Per Holmfeldt

Summary

Country: Sweden

Publications

  1. ncbi The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 is a membrane-binding protein that lacks the proposed microtubule-regulatory activity
    Per Holmfeldt
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biochem Parasitol 156:225-34. 2007
  2. pmc Interphase-specific phosphorylation-mediated regulation of tubulin dimer partitioning in human cells
    Per Holmfeldt
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 18:1909-17. 2007
  3. doi Predominant regulators of tubulin monomer-polymer partitioning and their implication for cell polarization
    Per Holmfeldt
    Department of Molecular Biology, University of Umea, Umea, Sweden
    Cell Mol Life Sci 66:3263-76. 2009
  4. pmc Deciphering the cellular functions of the Op18/Stathmin family of microtubule-regulators by plasma membrane-targeted localization
    Per Holmfeldt
    Department of Molecular Biology University of Umeå, SE 901 87 Umea, Sweden
    Mol Biol Cell 14:3716-29. 2003
  5. ncbi Interphase and monoastral-mitotic phenotypes of overexpressed MAP4 are modulated by free tubulin concentrations
    Per Holmfeldt
    Department of Molecular Biology, University of Umea, S 901 87 Umea, Sweden
    J Cell Sci 116:3701-11. 2003
  6. doi Op18/Stathmin counteracts the activity of overexpressed tubulin-disrupting proteins in a human leukemia cell line
    Mikael E Sellin
    Department of Molecular Biology, Umea University, Umea, Sweden
    Exp Cell Res 314:1367-77. 2008
  7. pmc Global regulation of the interphase microtubule system by abundantly expressed Op18/stathmin
    Mikael E Sellin
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 19:2897-906. 2008
  8. pmc Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells
    Per Holmfeldt
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 17:2921-30. 2006
  9. doi Upregulated Op18/stathmin activity causes chromosomal instability through a mechanism that evades the spindle assembly checkpoint
    Per Holmfeldt
    Department of Molecular Biology, Umea University, Umea, Sweden
    Exp Cell Res 316:2017-26. 2010
  10. pmc Microtubules support a disk-like septin arrangement at the plasma membrane of mammalian cells
    Mikael E Sellin
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 22:4588-601. 2011

