Magnus Bäck

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. doi request reprint Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus
    Xavier Houard
    INSERM U698, Paris 7 Denis Diderot University, Cardiovascular Hematology, Bio Engineering and Remodeling, Bichat Claude Bernard Hospital, 75877 Paris Cedex 18, France
    FASEB J 23:1376-83. 2009
  2. pmc Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis
    Carlos Labat
    aINSERM U1116, Department of Geriatrics, Faculty of Medicine, Université de Lorraine, Vandoeuvre les Nancy and University Hospital of Nancy, Nancy, France bTelomere Cardiology Center, Ghardaia, Algeria cDepartment of Cardiology, Karolinska University Hospital dDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden eCentre IPC fINSERM U698, Diderot University, Paris, France
    J Hypertens 31:2251-8; discussion 2258. 2013
  3. pmc Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression
    Alison Eaton
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 90:1223-31. 2012
  4. pmc Biomechanical factors in the biology of aortic wall and aortic valve diseases
    Magnus Bäck
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Cardiovasc Res 99:232-41. 2013
  5. doi request reprint Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib
    Magnus Bäck
    Department of Cardiology, Karolinska University Hospital, L8 03, SE 171 76 Stockholm, Sweden
    Eur Heart J 33:1928-33. 2012
  6. pmc Specific mediator inhibition by the NO donors SNP and NCX 2057 in the peripheral lung: implications for allergen-induced bronchoconstriction
    Anna Karin Larsson
    Unit of Lung Biology, Division of Vascular and Respiratory Research, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 10:46. 2009
  7. ncbi request reprint Inhibitors of the 5-lipoxygenase pathway in atherosclerosis
    Magnus Bäck
    Department of Cardiology and Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
    Curr Pharm Des 15:3116-32. 2009
  8. ncbi request reprint Inflammatory signaling through leukotriene receptors in atherosclerosis
    Magnus Bäck
    Department of Cardiology and Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
    Curr Atheroscler Rep 10:244-51. 2008
  9. pmc Leukotriene signaling in atherosclerosis and ischemia
    Magnus Bäck
    INSERM U698, Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France
    Cardiovasc Drugs Ther 23:41-8. 2009
  10. doi request reprint Matrix metalloproteinases in atherothrombosis
    Magnus Bäck
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Prog Cardiovasc Dis 52:410-28. 2010

Detail Information

Publications40

  1. doi request reprint Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus
    Xavier Houard
    INSERM U698, Paris 7 Denis Diderot University, Cardiovascular Hematology, Bio Engineering and Remodeling, Bichat Claude Bernard Hospital, 75877 Paris Cedex 18, France
    FASEB J 23:1376-83. 2009
    ....
  2. pmc Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis
    Carlos Labat
    aINSERM U1116, Department of Geriatrics, Faculty of Medicine, Université de Lorraine, Vandoeuvre les Nancy and University Hospital of Nancy, Nancy, France bTelomere Cardiology Center, Ghardaia, Algeria cDepartment of Cardiology, Karolinska University Hospital dDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden eCentre IPC fINSERM U698, Diderot University, Paris, France
    J Hypertens 31:2251-8; discussion 2258. 2013
    ..The aim of the present study was to establish the association of different salivary biomarkers of inflammation with subclinical cardiovascular disease...
  3. pmc Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression
    Alison Eaton
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 90:1223-31. 2012
    ..Taken together, these findings suggest a role of nuclear CysLT(1) receptor signaling in vascular SMCs inducing gene expression patterns associated with atherosclerosis...
  4. pmc Biomechanical factors in the biology of aortic wall and aortic valve diseases
    Magnus Bäck
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Cardiovasc Res 99:232-41. 2013
    ....
  5. doi request reprint Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib
    Magnus Bäck
    Department of Cardiology, Karolinska University Hospital, L8 03, SE 171 76 Stockholm, Sweden
    Eur Heart J 33:1928-33. 2012
    ....
  6. pmc Specific mediator inhibition by the NO donors SNP and NCX 2057 in the peripheral lung: implications for allergen-induced bronchoconstriction
    Anna Karin Larsson
    Unit of Lung Biology, Division of Vascular and Respiratory Research, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 10:46. 2009
    ....
  7. ncbi request reprint Inhibitors of the 5-lipoxygenase pathway in atherosclerosis
    Magnus Bäck
    Department of Cardiology and Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
    Curr Pharm Des 15:3116-32. 2009
    ..Several inhibitors of the 5-lipoxygenase pathway are now evaluated in clinical trials of patients with cardiovascular disease...
  8. ncbi request reprint Inflammatory signaling through leukotriene receptors in atherosclerosis
    Magnus Bäck
    Department of Cardiology and Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
    Curr Atheroscler Rep 10:244-51. 2008
    ..Taken together, the leukotriene pathway may represent a putative therapeutic target in the treatment of atherosclerotic vessel disease...
  9. pmc Leukotriene signaling in atherosclerosis and ischemia
    Magnus Bäck
    INSERM U698, Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France
    Cardiovasc Drugs Ther 23:41-8. 2009
    ....
