Research Topics
Species | Jan AdolfssonSummaryAffiliation: Karolinska University Hospital Country: Sweden Publications
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Detail Information
Publications
Individualized assessment of prostate cancer riskJan Adolfsson
Karolinska Institute, Stockholm, Sweden
Nat Clin Pract Urol 3:522-3. 2006- The 20-Yr outcome in patients with well- or moderately differentiated clinically localized prostate cancer diagnosed in the pre-PSA era: the prognostic value of tumour ploidy and comorbidityJan Adolfsson
Oncologic Center, CLINTEC, Karolinska Institute, Stockholm, Sweden
Eur Urol 52:1028-35. 2007..This observational cohort study describes the long-term outcome of patients with clinically localized prostate cancer managed with watchful waiting, the prognostic value of tumour ploidy, and the impact of comorbidity... - Commentary: on the incidence of histological prostate cancer and the probable diagnosis of cases with tumours too small to produce symptoms or to attract attention on physical examination--the findings of Dr Arnold Rice RichJan Adolfsson
Oncologic Centre, Karolinska University Hospital, CLINTEC, Karolinska Institute, Stockholm, Sweden
Int J Epidemiol 36:285-7. 2007 - Clinical characteristics and primary treatment of prostate cancer in Sweden between 1996 and 2005Jan Adolfsson
Oncological Centre, Karolinska University Hospital, CLINTEC, Karolinska Institute, Stockholm, Sweden
Scand J Urol Nephrol 41:456-77. 2007..The incidence of prostate cancer is rising rapidly in Sweden and there is a need to better understand the pattern of diagnosis, tumor characteristics and treatment... - Watchful waiting and active surveillance: the current positionJan Adolfsson
Oncological Centre, CLINTEC, Karolinska Institutet, Stockholm, Sweden
BJU Int 102:10-4. 2008 
Differences according to socioeconomic status in the management and mortality in men with high risk prostate cancerAnders Berglund
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Eur J Cancer 48:75-84. 2012..Outcomes for many cancer forms are associated with socioeconomic status (SES).We investigated if SES was associated with management and mortality in men with high risk prostate cancer...- Prostate-specific antigen levels as a predictor of lethal prostate cancerKatja Fall
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S 171 77 Stockholm, Sweden
J Natl Cancer Inst 99:526-32. 2007..Rates of long-term survival among patients with untreated localized prostate cancer are high. To avoid unnecessary treatment, tools are needed to identify the small proportion of patients who are destined to develop lethal prostate cancer... - Prognostic significance of homozygous deletions and multiple duplications at the CDKN2A (p16INK4a)/ARF (p14ARF) locus in urinary bladder cancerPetra J Berggren de Verdier
Clinical Center Epidemiology, Department of Oncology-Pathology, Karolinska University Hospital, Stockholm, Sweden
Scand J Urol Nephrol 40:363-9. 2006..This suggests that multiple duplications, in combination with other genetic changes, have cooperative effects which have a negative outcome on urinary bladder cancer prognosis... - A single-nucleotide polymorphism in the XPG gene, and tumour stage, grade, and clinical course in patients with nonmuscle-invasive neoplasms of the urinary bladderShigeru Sakano
Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
BJU Int 97:847-51. 2006.... - Incidence of fractures causing hospitalisation in prostate cancer patients: results from the population-based PCBaSe SwedenAndreas Thorstenson
Regional Cancer Centre, Karolinska University Hospital, Stockholm, Sweden
Eur J Cancer 48:1672-81. 2012..Data on incidence of fractures and risks in subgroups of men with prostate cancer are sparse. Our aim with this study is to report the risk of fractures among men with prostate cancer in a nationwide population-based study... - A population-based study of 538 patients with newly detected urinary bladder neoplasms followed during 5 yearsPer Larsson
Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
