Olof Beck

Summary

Affiliation: Karolinska University Hospital
Country: Sweden

Publications

  1. doi request reprint Exhaled breath for drugs of abuse testing - evaluation in criminal justice settings
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden Electronic address
    Sci Justice 54:57-60. 2014
  2. ncbi request reprint Detection of drugs of abuse in exhaled breath using a device for rapid collection: comparison with plasma, urine and self-reporting in 47 drug users
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Breath Res 7:026006. 2013
  3. doi request reprint Detection of drugs of abuse in exhaled breath from users following recovery from intoxication
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 36:638-46. 2012
  4. pmc Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination
    Muhammad Ntale
    Department of Pharmacology and Therapeutics, Makerere University, Kampala, Uganda
    Malar J 8:52. 2009
  5. doi request reprint Demonstration that methadone is being present in the exhaled breath aerosol fraction
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Pharm Biomed Anal 56:1024-8. 2011
  6. ncbi request reprint Amphetamines detected in exhaled breath from drug addicts: A new possible method for drugs-of-abuse testing
    Olof Beck
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 34:233-7. 2010
  7. ncbi request reprint Study on the sampling of methadone from exhaled breath
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 35:257-63. 2011
  8. ncbi request reprint Determination of methadone in exhaled breath condensate by liquid chromatography-tandem mass spectrometry
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 35:129-33. 2011
  9. ncbi request reprint Detection of Δ9-tetrahydrocannabinol in exhaled breath collected from cannabis users
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 35:541-4. 2011
  10. ncbi request reprint Paradoxical results in urine drug testing for 6-acetylmorphine and total opiates: implications for best analytical strategy
    Olof Beck
    Department of Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, SE 17176 Stockholm, Sweden
    J Anal Toxicol 30:73-9. 2006

Collaborators

Detail Information

Publications62

  1. doi request reprint Exhaled breath for drugs of abuse testing - evaluation in criminal justice settings
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden Electronic address
    Sci Justice 54:57-60. 2014
    ....
  2. ncbi request reprint Detection of drugs of abuse in exhaled breath using a device for rapid collection: comparison with plasma, urine and self-reporting in 47 drug users
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Breath Res 7:026006. 2013
    ..Analytes with low detection rates were benzodiazepines, and a further increase in analytical sensitivity is needed to overcome this. This study further supports use of exhaled breath as a new matrix in clinical toxicology...
  3. doi request reprint Detection of drugs of abuse in exhaled breath from users following recovery from intoxication
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 36:638-46. 2012
    ..This study gives further support to the possibility of developing exhaled breath into a new matrix for drugs-of-abuse testing by extending the number of analytes that are documented to be detectable in breath...
  4. pmc Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination
    Muhammad Ntale
    Department of Pharmacology and Therapeutics, Makerere University, Kampala, Uganda
    Malar J 8:52. 2009
    ..This study evaluates the field applicability of a new method to determine amodiaquine and its metabolite concentrations in whole blood dried on filter paper...
  5. doi request reprint Demonstration that methadone is being present in the exhaled breath aerosol fraction
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Pharm Biomed Anal 56:1024-8. 2011
    ..The conclusion of this study was that methadone in exhaled breath is carried in the aerosol fraction known to be formed in the lung as a result of normal breathing...
  6. ncbi request reprint Amphetamines detected in exhaled breath from drug addicts: A new possible method for drugs-of-abuse testing
    Olof Beck
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 34:233-7. 2010
    ..This finding, using a yet non-validated sampling procedure, opens a new possibility for drugs-of-abuse testing. Collection of exhaled breath is likely to be more convenient and safe as compared to matrices presently in use...
  7. ncbi request reprint Study on the sampling of methadone from exhaled breath
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 35:257-63. 2011
    ..The presented results confirm that breath testing is a new possibility for the detection of drugs of abuse...
  8. ncbi request reprint Determination of methadone in exhaled breath condensate by liquid chromatography-tandem mass spectrometry
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 35:129-33. 2011
    ..This finding confirms that methadone is present in exhaled breath from patients in methadone treatment. Collection of exhaled breath specimen is likely to be complementary to other matrices presently in use in testing for drugs-of-abuse...