Collaborators

Detail Information

Publications17

  1. ncbi The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 is a membrane-binding protein that lacks the proposed microtubule-regulatory activity
    Per Holmfeldt
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biochem Parasitol 156:225-34. 2007
    ....
  2. pmc Interphase-specific phosphorylation-mediated regulation of tubulin dimer partitioning in human cells
    Per Holmfeldt
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 18:1909-17. 2007
    ....
  3. doi Predominant regulators of tubulin monomer-polymer partitioning and their implication for cell polarization
    Per Holmfeldt
    Department of Molecular Biology, University of Umea, Umea, Sweden
    Cell Mol Life Sci 66:3263-76. 2009
    ..Finally, we discuss evidence indicating that partitioning regulation by MAP4 and Op18 may be of significance to establish cell polarity...
  4. pmc Deciphering the cellular functions of the Op18/Stathmin family of microtubule-regulators by plasma membrane-targeted localization
    Per Holmfeldt
    Department of Molecular Biology University of Umeå, SE 901 87 Umea, Sweden
    Mol Biol Cell 14:3716-29. 2003
    ....
  5. ncbi Interphase and monoastral-mitotic phenotypes of overexpressed MAP4 are modulated by free tubulin concentrations
    Per Holmfeldt
    Department of Molecular Biology, University of Umea, S 901 87 Umea, Sweden
    J Cell Sci 116:3701-11. 2003
    ..This chimera likewise suppressed the monoastral phenotype caused by overexpression of MAP4, suggesting a direct downregulation of MAP4 activity by reduced free tubulin concentrations...
  6. doi Op18/Stathmin counteracts the activity of overexpressed tubulin-disrupting proteins in a human leukemia cell line
    Mikael E Sellin
    Department of Molecular Biology, Umea University, Umea, Sweden
    Exp Cell Res 314:1367-77. 2008
    ..Hence, the present study reveals that Op18 at physiologically relevant levels functions to preserve the integrity of tubulin heterodimers, which may serve to regulate tubulin turnover rates...
  7. pmc Global regulation of the interphase microtubule system by abundantly expressed Op18/stathmin
    Mikael E Sellin
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 19:2897-906. 2008
    ..This, combined with potent regulation of tubulin monomer-polymer partitioning, enables Op18 to exert global regulation of the microtubule system...
  8. pmc Aneugenic activity of Op18/stathmin is potentiated by the somatic Q18-->e mutation in leukemic cells
    Per Holmfeldt
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 17:2921-30. 2006
    ..Thus, although Op18 is dispensable for mitosis, the hyperactive Q18-->E mutant, or overexpressed wild-type Op18, exerts aneugenic effects that are likely to contribute to chromosomal instability in tumors...
  9. doi Upregulated Op18/stathmin activity causes chromosomal instability through a mechanism that evades the spindle assembly checkpoint
    Per Holmfeldt
    Department of Molecular Biology, Umea University, Umea, Sweden
    Exp Cell Res 316:2017-26. 2010
    ..Similar to uncorrected merotelic attachment, this mechanism evades detection by the spindle assembly checkpoint and thus provides an additional route to chromosomal instability...
  10. pmc Microtubules support a disk-like septin arrangement at the plasma membrane of mammalian cells
    Mikael E Sellin
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 22:4588-601. 2011
    ..The combined data point to a mechanism by which densely arranged cortical microtubules, which are typical for nonadhered spherical cells, support plasma membrane-bound, disk-like septin assemblies...
  11. pmc Differential functional interplay of TOGp/XMAP215 and the KinI kinesin MCAK during interphase and mitosis
    Per Holmfeldt
    Department of Molecular Biology, Umea University, Sweden
    EMBO J 23:627-37. 2004
    ..We hypothesize that TOGp-dependent prevention of MCAK-mediated spindle disorganization, as evidenced by depletion experiments, reflects a primary physiological role for TOGp in human somatic cells...
  12. pmc The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 assembles into a nine-subunit oligomer with potential To inhibit Toll-like receptor signaling
    Kristoffer Brannstrom
    Department of Molecular Biology, Umea University, Umea, Sweden
    Infect Immun 77:1144-54. 2009
    ..Since Sm16 specifically inhibits the degradation of the IRAK1 signaling protein in LPS-stimulated monocytes, our findings indicate that inhibition is exerted proximal to the TLR complex...
  13. ncbi Autonomous and phosphorylation-responsive microtubule-regulating activities of the N-terminus of Op18/stathmin
    Bo Segerman
    Department of Molecular Biology, Umea University, Sweden
    J Cell Sci 116:197-205. 2003
    ..These results demonstrate that the N-terminus of Op18 has autonomous activity. Evidently, this activity is enhanced by the increase in tubulin affinity that is provided by the extended alpha-helical portion of native Op18...
  14. pmc CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation
    Per Holmfeldt
    Department of Molecular Biology, Umea University, Umea, Sweden
    EMBO J 24:1256-66. 2005
    ..These two mechanisms, involving CaMKIIgamma and TOGp, respectively, are both essential for spindle bipolarity in a normal physiological context, but not in MCAK-depleted cells...
  15. ncbi Microtubule-dependent regulation of Rho GTPases during internalisation of Yersinia pseudotuberculosis
    Karen McGee
    Department of Molecular Biology, Umea University, 901 87, Umea, Sweden
    FEBS Lett 533:35-41. 2003
    ....
  16. ncbi MAP4 counteracts microtubule catastrophe promotion but not tubulin-sequestering activity in intact cells
    Per Holmfeldt
    Department of Molecular Biology, Umea University, Sweden
    Curr Biol 12:1034-9. 2002
    ..These observations reveal specificity in the microtubule-stabilizing activity of MAP4 that differentiates between two mechanistically distinct types of MT destabilization...
  17. doi Metabolism-dependent taxis towards (methyl)phenols is coupled through the most abundant of three polar localized Aer-like proteins of Pseudomonas putida
    Inga Sarand
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Environ Microbiol 10:1320-34. 2008
    ..The results are discussed in the context of the versatility of metabolism-dependent coupling and the necessity for P. putida to integrate diverse metabolic signals from its native heterogeneous soil and water environments...