  10. doi request reprint Matrix metalloproteinases in atherothrombosis
    Magnus Bäck
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Prog Cardiovasc Dis 52:410-28. 2010
    ..Finally, experimental studies of hyperlipemic mice and vascular injury have suggested some of the MMPs function as modulators of atherogenesis, vascular remodeling, and plaque rupture...
  11. doi request reprint International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions
    Magnus Bäck
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Pharmacol Rev 63:539-84. 2011
    ..The aim of this review is to provide an update on the pharmacology, expression patterns, and pathophysiological roles of the leukotriene receptors as well as the therapeutic developments in this area of research...
  12. ncbi request reprint Leukotriene receptors: crucial components in vascular inflammation
    Magnus Bäck
    Department of Cardiology and Center for Molecular Medicine, Karolinska University Hospital, L8 03, Stockholm, Sweden
    ScientificWorldJournal 7:1422-39. 2007
    ..Results from in vitro and in vivo studies of LT receptor antagonists indicate potential beneficial effects in atherosclerosis and other inflammatory cardiovascular diseases...
  13. ncbi request reprint Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma
    Kiyoto Sakata
    Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden
    Eur J Pharmacol 436:119-26. 2002
    ..These results suggest that leukotriene E(4) solely activates a CysLT(1) receptor, and that the CysLT(1) receptor antagonist-resistant contraction to leukotriene D(4) and C(4) is mediated via another CysLT receptor...
  14. ncbi request reprint Endothelium-dependent vascular responses induced by leukotriene B4
    Magnus Bäck
    Department of Cardiology and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Prostaglandins Other Lipid Mediat 83:209-12. 2007
    ..Taken together, these results suggest that LTB(4) activates BLT(1) receptors on the endothelium of the guinea pig aorta, associated with the release of both contractile factors and NO...
  15. doi request reprint Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis
    Hanna Hlawaty
    INSERM U698, University of Paris, Paris, France
    Arterioscler Thromb Vasc Biol 29:518-24. 2009
    ..The lipid-derived inflammatory mediators leukotrienes (LTs) are produced during vascular injury. The aim of the present study was to determine the role of LT receptor signaling in the pathophysiology of in-stent stenosis...
  16. doi request reprint Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits
    Nabil Foudi
    Bichat Hospital, 1INSERM U698, Paris Cedex 18, France
    Am J Physiol Heart Circ Physiol 297:H1882-8. 2009
    ..These observations suggest that the local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions...
  17. ncbi request reprint The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release
    Magnus Bäck
    National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Adv Exp Med Biol 507:315-9. 2002
  18. doi request reprint Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity
    Edit Nagy
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 420:671-5. 2012
    ..38-fold in VICs. Taken together, these data suggest that valvular DNA-damage pathways may be associated with inflammation and the stenosis severity in tricuspid aortic valves...
  19. doi request reprint The role of matrix metalloproteinases in atherothrombosis
    Daniel F J Ketelhuth
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Curr Atheroscler Rep 13:162-9. 2011
    ..In addition, the regulation and expression of MMPs in atherosclerotic plaques is discussed, with an emphasis on the role of lipid-derived inflammatory mediators as modulators of MMP activity...
  20. ncbi request reprint 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation
    Magnus Bäck
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Res 100:946-9. 2007
    ..In conclusion, the results of the present study suggest a key role for mediators of the 5-lipoxygenase pathway in inflammatory reactions of atherosclerosis and metabolic disease...
  21. pmc The oral cavity and age: a site of chronic inflammation?
    Magnus Bäck
    INSERM U698, University of Paris 7, Bichat Hospital, Paris, France
    PLoS ONE 2:e1351. 2007
    ..The aim of this investigation was to determine the presence of different classes of inflammatory mediators in human saliva and correlate the levels with age...
  22. pmc The contractile action of leukotriene B4 in the guinea-pig lung involves a vascular component
    Kiyoto Sakata
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Br J Pharmacol 141:449-56. 2004
    ..British Journal of Pharmacology (2004) 141, 449-456. doi:10.1038/sj.bjp.0705641..
  23. ncbi request reprint Functional characteristics of cysteinyl-leukotriene receptor subtypes
    Magnus Bäck
    Experimental Asthma and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    Life Sci 71:611-22. 2002
    ..In addition, the existence of more than two receptor subtypes for cysteinyl-leukotrienes has been suggested...
  24. ncbi request reprint Inhibition of nitric-oxide synthase enhances antigen-induced contractions and increases release of cysteinyl-leukotrienes in guinea pig lung parenchyma: nitric oxide as a protective factor
    Anna Karin Larsson
    Experimental Asthma and Allergy Research, Division of Physiology, The Institute of Environmental Medicine, Karolinska Institutet, P O Box 287, SE 17177 Stockholm, Sweden
    J Pharmacol Exp Ther 315:458-65. 2005
    ..The findings support the belief that endogenous NO has a protective anti-inflammatory effect in the airways...