  9. ncbi request reprint Detection of Δ9-tetrahydrocannabinol in exhaled breath collected from cannabis users
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 35:541-4. 2011
    ..The results further support the idea that exhaled breath is a promising matrix for drugs-of-abuse testing...
  10. ncbi request reprint Paradoxical results in urine drug testing for 6-acetylmorphine and total opiates: implications for best analytical strategy
    Olof Beck
    Department of Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, SE 17176 Stockholm, Sweden
    J Anal Toxicol 30:73-9. 2006
    ..It is concluded that 6-AM is a valuable target analyte in the screening of drugs of abuse in urine and may be used in combination with opiate screening in clinical testing...
  11. ncbi request reprint Determination of lamotrigine and its metabolites in human plasma by liquid chromatography-mass spectrometry
    Olof Beck
    Department of Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Sweden
    Ther Drug Monit 28:603-7. 2006
    ..11 (range, <0.01 to 0.64). In conclusion, this liquid chromatographic-mass spectrometric method is suitable for simultaneous determination of lamotrigine and its metabolites in human plasma...
  12. doi request reprint Method for determination of methadone in exhaled breath collected from subjects undergoing methadone maintenance treatment
    Olof Beck
    Department of Medicine, Section of Clinical Pharmacology, Karolinska Institutet, SE 17176 Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2255-9. 2010
    ..This finding confirms that breath testing is a new possibility for drugs of abuse testing. Collection of exhaled breath specimen is likely to be more convenient and safe as compared to other matrices presently in use...
  13. ncbi request reprint Biomarkers to disclose recent intake of alcohol: potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods
    Olof Beck
    Department of Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
    Alcohol Alcohol 42:321-5. 2007
    ..This study compared two new methods for direct determination of 5-hydroxytryptophol glucuronide (GTOL) in urine, a biomarker for detection of recent alcohol consumption...
  14. doi request reprint Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification
    Anders Helander
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Alcohol Alcohol 44:55-61. 2009
    ..This study determined the detection times for EtG and EtS in alcoholic patients undergoing alcohol detoxification...
  15. doi request reprint Naltrexone for the treatment of amphetamine dependence: a randomized, placebo-controlled trial
    Nitya Jayaram-Lindström
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 165:1442-8. 2008
    ..The aim of this study was to investigate the efficacy of naltrexone in comparison with placebo in reducing relapse to amphetamine use in amphetamine-dependent patients...
  16. ncbi request reprint Acamprosate determinations in plasma and cerebrospinal fluid after multiple dosing measured by liquid chromatography-mass spectroscopy: a pharmacokinetic study in healthy volunteers
    Anders Hammarberg
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
    Ther Drug Monit 32:489-96. 2010
    ..Furthermore, the results suggest that the mechanism of action of acamprosate needs to be further explored with regard to the peripheral actions of the drug...
  17. ncbi request reprint Determination of urinary 5-hydroxytryptophol glucuronide by liquid chromatography-mass spectrometry
    Nikolai Stephanson
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Institute and University Hospital, SE 17176 Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 816:107-12. 2005
    ..99, n=70; mean 5-HTOL/GTOL ratio=1.10). This is the first direct assay for quantification of GTOL in urine. The method is suitable for routine application...
  18. doi request reprint The effects of acamprosate on alcohol-cue reactivity and alcohol priming in dependent patients: a randomized controlled trial
    Anders Hammarberg
    Department of Clinical Neuroscience, Division of Psychiatry, Karolinska University Hospital, M4 02SE 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 205:53-62. 2009
    ..Acamprosate is a widely utilized, efficacious treatment for relapse prevention in alcohol-dependent patients; yet, little is known regarding its therapeutic mechanism of action...
