Johan Askling

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Swedish registers to examine drug safety and clinical issues in RA
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 65:707-12. 2006
  2. pmc Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment
    Teresa A Simon
    Global Health Economics and Outcomes Research, Bristol Myers Squibb, Route 206 and Province Line Roads, Lawrenceville, NJ 08540, USA
    Arthritis Res Ther 12:R67. 2010
  3. doi request reprint The risk of malignancies in RA patients treated with biologics
    J Askling
    Clinical Epidemiology Unit T2 01, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, 171 76, Stockholm, Schweden
    Z Rheumatol 69:774-9. 2010
  4. doi request reprint Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register
    J Askling
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 68:648-53. 2009
  5. doi request reprint Malignancy and biologic therapy in rheumatoid arthritis
    Johan Askling
    Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital and Karolinska Institute, Sweden
    Curr Opin Rheumatol 20:334-9. 2008
  6. doi request reprint The safety of anti-tumour necrosis factor therapy in rheumatoid arthritis
    Johan Askling
    Department of Medicine Solna, Clinical Epidemiology Unit, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, Sweden
    Curr Opin Rheumatol 20:138-44. 2008
  7. doi request reprint Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?
    Johan Askling
    Department of Medicine Solna, Karolinska University Hospital at Solna and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:3180-9. 2009
  8. pmc Risk for malignant lymphoma in ankylosing spondylitis: a nationwide Swedish case-control study
    J Askling
    Department of Medicine, Clinical Epidemiology Unit M9 01, Karolinska University Hospital Solna, SE 171 77, Stockholm, Sweden
    Ann Rheum Dis 65:1184-7. 2006
  9. ncbi request reprint Malignancy and rheumatoid arthritis
    Johan Askling
    Clinical Epidemiology Unit M9 01, Department of Medicine Solna, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Curr Rheumatol Rep 9:421-6. 2007
  10. pmc Time-dependent increase in risk of hospitalisation with infection among Swedish RA patients treated with TNF antagonists
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 66:1339-44. 2007

Detail Information

Publications83

  1. pmc Swedish registers to examine drug safety and clinical issues in RA
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 65:707-12. 2006
    ..The approach described is a possible prototype for long term surveillance systems needed for the safe introduction of new treatments...
  2. pmc Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment
    Teresa A Simon
    Global Health Economics and Outcomes Research, Bristol Myers Squibb, Route 206 and Province Line Roads, Lawrenceville, NJ 08540, USA
    Arthritis Res Ther 12:R67. 2010
    ....
  3. doi request reprint The risk of malignancies in RA patients treated with biologics
    J Askling
    Clinical Epidemiology Unit T2 01, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, 171 76, Stockholm, Schweden
    Z Rheumatol 69:774-9. 2010
    ..So far, but with exceptions both in terms of risks observed and absence of data, the emerging picture is reassuring rather than alarming...
  4. doi request reprint Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas: relative risks and time trends in the Swedish Biologics Register
    J Askling
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 68:648-53. 2009
    ....
  5. doi request reprint Malignancy and biologic therapy in rheumatoid arthritis
    Johan Askling
    Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital and Karolinska Institute, Sweden
    Curr Opin Rheumatol 20:334-9. 2008
    ....
  6. doi request reprint The safety of anti-tumour necrosis factor therapy in rheumatoid arthritis
    Johan Askling
    Department of Medicine Solna, Clinical Epidemiology Unit, Karolinska University Hospital and Karolinska Institutet, Solna, Stockholm, Sweden
    Curr Opin Rheumatol 20:138-44. 2008
    ....
  7. doi request reprint Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?
    Johan Askling
    Department of Medicine Solna, Karolinska University Hospital at Solna and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:3180-9. 2009
    ..To determine the short-term and medium-term risks of cancer in patients receiving anti-tumor necrosis factor alpha (anti-TNFalpha) therapies that have proven effective in the treatment of chronic inflammatory conditions...
  8. pmc Risk for malignant lymphoma in ankylosing spondylitis: a nationwide Swedish case-control study
    J Askling
    Department of Medicine, Clinical Epidemiology Unit M9 01, Karolinska University Hospital Solna, SE 171 77, Stockholm, Sweden
    Ann Rheum Dis 65:1184-7. 2006
    ..Besides inflammation-lymphoma aetiology, information on risk of lymphoma in ankylosing spondylitis is particularly important as a benchmark in the evaluation of, for example, tumour necrosis factor inhibitors...
