Camilla Hollander

Summary

Country: Sweden

Publications

  1. ncbi request reprint Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells
    Yong Xin Sun
    Department of Medicine, Wallenberg Laboratory, University Hospital Malmo, S 20502 Malmo, Sweden
    J Neurosci Res 67:511-22. 2002
  2. ncbi request reprint Differential detection of PAS-positive inclusions formed by the Z, Siiyama, and Mmalton variants of alpha1-antitrypsin
    Sabina Janciauskiene
    Department of Medicine, University Hospital Malmo, Malmo, Sweden
    Hepatology 40:1203-10. 2004
  3. ncbi request reprint Do native and polymeric alpha1-antitrypsin activate human neutrophils in vitro?
    Caroline Persson
    Department of Clinical Sciences, Wallenberg Laboratory, University Hospital Malmo, S 20502 Malmo, Sweden
    Chest 129:1683-92. 2006
  4. pmc Human mast cells decrease SLPI levels in type II - like alveolar cell model, in vitro
    Camilla Hollander
    Department of Medicine, University of Lund, SE 205 02 Malm, Sweden
    Cancer Cell Int 3:14. 2003
  5. pmc Circulating monocytes from healthy individuals and COPD patients
    Ruta Aldonyte
    Department of Internal Medicine, University Hospital Malmo, Sweden
    Respir Res 4:11. 2003
  6. pmc Concentration-dependent effects of native and polymerised alpha1-antitrypsin on primary human monocytes, in vitro
    Ruta Aldonyte
    Department of Internal Medicine, Wallenberg Laboratory, Malmo, Sweden
    BMC Cell Biol 5:11. 2004
  7. ncbi request reprint Detection of circulating and endothelial cell polymers of Z and wild type alpha 1-antitrypsin by a monoclonal antibody
    Sabina Janciauskiene
    Department of Internal Medicine, University Hospital, Malmo, 20502 Malmo, Sweden
    J Biol Chem 277:26540-6. 2002
  8. ncbi request reprint Divergent effects of alpha1-antitrypsin on neutrophil activation, in vitro
    Sabina Janciauskiene
    Department of Medicine, University Hospital Malmo, Malmo, S 20502, Sweden
    Biochem Biophys Res Commun 315:288-96. 2004
  9. ncbi request reprint Inhibition of lipopolysaccharide-mediated human monocyte activation, in vitro, by alpha1-antitrypsin
    Sabina Janciauskiene
    Department of Medicine, Malmo University Hospital, 20502 Malmo, Sweden
    Biochem Biophys Res Commun 321:592-600. 2004
  10. ncbi request reprint C-terminal fragment of alpha1-antitrypsin activates human monocytes to a pro-inflammatory state through interactions with the CD36 scavenger receptor and LDL receptor
    S Janciauskiene
    Gastroenterology Hepatology Section, Department of Medicine, University Hospital Malmo, 20502 Malmo, Sweden
    Atherosclerosis 158:41-51. 2001

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells
    Yong Xin Sun
    Department of Medicine, Wallenberg Laboratory, University Hospital Malmo, S 20502 Malmo, Sweden
    J Neurosci Res 67:511-22. 2002
    ....
  2. ncbi request reprint Differential detection of PAS-positive inclusions formed by the Z, Siiyama, and Mmalton variants of alpha1-antitrypsin
    Sabina Janciauskiene
    Department of Medicine, University Hospital Malmo, Malmo, Sweden
    Hepatology 40:1203-10. 2004
    ..In conclusion, the ATZ11 monoclonal antibody detects Z alpha(1)-antitrypsin in hepatic inclusions by detecting a neoepitope that is specific to the polymeric conformer and that is localized close to residue 342...
  3. ncbi request reprint Do native and polymeric alpha1-antitrypsin activate human neutrophils in vitro?
    Caroline Persson
    Department of Clinical Sciences, Wallenberg Laboratory, University Hospital Malmo, S 20502 Malmo, Sweden
    Chest 129:1683-92. 2006
    ..The discrepancies between these observations prompted us to re-examine the effects of AAT...
  4. pmc Human mast cells decrease SLPI levels in type II - like alveolar cell model, in vitro
    Camilla Hollander
    Department of Medicine, University of Lund, SE 205 02 Malm, Sweden
    Cancer Cell Int 3:14. 2003
    ..Therefore, a "local relationship" between mast cells and airway epithelial cells might be an important step in the inflammatory response...
