Affiliation: Karolinska Institutet
Dahlman I, RydÃ©n M, Brodin D, Grallert H, Strawbridge R, Arner P. Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function. Diabetes. 2016;65:433-7 pubmed publisher
..In conclusion, the genetic influence on body fat distribution could be mediated via several specific alterations in adipose tissue morphology and function, which in turn may influence the development of type 2 diabetes. ..
Ryden M, Arner P. Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels. Arterioscler Thromb Vasc Biol. 2017;37:1782-1787 pubmed publisher
..Thus, although several other factors also play a role, subcutaneous adipose tissue may have a causal influence on dyslipidemia. ..
Petrus P, Rosqvist F, Edholm D, Mejhert N, Arner P, Dahlman I, et al
. Saturated fatty acids in human visceral adipose tissue are associated with increased 11- Î²-hydroxysteroid-dehydrogenase type 1 expression. Lipids Health Dis. 2015;14:42 pubmed publisher
..Nutritional regulation of visceral fat mass through HSD11B1 is of interest for the modulation of metabolic risk and warrants further investigation. ..
Arner P, Andersson D, Backdahl J, Dahlman I, Ryden M. Weight Gain and Impaired Glucose Metabolism in Women Are Predicted by Inefficient Subcutaneous Fat Cell Lipolysis. Cell Metab. 2018;28:45-54.e3 pubmed publisher
..Finally, low stimulated lipolysis could be accurately estimated in vivo by simple clinical/biochemical measures and may be used to identify risk individuals for intensified preventive measures. ..
Gao H, Kerr A, Jiao H, Hon C, Ryden M, Dahlman I, et al
. Long Non-Coding RNAs Associated with Metabolic Traits in Human White Adipose Tissue. EBioMedicine. 2018;30:248-260 pubmed publisher
..Altogether, our data demonstrate that lncRNAs are modulators of the metabolic and secretory functions in human fat cells and provide an emerging link between WAT and common metabolic conditions. ..
Gao H, Mejhert N, Fretz J, Arner E, Lorente Cebrián S, Ehrlund A, et al
. Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue. Cell Metab. 2014;19:981-92 pubmed publisher
..We conclude that EBF1 is an important regulator of adipose morphology and fat cell lipolysis and may constitute a link between WAT inflammation, altered lipid metabolism, adipose hypertrophy, and insulin resistance. ..
Hoffstedt J, Andersson D, Eriksson Hogling D, Theorell J, Naslund E, Thorell A, et al
. Long-term Protective Changes in Adipose Tissue After Gastric Bypass. Diabetes Care. 2017;40:77-84 pubmed publisher
..Postoperative beneficial alterations in adipose function may be involved in the diabetes-protective effect of bariatric surgery. ..
Arner P, Stenson B, Dungner E, Naslund E, Hoffstedt J, Ryden M, et al
. Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance. J Clin Endocrinol Metab. 2008;93:2249-54 pubmed publisher
..0006). Human WAT STAMP2 associates with obesity and insulin resistance independently of adiponectin, but the role of STAMP2 in obesity and its complications seems different from that in mice. ..
Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, et al
. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature. 2011;478:110-3 pubmed publisher
..Reduction of both triglyceride storage and removal decreases lipid shunting through adipose tissue and thus promotes dyslipidaemia. We identify adipocyte lipid turnover as a novel target for prevention and treatment of metabolic disease...