  9. ncbi request reprint Malignancy and rheumatoid arthritis
    Johan Askling
    Clinical Epidemiology Unit M9 01, Department of Medicine Solna, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Curr Rheumatol Rep 9:421-6. 2007
    ..This review summarizes our current understanding of the occurrence of cancer in RA, possible links to RA disease and to traditional and newer RA treatments...
  10. pmc Time-dependent increase in risk of hospitalisation with infection among Swedish RA patients treated with TNF antagonists
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 66:1339-44. 2007
    ..An observational cohort study was performed using prospectively collected data from the Swedish Biologics Register (ARTIS) and other national Swedish registers...
  11. doi request reprint Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: meta-analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data
    Johan Askling
    Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Pharmacoepidemiol Drug Saf 20:119-30. 2011
    ....
  12. doi request reprint Increased mortality risk in patients with phenotypic hereditary hemochromatosis but not in their first-degree relatives
    Maria Elmberg
    Department of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    Gastroenterology 137:1301-9. 2009
    ..However, little is known about their mortality or strategies for their management. We assessed mortality among Swedish patients with HH and their first-degree relatives using health and census registers...
  13. doi request reprint Inflammatory bowel disease confers a lower risk of colorectal cancer to females than to males
    Sverre Söderlund
    Department of Medicine, Karolinska Institutet, Stockholm Soder Hospital, Stockholm, Sweden
    Gastroenterology 138:1697-703. 2010
    ..Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC); we studied differences in inflammation-associated CRC between men and women patients with IBD...
  14. ncbi request reprint Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in Sweden
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital Solna, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 52:1986-92. 2005
    ....
  15. doi request reprint Occurrence and relative risk of stroke in incident and prevalent contemporary rheumatoid arthritis
    Marie Holmqvist
    Karolinska Institutet, Clinical Epidemiology Unit, Department of Medicine Solna, T2, Karolinska Universitetssjukhuset, Stockholm 17176, Sweden
    Ann Rheum Dis 72:541-6. 2013
    ..Our objective was to assess the risk of stroke (by subtype) in contemporary patients with RA, particularly in relation to time since RA diagnosis...
  16. doi request reprint Nationwide prevalence of rheumatoid arthritis and penetration of disease-modifying drugs in Sweden
    Martin Neovius
    Clinical Epidemiology Unit T2, Department of Medicine Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Ann Rheum Dis 70:624-9. 2011
    ..To provide Swedish nationwide data on the prevalence of rheumatoid arthritis (RA), including variations by age, sex, geography, demography and education level, and assess antirheumatic treatment penetration...
  17. doi request reprint How large are the productivity losses in contemporary patients with RA, and how soon in relation to diagnosis do they develop?
    Martin Neovius
    Clinical Epidemiology Unit T2, Department of Medicine Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Ann Rheum Dis 70:1010-5. 2011
    ..To estimate the sick leave and disability pension trajectory in patients diagnosed with early rheumatoid arthritis (RA) 1999-2007, and in prevalent patients in 2007...
  18. doi request reprint Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age
    Thomas Frisell
    Karolinska Institutet, Solna, Sweden
    Arthritis Rheum 65:2773-82. 2013
    ....
  19. ncbi request reprint Incidence of non-Hodgkin's lymphoma in Sweden, Denmark, and Finland from 1960 through 2003: an epidemic that was
    Sven Sandin
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 15:1295-300. 2006
    ..Insights into the descriptive epidemiology of NHL may shed light upon its elusive etiology...
  20. doi request reprint Rheumatoid arthritis, anti-tumour necrosis factor therapy, and risk of malignant melanoma: nationwide population based prospective cohort study from Sweden
    Pauline Raaschou
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    BMJ 346:f1939. 2013
    ....
  21. doi request reprint Smoking, use of moist snuff, and risk of chronic inflammatory diseases
    Cecilia Carlens
    Rheumatology Unit, Department of Medicine, Karolinska Universitetssjukhuset Solna, SE 171 76 Stockholm, Sweden
    Am J Respir Crit Care Med 181:1217-22. 2010
    ..Nicotine is a powerful modifier of the inflammatory response. By comparing risks associated with tobacco smoking and with smokeless tobacco, the role of nicotine in the development of chronic inflammation may be evaluated...
