haematol 118:1048-54. 2002
    ..Subsequent SCT/ASCT was feasible for half of the responders (< 65 years), and one individual underwent double ASCT. Novel therapeutic options for CML patients in AP/BP are needed...
  11. ncbi Parental longevity and prognosis in elderly patients with aggressive non-Hodgkin's lymphoma
    Eva Osby
    Division of Hematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Acta Oncol 43:297-301. 2004
    ..Maternal and paternal lifespan may predict survival in NHL, but with opposing effects. At present parental age appears not to be a clinically useful predictor of prognosis in the elderly with aggressive NHL...
  12. doi Temporal trends in mortality from diseases of the circulatory system after treatment for hodgkin lymphoma: a population-based cohort study in sweden (1973 to 2006)
    Sandra Eloranta
    MSc, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    J Clin Oncol 31:1435-41. 2013
    ..The main causes of death among long-term survivors today are causes other than HL, although other (non-DCS) excess mortality also persists for as long as 20 years after diagnosis, particularly among older patients...
  13. pmc Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study
    Ebba K Lindqvist
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 118:6284-91. 2011
    ..The association of both personal and family history of autoimmune disease with MGUS indicates the potential for shared susceptibility for these conditions...
  14. ncbi Differential expression of full-length telomerase reverse transcriptase mRNA and telomerase activity between normal and malignant renal tissues
    Yidong Fan
    Division of Urology, Department of Surgery, Karolinska University Hospital, Stockholm, Sweden
    Clin Cancer Res 11:4331-7. 2005
    ....
  15. doi The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells
    Jiping Zeng
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Gastroenterology 138:981-92. 2010
    ..It is unclear whether RBP2, a newly identified histone demethylase, is involved in cancer development/progression. We determined RBP2 expression in gastric cancer and its biologic function in cancer cells...
  16. pmc Arterial and venous thrombosis in monoclonal gammopathy of undetermined significance and multiple myeloma: a population-based study
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 115:4991-8. 2010
    ..0 g/L) at diagnosis. MGUS patients with (vs without) thrombosis had no excess risk of MM or Waldenström macroglobulinemia. Our findings are of relevance for future studies and for improvement of thrombosis prophylaxis strategies...
  17. doi Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas
    Frida Schain
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Clin Lymphoma Myeloma 8:340-7. 2008
    ....
  18. ncbi Phase II study of cyclophosphamide, interferon-alpha and betamethasone (CIB) as induction therapy for patients 60-75 years of age with multiple myeloma stages II and III
    Jeanette Lundin
    Department of Hematology, Karolinska Hospital, Stockholm, Sweden
    Hematol J 4:248-52. 2003
    ....
  19. doi 15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells
    Cheng Liu
    Department of Medicine, Division of Hematology, Hematology Laboratory, Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Lung Cell Mol Physiol 297:L196-203. 2009
    ..These results suggest that an increased expression and activity of 15-LOX-1 in lung epithelial cells is a proinflammatory event in the pathogenesis of asthma and other inflammatory lung disorders...
  20. pmc High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes
    Yilmaz Mahshid
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    BMC Immunol 10:2. 2009
    ..In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma...
  21. ncbi The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3
    Cheng Liu
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 67:2626-31. 2007
    ....
  22. pmc Patterns of survival and causes of death following a diagnosis of monoclonal gammopathy of undetermined significance: a population-based study
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Haematologica 94:1714-20. 2009
    ..There are limited data on survival patterns among patients with monoclonal gammopathy of undetermined significance...
  23. ncbi CHOP is superior to CNOP in elderly patients with aggressive lymphoma while outcome is unaffected by filgrastim treatment: results of a Nordic Lymphoma Group randomized trial
    Eva Osby
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Blood 101:3840-8. 2003
    ..Patients receiving CHOP fared better than those given CNOP chemotherapy. The addition of G-CSF reduces the incidence of severe granulocytopenia and infections in elderly patients with aggressive NHL receiving CHOP or CNOP chemotherapy...