  5. pmc Circulating monocytes from healthy individuals and COPD patients
    Ruta Aldonyte
    Department of Internal Medicine, University Hospital Malmo, Sweden
    Respir Res 4:11. 2003
    ..The only known genetic factor related to COPD is inherited PiZZ deficiency of alpha1-antitrypsin (AAT), an inhibitor of serine proteases...
  6. pmc Concentration-dependent effects of native and polymerised alpha1-antitrypsin on primary human monocytes, in vitro
    Ruta Aldonyte
    Department of Internal Medicine, Wallenberg Laboratory, Malmo, Sweden
    BMC Cell Biol 5:11. 2004
    ..01, 0.02, 0.05, 0.1, 0.5 and 1 mg/ml for 18 h, and analysed to determine the release of cytokines and to detect the activity of NF-kappaB...
  7. ncbi request reprint Detection of circulating and endothelial cell polymers of Z and wild type alpha 1-antitrypsin by a monoclonal antibody
    Sabina Janciauskiene
    Department of Internal Medicine, University Hospital, Malmo, 20502 Malmo, Sweden
    J Biol Chem 277:26540-6. 2002
    ..The antibody can be a powerful tool for the study of the molecular profile of AAT, not only in Z-deficiency cases but also in other (patho)physiological conditions...
  8. ncbi request reprint Divergent effects of alpha1-antitrypsin on neutrophil activation, in vitro
    Sabina Janciauskiene
    Department of Medicine, University Hospital Malmo, Malmo, S 20502, Sweden
    Biochem Biophys Res Commun 315:288-96. 2004
    ..These results suggest that cleavage of AAT may not only abolish its proteinase inhibitor activity, but can also generate a powerful pro-inflammatory activator for human neutrophils...
  9. ncbi request reprint Inhibition of lipopolysaccharide-mediated human monocyte activation, in vitro, by alpha1-antitrypsin
    Sabina Janciauskiene
    Department of Medicine, Malmo University Hospital, 20502 Malmo, Sweden
    Biochem Biophys Res Commun 321:592-600. 2004
    ..Thus, our data demonstrate for the first time that AAT exhibits anti-inflammatory activity in vitro that is unrelated to inhibition of serine proteases...
  10. ncbi request reprint C-terminal fragment of alpha1-antitrypsin activates human monocytes to a pro-inflammatory state through interactions with the CD36 scavenger receptor and LDL receptor
    S Janciauskiene
    Gastroenterology Hepatology Section, Department of Medicine, University Hospital Malmo, 20502 Malmo, Sweden
    Atherosclerosis 158:41-51. 2001
    ..This also supports important roles for CD36 and LDL receptors in atherogenesis and suggests that blockade of CD36 receptor can be protective in pro-inflammatory activation of human monocytes...
  11. ncbi request reprint Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles
    S Janciauskiene
    Department of Medicine, Wallenberg Laboratory, Ing 46, Malmo University Hospital, S 20502, Malmo, Sweden
    Biochim Biophys Acta 1535:221-35. 2001
    ..Elucidation of the biological activities of non-inhibitory forms of serpins may provide useful insights into the pathogenesis of diseases and suggest new therapeutic strategies...
  12. ncbi request reprint Secreted leukocyte protease inhibitor is present in aqueous humours from cataracts and other eye pathologies
    Sabina Janciauskiene
    Department of Clinical Sciences, Wallenberg Laboratory, Ing 46, plan 2, University Hospital Malmo, S 20502 Malmo, Sweden
    Exp Eye Res 82:505-11. 2006
    ..05). We show here for the first time that SLPI is present in AH and may play a role as well as serve as a marker in pathological states...
  13. ncbi request reprint Fibrillar Alzheimer's amyloid peptide Abeta(1-42) stimulates low density lipoprotein binding and cell association, free radical production and cell cytotoxicity in PC12 cells
    S Janciauskiene
    Gastroenterology Hepatology Division, Department of Medicine, University Hospital, Malmo, Sweden
    Neuropeptides 33:510-6. 1999
    ....
  14. ncbi request reprint Atherogenic properties of human monocytes induced by the carboxyl terminal proteolytic fragment of alpha-1-antitrypsin
    S Janciauskiene
    Gastroenterology Hepatology Division, Department of Medicine, Wallenberg Laboratory, University Hospital Malmo, S 20502, Malmo, Sweden
    Atherosclerosis 147:263-75. 1999
    ..This may be important for an understanding of the events conducive to atherogenesis...