  22. doi request reprint Do rheumatoid arthritis and lymphoma share risk factors?: a comparison of lymphoma and cancer risks before and after diagnosis of rheumatoid arthritis
    Karin Hellgren
    Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 62:1252-8. 2010
    ..We undertook this study to assess whether patients with RA are already at increased risk of lymphoma or of other cancers before the diagnosis of RA, and if the relative risk increases with time since RA diagnosis...
  23. doi request reprint Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Reg
    Saedis Saevarsdottir
    Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Rheum 63:26-36. 2011
    ..To determine whether cigarette smoking influences the response to treatment in patients with early rheumatoid arthritis (RA)...
  24. doi request reprint Cystic fibrosis gene mutations and gastrointestinal diseases
    Shahram Bahmanyar
    Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    J Cyst Fibros 9:288-91. 2010
    ..This study examined if CF mutation heterozygosity is associated with diseases of gastrointestinal epithelial barrier function...
  25. doi request reprint Incidence of rheumatoid arthritis in Sweden: a nationwide population-based assessment of incidence, its determinants, and treatment penetration
    Jonas K Eriksson
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Care Res (Hoboken) 65:870-8. 2013
    ....
  26. doi request reprint Risk of venous thromboembolism in patients with rheumatoid arthritis and association with disease duration and hospitalization
    Marie E Holmqvist
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, T2 01, SE 171 76 Stockholm, Sweden
    JAMA 308:1350-6. 2012
    ....
  27. ncbi request reprint Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype
    Karin Ekstrom Smedby
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Natl Cancer Inst 98:51-60. 2006
    ..Because different NHL subtypes develop at different stages of lymphocyte differentiation, associations of autoimmune and inflammatory disorders with specific NHL subtypes could lead to a better understanding of lymphomagenic mechanisms...
  28. ncbi request reprint Risk of malignant lymphomas in patients with rheumatoid arthritis and in their first-degree relatives
    Karin Ekström
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 48:963-70. 2003
    ....
  29. doi request reprint Colitis-associated DNA aneuploidy and dysplasia in Crohn's disease and risk of colorectal cancer
    Sverre Söderlund
    Department of Medicine, Karolinska Institutet, Stockholm Soder Hospital, Stockholm, Sweden
    Inflamm Bowel Dis 17:1101-7. 2011
    ..By analogy to ulcerative colitis, regular colonoscopy with biopsies for dysplasia has been used. We describe the occurrence of dysplasia and DNA aneuploidy in a cohort of patients with Crohn's colitis...
  30. doi request reprint Does cancer that occurs during or after anti-tumor necrosis factor therapy have a worse prognosis? A national assessment of overall and site-specific cancer survival in rheumatoid arthritis patients treated with biologic agents
    Pauline Raaschou
    Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 63:1812-22. 2011
    ..While data on the incidence of cancer following anti-TNF therapy have been published, the purpose of this study was to examine the clinical presentation and outcome of cancers that develop during or after anti-TNF therapy...
  31. doi request reprint Ten years with biologics: to whom do data on effectiveness and safety apply?
    Julia F Simard
    Department of Medicine, Clinical Epidemiology Unit, T2, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Rheumatology (Oxford) 50:204-13. 2011
    ..The aim of this study was to assess the extent to which contemporary patients who start or switch biologic therapies are comparable with those patients who gave rise to the currently available data on effectiveness and safety...
  32. ncbi request reprint Malignant lymphomas in autoimmunity and inflammation: a review of risks, risk factors, and lymphoma characteristics
    Karin Ekstrom Smedby
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 15:2069-77. 2006
    ..However, there is also obvious heterogeneity in risk and risk mediators among different inflammatory diseases...
  33. pmc The inflammatory reflex and risk for rheumatoid arthritis: a case-control study of human vagotomy
    Cecilia Carlens
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institute, Stockholm, Sweden
    Ann Rheum Dis 66:414-6. 2007
    ..21, 95% 1.11 to 1.33). Vagotomy has no specific effect on the risk of developing rheumatoid arthritis in humans. Gastroduodenal ulcers occur more often than expected even before the occurrence of rheumatoid arthritis...
