Goran Hedenstierna

Summary

Country: Sweden

Publications

  1. ncbi Alveolar collapse and closure of airways: regular effects of anaesthesia
    Goran Hedenstierna
    Department of Clinical Physiology, University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 23:123-9. 2003
  2. ncbi Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Respir Physiol Neurobiol 165:229-36. 2009
  3. ncbi Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury*
    João Batista Borges
    1Hedenstierna Laboratory, Department of Surgical Sciences, Section of Anaesthesiology and Critical Care, Uppsala University, Uppsala, Sweden 2Pulmonary Divison, Heart Institute InCor Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil 3Research and Education Institute, Hospital Sirio Libanes, Sao Paulo, Brazil 4Centros de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 5Department of Hospital Physics, Uppsala University Hospital, Uppsala, Sweden 6Hedenstierna Laboratory, Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Crit Care Med 42:e279-87. 2014
  4. ncbi Multiple inert gas elimination technique by micropore membrane inlet mass spectrometry--a comparison with reference gas chromatography
    Moritz Kretzschmar
    Department of Surgical Sciences, Anesthesia and Intensive Care, Uppsala University, Uppsala, Sweden
    J Appl Physiol (1985) 115:1107-18. 2013
  5. ncbi Lung aeration during sleep in patients with obstructive sleep apnoea
    Jonas Appelberg
    Department of Clinical Physiology, Sundsvall Hospital, Sundsvall, Sweden
    Clin Physiol Funct Imaging 30:301-7. 2010
  6. ncbi Deep-breathing exercises reduce atelectasis and improve pulmonary function after coronary artery bypass surgery
    Elisabeth Westerdahl
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Chest 128:3482-8. 2005
  7. ncbi Abdominal lymph flow in an endotoxin sepsis model: influence of spontaneous breathing and mechanical ventilation
    Marco Lattuada
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Crit Care Med 34:2792-8. 2006
  8. doi Pulmonary shunt is independent of decrease in cardiac output during unsupported spontaneous breathing in the pig
    Laszlo Vimlati
    Department of Surgical Sciences, Anesthesiology and Critical Care, Uppsala University, Uppsala, Sweden
    Anesthesiology 118:914-23. 2013
  9. doi Allergen-induced formation of F2-isoprostanes in a murine asthma model identifies oxidative stress in acute airway inflammation in vivo
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 80:1-7. 2009
  10. ncbi Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses
    Stina Marntell
    Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Anaesth Analg 32:83-93. 2005