  15. ncbi request reprint The C-terminal peptide of alpha-1-antitrypsin increases low density lipoprotein binding in HepG2 cells
    S Janciauskiene
    Department of Medicine, Lund University Hospital, Malmo, Sweden
    Eur J Biochem 254:460-7. 1998
    ..We conclude that interaction of AAT-(358-394)-peptide fibrils with cell surface receptor(s) disturbs intracellular cholesterol homeostasis and induces cell death...
  16. ncbi request reprint Effects of fibrillar C-terminal fragment of cleaved alpha1-antitrypsin on cholesterol homeostasis in HepG2 cells
    S Janciauskiene
    Gastroenterology Hepatology Division, Department of Medicine, University Hospital, Malmo, Sweden
    Hepatology 29:434-42. 1999
    ....
  17. ncbi request reprint Pravastatin down-regulates inflammatory mediators in human monocytes in vitro
    O Grip
    Department of Medicine, Division of Gastroenterology and Hepatology, Lund University, University Hospital MAS, S 20502, Malmo, Sweden
    Eur J Pharmacol 410:83-92. 2000
    ..4- to 5.5-fold. These data extend the findings of potential anti-inflammatory actions of statins and also suggest the possibility for pravastatin use in a broader spectrum of inflammatory situations...
  18. ncbi request reprint Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin, and their mixture
    Y X Sun
    Department of Medicine, Wallenberg Laboratory, Ing 46, UMAS, S 20502, Malmo, Sweden
    Cell Mol Life Sci 59:1734-43. 2002
    ..These data suggest a possible new role for Abeta in Alzheimer's disease through its interaction with the inflammatory reactant, ACT...
  19. ncbi request reprint Effects of differently oxidized LDL on the expression of pro-inflammatory molecules in human monocytes in vitro
    R Dominaitiene
    Department of Medicine, , , Sweden
    In Vitr Mol Toxicol 14:83-97. 2001
    ..In contrast to native and enzymatically ox LDL, copper ox LDL does not induce intracellular lipid accumulation. Differently oxidized LDL molecules may exert distinct effects in lesion development in atherosclerosis...
  20. ncbi request reprint Human monocyte activation by cleaved form of alpha-1-antitrypsin involvement of the phagocytic pathway
    S Janciauskiene
    Gastroenterology Hepatology Section, Department of Medicine, University Hospital Malmo, Sweden
    Eur J Biochem 265:875-82. 1999
    ....
  21. ncbi request reprint Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease
    Yong Xin Sun
    Department of Medicine, Malmo University Hospital, Malmo, Sweden
    Dement Geriatr Cogn Disord 16:136-44. 2003
    ....
  22. ncbi request reprint Alzheimer's peptide and serine proteinase inhibitors in glaucoma and exfoliation syndrome
    Sabina Janciauskiene
    Department of Medicine, University Hospital Malmo, S 20502, Malmo, Sweden
    Doc Ophthalmol 106:215-23. 2003
    ..The presence of Abeta and inflammation-associated proteins in aqueous from cataract cases without detectable PEX raises the possibility that these proteins may reflect early amyloid-related changes in the eye...
  23. pmc Prolastin, a pharmaceutical preparation of purified human alpha1-antitrypsin, blocks endotoxin-mediated cytokine release
    Izabela Nita
    Department of Medicine, Lund University, University Hospital Malmo, 20502 Malmo, Sweden
    Respir Res 6:12. 2005
    ..There is increasing evidence that AAT is able to exert effects other than protease inhibition. We investigated whether Prolastin, a preparation of purified pooled human AAT used for augmentation therapy, exhibits anti-bacterial effects...
  24. ncbi request reprint In vitro complex formation between cholesterol and alpha 1-proteinase inhibitor
    S Janciauskiene
    Department of Medicine, , University of Lund, Sweden
    FEBS Lett 316:269-72. 1993
    ..No size difference was noted on SDS-PAGE. These results suggest the occurrence of noncovalent complex formation between cholesterol and alpha 1-PI in vitro...