  24. pmc Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation
    Cheng Liu
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e52703. 2012
    ..Taken together, our data suggest that regulation of histone methylation/demethylation at the 15-LOX-1 promoter is important in 15-LOX-1 expression...
  25. doi Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase
    Zheng Ge
    Department of Medicine, Center for Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    FASEB J 24:579-86. 2010
    ..Our findings reveal a novel mechanism through which the Myc/Max/Mad network proteins control their target gene transcription and provide insights into mechanisms underlying telomerase silencing and activation...
  26. doi Interleukin-13 stimulation of the mediastinal B-cell lymphoma cell line Karpas-1106P induces a phenotype resembling the Hodgkin lymphoma cell line L1236
    Erik Andersson
    Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden
    Exp Hematol 38:116-23. 2010
    ..Interleukin (IL)-13 has an important pathophysiological role in HL. In this study, we asked the question of whether IL-13 is a major contributor to the observed difference in features of inflammation between HL and PMBCL...
  27. pmc Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene
    Qingjun Zhu
    Division of Hematology, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e1446. 2008
    ..It remains to be defined how exactly the transcriptional activation of the hTERT gene occurs during the oncogenic process...
  28. ncbi Stimulation of T-cell cytokine production and NK-cell function by IL-2, IFN-alpha and histamine treatment during remission of non-Hodgkin's lymphoma
    Richard Ahlberg
    Division of Hematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Hematol J 4:336-41. 2003
    ..The results indicate synergistic T- and NK-cell activation by tolerable doses of the combined immunotherapy, administered during remission after chemotherapy and ASCT in NHL...
  29. ncbi The effect of allogeneic stem cell transplantation on outcome in younger acute myeloid leukemia patients with minimal residual disease detected by flow cytometry at the end of post-remission chemotherapy
    Edward Laane
    Department of Pathology and Cytology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Haematologica 91:833-6. 2006
    ..003). Therefore allogeneic SCT should be considered in younger adult AML patients with detectable MRD at the end of post-remission chemotherapy. Autologous SCT may be an alternative for patients not eligible for allogeneic SCT...
  30. pmc Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Haematologica 97:854-8. 2012
    ..Our findings provide novel insights into the mechanisms behind infections in patients with plasma cell dyscrasias, and may have clinical implications...
  31. doi Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma
    Hans Erik Claesson
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, and Orexo AB, Uppsala, Sweden
    FEBS J 275:4222-34. 2008
    ..Furthermore, the discovery of the high 15-lipoxygenase-1 activity in L1236 cells demonstrates that this cell line comprises a useful model system to study the chemical and biological roles of 15-lipoxygenase-1...
  32. doi Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005
    Asa Rangert Derolf
    Division of Hematology, Department of Medicine, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 113:3666-72. 2009
    ..However, the majority of AML patients die of their disease and age remains an important predictor of prognosis. New effective agents with a more favorable toxicity profile are needed to improve survival, particularly in the elderly...
  33. pmc Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromes
    Sigurdur Y Kristinsson
    Dept of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 29:2897-903. 2011
    ....
  34. doi Connective tissue growth factor is expressed in malignant cells of Hodgkin lymphoma but not in other mature B-cell lymphomas
    Anna Birgersdotter
    Department of Microbiology, Tumor Biology and Cell Biology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Am J Clin Pathol 133:271-80. 2010
    ..Macrophages stained positively in Burkitt lymphomas and in some mantle cell lymphomas. The high occurrence of fibrosis in cHL may be related to CTGF expression by malignant H-RS cells...
  35. pmc Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in Sweden
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 125:2147-50. 2009
    ..0-1.5). No significantly increased risk was found for other hematologic or solid malignancies. Our findings support a role for a shared susceptibility (genetic, environmental or both) that predisposes to MM, MGUS, ALL and bladder cancer...
  36. doi Patterns of survival in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia: a population-based study of 1,555 patients diagnosed in Sweden from 1980 to 2005
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
    Am J Hematol 88:60-5. 2013
    ..Despite this progress, new effective agents with a more favourable toxicity profile are needed to further improve survival in LPL/WM, especially in the elderly...
