E S Arner

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. ncbi Superoxide production by dinitrophenyl-derivatized thioredoxin reductase--a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes
    E S Arner
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Biofactors 10:219-26. 1999
  2. ncbi Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase
    E S Arner
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 225:268-74. 1996
  3. ncbi High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes
    E S Arner
    Karolinska Institutet, Stockholm, S 171 77, Sweden
    J Mol Biol 292:1003-16. 1999
  4. ncbi Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue
    L Zhong
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 273:8581-91. 1998
  5. ncbi The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1, and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene
    A K Rundlöf
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 171 77 Stockholm, Sweden
    J Biol Chem 276:30542-51. 2001
  6. ncbi Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues
    T Spasokoukotskaja
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 31:202-8. 1995
  7. pmc Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5' untranslated region
    A K Rundlöf
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochem J 347:661-8. 2000
  8. ncbi Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
    E S Arner
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Stockholm, Sweden
    Free Radic Biol Med 31:1170-8. 2001
  9. ncbi Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma
    K Pekkari
    Medical Nobel Institute for Biochemistry, Department of Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 275:37474-80. 2000
  10. ncbi Physiological functions of thioredoxin and thioredoxin reductase
    E S Arner
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Eur J Biochem 267:6102-9. 2000

Collaborators

Detail Information

Publications12

  1. ncbi Superoxide production by dinitrophenyl-derivatized thioredoxin reductase--a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes
    E S Arner
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Biofactors 10:219-26. 1999
    ....
  2. ncbi Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase
    E S Arner
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 225:268-74. 1996
    ..Our results suggest that in mammalian cells a significant part of the therapeutically important reduction of lipoic acid is catalyzed by thioredoxin reductase...
  3. ncbi High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes
    E S Arner
    Karolinska Institutet, Stockholm, S 171 77, Sweden
    J Mol Biol 292:1003-16. 1999
    ..These results show that with the strategy utilized here, the capacity of selenoprotein synthesis in E. coli is more than sufficient for making possible the use of the bacteria for production of recombinant selenoproteins...
  4. ncbi Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue
    L Zhong
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 273:8581-91. 1998
    ..This showed that the carboxyl-terminal motif was essential for the catalytic activity of the enzyme...
  5. ncbi The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1, and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene
    A K Rundlöf
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 171 77 Stockholm, Sweden
    J Biol Chem 276:30542-51. 2001
    ..Expression of TrxR1 as an ARE-regulated housekeeping gene agrees with a role for the enzyme to maintain a balance between intracellular signaling via reactive oxygen species and protection of cells from excessive oxidative damage...
  6. ncbi Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues
    T Spasokoukotskaja
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Eur J Cancer 31:202-8. 1995
    ..The phosphorylation of CdA in crude extracts showed a close correlation to the dCK polypeptide level...
  7. pmc Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5' untranslated region
    A K Rundlöf
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Biochem J 347:661-8. 2000
    ..It can therefore be concluded that TrxR1 mRNA is expressed in at least three different variants that differ at their 5' UTRs...
  8. ncbi Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
    E S Arner
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Stockholm, Sweden
    Free Radic Biol Med 31:1170-8. 2001
    ....
  9. ncbi Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma
    K Pekkari
    Medical Nobel Institute for Biochemistry, Department of Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 275:37474-80. 2000
    ..In conclusion, the naturally occurring Trx80 is a novel mitogenic cytokine for normal resting human blood mononuclear cells...
  10. ncbi Physiological functions of thioredoxin and thioredoxin reductase
    E S Arner
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Eur J Biochem 267:6102-9. 2000
    ....
  11. ncbi Mammalian deoxyribonucleoside kinases
    E S Arner
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Sweden
    Pharmacol Ther 67:155-86. 1995
    ..Finally, alternative pathways for nucleoside analogue phosphorylation are surveyed, such as the phosphotransfer capacity of 5'-nucleotidase...
  12. ncbi Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
    J Nordberg
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Free Radic Biol Med 31:1287-312. 2001
    ..Dinitrohalobenzenes constitute a unique class of immunostimulatory TrxR inhibitors and we consider the immunomodulatory effects of dinitrohalobenzene compounds in view of their reactions with the Trx system...