  25. pmc Use of atorvastatin as an anti-inflammatory treatment in Crohn's disease
    O Grip
    Division of Gastroenterology and Hepatology, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
    Br J Pharmacol 155:1085-92. 2008
    ..Experimental and clinical investigations have revealed that statins can downregulate both acute and chronic inflammatory processes. Whether statins express anti-inflammatory activities in the treatment of Crohn's disease is unknown...
  26. ncbi request reprint Fibrillogenic C-terminal fragment of alpha-1-antitrypsin activates human monocytes via oxidative mechanisms
    D Bironaite
    Department of Medicine, Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Cell Tissue Res 305:87-98. 2001
    ....
  27. ncbi request reprint Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes
    O Grip
    Department of Medicine, Lund University, University Hospital MAS, Malmo, Sweden
    Inflamm Res 51:58-62. 2002
    ..To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) in primary human monocytes in culture...
  28. ncbi request reprint C-36 peptide, a degradation product of alpha1-antitrypsin, modulates human monocyte activation through LPS signaling pathways
    Devipriya Subramaniyam
    Department of Clinical Sciences, Wallenberg Laboratory, University Hospital Malmo, S 205 02 Malmo, Sweden
    Int J Biochem Cell Biol 38:563-75. 2006
    ..We suggest that C-36 mediates its effects though the activation of LPS signaling pathways...
  29. pmc Plasma levels of alpha1-antichymotrypsin and secretory leukocyte proteinase inhibitor in healthy and chronic obstructive pulmonary disease (COPD) subjects with and without severe alpha1-antitrypsin deficiency
    Camilla Hollander
    Department of Otolaryngology, Institution of Clinical Sciences, Lund University, University Hospital Malmo, SE 205 02 Malmo, Sweden
    BMC Pulm Med 7:1. 2007
    ..We analysed plasma levels of AAT, alpha1-antichymotrypsin (ACT) and secretory leukocyte protease inhibitor (SLPI) in healthy (asymptomatic) and COPD subjects with and without AAT deficiency...
  30. ncbi request reprint Serum and bronchial lavage fluid concentrations of IL-8, SLPI, sCD14 and sICAM-1 in patients with COPD and asthma
    Camilla Hollander
    Department of Otolaryngology and Head and Neck Surgery, University Hospital, 20502 Malmo, Sweden
    Respir Med 101:1947-53. 2007
    ....
  31. ncbi request reprint Diverse responses between human pancreatic cancer cell lines to native alpha 1-antitrypsin and its C-terminal fragment
    Inga Zelvyte
    Department of Medicine, University Hospital Malmo, S 20502, Malmo, Sweden
    Anticancer Res 23:2267-73. 2003
    ..Previous studies imply that human pancreatic cancer cells have a wide heterogeneity and their exposure to various agents may give unpredictable results in clinical situations...
  32. ncbi request reprint Multiple effects of alpha1-antitrypsin on breast carcinoma MDA-MB 468 cell growth and invasiveness
    I Zelvyte
    Department of Medicine, University Hospital Malmo, Malmo, Sweden
    Eur J Cancer Prev 12:117-24. 2003
    ..These results indicate that AAT, dependent on its molecular form, can both suppress and induce breast tumour cell biological activity in vitro...
  33. ncbi request reprint Effects of serpins on cholesterol crystallization in model bile
    S Janciauskiene
    Department of Medicine, University Hospital Malmo, Sweden
    J Hepatol 29:541-9. 1998
    ..Their role in gallstone pathogenesis is unclear, and it was the aim of this study to determine their effect on cholesterol crystal growth rate in model bile...
  34. ncbi request reprint Interactions of A beta with endogenous anti-inflammatory agents: a basis for chronic neuroinflammation in Alzheimer's disease
    S Janciauskiene
    Department of Medicine, University Hospital Malmo, 20502 Malmo, Sweden
    Neurobiol Dis 10:187-200. 2002
  35. ncbi request reprint Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro
    Inga Zelvyte
    Department of Medicine, Lund University, University Hospital MAS, S 20502 Malmo, Sweden
    Pharmacol Res 45:147-54. 2002
    ..These data corroborate previous findings of the pleiotropic role of statins and also suggest the involvement of transcription factors such as PPAR gamma and NF kappa B in the modulation of the inflammatory processes by statins...
  36. pmc Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease
    Olof Grip
    Division of Gastroenterology and Hepatology, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden
    PLoS ONE 4:e5263. 2009
    ..Because statins can reduce chemokine expression in patients with coronary diseases, we wanted to test whether this can be achieved in patients with Crohn's disease...