Scand J Urol Nephrol 37:195-201. 2003..In the present series, TaG1 tumours behaved benignly. The disease-specific mortality rate was low for initial TaG2 tumours, intermediate for initial TaG3 and T1 tumours and high for initial T2+ tumours... - Impact of comorbidity on management and mortality in women diagnosed with breast cancerAnders Berglund
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77 Stockholm, Sweden
Breast Cancer Res Treat 135:281-9. 2012..The observed differences in breast cancer-specific mortality may be due to less extensive treatment, impaired tumor defense and differences in general health status and lifestyle factors... - Mortality among men with locally advanced prostate cancer managed with noncurative intent: a nationwide study in PCBaSe SwedenOlof Akre
Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Eur Urol 60:554-63. 2011..There are limited prognostic data for locally advanced prostate cancer PCa to guide in the choice of treatment... - Concordance of tumor differentiation among brothers with prostate cancerK Fredrik Jansson
Urology Unit, Department of Surgery and Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
Eur Urol 62:656-61. 2012..Genetic factors seem to be of greater importance in prostate cancer than in other forms of cancer. Studies have suggested familial concordance in survival, but the extent to which that is due to tumor characteristics is not known... - Y chromosome haplotypes and prostate cancer in SwedenSara Lindstrom
Department of Medical Epidemiology and Biostatistics and Oncologic Center, Karolinska Institutet, Stockholm, Sweden
Clin Cancer Res 14:6712-6. 2008..Certain Y-chromosomal lineages have been suggested to predispose individuals to prostate cancer in the Japanese population; in other ethnic groups, however, the importance of the Y chromosome is poorly understood... - Incidence and prognosis of synchronous and metachronous bilateral breast cancerMikael Hartman
Department of Medical Epidemiology and Biostatistics, Stockholm Söder Hospital and Oncologic Center, CLINTEC, Stockholm, Sweden
J Clin Oncol 25:4210-6. 2007..Little is known, however, about incidence trends and prognostic features of bilateral breast cancer... - Need for and access to bereavement support after loss of a husband to urologic cancers: a nationwide follow-up of Swedish widowsUnnur Valdimarsdottir
Department of Medical Epidemiology and Biostatics, Karolinska Institutet, Stockholm, Sweden
Scand J Urol Nephrol 39:271-6. 2005..We investigated the prevalence and predictors of access to bereavement interventions during the first 6 months after the loss of a husband/male partner to prostate or urinary bladder cancer... - The Nordic Nutrition Recommendations and prostate cancer risk in the Cancer of the Prostate in Sweden (CAPS) studyElisabeth Möller
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden
Public Health Nutr 15:1897-908. 2012..We evaluated adherence to the NNR in relation to prostate cancer (PC) in Swedish men, including potential interaction with a genetic risk score and with lifestyle factors... - Age-specific trends of survival in metastatic breast cancer: 26 years longitudinal data from a population-based cancer registry in Stockholm, SwedenTheodoros Foukakis
Department of Oncology Pathology, Radiumhemmet, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden
Breast Cancer Res Treat 130:553-60. 2011..Treatment advancements in MBC are not reflected by better survival for the whole MBC population. An improvement is only observed after the year 2000 and is restricted to younger patients... - Awareness of husband's impending death from cancer and long-term anxiety in widowhood: a nationwide follow-upUnnur Valdimarsdottir
Unnur Valdimarsdóttir Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
Palliat Med 18:432-43. 2004..We investigated the predictors and long-term consequences of awareness time - the length of time a woman is aware of her husband's impending death from cancer... - The choice between a therapy-induced long-term symptom and shortened survival due to prostate cancerThomas Hopfgarten
Division of Clinical Cancer Epidemiology, Department of Oncology-Pathology, Radiumhemmet, Karolinska Institutet, Stockholm, Sweden
Eur Urol 50:280-9. 2006..Among symptoms, long-term fecal leakage was the one fewest men were willing to accept to gain survival... 