  34. doi request reprint No increased occurrence of ischemic heart disease prior to the onset of rheumatoid arthritis: results from two Swedish population-based rheumatoid arthritis cohorts
    Marie E Holmqvist
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 60:2861-9. 2009
    ....
  35. doi request reprint Rheumatoid arthritis, treatment with corticosteroids and risk of malignant lymphomas: results from a case-control study
    Karin Hellgren
    Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Ann Rheum Dis 69:654-9. 2010
    ..Patients with RA are at increased risk of malignant lymphomas. In a large case-control study of risk factors for lymphoma in RA, it was recently reported that steroid treatment was associated with decreased lymphoma risk...
  36. doi request reprint Increased risk of primary sclerosing cholangitis and ulcerative colitis in first-degree relatives of patients with primary sclerosing cholangitis
    Annika Bergquist
    Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institute, Huddinge and Solna, Stockholm, Sweden
    Clin Gastroenterol Hepatol 6:939-43. 2008
    ..This study assessed the risk of PSC and inflammatory bowel disease (IBD) among first-degree relatives of patients with PSC, compared with the first-degree relatives of a cohort without PSC...
  37. doi request reprint Increased risk of arthropathies and joint replacement surgery in patients with genetic hemochromatosis: a study of 3,531 patients and their 11,794 first-degree relatives
    Maria Elmberg
    Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
    Arthritis Care Res (Hoboken) 65:678-85. 2013
    ..We therefore assessed the risks of arthropathy and joint replacement surgery in patients with GH and in their first-degree relatives (FDRs)...
  38. ncbi request reprint Personal and family history of autoimmune diabetes mellitus and susceptibility to young-adult-onset Hodgkin lymphoma
    Ola Landgren
    Division of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
    Int J Cancer 118:449-52. 2006
    ..0) history of diabetes mellitus. These findings suggests that characteristics of the immune system associated with conditions such as diabetes mellitus type I are of importance in the pathogenesis of young-adult-onset HL...
  39. doi request reprint Mortality rates in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: drug-specific comparisons in the Swedish Biologics Register
    Julia F Simard
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 64:3502-10. 2012
    ..To determine whether the differences in the modes of action and safety profiles of individual tumor necrosis factor inhibitors (TNFi) translate into differential mortality risks, as investigated in etanercept, infliximab, and adalimumab...
  40. doi request reprint Incidence of progressive multifocal leukoencephalopathy in patients with rheumatoid arthritis: a national population-based study
    Elizabeth V Arkema
    Clinical Epidemiology Unit T2, Department of Medicine, Karolinska Institutet, Stockholm SE 171 76, Sweden
    Ann Rheum Dis 71:1865-7. 2012
    ....
  41. ncbi request reprint Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease
    Sverre Söderlund
    Department of Medicine, Karolinska Institutet, Stockholm Soder Hospital, Stockholm, Sweden
    Gastroenterology 136:1561-7; quiz 1818-9. 2009
    ..There have been marked changes in the management and treatment of IBD over the past decades, but little is known about how these changes have impacted morbidity and mortality (time trends in risk) of CRC in patients with IBD...
  42. ncbi request reprint Early-life exposures associated with antibiotic use and risk of subsequent Crohn's disease
    Hans Hildebrand
    Department of Women and Child Health, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Scand J Gastroenterol 43:961-6. 2008
    ..The aim of this study was to test the hypothesis that antibiotic therapy between birth and age 5 years may disrupt the pattern of bowel colonization and increase the risk of Crohn's disease...
  43. pmc Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:1414-20. 2005
    ..Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, and maybe also of leukaemia and multiple myeloma. The effect of tumour necrosis factor (TNF) antagonists on lymphoma risk and characteristics is unclear...
  44. ncbi request reprint Women smoking and testicular cancer: one epidemic causing another?
    Andreas Pettersson
    Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 109:941-4. 2004
    ....