  37. ncbi request reprint Analysis of systemic biomarkers in COPD patients
    Ruta Aldonyte
    Department of Medicine, Wallenberg Laboratory, University Hospital Malmo, Malmo, Sweden
    COPD 1:155-64. 2004
    ..These observations highlight the importance of the finding sets of biomolecules, which could offer new strategies for the diagnosis of COPD and may have value for monitoring progression of COPD...
  38. ncbi request reprint Macrophages in inflammatory bowel disease
    Olof Grip
    Gastroenterology and Hepatology Division, Department of Medicine, Malmo University Hospital, Lund University, S 20502 Malmo, Sweden
    Curr Drug Targets Inflamm Allergy 2:155-60. 2003
    ..e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel therapies...
  39. pmc Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro
    Sabina Janciauskiene
    Lund University, Department of Clinical Sciences, The Wallenberg Laboratory, Malmo University Hospital, Malmo, Sweden
    Am J Respir Cell Mol Biol 39:631-7. 2008
    ..Since matriptase is involved in a number of physiologic processes, including activation of epithelial sodium channels, our findings offer considerable new insights into new regulatory function of AAT in vivo...
  40. ncbi request reprint Pravastatin inhibits pro-inflammatory effects of Alzheimer's peptide Abeta(1-42) in glioma cell culture in vitro
    Yong Xin Sun
    Department of Medicine, University Hospital Malmo, Ing 46, UMAS, S 20502, Malmo, Sweden
    Pharmacol Res 47:119-26. 2003
    ..These data indicate that soluble forms of Abeta(1-42), which are a potent stimulus of pro-inflammatory activation of glioma cells in vitro, could be a good target for pravastatin...
  41. ncbi request reprint Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis
    Alexandru Schiopu
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Circulation 110:2047-52. 2004
    ..Aldehyde-modified peptide sequences in apolipoprotein B-100 (apoB-100) are major targets for these immune responses...
  42. ncbi request reprint Circulating monocytes and plasma inflammatory biomarkers in active Crohn's disease: elevated oxidized low-density lipoprotein and the anti-inflammatory effect of atorvastatin
    Olof Grip
    Gastroenterology and Hepatology Division, Department of Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    Inflamm Bowel Dis 10:193-200. 2004
    ..Treatment with atorvastatin may be a potential strategy to reduce oxLDL and inhibit monocyte migration to inflamed tissue, thus attenuating the inflammatory response...
  43. ncbi request reprint Conformational changes of the alpha 1-proteinase inhibitor affecting its cholesterol binding ability
    S Janciauskiene
    Department of Medicine, University of Lund, , Sweden
    FEBS Lett 323:236-8. 1993
    ..The data suggest alpha 1PI-cholesterol binding to be affected by both direct and indirect modifications of the alpha 1PI-reactive center, that is situated on a mobile peptide loop...
  44. doi request reprint Macrophage responses to interferon-gamma are dependent on cystatin C levels
    Katarina H Frendéus
    Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Lund University, University Hospital, SE 221 85 Lund, Sweden
    Int J Biochem Cell Biol 41:2262-9. 2009
    ..It is concluded that cystatin C through this effect can act as an immunomodulatory molecule...
  45. doi request reprint An association between Type 2 diabetes and alpha-antitrypsin deficiency
    C S Sandström
    Chronic and Degenerative Disease Research Unit, University Hospital Malmoe, Lund University, Malmo, Sweden
    Diabet Med 25:1370-3. 2008
    ..We have investigated whether plasma AAT levels are altered in Type 2 diabetes...
  46. ncbi request reprint rCBF pathology in Alzheimer's disease is associated with slow processing speed
    S Warkentin
    Department of Clinical Sciences, Malmo University Hospital, Lund University, Sweden
    Neuropsychologia 46:1193-200. 2008
    ..These findings suggest that pause time (in contrast to articulation time) may serve as a sensitive measure in the assessment of information processing speed deficits in dementia, by virtue of its close association with brain pathology...
  47. ncbi request reprint Alpha-1-antitrypsin is present in the specific granules of human eosinophilic granulocytes
    B Johansson
    Departments of Medical Microbiology, Lund University, Malmo University Hospital, Malmo, Sweden
    Clin Exp Allergy 31:379-86. 2001
    ..On the basis of these findings it is suggested that by releasing AAT, eosinophils may, in a microenvironment, play a role in counteracting the tissue damage caused by serine proteinases released by neutrophils in inflammatory conditions...