Collaborators

Detail Information

Publications34

  1. ncbi Alveolar collapse and closure of airways: regular effects of anaesthesia
    Goran Hedenstierna
    Department of Clinical Physiology, University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 23:123-9. 2003
    ..Avoiding high inspired oxygen fractions during both induction and maintenance of anaesthesia prevents or reduces atelectasis, while intermittent 'vital capacity' manoeuvres, recruit atelectatic lung regions...
  2. ncbi Comparisons of effects of intravenous and inhaled methacholine on airway physiology in a murine asthma model
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Respir Physiol Neurobiol 165:229-36. 2009
    ..The two methods of MCh delivery have important advantages but also certain limitations with regard to measuring airway reactivity in a murine model of allergic asthma...
  3. ncbi Early inflammation mainly affects normally and poorly aerated lung in experimental ventilator-induced lung injury*
    João Batista Borges
    1Hedenstierna Laboratory, Department of Surgical Sciences, Section of Anaesthesiology and Critical Care, Uppsala University, Uppsala, Sweden 2Pulmonary Divison, Heart Institute InCor Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil 3Research and Education Institute, Hospital Sirio Libanes, Sao Paulo, Brazil 4Centros de Investigación Biomédica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain 5Department of Hospital Physics, Uppsala University Hospital, Uppsala, Sweden 6Hedenstierna Laboratory, Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Crit Care Med 42:e279-87. 2014
    ..The aim of this study was to assess the location and magnitude of lung inflammation using PET imaging of [(18)F]fluoro-2-deoxy-D-glucose in a porcine experimental model of early acute respiratory distress syndrome...
  4. ncbi Multiple inert gas elimination technique by micropore membrane inlet mass spectrometry--a comparison with reference gas chromatography
    Moritz Kretzschmar
    Department of Surgical Sciences, Anesthesia and Intensive Care, Uppsala University, Uppsala, Sweden
    J Appl Physiol (1985) 115:1107-18. 2013
    ..In conclusion, MMIMS enables faster measurement of VA/Q, is less demanding than GC, and produces comparable results. ..
  5. ncbi Lung aeration during sleep in patients with obstructive sleep apnoea
    Jonas Appelberg
    Department of Clinical Physiology, Sundsvall Hospital, Sundsvall, Sweden
    Clin Physiol Funct Imaging 30:301-7. 2010
    ..However, little is known about regional lung aeration during sleep in patients with OSA...
  6. ncbi Deep-breathing exercises reduce atelectasis and improve pulmonary function after coronary artery bypass surgery
    Elisabeth Westerdahl
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Chest 128:3482-8. 2005
    ..To investigate the effects of deep-breathing exercises on pulmonary function, atelectasis, and arterial blood gas levels after coronary artery bypass graft (CABG) surgery...
  7. ncbi Abdominal lymph flow in an endotoxin sepsis model: influence of spontaneous breathing and mechanical ventilation
    Marco Lattuada
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Crit Care Med 34:2792-8. 2006
    ..We also compared the effect on thoracic duct lymph flow of mechanical ventilation with different levels of positive end-expiratory pressure (PEEP) and spontaneous breathing with continuous positive airway pressure (CPAP)...
  8. doi Pulmonary shunt is independent of decrease in cardiac output during unsupported spontaneous breathing in the pig
    Laszlo Vimlati
    Department of Surgical Sciences, Anesthesiology and Critical Care, Uppsala University, Uppsala, Sweden
    Anesthesiology 118:914-23. 2013
    ..The CO dependency of the calculated venous admixture was investigated, with both minor and major shunt, during unsupported SB, MV, and SB with continuous positive airway pressure (CPAP)...
  9. doi Allergen-induced formation of F2-isoprostanes in a murine asthma model identifies oxidative stress in acute airway inflammation in vivo
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Prostaglandins Leukot Essent Fatty Acids 80:1-7. 2009
    ..This study showed an accumulation of F(2)-isoprostanes in acute airway inflammation and a markedly increased tissue damage caused by oxidative stress in an ongoing inflammation...
  10. ncbi Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses
    Stina Marntell
    Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Anaesth Analg 32:83-93. 2005
    ..To study pulmonary gas exchange and cardiovascular responses to sedation achieved with romifidine and butorphanol (RB) alone, or combined with acepromazine, and during subsequent tiletamine-zolazepam anaesthesia in horses...
  11. doi Ventilation distribution studies comparing Technegas and "Gallgas" using 68GaCl3 as the label
    João Batista Borges
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    J Nucl Med 52:206-9. 2011
    ..Ventilation distribution can be assessed by SPECT with Technegas. This study was undertaken in piglets with different degrees of ventilation inhomogeneity to compare PET using (68)Ga-labeled pseudogas or "Gallgas" with Technegas...
  12. ncbi Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model
    Luni Chen
    Department of Medical Sciences, Clinical Physiology, University Hospital, SE 751 85 Uppsala, Sweden
    Am J Physiol Heart Circ Physiol 284:H290-8. 2003
    ..We conclude that the rebound response to INO discontinuation is related to COX products...
  13. doi Regional lung perfusion estimated by electrical impedance tomography in a piglet model of lung collapse
    João Batista Borges
    Department of Surgical Sciences, Section of Anaesthesiology and Critical Care, Uppsala University, Uppsala, Sweden
    J Appl Physiol (1985) 112:225-36. 2012
    ..The method proposed in this study has the potential to contribute to a better understanding of the behavior of regional perfusion under different lung and therapeutic conditions...
  14. doi Evaluating abdominal oedema during experimental sepsis using an isotope technique
    Marco Lattuada
    Hedenstierna Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Clin Physiol Funct Imaging 32:197-204. 2012
    ..Abdominal oedema is common in sepsis. A technique for the study of such oedema may guide in the fluid regime of these patients...
  15. doi Lung sound analysis correlates to injury and recruitment as identified by computed tomography: an experimental study
    Antonio Vena
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Intensive Care Med 37:1378-83. 2011
    ..The aim of this study is to assess how analysis of the spectral characteristics of lung sounds can help in detecting lung injury and subsequent recruitment as verified by computed tomography (CT)...
  16. doi Improved ventilation-perfusion matching with increasing abdominal pressure during CO(2) -pneumoperitoneum in pigs
    C M Strang
    Department of Medical Sciences, Clinical Physiology, University of Uppsala, Uppsala, Sweden