  45. pmc Do steroids increase lymphoma risk? A case-control study of lymphoma risk in polymyalgia rheumatica/giant cell arteritis
    J Askling
    Clinical Epidemiology Unit M9 01, Department of Medicine, Karolinska University Hospital Solna, SE 171 77 Stockholm, Sweden
    Ann Rheum Dis 64:1765-8. 2005
    ..Polymyalgia rheumatica (PMR) and temporal arteritis (giant cell arteritis, GCA) are common inflammatory conditions treated with steroids as single immunosuppressive therapy, but data on lymphoma risk in GCA/PMR are limited...
  46. doi request reprint Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006
    M E Holmqvist
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Intern Med 268:578-85. 2010
    ..Few studies have included contemporary patients with RA. We recently reported that the risk of IHD is not elevated before the onset of RA symptoms. However, when, in relation to RA diagnosis, the risk is increased is unknown...
  47. doi request reprint Small-area variations in sales of TNF inhibitors in Sweden between 2000 and 2009
    M Neovius
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm
    Scand J Rheumatol 40:8-15. 2011
    ..To measure small-area variations in sales per capita of tumour necrosis factor (TNF) inhibitors...
  48. doi request reprint Generalisability of clinical registers used for drug safety and comparative effectiveness research: coverage of the Swedish Biologics Register
    M Neovius
    Department of Medicine, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Ann Rheum Dis 70:516-9. 2011
    ..To determine coverage and generalisability of data in the Swedish Biologics Register ARTIS...
  49. doi request reprint Perinatal characteristics, early life infections and later risk of rheumatoid arthritis and juvenile idiopathic arthritis
    C Carlens
    Department of Medicine, Karolinska University Hospital and Institute, Stockholm, Sweden
    Ann Rheum Dis 68:1159-64. 2009
    ..To investigate the importance of birth characteristics and early life infections on the risk of later rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA)...
  50. doi request reprint Autoimmune and inflammatory disorders and risk of malignant lymphomas--an update
    K E Smedby
    Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm, Sweden
    J Intern Med 264:514-27. 2008
    ..Future studies of high-risk patient subsets using detailed assessments of autoimmunity/inflammation and lymphoma may give important clues to lymphomagenesis...
  51. pmc Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonists
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 64:1421-6. 2005
    ..Existing studies of solid cancers in rheumatoid arthritis (RA) reflect cancer morbidity up until the early 1990s in prevalent cohorts admitted to hospital during the 1980s...
  52. ncbi request reprint Maternal breast cancer risk after the death of a child
    Mats Lambe
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 110:763-6. 2004
    ..Based on a small number of subjects, our finding of an increased risk in a subgroup of uniparous women losing their only child could be due to chance...
  53. ncbi request reprint Potential role for the common cystic fibrosis DeltaF508 mutation in Crohn's disease
    Francesca Bresso
    Strategic Research Center IRIS, Karolinska Institutet, Stockholm, Sweden
    Inflamm Bowel Dis 13:531-6. 2007
    ..Given the important biological functions of CFTR in the intestine, we tested whether this mutation is of relevance to IBD...
  54. ncbi request reprint Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis
    Johan Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute Hospital, Stockholm, Sweden
    Gastroenterology 123:1428-35. 2002
    ....
  55. ncbi request reprint Rheumatoid arthritis registries in Sweden
    R F van Vollenhoven
    Rheumatology Unit, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
    Clin Exp Rheumatol 23:S195-200. 2005
    ..Data obtained from analyses based on these registries are reviewed. It is concluded that rheumatology registries are excellent tools for improving our knowledge base regarding rheumatic diseases...
  56. pmc Risk of haematopoietic cancer in patients with inflammatory bowel disease
    J Askling
    Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet and Hospital, SE 171 76 Stockholm, Sweden
    Gut 54:617-22. 2005
    ..Reports also indicate a possible increase in the risk of leukaemia in IBD. We therefore assessed the risk of haematopoietic cancers in a large cohort of patients with IBD. Subjects and..
  57. ncbi request reprint Parental longevity and prognosis in elderly patients with aggressive non-Hodgkin's lymphoma
    Eva Osby
    Division of Hematology, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden
    Acta Oncol 43:297-301. 2004
    ..Maternal and paternal lifespan may predict survival in NHL, but with opposing effects. At present parental age appears not to be a clinically useful predictor of prognosis in the elderly with aggressive NHL...