  37. pmc Patterns of survival among patients with myeloproliferative neoplasms diagnosed in Sweden from 1973 to 2008: a population-based study
    Malin Hultcrantz
    Karolinska University Hospital, Stockholm, Sweden
    J Clin Oncol 30:2995-3001. 2012
    ..We conducted a large population-based study to establish patterns of survival in more than 9,000 patients with MPNs...
  38. doi Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line
    Cheng Liu
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Exp Cell Res 318:169-76. 2012
    ..These prerequisites are fulfilled in the L1236 cell line, but not in the L428 cell line...
  39. doi Progress in Hodgkin lymphoma: a population-based study on patients diagnosed in Sweden from 1973-2009
    Jan Sjoberg
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 119:990-6. 2012
    ..In addition, our findings support that long-term mortality of HL therapy has decreased. Elderly HL patients still do poorly, and targeted treatment options associated with fewer side effects will advance the clinical HL field...
  40. doi Activation of telomerase by human cytomegalovirus
    Klas Strååt
    Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 101:488-97. 2009
    ..Because cellular immortalization and transformation require telomerase activation by expression of the telomerase reverse transcriptase (hTERT) gene, we examined the role of HCMV in telomerase activation...
  41. doi Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma
    Frida Schain
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 123:2285-93. 2008
    ..As these cells are surrounded by CysLT-producing eosinophils, macrophages and mast cells, our results suggest the CysLTs as mediators in the pathogenesis of cHL, contributing to the aberrant cytokine network of this lymphoma...
  42. ncbi Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase reverse transcriptase (hTERT) mRNA
    Marit Jalink
    Department of Medicine, Division of Haematology, Karolinska University Hospital Solna and Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Biochem Biophys Res Commun 353:999-1003. 2007
    ..Collectively, human normal and malignant lymphocytes, like other human cells, express splicing variants of hTERT mRNA and require transcriptional activation of the hTERT gene to acquire telomerase activity...
  43. pmc Monoclonal gammopathy of undetermined significance and risk of skeletal fractures: a population-based study
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 116:2651-5. 2010
    ..Our findings may have implications for the development of better prophylaxis for bone disease in MGUS, and they provide novel clues on pathogenesis of MM bone disease...
  44. doi Temporal trends in the proportion cured among adults diagnosed with acute myeloid leukaemia in Sweden 1973-2001, a population-based study
    Therese M L Andersson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Br J Haematol 148:918-24. 2010
    ..This novel approach of analysing survival data could be a valuable tool for physicians, patients, health care planners and health economists...
  45. pmc Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Haematologica 94:1581-9. 2009
    ..Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings...
  46. ncbi Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003
    Sigurdur Yngvi Kristinsson
    Division of Hematology, Department of Medicine, Karolinska Karolinska University Hospital and Institutet, Stockholm, Sweden
    J Clin Oncol 25:1993-9. 2007
    ..To define patterns of survival among all multiple myeloma (MM) patients diagnosed in Sweden during a 30-year period...
  47. pmc Partitioning of excess mortality in population-based cancer patient survival studies using flexible parametric survival models
    Sandra Eloranta
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, Stockholm, Sweden
    BMC Med Res Methodol 12:86. 2012
    ..For this purpose we extend flexible parametric survival models for relative survival, which use restricted cubic splines for the baseline cumulative excess hazard and for any time-dependent effects...
  48. doi Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells
    Ping Li
    Department of Medicine, Division of Haematology and Centre for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Int J Biochem Cell Biol 44:1531-40. 2012
    ..Conceivably telomere dysfunction causes shortened life-span and genomic instability of normal human cells, and thereby contributes to tissue/organ damage and secondary malignancies in long-term survivors of cancer...
  49. ncbi Surveillance of triazole susceptibility of colonizing yeasts in patients with haematological malignancies
    Erja Chryssanthou
    Departments of Clinical Microbiology, and Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    Scand J Infect Dis 36:855-9. 2004
    ..Fluconazole prophylaxis may contribute to emergence of less susceptible yeast strains also in patients with haematological malignancies not treated with allogeneic bone marrow transplantation...