  19. ncbi request reprint Alcohol biomarker analysis: simultaneous determination of 5-hydroxytryptophol glucuronide and 5-hydroxyindoleacetic acid by direct injection of urine using ultra-performance liquid chromatography-tandem mass spectrometry
    Nikolai Stephanson
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Institute and University Hospital, SE 171 76 Stockholm, Sweden
    J Mass Spectrom 42:940-9. 2007
    ..In conclusion, a fully validated and robust direct method for the routine measurement of urinary GTOL and 5-HIAA was developed...
  20. ncbi request reprint Naltrexone attenuates the subjective effects of amphetamine in patients with amphetamine dependence
    Nitya Jayaram-Lindström
    Department of Clinical Neuroscience, Section for Alcohol and Drug Dependence Research, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 33:1856-63. 2008
    ..The results suggest that the subjective effects of amphetamine could be modulated via the endogenous opioid system. The potential of naltrexone as an adjunct pharmaceutical for amphetamine dependence is promising...
  21. ncbi request reprint Ethyl sulfate: a metabolite of ethanol in humans and a potential biomarker of acute alcohol intake
    Anders Helander
    Department of Clinical Neuroscience and University Hospital, Stockholm, Sweden
    J Anal Toxicol 29:270-4. 2005
    ..It is also indicated that the concurrent determination of EtS and EtG will improve sensitivity, when being used as biomarkers of recent drinking...
  22. ncbi request reprint Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide
    Helen Dahl
    Department of Clinical Neuroscience, Karolinska Institute and Hospital, Stockholm, Sweden
    J Anal Toxicol 26:201-4. 2002
    ..Moreover, it was possible to lower the concentration of EtG by drinking large amounts of water prior to voiding, whereas this strategy did not influence the EtG/creatinine ratio or the concentration of ethanol...
  23. ncbi request reprint Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications
    Kristian Björnstad
    Alcohol Laboratory, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 33:604-9. 2009
    ..calamus. The main clinical symptom reported by the patients was prolonged vomiting that sometimes lasted more than 15 h...
  24. doi request reprint Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: a pilot study
    Maija Konstenius
    Division of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, 17176 Stockholm, Sweden
    Drug Alcohol Depend 108:130-3. 2010
    ..No difference was found between the two groups with regards to craving for amphetamine or in retention in treatment. Larger studies with higher doses combined with individual dosage and longer follow-up periods are warranted...
  25. doi request reprint Unreliable alcohol testing in a shipping safety programme
    Anders Helander
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Forensic Sci Int 189:e45-7. 2009
    ..This and other questionable cases prompted investigation of the suitability of urine alcohol testing for the intended application...
  26. doi request reprint Identification of novel psychoactive drug use in Sweden based on laboratory analysis--initial experiences from the STRIDA project
    Anders Helander
    Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Laboratory, Stockholm, Sweden
    Scand J Clin Lab Invest 73:400-6. 2013
    ....
  27. ncbi request reprint Direct quantification of ethyl glucuronide in clinical urine samples by liquid chromatography-mass spectrometry
    Nikolai Stephanson
    Department of Medicine, Division of Clinical Pharmacology, Alcohol Laboratory, Karolinska Institute and Hospital, Stockholm, Sweden
    Ther Drug Monit 24:645-51. 2002
    ....
  28. ncbi request reprint Use of morphine and 6-monoacetylmorphine in blood for the evaluation of possible risk factors for sudden death in 192 heroin users
    Anna Fugelstad
    Department of Clinical Neurosciences, Karolinska Hospital, Stockholm, Sweden
    Addiction 98:463-70. 2003
    ..To detect risk factors for sudden death from heroin injection...
  29. pmc Measuring substance use in the club setting: a feasibility study using biochemical markers
    Johanna Gripenberg-Abdon
    Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Subst Abuse Treat Prev Policy 7:7. 2012
    ..The objective of this study is to evaluate the feasibility of measuring the frequency of alcohol and drug use among Swedish clubbers using breath alcohol and oral fluid drug testing...
  30. doi request reprint Accurate identification and quantification of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid in urine drug testing: evaluation of a direct high efficiency liquid chromatographic-mass spectrometric method
    Nikolai Stephanson
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Institute and University Hospital, Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 871:101-8. 2008
    ..In conclusion, the high efficiency LC-MS/MS method was capable of accurately identify and quantify THCA in urine with a capacity of 14 samples per hour...