Association of reported prostate cancer risk alleles with PSA levels among men without a diagnosis of prostate cancerFredrik Wiklund
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Prostate 69:419-27. 2009..Prostate specific antigen (PSA) is widely used for prostate cancer screening but its levels are influenced by many non cancer-related factors. The goal of the study is to estimate the effect of genetic variants on PSA levels...- Disseminating evidence from health technology assessment: the case of tobacco preventionSusanna Axelsson
The Swedish Council on Technology Assessment in Health Care, Stockholm, Sweden
Int J Technol Assess Health Care 22:500-5. 2006..The aims of the present study were to investigate the awareness among dentists and dental hygienists of evidence-based reports and guidelines on tobacco cessation activities and the impact these publications had on clinical practice... - Prognosis of patients with breast cancer: causes of death and effects of time since diagnosis, age, and tumor characteristicsEdoardo Colzani
Department of Medical Epidemiology and Biostatistics MEB, Karolinska Institutet, Stockholm, Sweden
J Clin Oncol 29:4014-21. 2011..Because breast cancer-specific deaths decrease with time since diagnosis, it is important to assess the burden of other causes of death in women diagnosed with breast cancer... - Reliability of assessment of urgency and other symptoms indicating anal sphincter, large bowel or urinary dysfunctionMassoud al-Abany
Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
Scand J Urol Nephrol 40:397-408. 2006..This error dilutes assessed associations with, for example, decreased quality of life. Nevertheless, the test-retest reliability for anal sphincter, large bowel and urinary symptoms indicates that surveys yield meaningful information... - Polygenic risk score improves prostate cancer risk prediction: results from the Stockholm-1 cohort studyMarkus Aly
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
Eur Urol 60:21-8. 2011..The low specificity of prostate-specific antigen (PSA) results in diagnostic biopsies in men without prostate cancer (PCa). Additional information, such as genetic markers, could be used to avoid unnecessary biopsies... - Bladder neoplasms--regions at chromosome 9 with putative tumour suppressor genesTakashi Wada
Department of Biosciences at Novum, Karolinska Institute, SE-171 76 Stockholm, Sweden
Scand J Urol Nephrol 37:106-11. 2003..CONCLUSIONS: Our observation of relatively frequent minor LOH at 9p22.1, 9q22.3 and 9q32-33.1 identifies regions within which putative tumour suppressor genes, including the PTCH and the DBCCR1 genes, may reside... - Long-term effects of widowhood after terminal cancer: a Swedish nationwide follow-upUnnur Valdimarsdottir
Department of Clinical Cancer Epidemiology, Institute of Oncology Pathology, Karolinska Institute, Box 4402, 10268 Stockholm, Sweden
Scand J Public Health 31:31-6. 2003..The authors investigated whether becoming a widow after the death of a husband from cancer results in long-term psychological or physical morbidity... - How can we make cancer survival statistics more useful for patients and clinicians: an illustration using localized prostate cancer in SwedenSandra Eloranta
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden
Cancer Causes Control 24:505-15. 2013..In this paper, we discuss the relative merits of recently developed alternatives to traditionally reported measures of cancer patient survival... - The Internet and prostate cancer patients: searching for and finding informationStefan Buntrock
Division of Clinical Cancer Epidemiology, Karolinska Institute, Stockholm, Sweden
Scand J Urol Nephrol 41:367-74. 2007..To define the characteristics of prostate cancer patients who use the Internet... - Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A geneShigeru Sakano
Department of Biosciences, Karolinska Institute, Huddinge, Sweden
Int J Cancer 104:98-103. 2003..Further, the results indicate, a role for the 3' UTR polymorphisms in the CDKN2A gene in tumor invasiveness... - Hip fractures in men with prostate cancer treated with orchiectomyPaul W Dickman
Department of Oncology, Karolinska Institutet, Stockholm, Sweden
J Urol 172:2208-12. 2004..Data directly addressing the long-term fracture risk in men diagnosed with prostate cancer are limited... - Alcohol influence on acrylamide to glycidamide metabolism assessed with hemoglobin-adducts and questionnaire dataAnna C Vikström
Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden
Food Chem Toxicol 48:820-4. 2010.... - Placental weight and mortality in premenopausal breast cancer by tumor characteristicsMohammad Hossein Hajiebrahimi
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden
Breast Cancer Res Treat 137:297-305. 2013..The increased mortality risk in premenopausal breast cancer associated with higher placental weight was most pronounced among ER(-) and PR(-) tumors... - Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphismMaria Hedelin
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
Int J Cancer 120:398-405. 2007..Frequent consumption of fatty fish and marine fatty acids appears to reduce the risk of prostate cancer, and this association is modified by genetic variation in the COX-2 gene... - Health-related quality-of-life assessments in patients with advanced cancer of the prostateJan Adolfsson
Center for Surgical Sciences, Karolinska Institute, Stockholm, Sweden