  58. doi request reprint Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    Cecilia Söderberg
    Department of Medicine, Karolinska Institute, Solna, Stockholm, Sweden
    Hepatology 51:595-602. 2010
    ..69; 95% confidence interval [CI], 1.24-2.25); subjects with bland steatosis, a 55% increase (SMR, 1.55; 95% CI, 0.98-2.32; P = 0.062); and subjects with NASH, 86% (SMR, 1.86; 95% CI, 1.19-2.76; P = 0.007)...
  59. pmc Impact of parental history on patients' cardiovascular mortality in rheumatoid arthritis
    L Björnådal
    Rheumatology Unit, Department of Medicine, Karolinska University Hospital Solna, and Karolinska Institutet, Stockholm, Sweden
    Ann Rheum Dis 65:741-5. 2006
    ..However, little is known about whether or to what extent hereditary factors for CVD contribute additional risk in patients with rheumatoid arthritis...
  60. pmc Risk of non-Hodgkin's lymphoma following tuberculosis
    J Askling
    Department of Medical Epidemiology, Karolinska Institute, Box 281, Stockholm, S 171 77, Sweden
    Br J Cancer 84:113-5. 2001
    ..The overall relative risk was moderately increased, largely accounted for by high risks following severe tuberculosis diagnosed a long time ago...
  61. ncbi request reprint Influenza vaccination and mortality: prospective cohort study of the elderly in a large geographical area
    A Ortqvist
    Department of Communicable Diseases Control and Prevention Smittskyddsenheten, Norrbacka, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Eur Respir J 30:414-22. 2007
    ..Vaccination remains the most important measure for prevention of influenza complications in elderly people, although the effectiveness in reducing all-cause mortality in elderly persons is lower than previously thought...
  62. pmc Long term alcohol intake and risk of rheumatoid arthritis in women: a population based cohort study
    Daniela Di Giuseppe
    Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Box 210, 171 77 Stockholm, Sweden
    BMJ 345:e4230. 2012
    ..To analyse the association between alcohol intake and incidence of rheumatoid arthritis in women...
  63. ncbi request reprint Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives
    Maria Elmberg
    Department of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm, Sweden
    Gastroenterology 125:1733-41. 2003
    ..The risk of cancer in heterozygous individuals (estimated allele frequency, 1/10 to 1/20) is unknown. This study aimed to better assess these risks...
  64. pmc Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001
    H Hildebrand
    Department of Women and Child Health, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Gut 52:1432-4. 2003
    ..An increased incidence of paediatric Crohn's disease was reported recently by our group...
  65. ncbi request reprint Colorectal cancer rates among first-degree relatives of patients with inflammatory bowel disease: a population-based cohort study
    J Askling
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Lancet 357:262-6. 2001
    ..We aimed to assess cancer rates among first-degree relatives of patients with IBD to try to determine whether an association between the two diseases exists...
  66. ncbi request reprint Increased risk for cancer following sarcoidosis
    J Askling
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 160:1668-72. 1999
    ..4; 95% CI 0.8 to 2.2). Thus, sarcoidosis appears to be associated with a significantly increased risk for cancer in affected organs. Chronic inflammation is a putative mediator of this risk...
  67. pmc Malignant lymphomas in coeliac disease: evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma
    K E Smedby
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE 171 77 Stockholm, Sweden
    Gut 54:54-9. 2005
    ..A systematic risk assessment of more prevalent lymphoma entities, such as B cell and non-intestinal lymphomas, in coeliac disease has not been performed...
  68. ncbi request reprint Parental longevity and survival in elderly patients with Hodgkin's lymphoma
    Ola Landgren
    Division of Hematology, Department of Medicine, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Haematologica 87:596-601. 2002
    ..The aim of this study was to test the hypothesis that parental longevity alone--an easily accessible and non-disease associated variable--is also associated with improved outcome using an enlarged series of elderly HL patients...
  69. ncbi request reprint Is history of squamous-cell skin cancer a marker of poor prognosis in patients with cancer?
    J Askling
    Karolinska Institute, Stockholm, Sweden
    Ann Intern Med 131:655-9. 1999
    ..Nonmelanoma skin cancer is associated with increased occurrence of subsequent cancer and death from cancer, but it is not known whether a history of skin cancer is associated with poor prognosis after a second diagnosis of cancer...
