L Bertilsson

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects
    L Bertilsson
    Division of Clinical Pharmacology, Department of Laboratory Medicine at Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Clin Pharmacol Ther 82:606-9. 2007
  2. pmc Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:1414-20. 2005
  3. ncbi request reprint Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test
    K Laine
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Clin Pharmacol Ther 70:327-35. 2001
  4. doi request reprint Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register
    J Askling
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 68:648-53. 2009
  5. ncbi request reprint Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients
    H K Roh
    Department of Medical Laboratory Sciences and Toxicology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Eur J Clin Pharmacol 57:671-5. 2001
  6. pmc Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians
    P Dalen
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Br J Clin Pharmacol 55:630-4. 2003
  7. doi request reprint Effect of rifampicin and CYP2B6 genotype on long-term efavirenz autoinduction and plasma exposure in HIV patients with or without tuberculosis
    E Ngaimisi
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden
    Clin Pharmacol Ther 90:406-13. 2011
  8. pmc Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients
    H K Roh
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Br J Clin Pharmacol 52:265-71. 2001
  9. ncbi request reprint Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity
    A Wennerholm
    Division of Clinical Pharmacology, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Pharmacogenetics 11:417-27. 2001
  10. ncbi request reprint Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients
    I Persson
    Institute of Environmental Medicine, Division of Molecular Toxicology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 81:325-9. 1999

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Metabolism of antidepressant and neuroleptic drugs by cytochrome p450s: clinical and interethnic aspects
    L Bertilsson
    Division of Clinical Pharmacology, Department of Laboratory Medicine at Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Clin Pharmacol Ther 82:606-9. 2007
    ..This brief review highlights the clinical importance and ethnic differences in the metabolism of these drugs...
  2. pmc Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:1414-20. 2005
    ..Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, and maybe also of leukaemia and multiple myeloma. The effect of tumour necrosis factor (TNF) antagonists on lymphoma risk and characteristics is unclear...
  3. ncbi request reprint Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test
    K Laine
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Clin Pharmacol Ther 70:327-35. 2001
    ..Normalization of the metabolic status of ultrarapid metabolizers by inhibition of CYP2D6 activity could offer a clinically acceptable method to successfully treat such patients with antidepressants...
  4. doi request reprint Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register
    J Askling
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 68:648-53. 2009
    ....
  5. ncbi request reprint Risperidone metabolism in relation to CYP2D6*10 allele in Korean schizophrenic patients
    H K Roh
    Department of Medical Laboratory Sciences and Toxicology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Eur J Clin Pharmacol 57:671-5. 2001
    ..This study aimed to investigate the relationship between the CYP2D6*10 allele and the plasma levels of risperidone and 9-hydroxyrisperidone in Korean schizophrenic patients...
  6. pmc Disposition of debrisoquine and nortriptyline in Korean subjects in relation to CYP2D6 genotypes, and comparison with Caucasians
    P Dalen
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Br J Clin Pharmacol 55:630-4. 2003
    ..To study the influence of the CYP2D6*10 allele on the disposition of debrisoquine and nortriptyline...
  7. doi request reprint Effect of rifampicin and CYP2B6 genotype on long-term efavirenz autoinduction and plasma exposure in HIV patients with or without tuberculosis
    E Ngaimisi
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden
    Clin Pharmacol Ther 90:406-13. 2011
    ..When stratified by CYP2B6 genotype, significant differences were observed only with respect to CYP2B6*1/*1 genotypes. Ours is the first report of the CYP2B6 genotype-dependent effect of RIF on long-term EFV autoinduction...
  8. pmc Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients
    H K Roh
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Br J Clin Pharmacol 52:265-71. 2001
    ..This study was carried out to evaluate the influence of CYP2D6 genotype on the steady state plasma concentrations of haloperidol and reduced haloperidol in Korean schizophrenic patients...
  9. ncbi request reprint Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity
    A Wennerholm
    Division of Clinical Pharmacology, Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Pharmacogenetics 11:417-27. 2001
    ..The results indicate the common existence in Tanzanians of a variant CYP2D6 form with different substrate specificity as compared to the wild-type form of the enzyme causing reduced capacity for debrisoquine metabolism...
  10. ncbi request reprint Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients
    I Persson
    Institute of Environmental Medicine, Division of Molecular Toxicology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 81:325-9. 1999
    ..An increased risk for lung cancer in subjects carrying the HYL*3 allele was observed and suggests that polymorphism in this gene might possibly be a susceptibility factor in the Chinese population...
  11. pmc A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity
    C Masimirembwa
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Br J Clin Pharmacol 42:713-9. 1996
    ..We therefore postulate that the CYP2D6*17 allele might contribute to the molecular basis of the previously established diminished debrisoquine hydroxylase activity in African Bantu populations...
  12. doi request reprint CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels
    F Josephson
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Eur J Clin Pharmacol 64:775-81. 2008
    ..Efavirenz is an inducer of CYP3A, whereas the ritonavir-boosted regimens are net inhibitors of CYP3A...
  13. doi request reprint Clinically significant CYP2C inhibition by noscapine but not by glucosamine
    S Rosenborg
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Pharmacol Ther 88:343-6. 2010
    ..9-fold increase in urinary losartan/E3174 ratio) and CYP2C19 (3.6-fold increase in the plasma omeprazole/5-hydroxyomeprazole ratio). Noscapine-dependent inhibition of CYP2C9 may explain the interaction with warfarin...