  48. ncbi request reprint Polymerized alpha-antitrypsin is present on lung vascular endothelium. New insights into the biological significance of alpha-antitrypsin polymerization
    R Aldonyte
    Department of Pathology, University Hospital Malmo, Malmo, Sweden
    Histopathology 45:587-92. 2004
    ..Therefore, in the present study we aimed to investigate if alpha1-AT is present on the lung vascular endothelium, and if it is in a polymeric form...
  49. pmc Endotoxin receptor CD14 in PiZ alpha-1-antitrypsin deficiency individuals
    Caroline S Sandstrom
    Department of Clinical Sciences, Chronic and Degenerative Disease Research Unit, University Hospital Malmoe, Lund University, S 20502, Malmo, Sweden
    Respir Res 9:34. 2008
    ....
  50. ncbi request reprint Increased plasma levels of serine proteinase inhibitors in lung cancer patients
    Inga Zelvyte
    Department of Medicine, University Hospital Malmo, 20502 Malmo, Sweden
    Anticancer Res 24:241-7. 2004
    ..A number of studies have revealed variations in the plasma levels of serine proteases and their inhibitors among tumor types...
  51. ncbi request reprint TNF-alpha-induced self expression in human lung endothelial cells is inhibited by native and oxidized alpha1-antitrypsin
    Devipriya Subramaniyam
    Department of Clinical Sciences, University Hospital Malmo, Lund University, S 20502 Malmo, Sweden
    Int J Biochem Cell Biol 40:258-71. 2008
    ....
  52. doi request reprint C4b-binding protein in Alzheimer's disease: binding to Abeta1-42 and to dead cells
    Leendert A Trouw
    Department of Laboratory Medicine, Lund University, Malmo, Sweden
    Mol Immunol 45:3649-60. 2008
    ..In conclusion, C4BP binds to dead brain cells and Abeta peptide in vitro, is present in CSF and possibly protects against excessive complement activation in AD brains...
  53. ncbi request reprint Alpha1-antitrypsin inhibits Moraxella catarrhalis MID protein-induced tonsillar B cell proliferation and IL-6 release
    Radinka Hadzic
    Department of Medical Microbiology, Wallenberg Laboratory, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Immunol Lett 102:141-7. 2006
    ..Thus, our data demonstrate that AAT inhibits MID-induced B cell activation in vitro that is unrelated to its protease inhibitory activity and is not dependent on MID binding to the cell surface...
  54. ncbi request reprint ELISA for specific detection of PiZ-related alpha(1)-antitrypsin deficiency
    Sten Gershagen
    Wieslab AB, IDEON, Science Park, Lund, Sweden
    Clin Chem 50:2407-10. 2004
  55. pmc Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo
    Ravi Mahadeva
    Department of Medicine, Box 157, Level 5, Addenbrookes NHS Trust, Hills Road, Cambridge CB2 2QQ, UK
    Am J Pathol 166:377-86. 2005
    ..These findings may also explain the progression of emphysema in some individuals despite alpha(1)-antitrypsin replacement therapy...
  56. ncbi request reprint Suppression of cholesterol 7alpha-hydroxylase transcription and bile acid synthesis by an alpha1-antitrypsin peptide via interaction with alpha1-fetoprotein transcription factor
    Marie Christine Gerbod-Giannone
    Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 277:42973-80. 2002
    ..These results suggest that peptides derived from specific serum proteins may alter hepatic gene expression in a highly specific manner...
  57. ncbi request reprint [Hereditary alpha-1-antitrypsin deficiency can cause COPD. Substitution treatment seems to result in fewer infections and prolonged survival]
    Sabina Janciauskiene
    Wallenberglaboratoriet, Universitetssjukhuset MAS, Malmo
    Lakartidningen 104:3631-4, 3637-8. 2007
  58. ncbi request reprint Effects of native and cleaved forms of alpha1-antitrypsin on ME 1477 tumor cell functional activity
    Inga Zelvyte
    Department of Medicine, Sweden University Hospital Malmö
    Cancer Detect Prev 26:256-65. 2002
    ..Cleaved form of AAT had no significant effects on parameters measured. Data obtained from this study suggest that specific forms of AAT have multiple effects on tumor cell viability and play diverse roles in tumorogenesis...