L Backman

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi request reprint Rate of cognitive decline in preclinical Alzheimer's disease: the role of comorbidity
    Lars Backman
    Aging Research Center at the Karolinska Institute and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 58:P228-36. 2003
  2. ncbi request reprint The correlative triad among aging, dopamine, and cognition: current status and future prospects
    Lars Backman
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Box 6401, S 113 82 Stockholm, Sweden
    Neurosci Biobehav Rev 30:791-807. 2006
  3. ncbi request reprint Influences of preclinical dementia and impending death on the magnitude of age-related cognitive deficits
    Lars Backman
    Department of Psychology, Uppsala University, Sweden
    Psychol Aging 17:435-42. 2002
  4. ncbi request reprint Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis
    Lars Backman
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neuropsychology 19:520-31. 2005
  5. ncbi request reprint Stability of the preclinical episodic memory deficit in Alzheimer's disease
    L Backman
    Department of Psychology, Uppsala University, Uppsala, Sweden
    Brain 124:96-102. 2001
  6. doi request reprint Occurrence of cognitive impairment and dementia in the community: a 9-year-long prospective study
    B Caracciolo
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 70:1778-85. 2008
  7. doi request reprint The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
    B Caracciolo
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, Stockholm 113 30, Sweden
    J Neurol Neurosurg Psychiatry 82:788-93. 2011
  8. ncbi request reprint Episodic remembering in a population-based sample of nonagenarians: does major depression exacerbate the memory deficits seen in Alzheimer's disease?
    L Backman
    Department of Psychology, Goteborg University, Sweden
    Psychol Aging 11:649-57. 1996
  9. doi request reprint The influence of vascular disease on cognitive performance in the preclinical and early phases of Alzheimer's disease
    E J Laukka
    Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 29:498-503. 2010
  10. ncbi request reprint Influences of cognitive support on episodic remembering: tracing the process of loss from normal aging to Alzheimer's disease
    L Backman
    Department of Psychology, Goteborg University, Sweden
    Psychol Aging 13:267-76. 1998

Detail Information

Publications89

  1. ncbi request reprint Rate of cognitive decline in preclinical Alzheimer's disease: the role of comorbidity
    Lars Backman
    Aging Research Center at the Karolinska Institute and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 58:P228-36. 2003
    ..A possible exception to this pattern is that an increasing number of concomitant health conditions may exacerbate the rate of cognitive decline during the final portion of the preclinical phase in AD...
  2. ncbi request reprint The correlative triad among aging, dopamine, and cognition: current status and future prospects
    Lars Backman
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Box 6401, S 113 82 Stockholm, Sweden
    Neurosci Biobehav Rev 30:791-807. 2006
    ....
  3. ncbi request reprint Influences of preclinical dementia and impending death on the magnitude of age-related cognitive deficits
    Lars Backman
    Department of Psychology, Uppsala University, Sweden
    Psychol Aging 17:435-42. 2002
    ..This pattern of findings suggests that the biological aging process exerts negative influences on cognitive functioning beyond those resulting from disease and mortality...
  4. ncbi request reprint Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis
    Lars Backman
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Stockholm, Sweden
    Neuropsychology 19:520-31. 2005
    ..The generalized nature of the deficit is consistent with recent observations that multiple brain structures and functions are affected long before the AD diagnosis...
  5. ncbi request reprint Stability of the preclinical episodic memory deficit in Alzheimer's disease
    L Backman
    Department of Psychology, Uppsala University, Uppsala, Sweden
    Brain 124:96-102. 2001
    ..This may reflect the fact that those biological events that eventually result in clinically diagnosed Alzheimer's disease e.g. the appearance of amyloid plaques and neurofibrillary tangles) accumulate at a relatively slow rate...
  6. doi request reprint Occurrence of cognitive impairment and dementia in the community: a 9-year-long prospective study
    B Caracciolo
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 70:1778-85. 2008
    ....
  7. doi request reprint The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
    B Caracciolo
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, Stockholm 113 30, Sweden
    J Neurol Neurosurg Psychiatry 82:788-93. 2011
    ..To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: (i) MCI severity, (ii) time of assessment and (iii) interaction with other factors...
  8. ncbi request reprint Episodic remembering in a population-based sample of nonagenarians: does major depression exacerbate the memory deficits seen in Alzheimer's disease?