  50. pmc Familial aggregation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia with solid tumors and myeloid malignancies
    Sigurdur Y Kristinsson
    Division of Hematology, Department of Medicine, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
    Acta Haematol 127:173-7. 2012
    ..In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients...
  51. doi Expression patterns of CD33 and CD15 predict outcome in patients with acute myeloid leukemia
    Asa Rangert Derolf
    Department of Medicine, Division of Hematology, Karolinska Institutet and Karolinska University Hospital, Solna, Stockholm, Sweden
    Leuk Lymphoma 49:1279-91. 2008
    ..004, cytogenetics p = 0.011, immunophenotype pattern p = 0.024, CD15 p = 0.031). Age (p = 0.001) and immunophenotypic classifications (p = 0.015) were significant for disease-free survival in patients who achieved complete remission...
  52. doi Socioeconomic differences in patient survival are increasing for acute myeloid leukemia and multiple myeloma in sweden
    Sigurdur Yngvi Kristinsson
    Division of Hematology, Department of Medicine, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    J Clin Oncol 27:2073-80. 2009
    ..We assessed the impact of SES on survival in two large population-based cohorts of AML and MM patients diagnosed in Sweden 1973 to 2005...
  53. ncbi Real-time polymerase chain reaction determination of cytokine mRNA expression profiles in Hodgkin's lymphoma
    Maria Malec
    Karolinska Institutet at Department of Pathology, Stockholm, Sweden
    Haematologica 89:679-85. 2004
    ..Quantification of these cytokines at a protein level is still somewhat imprecise. We, therefore, used a method to quantify cytokine mRNA expression in HL cell lines and lymph node biopsies...
  54. pmc Thrombosis is associated with inferior survival in multiple myeloma
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Haematologica 97:1603-7. 2012
    ..The prevention of thrombosis in multiple myeloma is an important goal in the management of these patients...
  55. ncbi The feasibility of early hospital discharge with oral antimicrobial therapy in low risk patients with febrile neutropenia following chemotherapy for hematologic malignancies
    Honar Cherif
    Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Haematologica 91:215-22. 2006
    ..With increasing accuracy it is now possible to identify low-risk patients for whom less intensive and more convenient treatment may be appropriate...
  56. pmc Risk of lymphoproliferative disorders among first-degree relatives of lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia patients: a population-based study in Sweden
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Blood 112:3052-6. 2008
    ..Our findings of highly increased risks of developing LPL/WM, NHL, CLL, and MGUS support the operation of shared susceptibility genes that predispose to LPL/WM and other lymphoproliferative disorders...
  57. pmc Autoimmunity and the risk of myeloproliferative neoplasms
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Haematologica 95:1216-20. 2010
    ..Future studies are needed to unravel the effects of these autoimmune diseases themselves, their treatment, or common genetic susceptibility...
  58. pmc Genetics- and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/ Waldenström's macroglobulinemia
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital, Solna and Karolinska Institutet, Stockholm, Sweden
    Clin Lymphoma Myeloma 9:23-6. 2009
    ..Finally, based on novel insights on this topic, we discuss clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up...
  59. ncbi Three-dimensional culturing of the Hodgkin lymphoma cell-line L1236 induces a HL tissue-like gene expression pattern
    Anna Birgersdotter
    Department of Microbiology, Tumor Biology and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Leuk Lymphoma 48:2042-53. 2007
    ..3D culture affected the expression of 500 genes in L1236, upregulating genes involved in immune response and apoptosis and downregulating genes involved in cell division. It also affected genes involved in actin filament polymerization...
  60. ncbi Antifungal therapy in patients with hematological malignancies: how to avoid overtreatment?
    Honar Cherif
    Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Eur J Haematol 77:288-92. 2006
    ..However, new therapeutic agents have recently been introduced. At the same time, the relatively low incidence of IFI and the progress in the diagnostic accuracy of IFI have made routine use of empirical antifungal therapy questionable...