  70. pmc Urinary bladder cancer in Wegener's granulomatosis: risks and relation to cyclophosphamide
    A Knight
    Department of Medicine, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Ann Rheum Dis 63:1307-11. 2004
    ..To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis...
  71. ncbi request reprint Appendectomy during childhood and adolescence and the subsequent risk of cancer in Sweden
    Judith U Cope
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892 7244, USA
    Pediatrics 111:1343-50. 2003
    ..In this study, we determined the risks of cancer for people who had appendectomy performed during childhood...
  72. ncbi request reprint Characteristics of diffuse large B cell lymphomas in rheumatoid arthritis
    Eva Baecklund
    Department of Rheumatology, Akademiska Hospital, Uppsala, Sweden
    Arthritis Rheum 54:3774-81. 2006
    ..This study was undertaken to investigate whether RA displays a specific association with any of the DLBCL subtypes...
  73. ncbi request reprint Rheumatoid arthritis and malignant lymphomas
    Eva Baecklund
    Department of Rheumatology, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Curr Opin Rheumatol 16:254-61. 2004
    ..This review summarizes data on possible associations between RA and lymphomas, including different treatments and RA disease related risk factors...
  74. ncbi request reprint Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis
    Eva Baecklund
    Department of Rheumatology, Akademiska Hospital, Uppsala, Sweden
    Arthritis Rheum 54:692-701. 2006
    ..This study was undertaken to investigate which patients are at highest risk, and whether antirheumatic treatment is hazardous or protective...
  75. ncbi request reprint Causes of death in patients with celiac disease in a population-based Swedish cohort
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7273, USA
    Arch Intern Med 163:1566-72. 2003
    ..Patients with celiac disease have an increased risk of death from gastrointestinal malignancies and lymphomas, but little is known about mortality from other causes and few studies have assessed long-term outcomes...
  76. doi request reprint Risks and relative risks of Wegener's granulomatosis among close relatives of patients with the disease
    Ann Knight
    Uppsala University Hospital, Uppsala, Sweden
    Arthritis Rheum 58:302-7. 2008
    ..The aim of this study was to investigate the risk of WG in relatives of patients with WG...
  77. ncbi request reprint Hematopoietic and lymphatic cancers in relatives of patients with infectious mononucleosis
    Henrik Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Natl Cancer Inst 94:678-81. 2002
    ....
  78. doi request reprint Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
    Eva Baecklund
    Department of Rheumatology, University Hospital, Uppsala, Sweden
    Br J Haematol 141:69-72. 2008
    ..This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL...
  79. ncbi request reprint Cancer incidence in a population-based cohort of patients with Wegener's granulomatosis
    Ann Knight
    Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden
    Int J Cancer 100:82-5. 2002
    ..7; 95% CI 2.3-12) and for malignant lymphomas (SIR = 4.2; 95% CI 4.2-8.3). The results confirm previous indications of an increased risk for cancer of the urinary bladder but also points to increased risks for cancer at other sites...
  80. pmc Perinatal characteristics and risk of rheumatoid arthritis
    Lennart T H Jacobsson
    Department of Rheumatology, Malmo University Hospital, Sweden
    BMJ 326:1068-9. 2003
  81. ncbi request reprint Body size at birth and adulthood and the risk for germ-cell testicular cancer
    Lorenzo Richiardi
    Department of Medical Epidemiology and Biostatistics Karolinska Institutet, SE 17177 Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 12:669-73. 2003
    ....
  82. ncbi request reprint Characteristics of Hodgkin's lymphoma after infectious mononucleosis
    Henrik Hjalgrim
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    N Engl J Med 349:1324-32. 2003
    ..Infectious mononucleosis-related Epstein-Barr virus (EBV) infection has been associated with an increased risk of Hodgkin's lymphoma in young adults. Whether the association is causal remains unclear...
  83. ncbi request reprint Increasing incidence of Wegener's granulomatosis in Sweden, 1975-2001
    Ann Knight
    Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden
    J Rheumatol 33:2060-3. 2006
    ..To extend these observations and to include calendar periods before ANCA was introduced, we assessed time trends in the incidence of WG in Sweden in the period 1975-2001...