    L Backman
    Department of Psychology, Goteborg University, Sweden
    Psychol Aging 11:649-57. 1996
    ..g., loss of energy, concentration difficulties) are common in AD as well as in nondepressed people in the 10th decade of life...
  9. doi request reprint The influence of vascular disease on cognitive performance in the preclinical and early phases of Alzheimer's disease
    E J Laukka
    Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 29:498-503. 2010
    ..Alzheimer's disease (AD) is one of the most important causes of old-age cognitive impairment. We aimed to examine the influence of history of vascular disease on cognition in preclinical and early AD...
  10. ncbi request reprint Influences of cognitive support on episodic remembering: tracing the process of loss from normal aging to Alzheimer's disease
    L Backman
    Department of Psychology, Goteborg University, Sweden
    Psychol Aging 13:267-76. 1998
    ..These results indicate that a general impairment of episodic memory may precede reductions in cognitive reserve capacity in the early development of AD...
  11. ncbi request reprint Preclinical symptoms of major depression in very old age: a prospective longitudinal study
    A K Berger
    Stockholm Gerontology Research Center and the Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Psychiatry 155:1039-43. 1998
    ..The authors' goal was to examine whether individuals diagnosed as having major depression experienced greater levels of depressive symptoms and cognitive dysfunction up to 3 years before the clinical diagnosis was rendered...
  12. ncbi request reprint Influences of thyroid stimulating hormone on cognitive functioning in very old age
    A Wahlin
    Stockholm Gerontology Research Center, Karolinska Institute, Stockholm, Sweden
    J Gerontol B Psychol Sci Soc Sci 53:P234-9. 1998
    ..The influence of TSH on episodic memory was interpreted in terms of its potential effects on encoding and consolidation processes...
  13. ncbi request reprint Multiple cognitive deficits during the transition to Alzheimer's disease
    L Backman
    Department of Geriatric Epidemiology, Aging Research Center, Neurotec, Karolinska Institute, Stockholm, Sweden
    J Intern Med 256:195-204. 2004
    ..Future research should consider combining cognitive indicators with other types of markers (i.e. social, somatic, genetic, brain-based) in order to increase prediction accuracy...
  14. doi request reprint Medial temporal lobe is vulnerable to vascular risk factors in men: a population-based study
    C Qiu
    Department of Neurobiology, Karolinska Institutet Stockholm University, Stockholm, Sweden
    Eur J Neurol 19:876-83. 2012
    ..We investigate whether an aggregation of VRFs is associated with volume of hippocampus and entorhinal cortex in elderly people living in the community...
  15. ncbi request reprint Detection of mild dementia in community surveys. Is it possible to increase the accuracy of our diagnostic instruments?
    A Herlitz
    Stockholm Gerontology Research Center, Karolinska Institute, Stockholm, Sweden
    Arch Neurol 54:319-24. 1997
    ..To investigate the accuracy of cognitive tests and clinical dementia diagnosis in distinguishing between mildly demented and nondemented subjects...
  16. ncbi request reprint Cognitive deficits in preclinical Alzheimer's disease and vascular dementia: patterns of findings from the Kungsholmen Project
    Lars Backman
    Karolinska Institutet, Aging Research Center, S 113 30 Stockholm, Sweden
    Physiol Behav 92:80-6. 2007
    ..In order to improve group classification, future research should consider combining cognitive markers with preclinical indicators from other domains (e.g., biological, clinical, social, genetic) into multivariate prediction models...
  17. ncbi request reprint Predictors of progression from mild cognitive impairment to Alzheimer disease
    K Palmer
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neurology 68:1596-602. 2007
    ..To determine the occurrence of neuropsychiatric symptomatology and the relation to future development of Alzheimer disease (AD) in persons with and without mild cognitive impairment (MCI)...
  18. ncbi request reprint The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen Project
    C Qiu
    Stockholm Gerontology Research Center, Box 6401 Olivecronas väg 4, S 113 82 Stockholm, Sweden
    Arch Neurol 58:2034-9. 2001
    ..The relationship between education and Alzheimer disease (AD) or dementia has been widely examined and the evidence obtained is mixed. Several hypotheses have been proposed to explain the observed association between them...