  31. ncbi request reprint 5-hydroxytryptophol as a marker for recent alcohol intake
    Olof Beck
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Hospital, Stockholm, Sweden
    Addiction 98:63-72. 2003
    ..To review the mechanism behind the alcohol-induced shift in serotonin metabolism, and the use of urinary 5-hydroxytryptophol (5-HTOL) as a biochemical marker of acute alcohol consumption...
  32. ncbi request reprint Application of direct urine LC-MS-MS analysis for screening of novel substances in drug abusers
    Helena K Nordgren
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Sweden
    J Anal Toxicol 29:234-9. 2005
    ..In conclusion, LC-MS-MS was found to be a robust alternative for drugs of abuse screening, offering high sensitivity compared with immunochemical screening methodology...
  33. doi request reprint Comparison of analytical approaches for liquid chromatography/mass spectrometry determination of the alcohol biomarker ethyl glucuronide in urine
    Anders Helander
    Karolinska Institutet, Department of Laboratory Medicine, Stockholm, Sweden
    Rapid Commun Mass Spectrom 24:1737-43. 2010
    ..These results indicate that the likelihood of different analytical methods to provide reliable analytical results depends on the reporting limit applied...
  34. ncbi request reprint Multicomponent screening for drugs of abuse: direct analysis of urine by LC-MS-MS
    Helena K Nordgren
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Ther Drug Monit 26:90-7. 2004
    ..This study demonstrates that LC-MS-MS is a valuable complement to immunochemical screening analysis, especially for substances for which immunochemical methods are not yet available or when an increased sensitivity is needed...
  35. ncbi request reprint Direct and efficient liquid chromatographic-tandem mass spectrometric method for opiates in urine drug testing - importance of 6-acetylmorphine and reduction of analytes
    Maria Andersson
    Division of Clinical Pharmacology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Drug Test Anal 6:317-24. 2014
    ..The method might be further developed by reducing the number of analytes to morphine-3-glucuronide, codeine-6-glucuronide and 6-acetylmorphine without compromising test performance. Copyright © 2013 John Wiley & Sons, Ltd. ..
  36. doi request reprint Determination of four immunosuppressive drugs in whole blood using MEPS and LC-MS/MS allowing automated sample work-up and analysis
    Rana Said
    Department of Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, 17176 Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 897:42-9. 2012
    ..This method provides an accurate, precise and automated procedure that can be applied for therapeutic drug monitoring of immunosuppressive drugs in clinical laboratories equipped with LC-MS/MS...
  37. doi request reprint Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials
    Kristian Björnstad
    Department of Clinical Neuroscience, Alcohol Laboratory, Karolinska Institutet, Stockholm, Sweden
    Clin Toxicol (Phila) 47:566-72. 2009
    ..This study involved bioanalytical and clinical examinations of intoxication cases suspected to be linked to such plant materials...
  38. doi request reprint A multi-component LC-MS/MS method for detection of ten plant-derived psychoactive substances in urine
    Kristian Björnstad
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1162-8. 2009
    ..The multi-component method proved to be useful for investigation of authentic cases of intoxication with plant-derived psychoactive drugs and was indicated to cover the clinically relevant concentration ranges...
  39. ncbi request reprint Development and clinical application of an LC-MS-MS method for mescaline in urine
    Kristian Björnstad
    Department of Clinical Neuroscience, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
    J Anal Toxicol 32:227-31. 2008
    ..Among 462 urine samples collected from young people with alcohol or drug problems, 32% were positive for illicit drugs, but none for mescaline...
  40. ncbi request reprint Direct screening of urine for MDMA and MDA by liquid chromatography-tandem mass spectrometry
    Helena K Nordgren
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Anal Toxicol 27:15-9. 2003
    ..Our study suggests that LC-MS-MS offers an alternative to immunochemical methods in drug of abuse screening...