  14. pmc Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity
    N Brynne
    Department of Clinical Pharmacology, Pharmacia and Upjohn AB, Stockholm, Sweden
    Br J Clin Pharmacol 48:564-72. 1999
    ..e. poor metabolisers of debrisoquine...
  15. doi request reprint The dopaminergic stabilizer pridopidine is to a major extent N-depropylated by CYP2D6 in humans
    A Helldén
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Eur J Clin Pharmacol 68:1281-6. 2012
    ..The influence of the cytochrome P450 enzyme CYP2D6 in the metabolism of the novel dopaminergic stabilizer pridopidine was investigated in healthy Swedish Caucasians...
  16. ncbi request reprint Determination of exogenous melatonin and its 6-hydroxy metabolite in human plasma by liquid chromatography-mass spectrometry
    S Hartter
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital Department of Internal Medicine, South Hospital, Stockholm, Sweden
    Ther Drug Monit 23:282-6. 2001
    ..The method was applied to the analysis of plasma from a healthy volunteer who had received a single oral dose of 25 mg melatonin...
  17. ncbi request reprint Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study
    S Hartter
    Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Clin Pharmacol Ther 70:10-6. 2001
    ..Melatonin is a hormone that is metabolized by cytochrome P450 (CYP) 1A2 to its main primary metabolite 6-hydroxymelatonin. We therefore evaluated the utility of oral melatonin as a marker of hepatic CYP1A2 activity...
  18. pmc Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    I Johansson
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Proc Natl Acad Sci U S A 90:11825-9. 1993
    ..Furthermore, the finding of a specific haplotype with two or more active CYP2D6 genes allows genotyping for ultrarapid drug metabolizers. This genotyping could be of predictive value for individualized and more efficient drug therapy...
  19. ncbi request reprint CYP3A5 genotype has an impact on the metabolism of the HIV protease inhibitor saquinavir
    F Josephson
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Pharmacol Ther 81:708-12. 2007
    ..To clarify the clinical importance of the CYP3A5 polymorphism, further studies should be conducted on saquinavir, dosed to steady state, in the presence of ritonavir boosting...
  20. doi request reprint Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol
    K P Kanebratt
    Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Clin Pharmacol Ther 84:589-94. 2008
    ..4-fold, P < 0.05; and 4.2-fold, P < 0.01, respectively). In conclusion, we have shown that the Karolinska cocktail and 4beta-hydroxycholesterol can be used for an initial screening of the induction properties of a drug candidate...
  21. ncbi request reprint The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population
    B Ding
    Center for Genomics and Bioinformatics, Karolinska Institute, S 171 77, Stockholm, S 17186, Sweden
    J Clin Pharm Ther 27:211-2. 2002
    ..However, this SNP was not identified in the Japanese population. We asked if this is also true in the Korean population...
  22. ncbi request reprint Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder
    A Wagner
    Department of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden
    Arch Gen Psychiatry 44:870-7. 1987
    ..There was no correlation between binding parameters and monoamine metabolite concentrations in the cerebrospinal fluid, either before or during treatment...
  23. pmc Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:1421-6. 2005
    ..Existing studies of solid cancers in rheumatoid arthritis (RA) reflect cancer morbidity up until the early 1990s in prevalent cohorts admitted to hospital during the 1980s...
  24. ncbi request reprint Effect of terbinafine and voriconazole on the pharmacokinetics of the antidepressant venlafaxine
    V V Hynninen
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku University Hospital, Turku, Finland
    Clin Pharmacol Ther 83:342-8. 2008
    ....
  25. ncbi request reprint Individualized medicine - implementation of pharmacogenetic diagnostics in antidepressant drug treatment of major depressive disorders
    J Kirchheiner
    Institute of Clinical Pharmacology, Charite University Medicine Berlin, Campus Charité Mitte CCM, Berlin, Germany
    Pharmacopsychiatry 36:S235-43. 2003
    ....
  26. pmc Results from a nationwide postmarketing cohort study of patients in Sweden treated with etanercept
    N Feltelius
    Swedish Medical Products Agency, PO Box 26, SE 751 03 Uppsala, Sweden
    Ann Rheum Dis 64:246-52. 2005
    ..To describe a nationwide system for postmarketing follow up of new antirheumatic drugs in Sweden, and to analyse safety and effectiveness in an etanercept treated patient cohort...
  27. ncbi request reprint Does hepatic metabolism of melatonin affect the endogenous serum melatonin level in man?
    C Ursing
    Department of Internal Medicine, Stockholm Soder Hospital, Sweden
    J Endocrinol Invest 25:459-62. 2002
    ..If so, this could explain why the MT-AUCs and the CA clearance values were not inversely correlated in this study...
  28. ncbi request reprint Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4
    K Bodin
    Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Huddinge, Sweden
    J Biol Chem 276:38685-9. 2001
    ..Together, these data suggest that 4beta-hydroxycholesterol in human circulation is formed by a cytochrome P450 enzyme...
  29. ncbi request reprint CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients
    M G Scordo
    Department of Medical Laboratory Sciences and Technology, Karolinska Institutet, Huddinge University Hospital, Sweden
    Eur J Clin Pharmacol 56:679-83. 2000
    ....