  19. ncbi request reprint Rate of acquisition, adult age, and basic cognitive abilities predict forgetting: new views on a classic problem
    Stuart W S MacDonald
    Section of Psychology, Stockholm Gerontology Research Center, Stockholm, Sweden
    J Exp Psychol Gen 135:368-90. 2006
    ..Observed correlates of differential forgetting slopes are similar to those previously found to affect encoding, suggesting continuity rather than asymmetry of prediction for these memory processes...
  20. ncbi request reprint Vitamin B status and cognitive performance in preclinical and clinical Alzheimer's disease: data from the Kungsholmen Project
    Ake Wahlin
    Department of Psychology, Stockholm University, Stockholm, Sweden
    Dement Geriatr Cogn Disord 25:23-31. 2008
    ..Using a population-based sample, we examined the associations of vitamin B(12) and folate with cognitive functioning in clinical (n = 44) and preclinical (n = 39) AD...
  21. doi request reprint Terminal-decline effects for select cognitive tasks after controlling for preclinical dementia
    Erika J Laukka
    Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Geriatr Psychiatry 16:355-65. 2008
    ..However, specific cognitive tasks might be more sensitive to terminal-decline effects. The purpose of this study was to explore possible terminal-decline effects for a range of cognitive tasks after controlling for preclinical dementia...
  22. doi request reprint Age-related differences in brain regions supporting successful encoding of emotional faces
    Hakan Fischer
    Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Cortex 46:490-7. 2010
    ..The results indicate an age-related shift in the neural underpinnings of negative emotional face processing from medial-temporal to neocortical regions...
  23. doi request reprint Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease
    Katie Palmer
    Aging Research Center, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Am J Geriatr Psychiatry 16:603-11. 2008
    ....
  24. ncbi request reprint Effects of division of attention during encoding and retrieval on age differences in episodic memory
    L Nyberg
    Department of Psychology, Umea University, Sweden
    Exp Aging Res 23:137-43. 1997
    ..These results do not support the hypothesis that reduced attentional capacity in old age is underlying age differences in episodic memory...
  25. ncbi request reprint Reduced food intake after jejunoileal bypass: a possible association with prolonged gastric emptying and altered gut hormone patterns
    E Naslund
    Department of Surgery, Karolinska Institute, Danderyd Hospital, Sweden
    Am J Clin Nutr 66:26-32. 1997
    ..That gastric emptying is prolonged and gut hormone patterns are altered with low postprandial plasma cholecystokinin and high neurotensin plasma concentrations may at least partly account for these observations...
  26. ncbi request reprint Stability, growth, and decline in adult life span development of declarative memory: cross-sectional and longitudinal data from a population-based study
    Michael Ronnlund
    Department of Psychology, Umea University, Umea, Sweden
    Psychol Aging 20:3-18. 2005
    ..Collectively, the results show that age trajectories for episodic and semantic memory differ and underscore the need to control for cohort and retest effects in cross-sectional and longitudinal studies, respectively...
  27. doi request reprint Prospective and retrospective memory in Alzheimer's disease and vascular dementia: similar patterns of impairment
    Asa Livner
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Neurol Sci 283:235-9. 2009
    ..The results are discussed relative to a network view of episodic memory, in which alterations at different sites may result in similar functional impairments...
  28. ncbi request reprint Cognitive functioning in Alzheimer's disease and vascular dementia: further evidence for similar patterns of deficits
    Kjell Fahlander
    Stockholm Gerontology Research Center and NEUROTEC, Division of Geriatric Epidemiology, Karolinska Institute, Stockholm, Sweden
    J Clin Exp Neuropsychol 24:734-44. 2002
    ..These findings suggest that AD and AD may affect several basic cognitive functions in an equal manner...
  29. ncbi request reprint The influence of APOE status on episodic and semantic memory: data from a population-based study
    Lars Göran Nilsson
    Department of Psychology, Stockholm University, Stockholm, Sweden
    Neuropsychology 20:645-57. 2006
    ..On the basis of the data obtained, the authors argue that analyses of the effect of specific genes in cognition should be accompanied by assessment of performance at a specific level, with due attention to the individual's age...