  41. doi request reprint Methylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trial
    Maija Konstenius
    Division of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Addiction 109:440-9. 2014
    ....
  42. doi request reprint Synthesis and bioanalytical evaluation of morphine-3-O-sulfate and morphine-6-O-sulfate in human urine and plasma using LC-MS/MS
    Maria Andersson
    Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden
    J Sep Sci 35:367-75. 2012
    ..Only one authentic urine sample contained a detectable level of morphine-6-O-sulfate, while no detectable morphine-6-O-sulfate was found in plasma samples...
  43. ncbi request reprint Mass spectrometric identification of ethyl sulfate as an ethanol metabolite in humans
    Anders Helander
    Karolinska Institutet and University Hospital, Department of Clinical Neuroscience, Stockholm, Sweden
    Clin Chem 50:936-7. 2004
  44. ncbi request reprint Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy
    Inger Ohman
    Department of Medicine, Clinical Pharmacology Unit, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden
    Epilepsia 49:1075-80. 2008
    ..To further characterize pregnancy-induced alterations in the pharmacokinetics of lamotrigine (LTG)...
  45. ncbi request reprint Detectability of new psychoactive substances, 'legal highs', in CEDIA, EMIT, and KIMS immunochemical screening assays for drugs of abuse
    Olof Beck
    Department of Laboratory Medicine, Section of Clinical Pharmacology, Karolinska University Hospital, Sweden
    Drug Test Anal 6:492-9. 2014
    ..In both spiked and authentic urine samples, some new substances showed significant cross-reactivity and are thus detectable in the routine screening methods...
  46. ncbi request reprint Evaluation of coagulation assays versus LC-MS/MS for determinations of dabigatran concentrations in plasma
    Jovan P Antovic
    Department of Coagulation Research, Institute for Molecular Medicine and Surgery, Karolinska Institutet, and Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden
    Eur J Clin Pharmacol 69:1875-81. 2013
    ....
  47. doi request reprint Quantification of tacrolimus and three demethylated metabolites in human whole blood using LC-ESI-MS/MS
    Ilse R Dubbelboer
    Laboratory for TDM and Clinical Toxicology, Department of Pharmacy, University Medical Center Groningen, Groningen, The Netherlands
    Ther Drug Monit 34:134-42. 2012
    ....
  48. doi request reprint Method development for routine liquid chromatography-mass spectrometry measurement of the alcohol biomarker phosphatidylethanol (PEth) in blood
    Yufang Zheng
    Alcohol Laboratory, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
    Clin Chim Acta 412:1428-35. 2011
    ..Measurement of PEth in whole blood samples is employed as an alcohol biomarker. This work aimed to further develop an LC-MS method for PEth to make it practical for routine laboratory use...
  49. ncbi request reprint A comparison of two intensities of psychosocial intervention for alcohol dependent patients treated with acamprosate
    Anders Hammarberg
    Department of Clinical Neuroscience, Alcohol and Drug Dependence Research, Karolinska Institutet, Stockholm
    Alcohol Alcohol 39:251-5. 2004
    ..To compare two levels of psychosocial intervention in combination with acamprosate medication for the treatment of alcohol dependence...
  50. ncbi request reprint An open clinical trial of naltrexone for amphetamine dependence: compliance and tolerability
    Nitya Jayaram-Lindström
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Nord J Psychiatry 59:167-71. 2005
    ..01). In conclusion, naltrexone was well tolerated with moderate rates of compliance, supporting the feasibility of investigating this compound in a larger placebo-controlled trial as a potential pharmacotherapy for amphetamine dependence...
  51. ncbi request reprint Chromatographic screening for zopiclone and metabolites in urine using liquid chromatography and liquid chromatography-mass spectrometry techniques
    Helena K Nordgren
    Institution of Medicine, Department of Clinical Pharmacology, L7 05, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Ther Drug Monit 24:410-6. 2002
    ..However, due to the high background in these patients' urine, a single therapeutic dose was impossible to detect...
