Dan Hultmark

Summary

Country: Sweden

Publications

  1. ncbi request reprint Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    Kwang Min Choe
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 296:359-62. 2002
  2. pmc Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    EMBO J 24:3423-34. 2005
  3. ncbi request reprint Rac1 signalling in the Drosophila larval cellular immune response
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 119:2015-24. 2006
  4. pmc Comparative genomic analysis of the Tribolium immune system
    Zhen Zou
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Genome Biol 8:R177. 2007
  5. ncbi request reprint Drosophila immunity: is antigen processing the first step?
    Dan Hultmark
    Umea Centre for Molecular Pathogenesis, By 6L, Umea University, S 901 87 Umea, Sweden
    Curr Biol 17:R22-4. 2007
  6. ncbi request reprint Drosophila immunity: paths and patterns
    Dan Hultmark
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Curr Opin Immunol 15:12-9. 2003
  7. doi request reprint The N-terminal half of the Drosophila Rel/NF-kappaB factor Relish, REL-68, constitutively activates transcription of specific Relish target genes
    Magda Lena Wiklund
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, Sweden
    Dev Comp Immunol 33:690-6. 2009
  8. ncbi request reprint Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 120:502-11. 2007
  9. pmc A directed screen for genes involved in Drosophila blood cell activation
    Carl Johan Zettervall
    Umea Centre for Molecular Pathogenesis, Byggnad 6L, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:14192-7. 2004
  10. pmc Uptake of aggregating transthyretin by fat body in a Drosophila model for TTR-associated amyloidosis
    Malgorzata Pokrzywa
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 5:e14343. 2010