  30. ncbi request reprint Age-related cognitive deficits mediated by changes in the striatal dopamine system
    L Backman
    Department of Psychology, Uppsala University, Sweden
    Am J Psychiatry 157:635-7. 2000
    ..The study examined the influence of losses in dopaminergic function on age-related cognitive deficits...
  31. ncbi request reprint Cognitive correlates of mortality: evidence from a population-based sample of very old adults
    B J Small
    Stockholm Gerontology Research Center, Karolinska Institute, Sweden
    Psychol Aging 12:309-13. 1997
    ..The results indicate a relationship between cognitive performance and subsequent mortality status in very old age and suggest that episodic memory and verbal skill may be particularly sensitive in predicting such effects...
  32. ncbi request reprint Episodic memory functioning in population-based samples of very old adults with Alzheimer's disease and vascular dementia
    L Hassing
    Department of Psychology, Goteborg University, Sweden
    Dement Geriatr Cogn Disord 8:376-83. 1997
    ..In addition, the selective AD-related deficit in word recall was interpreted in terms of a greater impairment of various language-related skills in AD compared with VaD...
  33. ncbi request reprint Contrasting cognitive trajectories of impending death and preclinical dementia in the very old
    E J Laukka
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Neurology 66:833-8. 2006
    ..Both impending death and preclinical dementia are associated with cognitive impairment in old age, although their effects on cognitive functioning have rarely been examined within the same study...
  34. ncbi request reprint Genetic variation in memory functioning
    Lars Göran Nilsson
    Department of Psychology, Stockholm University, Stockholm SE 10691, Sweden
    Neurosci Biobehav Rev 26:841-8. 2002
    ..This effect was most pronounced in tasks providing cognitive support at both encoding and retrieval, suggesting a deficit in utilizing such support in carriers of the epsilon 4 allele...
  35. ncbi request reprint Recollective experience in odor recognition: influences of adult age and familiarity
    Maria Larsson
    Department of Psychology, Stockholm University, Frescati Hagväg 14, 10691 Stockholm, Sweden
    Psychol Res 70:68-75. 2006
    ..This suggests that age-related deficits in activating specific odor knowledge (i.e., odor names) play an important role for age differences in recollective experience of olfactory information...
  36. doi request reprint Early symptoms and signs of cognitive deficits might not always be detectable in persons who develop Alzheimer's disease
    Katie Palmer
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Int Psychogeriatr 20:252-8. 2008
    ..This study aims to determine how many individuals with AD show detectable symptoms or clinical signs of cognitive deficits three years before diagnosis...
  37. doi request reprint Simulating neurocognitive aging: effects of a dopaminergic antagonist on brain activity during working memory
    Hakan Fischer
    Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 67:575-80. 2010
    ..Previous correlational studies have indirectly linked dysfunctional dopaminergic neurotransmission to age-related cognitive deficits and associated reductions in task-induced functional brain activity...
  38. ncbi request reprint Dopamine and cognitive functioning: brain imaging findings in Huntington's disease and normal aging
    L Backman
    Department of Psychology, Uppsala University, Sweden
    Scand J Psychol 42:287-96. 2001
    ..In general, the research reviewed in this article indicates that the nigrostriatal DA system is an important component of a frontostriatal circuitry that is critically involved in cognitive functioning...
  39. ncbi request reprint High suicidal ideation in persons testing for Huntington's disease
    T B Robins Wahlin
    Stockholm Gerontology Research Center, Department of Clinical Neuroscience and Occupational Therapy and Elderly Care Research, Karolinska Institute, Sweden
    Acta Neurol Scand 102:150-61. 2000
    ..The need for counseling, using a well designed protocol, and the importance of focusing on suicide risk of participants in predictive testing programs is emphasized...
  40. doi request reprint Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study
    M Kivipelto
    Aging Research Center, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Eur J Neurol 16:808-13. 2009
    ..Another marker of vitamin B12 deficiency, holo-transcobalamin (holo-TC), has not been studied in a prospective setting...
  41. ncbi request reprint Aging and memory for expected and unexpected objects in real-world settings
    T Mantyla
    Department of Psychology, University of Stockholm, Sweden
    J Exp Psychol Learn Mem Cogn 18:1298-309. 1992
    ..Also, under divided attention, young adults revealed the same pattern of data as did elderly adults under full attention. The results are discussed in terms of capacity-related differences in distinctive encoding...