  61. ncbi A prospective, randomized study comparing cefepime and imipenem-cilastatin in the empirical treatment of febrile neutropenia in patients treated for haematological malignancies
    Honar Cherif
    Department of Medicine, Division of Haematology, Karolinska Hospital and Institute, Stockholm, Sweden
    Scand J Infect Dis 36:593-600. 2004
    ..Early discontinuation of antibiotic therapy in 31 patients with FUO 48 h after defervescence was not associated with an increased rate of fever relapse or mortality compared with a subgroup of 29 patients where therapy was continued...
  62. ncbi Response to splenectomy is durable after a certain point in time in adult patients with chronic immune thrombocytopenic purpura
    Eva Johansson
    Department of Medicine, Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Eur J Haematol 77:61-6. 2006
    ....
  63. doi FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1
    Jiping Zeng
    Department of Medicine, Division of Haematology, Karolinska University Hospital, Solna, and Karolinska Institutet, Stockholm, Sweden
    J Pathol 218:419-27. 2009
    ..These findings provide mechanistic insights into the role of FoxM1 in the pathogenesis of gastric cancer, which may have diagnostic and therapeutic implications in gastric cancer...
  64. doi Sorafenib has potent antitumor activity against multiple myeloma in vitro, ex vivo, and in vivo in the 5T33MM mouse model
    Pedram Kharaziha
    Department of Oncology Pathology, Cancer Centre Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden
    Cancer Res 72:5348-62. 2012
    ..Altogether, our data support the use of sorafenib as a novel therapeutic modality against human multiple myeloma, and its efficacy may be potentiated in combination with ABT737...
  65. pmc Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden
    Blood 112:3582-6. 2008
    ..5%) that progressed to MM, only one person had a DVT diagnosis before transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM...
  66. pmc TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders
    Jan Palmblad
    Hematology Center, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Int J Med Sci 5:87-91. 2008
    ..Thus, a pronounced increase of TPO levels after 6 months of anagrelide treatment indicated that this treatment affected a major regulatory mechanism for megakaryocyte and platelet formation in MPD...
  67. ncbi Hodgkin's lymphoma in the elderly with special reference to type and intensity of chemotherapy in relation to prognosis
    Ola Landgren
    Division of Hematology, Department of Medicine, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Haematologica 88:438-44. 2003
    ..This study was undertaken to evaluate potential clinical factors of importance for prognosis with special reference to relative dose intensity (RDI) of chemotherapy (CT)...
  68. ncbi Personal and family history of autoimmune diabetes mellitus and susceptibility to young-adult-onset Hodgkin lymphoma
    Ola Landgren
    Division of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
    Int J Cancer 118:449-52. 2006
    ..0) history of diabetes mellitus. These findings suggests that characteristics of the immune system associated with conditions such as diabetes mellitus type I are of importance in the pathogenesis of young-adult-onset HL...
  69. ncbi Ascertainment and diagnostic accuracy for hematopoietic lymphoproliferative malignancies in Sweden 1964-2003
    Ingemar Turesson
    Section of Hematology, Department of Medicine, Malmo University Hospital, University of Lund, Malmo, Sweden
    Int J Cancer 121:2260-6. 2007
    ..However, we found under-ascertainment of patients with indolent LP tumors, particularly among patients diagnosed at older ages, with early-stage disease and diagnosed in earlier years...
  70. pmc Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation
    Zheng Ge
    Division of Hematology, Deaprtment of Medicine, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Mol Cell Biol 26:230-7. 2006
    ..These results define H3 phosphorylation as a key to hTERT transactivation induced by proliferation and reveal a fundamental mechanism for telomerase regulation in both normal human cells and transformed T cells...
  71. pmc Improved survival in chronic lymphocytic leukemia in the past decade: a population-based study including 11,179 patients diagnosed between 1973-2003 in Sweden
    Sigurdur Y Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital, Stockholm, Sweden
    Haematologica 94:1259-65. 2009
    ..However, to date, clinical trials have not shown a survival benefit...