Detail Information

Publications28

  1. ncbi request reprint Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    Kwang Min Choe
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 296:359-62. 2002
    ....
  2. pmc Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    EMBO J 24:3423-34. 2005
    ..Our results show that an RNAi-based approach is suitable to identify genes in conserved signaling cascades...
  3. ncbi request reprint Rac1 signalling in the Drosophila larval cellular immune response
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 119:2015-24. 2006
    ..From these data we conclude that Rac1 induces Bsk activity and stable actin formation for cellular immune activation, leading to sessile hemocyte release and an increase in the number of circulating hemocytes...
  4. pmc Comparative genomic analysis of the Tribolium immune system
    Zhen Zou
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Genome Biol 8:R177. 2007
    ..We have annotated immunity-related genes and compared them with homologous molecules from other species...
  5. ncbi request reprint Drosophila immunity: is antigen processing the first step?
    Dan Hultmark
    Umea Centre for Molecular Pathogenesis, By 6L, Umea University, S 901 87 Umea, Sweden
    Curr Biol 17:R22-4. 2007
    ..A new genetic study has shown that the phagocytic ability of Drosophila blood cells, the hemocytes, may be important for the further induction of an antibacterial response in other tissues...
  6. ncbi request reprint Drosophila immunity: paths and patterns
    Dan Hultmark
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Curr Opin Immunol 15:12-9. 2003
  7. doi request reprint The N-terminal half of the Drosophila Rel/NF-kappaB factor Relish, REL-68, constitutively activates transcription of specific Relish target genes
    Magda Lena Wiklund
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, Sweden
    Dev Comp Immunol 33:690-6. 2009
    ..Instead, we propose that the C-terminal IkappaB-like domain executes a scaffolding and recruiting function for full activation of Relish...
  8. ncbi request reprint Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells
    Michael J Williams
    Umeå Centre for Molecular Pathogenesis UCMP, Umea University, S 901 87, Umea, Sweden
    J Cell Sci 120:502-11. 2007
    ..Finally, though dominant negative Rac1 is able to block filopodia formation in the overexpression experiments, only Rac2 is necessary for filopodia formed by hemocytes after parasitization...
  9. pmc A directed screen for genes involved in Drosophila blood cell activation
    Carl Johan Zettervall
    Umea Centre for Molecular Pathogenesis, Byggnad 6L, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 101:14192-7. 2004
    ..We conclude that the activation of a cellular response is complex and affected by multiple signaling pathways...
  10. pmc Uptake of aggregating transthyretin by fat body in a Drosophila model for TTR-associated amyloidosis
    Malgorzata Pokrzywa
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 5:e14343. 2010
    ..Remarkably, the severity of the phenotype was greater in flies that expressed a single copy than with two copies of the mutated gene...
  11. ncbi request reprint Drosophila melanogaster Rac2 is necessary for a proper cellular immune response
    Michael J Williams
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Genes Cells 10:813-23. 2005
    ..Finally, larger cells known as lamellocytes attach to the capsule but also fail to spread, and there is a lack of melanization. From these results it appears that Rac2 is necessary for the larval cellular immune response...
  12. ncbi request reprint A cytokine in the Drosophila stress response
    Dan Hultmark
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87, Umea, Sweden
    Dev Cell 5:360-1. 2003
    ..However, in this issue of Developmental Cell, show that cytokines do play a role in mediating an acute phase response in this organism...
  13. ncbi request reprint Misfolded transthyretin causes behavioral changes in a Drosophila model for transthyretin-associated amyloidosis
    Malgorzata Pokrzywa
    Department of Molecular Biology, Umea University, Umeå S 901 87, Sweden
    Eur J Neurosci 26:913-24. 2007
    ..These results suggest that Drosophila can be used as a disease-model to study TTR amyloid formation, and to screen for pharmacological agents and modifying genes...
  14. doi request reprint The Drosophila Nora virus is an enteric virus, transmitted via feces
    Mazen S Habayeb
    Department of Molecular Biology, By 6L, Umea University, S 90187 Umea, Sweden
    J Invertebr Pathol 101:29-33. 2009
    ..The Nora virus infection has a very mild effect on the longevity of the flies, and no significant effect on the number of eggs laid and the percent of eggs that develop to adults...
  15. pmc Nora virus persistent infections are not affected by the RNAi machinery
    Mazen S Habayeb
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS ONE 4:e5731. 2009
    ..Nora virus infections are also unaffected by mutations in the Toll and Jak-Stat pathways. In these respects, the Nora virus differs from other studied Drosophila RNA viruses...
  16. doi request reprint Drosophila Nora virus capsid proteins differ from those of other picorna-like viruses
    Jens Ola Ekström
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    Virus Res 160:51-8. 2011
    ..This opens a possibility that VP4C is produced in non-equimolar quantities. Altogether, our results suggest that the Nora virus capsid has a different protein organization compared to the order Picornavirales...
  17. ncbi request reprint Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycan
    Thomas Werner
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    J Biol Chem 278:26319-22. 2003
    ..Two additional PGRP domains in the gene cluster, z and w, are both included in a single transcript of a separate gene, PGRP-LF. Suppression of this transcript does not block the response to any of the microorganisms tested...
  18. ncbi request reprint Nora virus, a persistent virus in Drosophila, defines a new picorna-like virus family
    Mazen S Habayeb
    Umea Centre for Molecular Pathogenesis, By 6L, Umea University, S 901 87 Umea, Sweden
    J Gen Virol 87:3045-51. 2006
    ..melanogaster, but not in more distantly related Drosophila species. It will now be possible to use Drosophila genetics to study the factors that control this persistent infection...
  19. ncbi request reprint The Drosophila NFAT homolog is involved in salt stress tolerance
    Pia Keyser
    Umea Centre for Molecular Pathogenesis, By 6L, Umea University, S 901 87 Umea, Sweden
    Insect Biochem Mol Biol 37:356-62. 2007
    ..A phylogenetic reconstruction puts the Drosophila gene near the root of the NFAT tree, indicating that regulation of tonicity may be an ancestral function of the NFAT family...
  20. pmc Caspase-mediated processing of the Drosophila NF-kappaB factor Relish
    Svenja Stoven
    Umea Centre for Molecular Pathogenesis, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 100:5991-6. 2003
    ..Finally, an N-terminal serine-rich region in Relish and the PEST domain were found to negatively regulate Relish activation...
  21. pmc Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila
    Eva Kurucz
    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, P O Box 521, H 6701 Szeged, Hungary Umeå Centre for Molecular Pathogenesis, By 6L, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 100:2622-7. 2003
    ..This finding indicates that Hemese plays a modulatory role in the activation or recruitment of the hemocytes...
  22. ncbi request reprint A rapid rosetting method for separation of hemocyte sub-populations of Drosophila melanogaster
    Peter Vilmos
    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, H 6701 Szeged, P O Box 521, Hungary
    Dev Comp Immunol 28:555-63. 2004
    ..The method can be used for functional and molecular characterisation of hemocyte sub-populations. The procedure is sensitive, reproducible and easy to perform...
  23. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  24. ncbi request reprint Dynamic evolution of the innate immune system in Drosophila
    Timothy B Sackton
    Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Nat Genet 39:1461-8. 2007
    ....
  25. ncbi request reprint Expression pattern of Filamin-240 in Drosophila blood cells
    Florentina Rus
    Biological Research Center of the Hungarian Academy of Sciences, H 6726 Szeged, Temesvari krt 62, Hungary
    Gene Expr Patterns 6:928-34. 2006
    ..These data demonstrate that the expression of Filamin-240 is strictly lamellocyte specific in Drosophila blood cells and that the protein is a suppressor of lamellocyte development...
  26. ncbi request reprint Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes
    Eva Kurucz
    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, H 6701 Szeged, Hungary
    Curr Biol 17:649-54. 2007
    ..melanogaster and CED-1 from C. elegans. Together, they form a superfamily that also includes proteins that are encoded in the human genome...
  27. ncbi request reprint Pirk is a negative regulator of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Finland
    J Immunol 180:5413-22. 2008
    ..Furthermore, pirk-overexpressing flies were more susceptible to Gram-negative bacterial infection than wild-type flies. We conclude that Pirk is a negative regulator of the Imd pathway...
  28. doi request reprint The genome of the model beetle and pest Tribolium castaneum
    Stephen Richards
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 452:949-55. 2008
    ..Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control...