  42. ncbi request reprint Modality memory across the adult life span: evidence for selective age-related olfactory deficits
    M Larsson
    Karolinska Institute, Stockholm, Sweden
    Exp Aging Res 24:63-82. 1998
    ..Taken together, these results suggest that elaborating and reconstructing the source of olfactory information may be particularly difficult for older adults...
  43. ncbi request reprint The influence of serum vitamin B12 and folate status on cognitive functioning in very old age
    T B Robins Wahlin
    Stockholm Gerontology Research Center, Olivecronas vag 4, Box 6401, 113 82, Stockholm, Sweden
    Biol Psychol 56:247-65. 2001
    ....
  44. ncbi request reprint Cognitive support at episodic encoding and retrieval: similar patterns of utilization in community-based samples of Alzheimer's disease and vascular dementia patients
    O Almkvist
    Stockholm Gerontology Research Center, Sweden
    J Clin Exp Neuropsychol 21:816-30. 1999
    ..The results suggests a similarity between AD and VaD patients with regard to the nature of the episodic memory impairment, despite etiologic differences between the diseases...
  45. ncbi request reprint Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  46. ncbi request reprint Negligible effects of depression on verbal and spatial performance in Alzheimer's disease
    Anna Karin Berger
    Stockholm Gerontology Research Center and Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research NEUROTEC, Division of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden
    Dement Geriatr Cogn Disord 13:1-7. 2002
    ..g. concentration difficulties, lack of interest, loss of energy) may already be present in AD as a result of the neurodegenerative process...
  47. ncbi request reprint Differential evolution of cognitive impairment in nondemented older persons: results from the Kungsholmen Project
    Katie Palmer
    Stockholm Gerontology Research Center and Division of Geriatric Epidemiology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Uppsala University, Sweden
    Am J Psychiatry 159:436-42. 2002
    ..This study was a prospective, population-based examination of the evolution of cognitive impairment, no dementia (CIND)...
  48. ncbi request reprint Reference values for serum levels of vitamin B12 and folic acid in a population-based sample of adults between 35 and 80 years of age
    Ake Wahlin
    Stockholm Getontology Research Center, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Karolinska Institute, Box 6401, SE 113 82 Stockholm, Sweden
    Public Health Nutr 5:505-11. 2002
    ..Reference data for folate and age-stratified reference data for vitamin B12 are presented, together with an examination of potential confounders...
  49. ncbi request reprint Differential sex effects in olfactory functioning: the role of verbal processing
    Christina Oberg
    Department of Psychology, Uppsala University, Sweden
    J Int Neuropsychol Soc 8:691-8. 2002
    ..This outcome suggests that women's superiority in episodic odor memory is largely mediated by their higher proficiency in odor identification...
  50. pmc Detection of Alzheimer's disease and dementia in the preclinical phase: population based cohort study
    Katie Palmer
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec, Karolinska Institute, and Stockholm Gerontology Research Center, Box 6401, 11382, Stockholm, Sweden
    BMJ 326:245. 2003
    ..To evaluate a simple three step procedure to identify people in the general population who are in the preclinical phase of Alzheimer's disease and dementia...
  51. pmc Accelerated progression from mild cognitive impairment to dementia in people with diabetes
    Weili Xu
    Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
    Diabetes 59:2928-35. 2010
    ..We sought to examine whether diabetes and pre-diabetes are associated with MCI and accelerate the progression from MCI to dementia...
  52. ncbi request reprint Memory and cognition in preclinical dementia: what we know and what we do not know
    Lars Backman
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Can J Psychiatry 53:354-60. 2008
    ..This approach would also facilitate the examination of interactive effects among classes of preclinical markers...
  53. doi request reprint Modulation of striatal dopamine D1 binding by cognitive processing
    Sari Karlsson
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, SE 113 30 Stockholm, Sweden
    Neuroimage 48:398-404. 2009
    ....
  54. doi request reprint Increased response-time variability is associated with reduced inferior parietal activation during episodic recognition in aging
    Stuart W S MacDonald
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    J Cogn Neurosci 20:779-86. 2008
    ..In support of extant findings and theory from neuroscience, neuropsychology, and cognitive aging, the present results suggest that behavioral IIV represents a proxy for neural integrity...