  72. doi Hematological: Low all-cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single-center study
    Christian Kjellander
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Eur J Haematol 88:422-30. 2012
    ..Bacteremia is a major cause of morbidity and mortality in patients with hematological malignancies...
  73. ncbi Predictors of short and long-term outcome in patients with hematological disorders admitted to the intensive care unit for a life-threatening complication
    Honar Cherif
    Division of Haematology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden
    Support Care Cancer 15:1393-8. 2007
    ..We assessed both early and long-term outcomes in relation to clinical characteristics with the aim to facilitate clinical decision making...
  74. ncbi The expression of cytosolic phospholipase A2 and biosynthesis of leukotriene B4 in acute myeloid leukemia cells
    Gudmundur Runarsson
    Department of Medicine, Division of Hematology, Karolinska Institutet, Stockholm, Sweden
    Eur J Haematol 79:468-76. 2007
    ..High expression of cPLA2 in AML suggests a putative role of this enzyme in the pathophysiology of this disease...
  75. ncbi Sick leave due to depressive disease: not a risk factor for the development of malignant lymphoma
    Marie Nordstrom
    Division of Hematology, Department of Medicine, Karolinska Institute and University Hospital, SE 171 76, Stockholm, Sweden
    Eur J Epidemiol 20:769-73. 2005
    ..We conclude that the increase in the incidence of malignant lymphomas observed during the last decades seems not to be associated with a concurrent increase of depressive disorders...
  76. doi Hypercoagulability in multiple myeloma and its precursor state, monoclonal gammopathy of undetermined significance
    Sigurdur Yngvi Kristinsson
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden
    Semin Hematol 48:46-54. 2011
    ..In this review, we discuss risk factors for thrombosis in multiple myeloma, as well as prophylactic strategies, the evidence for thrombosis among patients with MGUS, and proposed mechanisms for the hypercoagulability...
  77. ncbi A prospective comparison of fine-needle aspiration cytology and histopathology in the diagnosis and classification of lymphomas
    Ola Landgren
    Department of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
    Hematol J 5:69-76. 2004
    ..This prospective study compares the diagnostic outcome between FNAC and surgical biopsy...
  78. ncbi A phase II trial of pegylated interferon alpha-2b therapy for polycythemia vera and essential thrombocythemia: feasibility, clinical and biologic effects, and impact on quality of life
    Jan Samuelsson
    Department of Medicine, Stockholm South Hospital, Stockholm, Sweden, and Department of Medicine, Roskilde University Hospital, Denmark
    Cancer 106:2397-405. 2006
    ..Conventional interferon-alpha (IFN) is an effective treatment for patients with myeloproliferative disorders. However, many patients discontinue therapy because of side effects...
  79. ncbi Characterization of red cell autoantibodies in consecutive DAT-positive patients with relation to in vivo haemolysis
    Agneta Wikman
    Division of Transfusion Medicine, Huddinge, Department of Laboratory Medicine, Karolinska University Hospital, 141 86 Stockholm, Sweden
    Ann Hematol 84:150-8. 2005
    ..This may be of importance in understanding the mechanisms of haemolysis and in predicting the harmfulness of antibodies, especially when blood transfusions are needed...
  80. ncbi Combined genetic and transcriptional profiling of acute myeloid leukemia with normal and complex karyotypes
    Charlotta Lindvall
    Department of Molecular Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Haematologica 89:1072-81. 2004
    ..In the current study, we have systematically combined transcriptional profiles with cytogenetic data from 15 AML patients with either normal or complex karyotypes...
  81. ncbi Poor antibody response to pneumococcal polysaccharide vaccination suggests increased susceptibility to pneumococcal infection in splenectomized patients with hematological diseases
    Honar Cherif
    Department of Medicine, Division of Hematology, Karolinska University Hospital and Institute, SE 171 76 Stockholm, Sweden
    Vaccine 24:75-81. 2006
    ..Poor responders do not benefit from revaccination, and should be offered other prophylactic measures...