Pharmacoeconomics 21:241-7. 2003..Also, we need an increased understanding of the mechanisms behind patients' trade-offs and of how information should be communicated to patients in order to give the best possibilities for making informed treatment decisions... - Prostate-specific antigen (PSA) testing is prevalent and increasing in Stockholm County, Sweden, Despite no recommendations for PSA screening: results from a population-based study, 2003-2011Tobias Nordström
Department of Clinical Sciences at Danderyds Hospital, Karolinska Institutet, Stockholm, Sweden
Eur Urol 63:419-25. 2013..Prostate-specific antigen (PSA) testing has increased in several countries. There is incomplete knowledge of PSA testing patterns... - Tobacco prevention in Swedish dental careAsgeir R Helgason
Stockholm Center of Public Health, Center for Tobacco Prevention, Karolinska Institute, Stockholm, Sweden
Community Dent Oral Epidemiol 31:378-85. 2003..To assess tobacco prevention in Swedish dental care and to identify barriers. Also, to investigate whether dentists and dental hygienists were familiar with recently published review of smoking cessation methods... - Reductions in use of hormone replacement therapy: effects on Swedish breast cancer incidence trends only seen after several yearsMats Lambe
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77 Stockholm, Sweden
Breast Cancer Res Treat 121:679-83. 2010..The present findings give further support to the notion that HRT use is a driver of breast cancer incidence trends on the population level... - A hierarchical step-model for causation of bias-evaluating cancer treatment with epidemiological methodsGunnar Steineck
Division of Clinical Cancer Epidemiology, Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
Acta Oncol 45:421-9. 2006..Acceptance of this model has implications for ascertaining the degree to which a study effectively evaluates the effects of cancer treatment (level of scientific evidence)... - Quality of life after radical prostatectomy or watchful waitingGunnar Steineck
Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
N Engl J Med 347:790-6. 2002..We evaluated symptoms and self-assessments of quality of life in men with localized prostate cancer who participated in a randomized comparison between radical prostatectomy and watchful waiting... - The National Prostate Cancer Register in Sweden 1998-2002: trends in incidence, treatment and survivalEberhard Varenhorst
Department of Urology, Faculty of Health Sciences, University Hospital Linkoping, Linkoping, Sweden
Scand J Urol Nephrol 39:117-23. 2005..To provide a descriptive review of the establishment of the National Prostate Cancer Register (NPCR) in Sweden, to present clinical characteristics at diagnosis and to calculate the relative survival of different risk groups after 5 years... - Economic conditions and marriage quality of men with prostate cancerLizzy Sunny
Division of Clinical Cancer Epidemiology, Department of Oncology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
BJU Int 99:1391-7. 2007.... - Interleukin-6 sequence variants are not associated with prostate cancer riskJielin Sun
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Cancer Epidemiol Biomarkers Prev 13:1677-9. 2004 - Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer developmentSara Lindstrom
Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
Cancer Res 66:11077-83. 2006..Carriers of five high-risk alleles in the AR, CYP17, and SRD5A2 genes are at approximately 2-fold excess risk to develop prostate cancer... - Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancerFredrik Wiklund
Department of Radiation Sciences, Oncology, and Medical Biosciences, Pathology, University of Umea, Umea, Sweden
Clin Cancer Res 10:7150-6. 2004..To additionally evaluate the possible role of RNASEL in susceptibility to prostate cancer risk, we performed a comprehensive genetic analysis of sequence variants in RNASEL in the Swedish population... - Predictors for the symptomatic prostate cancer patient's delays in seeking careLizzy Sunny
Division of Clinical Cancer Epidemiology, Department of Oncology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
Eur J Cancer 44:733-9. 2008..This study aims to determine the predictors for the symptomatic prostate cancer patient's delays in seeking care... - The management of category T1a-T1b (incidental) prostate cancer: can we predict who needs treatment?Jan Adolfsson
Eur Urol 54:16-8. 2008 - Systematic replication study of reported genetic associations in prostate cancer: Strong support for genetic variation in the androgen pathwaySara Lindstrom
Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
Prostate 66:1729-43. 2006..Despite considerable efforts and initial promising findings, the field of prostate cancer genetics is characterized by inconclusive reports and no prostate cancer gene has yet been established... - Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12Jielin Sun
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Nat Genet 40:1153-5. 2008..7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP... - Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNPSara Lindstrom
Department of Radiation Sciences, Oncology, University of Umea, 901 87, Umea, Sweden
Hum Genet 118:339-47. 2005..Due to the difficulties in replication of genetic association studies, this finding is unusual and novel...