  25. ncbi request reprint Release of leukotriene B4, transforming growth factor-beta1 and microparticles in relation to aortic valve calcification
    Najlah Kochtebane
    Inserm UMR698, Cardiovascular Haematology, Bio Engineering and Remodeling, Paris, Denis Diderot University, Hopital Bichat Claude Bernard, Paris, France
    J Heart Valve Dis 22:782-8. 2013
    ..Another recent notion is the active involvement of inflammatory mediators in the calcification process of aortic stenosis...
  26. doi request reprint Valvular osteoclasts in calcification and aortic valve stenosis severity
    Edit Nagy
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden Electronic address
    Int J Cardiol 168:2264-71. 2013
    ....
  27. doi request reprint Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis
    Edit Nagy
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 586:1325-9. 2012
    ..These findings provide a first piece of evidence for epigenetic modifications of VICs in valvular heart disease...
  28. ncbi request reprint Leukotriene receptors in atherosclerosis
    Magnus Bäck
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Med 38:493-502. 2006
    ..Taken together, recent evidence suggests that leukotriene receptors may be a potential target in the treatment of atherosclerosis and in the prevention of restenosis after coronary interventions...
  29. ncbi request reprint Leukotriene B4 is an indirectly acting vasoconstrictor in guinea pig aorta via an inducible type of BLT receptor
    Magnus Bäck
    Division of Physiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 287:H419-24. 2004
    ..These results suggest that LTB(4) contracts the guinea pig aorta via an indirect mechanism involving the release of histamine and thromboxane and that this BLT(1) receptor-mediated response can be upregulated by all-trans-retinoic acid...
  30. doi request reprint NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis
    Hui Qing Liu
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 33:2193-201. 2013
    ..Here, we address whether the innate immune signals of nucleotide-binding oligomerization domain-containing protein (NOD) 2 affect eicosanoids metabolism in atherosclerosis...
  31. doi request reprint Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease
    Erik Ingelsson
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 129:702-707.e2. 2012
    ..The leukotriene pathway has been associated with an increased cardiovascular risk. However, the effects of the antileukotriene treatment used in asthmatic patients on cardiovascular outcomes have remained largely unexplored...
  32. doi request reprint Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts
    Edit Nagy
    Center for Molecular Medicine, CMM L8 03, Karolinska University Hospital, Stockholm, Sweden
    Circulation 123:1316-25. 2011
    ..The aim of this study was to determine the role of proinflammatory signaling through the leukotriene (LT) pathway in aortic stenosis...
  33. doi request reprint Effects of the dual TP receptor antagonist and thromboxane synthase inhibitor EV-077 on human endothelial and vascular smooth muscle cells
    Marcelo H Petri
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Biochem Biophys Res Commun 441:393-8. 2013
    ....
  34. ncbi request reprint Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle
    Magnus Bäck
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol Scand Suppl 648:1-55. 2002
    ..Moreover, the interconversion between LTC4 and LTD4 and the metabolism into LTE4 may represent a major modulatory mechanism in the guinea-pig trachea by deciding which CysLT receptor is activated by the cysteinyl-leukotrienes...
  35. pmc Transesophageal echocardiography measurements of aortic annulus diameter using biplane mode in patients undergoing transcatheter aortic valve implantation
    Kambiz Shahgaldi
    Karolinska Institutet, Department of Cardiology, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden
    Cardiovasc Ultrasound 11:5. 2013
    ....
  36. pmc Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia
    Magnus Bäck
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:17501-6. 2005
    ..Inhibition of LTB(4)/BLT(1) signaling during the response to vascular injury reduced intimal hyperplasia, suggesting this pathway as a possible target for therapy...
  37. ncbi request reprint Effect of cold storage on cholinergic responses induced by electrical field stimulation in human bronchi
    Magnus Bäck
    Center for Molecular Medicine, Karolinska University Hospital, L8 03, 171 76 Stockholm, Sweden
    Pulm Pharmacol Ther 19:297-302. 2006
    ..These results suggest that the reactivity of human bronchial preparations to EFS is not altered when tissues are conserved for 24h, whereas prolonged storage should be avoided...
  38. pmc Urinary leukotriene E4 is associated with renal function but not with endothelial function in type 2 diabetes
    Arnar Rafnsson
    Department of Medicine, Karolinska Institute and Department of Cardiology, Karolinska University Hospital, 17176 Stockholm, Sweden
    Dis Markers 35:475-80. 2013
    ..However, eGFR was an independent predictor of U-LTE4, but not CRP, in this cohort, suggesting that GFR should be considered in biomarker studies of U-LTE4...
  39. ncbi request reprint Increased leukotriene concentrations in gingival crevicular fluid from subjects with periodontal disease and atherosclerosis
    Magnus Bäck
    Department of Medicine, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, L8 03, SE 171 76 Stockholm, Sweden
    Atherosclerosis 193:389-94. 2007
    ..These results suggest that increased leukotriene formation may represent a possible link between periodontitis and atherosclerosis and a risk factor marker for both diseases...
  40. doi request reprint Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion
    Anders Gabrielsen
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Mol Med (Berl) 88:795-806. 2010
    ..The findings suggest that intraplaque TXA(2) generation may contribute to the development of atherosclerosis and its thrombotic complications in humans...