  82. ncbi Bacteraemia in hospitalised patients with malignant blood disorders: a retrospective study of causative agents and their resistance profiles during a 14-year period without antibacterial prophylaxis
    Honar Cherif
    Division of Hematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Hematol J 4:420-6. 2003
    ..The 7- and 30-day mortality rates were 6.3 and 15.6%, respectively, being significantly higher in patients with bacteraemia caused by Pseudomonas aeruginosa, Stenotrophomonas maltophilia, or E. faecium...
  83. doi Patients' perceptions of having a central venous catheter or a totally implantable subcutaneous port system-results from a randomised study in acute leukaemia
    Eva Johansson
    Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, SE 171 76, Stockholm, Sweden
    Support Care Cancer 17:137-43. 2009
    ....
  84. ncbi Totally implantable subcutaneous port system versus central venous catheter placed before induction chemotherapy in patients with acute leukaemia-a randomized study
    Eva Johansson
    Division of Hematology, Department of Medicine, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Support Care Cancer 12:99-105. 2004
    ..02). Despite fewer infectious complications in the PORT group the use of a double-lumen CVC is advocated in patients with AL undergoing induction treatment due to the risk of extensive local bleeding after placement of the PORT...
  85. ncbi Comparison of busulphan, hydroxyurea and allogeneic bone marrow transplantation (BMT) in chronic myeloid leukaemia: BMT prolongs survival
    Ulla Olsson-Stromberg
    Department of Medicine, University Hospital, Uppsala, Sweden
    Hematol J 5:462-6. 2004
    ..When we opened our study in 1984, the clinical benefit of allogeneic bone marrow transplantation (BMT) was not well known; to follow up the long-time outcome of this treatment was therefore of great interest...
  86. ncbi Treatment options in Waldenstrom's macroglobulinemia
    Magnus Bjorkholm
    Department of Medicine, Division of Hematology, Karolinska Hospital, SE 17176, Stockholm, Sweden
    Clin Lymphoma 5:155-62. 2004
    ..Thalidomide alone or in combination with steroids/clarithromycin may be a useful salvage regimen for some heavily pretreated patients with cytopenia, even though toxicity is considerable. Splenectomy is rarely indicated...
  87. ncbi Expression of the signal transduction molecule zeta in peripheral and tumour-associated lymphocytes in Hodgkin's disease in relation to the Epstein-Barr virus status of the tumour cells
    Jan Sjoberg
    Department of Medicine, Pathology and Oncology, Radiumhemmet, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Br J Haematol 116:765-73. 2002
    ..In conclusion, these results do not support downregulation of zeta in TAL as a critical mechanism contributing specifically to the immune escape of EBV+ HRS cells...
  88. ncbi Parental longevity and survival in elderly patients with Hodgkin's lymphoma
    Ola Landgren
    Division of Hematology, Department of Medicine, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Haematologica 87:596-601. 2002
    ..The aim of this study was to test the hypothesis that parental longevity alone--an easily accessible and non-disease associated variable--is also associated with improved outcome using an enlarged series of elderly HL patients...
  89. ncbi Molecular cytogenetic approach to the diagnosis of splenic lymphoma: a case report of blastoid mantle cell lymphoma
    Erik Björck
    Department of Molecular Medicine, CMM L8 02 Karolinska Hospital and Institutet, SE 171 76, Stockholm, Sweden
    Leuk Lymphoma 44:1229-34. 2003
    ..Overexpression of cyclin D1 was detected by immunostaining. Thus the diagnosis of a splenic blastoid mantle cell lymphoma could be established. In this report, various aspects of differential diagnosis of splenic lymphomas are discussed...
  90. ncbi Transcriptional regulation of 15-lipoxygenase expression by promoter methylation
    Cheng Liu
    Division of Hematology, Department of Medicine, Karolinska Institutet and Hospital, Stockholm, Sweden
    Exp Cell Res 297:61-7. 2004
    ..Taken together, demethylation of the 15-LO promoter is a prerequisite for the gene transactivation, which contributes to tissue- and cell-type-specific regulation of 15-LO expression...