  55. ncbi request reprint Enhanced occipital and anterior cingulate activation in men but not in women during exposure to angry and fearful male faces
    Hakan Fischer
    Aging Research Center, Karolinska Institute, Box 6401, 113 82 Stockholm, Sweden
    Cogn Affect Behav Neurosci 4:326-34. 2004
    ..Hence, we suggest that the elevated occipital and anterior cingulate activation in men during confrontation with other angry and fearful males may reflect enhanced vigilance in a potentially dangerous situation...
  56. doi request reprint Influence of COMT gene polymorphism on fMRI-assessed sustained and transient activity during a working memory task
    Cindy M de Frias
    Stockholm University, Stockholm, Sweden
    J Cogn Neurosci 22:1614-22. 2010
    ..These results support the tonic-phasic theory of DA function in elucidating the specific phenotypic influence of the COMT val(158)met polymorphism on different components of working memory...
  57. doi request reprint Activation in striatum and medial temporal lobe during sequence learning in younger and older adults: relations to performance
    Anna Rieckmann
    Aging Research Center, Karolinska Institutet, Stockholm, Sweden
    Neuroimage 50:1303-12. 2010
    ..The results are discussed in terms of the functional role of the MTL in SL, and offer a novel explanation of the fact that SL is little affected in aging...
  58. ncbi request reprint Cognitive and neural plasticity in aging: general and task-specific limitations
    Sari Jones
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Neurosci Biobehav Rev 30:864-71. 2006
    ..Future attempts to optimize intervention-related gains in old age should consider targeting both general processing and task-specific origins of age-associated reductions in cognitive plasticity...
  59. ncbi request reprint [A simple three-step model for detection of preclinical dementia among the elderly]
    Katie Palmer
    sektionen för geriatrik, Neurotec, Karolinska Institutet, Stockholm
    Lakartidningen 100:2606-8. 2003
  60. pmc Neural correlates of training-related memory improvement in adulthood and aging
    Lars Nyberg
    Department of Psychology, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 100:13728-33. 2003
    ..These findings suggest that age-related differences in cognitive reserve capacity may reflect both a frontal processing deficiency and a posterior production deficiency...
  61. ncbi request reprint Forgetting numbers in old age: strategy and learning speed matter
    Anna Derwinger
    Aging Research Center, Department of Geriatric Epidemiology, Neurotec, Karolinska Institute, Stockholm, Sweden
    Gerontology 51:277-84. 2005
    ..Memory intervention research with older adults has primarily focused on immediate effects of training. Little is known about whether memory training can prevent forgetting of a learned material over time...
  62. ncbi request reprint Age-differential patterns of brain activation during perception of angry faces
    Hakan Fischer
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Olivecronas vag 4, Box 6401, 113 82 Stockholm, Sweden
    Neurosci Lett 386:99-104. 2005
    ....
  63. ncbi request reprint Similar patterns of cognitive deficits in the preclinical phases of vascular dementia and Alzheimer's disease
    Erika Jonsson Laukka
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    J Int Neuropsychol Soc 10:382-91. 2004
    ..These results extend previous findings of similar patterns of cognitive deficits in the early clinical phases of AD and VaD to the preclinical phases of these diseases...
  64. ncbi request reprint Alzheimer's disease and depression: preclinical comorbidity effects on cognitive functioning
    Anna Karin Berger
    Aging Research Center ARC, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Stockholm
    Cortex 41:603-12. 2005
    ..Thus, although depressive symptoms may result in slight cognitive deficits in preclinical AD, at the time of the dementia diagnosis these effects may be absorbed by the neurodegenerative process...
  65. ncbi request reprint Sex-differential brain activation during exposure to female and male faces
    Hakan Fischer
    Aging Research Center, Division of Geriatric Epidemiology, NEUROTEC Karolinska Institutet, Box 6401, 11382 Stockholm, Sweden
    Neuroreport 15:235-8. 2004
    ..The sex-differential nature of this activation pattern may reflect sex differences in cognitive style and attentional processes when confronting faces of the opposite sex...