    Acta Anaesthesiol Scand 55:887-96. 2011
    ..CO(2) -pneumoperitoneum (PP) is performed at varying abdominal pressures. We studied in an animal preparation the effect of increasing abdominal pressures on gas exchange during PP...
  17. doi Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study
    Henrik Reinius
    Department of Anesthesia and Intensive Care, University Hospital, Uppsala, Sweden
    Anesthesiology 111:979-87. 2009
    ..This study analyzed the effect of general anesthesia and three different ventilatory strategies to reduce the amount of atelectasis and improve respiratory function...
  18. ncbi Effects of hyperosmolarity and airway epithelial ion transport inhibitors on sodium nitroprusside-induced relaxation of guinea pig trachea
    Josephine Hjoberg
    Department of Medical Sciences, Clinical Physiology, University Hospital, S 751 85 Uppsala, Sweden
    Respir Physiol Neurobiol 146:239-46. 2005
    ....
  19. doi Respiratory function during anesthesia: effects on gas exchange
    Goran Hedenstierna
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Compr Physiol 2:69-96. 2012
    ..CO2 pneumoperitoneum increases atelectasis formation but not shunt, likely explained by enhanced hypoxic pulmonary vasoconstriction by CO2. Atelectasis may persist in the postoperative period and contribute to pneumonia...
  20. doi Influence of abdominal pressure on respiratory and abdominal organ function
    Goran Hedenstierna
    Department of Clinical Physiology, Uppsala University, Uppsala, Sweden
    Curr Opin Crit Care 18:80-5. 2012
    ..Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) have been realized as severe complications in the intensive care patient. Laparoscopic surgery in older and more obese patients increases the risk of IAH and ACS...
  21. pmc Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice
    Sofia Jonasson
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Respir Res 9:23. 2008
    ..We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic airway inflammation...
  22. ncbi Change in expiratory flow detects partial endotracheal tube obstruction in pressure-controlled ventilation
    Rafael Kawati
    Department of Surgical Sciences Anesthesiology and Intensive Care, Uppsala University Hospital, Uppsala, Sweden
    Anesth Analg 103:650-7. 2006
    ..0, 8.0, 7.0, and 6.0 respectively). We conclude that when the elastic recoil that drives (e) is appropriately considered, analysis of (e) and V(ex fract,15) detects partial ETT obstruction during PCV...
  23. pmc Pharyngeal oxygen administration increases the time to serious desaturation at intubation in acute lung injury: an experimental study
    Joakim Engström
    Department of Anesthesiology and Intensive Care, Uppsala University, ANIVA ing 70 1tr, University Hospital, S 75185 Uppsala, Sweden
    Crit Care 14:R93. 2010
    ....
  24. ncbi Inhalation of nitric oxide in the treatment of severe acute respiratory syndrome: a rescue trial in Beijing
    Luni Chen
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Clin Infect Dis 39:1531-5. 2004
    ..These findings suggest not only a pulmonary vasodilator effect of inhaled NO, but also an effect on SARS...
  25. ncbi High inspired oxygen concentrations increase intrapulmonary shunt in anaesthetized horses
    Stina Marntell
    Department of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Vet Anaesth Analg 32:338-47. 2005
    ..To compare pulmonary function and gas exchange in anaesthetized horses during and after breathing either O2-rich gas mixtures or air...
  26. ncbi The immediate effects of deep breathing exercises on atelectasis and oxygenation after cardiac surgery
    Elisabeth Westerdahl
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Scand Cardiovasc J 37:363-7. 2003
    ..Conclusion--A significant decrease of atelectatic area, increase in aerated lung area and a small increase in PaO (2) were found after performance of 30 deep breaths. No difference between the three breathing techniques was found...
  27. ncbi The effects of anesthesia and muscle paralysis on the respiratory system
    Goran Hedenstierna
    Clinical Physiology, Department of Medical Sciences, University Hospital, 75185 Uppsala, Sweden
    Intensive Care Med 31:1327-35. 2005
    ..Moreover, postoperative lung complications occur in 3-10% after elective abdominal surgery and more in emergency operations...
  28. ncbi Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis
    Jiping Da
    Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala University, Sweden
    Crit Care Med 35:26-32. 2007
    ..We hypothesized that there may be an interaction between nitric oxide and glucocorticoids, with the potential to enhance the anti-inflammatory effect when administered simultaneously...
  29. ncbi Lung aeration during sleep
    Jonas Appelberg
    Department of Clinical Physiology, Sundsvall Hospital, Sundsvall, Sweden
    Chest 131:122-9. 2007
    ..During sleep, ventilation and functional residual capacity (FRC) decrease slightly. This study addresses regional lung aeration during wakefulness and sleep...
  30. doi Lymphatics and lymph in acute lung injury
    Goran Hedenstierna
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Curr Opin Crit Care 14:31-6. 2008
    ..Lymph flow will be discussed as part of the drainage and fluid balance of lung tissue and abdomen as well as a qualitative analysis of inflammatory processes...
  31. doi Increased alveolar damage after mechanical ventilation in a porcine model of thoracic surgery
    Alf Kozian
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    J Cardiothorac Vasc Anesth 24:617-23. 2010
    ..This study compared the effects of mechanical ventilation, OLV, and surgical manipulation on diffuse alveolar damage (DAD) after application of different anesthetic regimens...
  32. ncbi Acoustic effects of positive end-expiratory pressure on normal lung sounds in mechanically ventilated pigs
    Antonio Vena
    Department of Medical Sciences, Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
    Clin Physiol Funct Imaging 26:45-53. 2006
    ..The application of increasing levels of PEEP reduced the amplitude and changed the spectral characteristics of normal lung sounds...
  33. ncbi Optimal oxygen concentration during induction of general anesthesia
    Lennart Edmark
    Department of Anesthesiology and Intensive Care, Central Hospital, Vasteras, and Research Associate, Department of Medical Sciences, Clinical Physiology, University Hospital, Uppsala, Sweden
    Anesthesiology 98:28-33. 2003
    ..The use of 100% oxygen during induction of anesthesia may produce atelectasis. The authors investigated how different oxygen concentrations affect the formation of atelectasis and the fall in arterial oxygen saturation during apnea...
  34. doi Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma
    Sofia Jonasson
    Dept of Medical Sciences, Clinical Physiology, University Hospital, SE 751 85 Uppsala, Sweden
    J Appl Physiol (1985) 109:521-31. 2010
    ....