  52. doi request reprint Multicomponent LC-MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine-experience from the Swedish population
    Yasir Al-Saffar
    Department of Medicine, Section of Clinical Pharmacology, Karolinska University Hospital, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 930:112-20. 2013
    ....
  53. doi request reprint Therapeutic drug monitoring for tomorrow
    Erik Eliasson
    Karolinska University Laboratory, Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden
    Eur J Clin Pharmacol 69:25-32. 2013
    ....
  54. doi request reprint Precise determination of glucose-d(2)/glucose ratio in human serum and plasma by APCI LC-MS/MS
    Shahid Ullah
    Department of Medicine, Division of Clinical Pharmacology, Karolinska Institute and University Hospital, Stockholm, Sweden
    Scand J Clin Lab Invest 69:837-42. 2009
    ..Determinations of glucose turnover based on infusion of deuterium-labelled glucose are frequently undertaken in studies involving the pathophysiology of diabetes or obesity or the metabolic response to physical exercise...
  55. doi request reprint Determination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry
    Yuko Rönquist-Nii
    Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 879:326-34. 2011
    ..The new LC-MS/MS method showed sufficient sensitivity and selectivity for determination of picropodophyllin and its isomer podophyllotoxin levels in human serum from subjects receiving therapeutic doses of AXL1717...
  56. doi request reprint Determination of remifentanil in human plasma by liquid chromatography-tandem mass spectrometry utilizing micro extraction in packed syringe (MEPS) as sample preparation
    Rana Said
    Department of Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden
    J Chromatogr B Analyt Technol Biomed Life Sci 879:815-8. 2011
    ..With this method using MEPS, a low limit of quantification and much reduced sample volume was obtained as compared with previous methods...
  57. ncbi request reprint Pharmacokinetics of dexamphetamine in acute stroke
    Louise Martinsson
    Stroke Research Unit, Department of Neurology R2 03, Institution of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Clin Neuropharmacol 26:270-6. 2003
    ..In the present patient population, a predetermined AUC value can be obtained by a dosing regimen of dexamphetamine based on body weight (ie, mg/kg), with precautions for patients with elevated s-creatinine...
  58. ncbi request reprint Urinary ethyl glucuronide testing detects alcohol consumption in alcoholic liver disease patients awaiting liver transplantation
    Yesim Erim
    Department of Psychosomatic Medicine and Psychotherapy, University Hospital of Essen, Germany
    Liver Transpl 13:757-61. 2007
    ....
  59. ncbi request reprint Evaluation of buprenorphine CEDIA assay versus GC-MS and ELISA using urine samples from patients in substitution treatment
    Michael Böttcher
    Arztpraxis f Medizinische Mikrobiologie, Labordiagnostik und Hygiene, Dessau, Germany
    J Anal Toxicol 29:769-76. 2005
    ..23 (95% were below 1). We conclude that the CEDIA assay is suitable for application in high-volume screening of buprenorphine for urine drug testing...
  60. ncbi request reprint Evaluation of a new immunoassay for urinary ethyl glucuronide testing
    Michael Böttcher
    Arztpraxis für Medizinische Mikrobiologie und Labordiagnostik, Dessau, Germany
    Alcohol Alcohol 43:46-8. 2008
    ..This study evaluated a new enzyme immunoassay (DRI-EtG EIA, Microgenics Corp.) for determination of the EtG concentration in urine samples...
  61. ncbi request reprint Determination of glucuronidated 5-hydroxytryptophol (GTOL), a marker of recent alcohol intake, by ELISA technique
    Jutta Dierkes
    Institute of Clinical Chemistry, Otto von Guericke University, Magdeburg, Germany
    Clin Biochem 40:128-31. 2007
    ..To compare markers of alcohol consumption...
  62. ncbi request reprint Patterns of illicit drug use and retention in a methadone program: a longitudinal study
    Ingrid Davstad
    Stockholm Addiction Centre, Magnus Huss, Sweden
    J Opioid Manag 3:27-34. 2007
    ..This study aimed to analyze illicit drug use of participants in a methadone treatment program in relation to methadone dose, counseling, and retention...