  66. ncbi request reprint Design your own memory strategies! Self-generated strategy training versus mnemonic training in old age: an 8-month follow-up
    Anna Derwinger
    Stockholm Gerontology Research Centre, and Aging Research Centre, Neurotec, Karolinska Institute, Sweden
    Neuropsychol Rehabil 15:37-54. 2005
    ..These data indicate the numerical memory training may result in long-term effects in older adults and that, under some conditions, practising one's own memory strategies may have advantages over mnemonic training in old age...
  67. ncbi request reprint Cognitive functioning in preclinical vascular dementia: a 6-year follow-up
    Erika Jonsson Laukka
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Stroke 35:1805-9. 2004
    ....
  68. ncbi request reprint Differential verbal fluency deficits in the preclinical stages of Alzheimer's disease and vascular dementia
    Sari Jones
    Aging Research Center ARC, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Stockholm, Sweden
    Cortex 42:347-55. 2006
    ..The patterns of fluency impairment in preclinical AD and VaD generalized across early and late word retrieval...
  69. ncbi request reprint Interrelations between subjective health and episodic memory change in Swedish and Canadian samples of older adults
    Ake Wahlin
    Stockholm Gerontology Research Center, SE 113 82 Stockholm, Sweden
    Int J Aging Hum Dev 57:21-35. 2003
    ..Thus, the present findings suggest that subjective health may be added to the growing number of individual-difference variables that are predictive of episodic memory change in very old age...
  70. ncbi request reprint Patterns of prospective and retrospective memory impairment in preclinical Alzheimer's disease
    Sari Jones
    Karolinska Institutet, Stockholm, Sweden
    Neuropsychology 20:144-52. 2006
    ..Hence, the findings indicate a rather global episodic memory impairment in preclinical AD that cuts across type of memory assessed (ProM and RetM) as well as across different components of both the ProM and RetM tasks...
  71. ncbi request reprint A preclinical phase in vascular dementia: cognitive impairment three years before diagnosis
    Sari Jones
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, Stockholm, Sweden
    Dement Geriatr Cogn Disord 18:233-9. 2004
    ..This observation suggests that circulatory disturbance is associated with cognitive problems several years before the actual VaD diagnosis...
  72. ncbi request reprint Source memory in major depression
    A degl'Innocenti
    Department of Psychology, Goteborg University, Sweden
    J Affect Disord 54:205-9. 1999
    ..Research demonstrating episodic memory deficits in clinical depression has dealt with item memory exclusively. The present research sought to determine whether memory for source is differentially affected by depression...
  73. doi request reprint Linking cognitive aging to alterations in dopamine neurotransmitter functioning: recent data and future avenues
    Lars Backman
    Aging Research Center, Karolinska Institute, Gavlegatan 16, 113 30 Stockholm, Sweden
    Neurosci Biobehav Rev 34:670-7. 2010
    ..Based on these lines of empirical inquiry, we outline a series of avenues for future research on aging, DA, and cognition...
  74. ncbi request reprint The role of the striatal dopamine transporter in cognitive aging
    Nina Erixon-Lindroth
    Department of Psychiatry, Department of Clinical Neuroscience, Karolinska Hospital, Box 6401, S 113 82 Stockholm, Sweden
    Psychiatry Res 138:1-12. 2005
    ..The findings were discussed relative to the view that the frontostriatal network is critically involved in multiple cognitive functions...
  75. ncbi request reprint The extent of stability and change in episodic and semantic memory in old age: demographic predictors of level and change
    Martin Lövdén
    Department of Psychology, Stockholm University, Sweden
    J Gerontol B Psychol Sci Soc Sci 59:P130-4. 2004
    ..Collectively, these results depict relatively high degrees of structural stability and stability of interindividual differences in declarative memory in old age...
  76. ncbi request reprint Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers
    Johanna Lind
    Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N 8, Stockholm, Sweden
    Brain 129:1240-8. 2006
    ..Collectively, these findings indicate that genetic risk translates into reduced functional brain activity, in regions pertinent to Alzheimer's disease, well before alterations can be detected at the behavioural level...
  77. doi request reprint Age-related loss of olfactory sensitivity: association to dopamine transporter binding in putamen
    M Larsson
    Department of Psychology, Stockholm University, Frescati Hagväg 14, S 106 91 Stockholm, Sweden
    Neuroscience 161:422-6. 2009
    ..The findings indicate that DAT binding in putamen is related to age-related olfactory deficits, as well as to odor sensitivity independently of age...
  78. ncbi request reprint Gender differences in episodic memory
    A Herlitz
    Karolinska Institutet, Stockholm, Sweden
    Mem Cognit 25:801-11. 1997
    ..The women's higher level of performance on the episodic memory tasks could not be fully explained by their higher verbal ability...
  79. ncbi request reprint Brain activation while forming memories of fearful and neutral faces in women and men
    Hakan Fischer
    Karolinska Institute, Aging Research Center, Stockholm, Sweden
    Emotion 7:767-73. 2007
    ..These findings suggest that women and men use similar neural networks to encode facial information, with only subtle sex differences observed for neutral faces...
  80. doi request reprint Working memory plasticity modulated by dopamine transporter genotype
    Yvonne Brehmer
    Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Neurosci Lett 467:117-20. 2009
    ..This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores...
  81. doi request reprint Acceleration of hippocampal atrophy in a non-demented elderly population: the SNAC-K study
    Yi Zhang
    Department of Clinical Science, Intervention and Technology, Division of Radiology, Karolinska Institutet, Stockholm, Sweden
    Int Psychogeriatr 22:14-25. 2010
    ..The aim is to study the aging atrophy speed and acceleration of brain atrophy in a cross-sectional database, to identify the age at which acceleration of hippocampal atrophy starts in non-demented elderly persons...
  82. ncbi request reprint Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity
    E Naslund
    Department of Surgery, Karolinska Institute, Stockholm, Sweden
    Obes Surg 8:253-60. 1998
    ..The aim of the present study was to examine the long-term effect of JIB on glucose metabolism...
  83. ncbi request reprint An adjustable vertical banded gastroplasty does not eliminate the risk of staple-line disruption
    E Naslund
    Division of Surgery, Karolinska Institute at Danderyd Hospital, Stockholm, Sweden
    Obes Surg 8:434-6. 1998
    ..The two main reasons for reoperation after vertical banded gastroplasty (VBG) in the treatment of obesity are staple-line disruption and stomal stenosis...
  84. doi request reprint Immigrant girls perceive less stress
    F Lindblad
    Stress Research Institute, Stockholm University, Stockholm, Sweden
    Acta Paediatr 97:889-93. 2008
    ..To develop a new stress scale and use it for investigating impact of ethnicity on perception of stress...
  85. ncbi request reprint A Swedish study of chemoradiation in squamous cell carcinoma of the esophagus
    D Stockeld
    Department of Surgery, Danderyd Hospital, Stockholm, Sweden
    Acta Oncol 40:566-73. 2001
    ..With a minimum follow-up of 37 months, the 3-year survival for the whole group was 31% compared with 57% for the CR patients. Total 5-year survival thus far (July 1999) is 26%...
  86. doi request reprint Implicit learning in aging: extant patterns and new directions
    Anna Rieckmann
    Aging Research Center, Karolinska Institute, Gavlegatan 16, 11330 Stockholm, Sweden
    Neuropsychol Rev 19:490-503. 2009
    ..g., medial-temporal, frontal) during IL. This reorganization of function may be beneficial under less taxing performance conditions, but not when task demands become more challenging...
  87. ncbi request reprint Intra-individual variability in behavior: links to brain structure, neurotransmission and neuronal activity
    Stuart W S MacDonald
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 113 30 Stockholm, Sweden
    Trends Neurosci 29:474-80. 2006
    ....
  88. ncbi request reprint Selective adult age differences in an age-invariant multifactor model of declarative memory
    Lars Nyberg
    Department of Psychology, Umea University, Sweden
    Psychol Aging 18:149-60. 2003
    ..Overall, the results support the view that episodic memory is more age sensitive than semantic memory, but they also indicate that aging has differential effects within these 2 forms of memory...
  89. doi request reprint Thyroid stimulating hormone and prospective memory functioning in old age
    Asa Livner
    Aging Research Center, Karolinska Institutet, Gavlegatan 16, S 113 30 Stockholm, Sweden
    Psychoneuroendocrinology 34:1554-9. 2009
    ..T4 levels were unrelated to ProM performance. This pattern suggests that the previously identified "normal-range" interval for TSH should be moved further up in old age, at least when cognitive functioning is considered...