Gunnar C Hansson

Summary

Country: Sweden

Publications

  1. Hansson G. Role of mucus layers in gut infection and inflammation. Curr Opin Microbiol. 2012;15:57-62 pubmed publisher
    ..Pathogenic microorganisms, in turn, have developed mechanisms for circumventing this well-organized mucus protective system. ..
  2. Ermund A, Meiss L, Dolan B, Bähr A, Klymiuk N, Hansson G. The mucin bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. Eur Respir J. 2018;: pubmed publisher
  3. Trillo Muyo S, Nilsson H, Recktenwald C, Ermund A, Ridley C, Meiss L, et al. Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers. J Biol Chem. 2018;293:5746-5754 pubmed publisher
    ..We conclude that the combination of intracellular packing of the MUC5B mucin and the submucosal gland morphology creates an efficient machine for producing linear mucin bundles. ..
  4. Ermund A, Meiss L, Gustafsson J, Hansson G. Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 2015;764:109-17 pubmed publisher
    ..We found that increasing the concentration of bicarbonate, both alone or in combination with increased osmolarity of the solution, detached the otherwise attached CF mucus. ..
  5. Johansson M, Jakobsson H, Holmén Larsson J, Schütte A, Ermund A, Rodríguez Piñeiro A, et al. Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization. Cell Host Microbe. 2015;18:582-92 pubmed publisher
    ..These findings highlight the dynamics of mucus layer development and indicate that studies of mature microbe-mucus interactions should be conducted weeks after colonization. ..
  6. Arike L, Hansson G. The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J Mol Biol. 2016;428:3221-3229 pubmed publisher
    ..This review will discuss the mucin-type O-glycosylation and especially the O-glycosylation of human and mice intestinal mucin MUC2 in relation to bacteria and disease. ..
  7. Recktenwald C, Hansson G. The Reduction-insensitive Bonds of the MUC2 Mucin Are Isopeptide Bonds. J Biol Chem. 2016;291:13580-90 pubmed publisher
    ..This shows for the first time that transamidation is not only stabilizing the skin and the fibrin clot, but is also important for the correct intracellular processing of MUC2 to generate protective mucus. ..
  8. Schroeder B, Birchenough G, Ståhlman M, Arike L, Johansson M, Hansson G, et al. Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration. Cell Host Microbe. 2018;23:27-40.e7 pubmed publisher
    ..We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis. ..
  9. Ermund A, Schütte A, Johansson M, Gustafsson J, Hansson G. Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches. Am J Physiol Gastrointest Liver Physiol. 2013;305:G341-7 pubmed publisher
    ..This knowledge of the mucus system and its organization improves our understanding of the gastrointestinal tract physiology. ..

More Information

Publications17

  1. Schütte A, Ermund A, Becker Pauly C, Johansson M, Rodríguez Piñeiro A, Bäckhed F, et al. Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus. Proc Natl Acad Sci U S A. 2014;111:12396-401 pubmed publisher
    ..This process regulates mucus properties, can be triggered by bacterial contact, and is nonfunctional in CF due to poor mucin unfolding. ..
  2. Rodríguez Piñeiro A, Bergström J, Ermund A, Gustafsson J, Schütte A, Johansson M, et al. Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins. Am J Physiol Gastrointest Liver Physiol. 2013;305:G348-56 pubmed publisher
    ..g., Clca1, Zg16, Klk1). This study provides a deeper knowledge of the gastrointestinal mucus proteome that will be important in further understanding this poorly studied mucosal protection system. ..
  3. Birchenough G, Nyström E, Johansson M, Hansson G. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science. 2016;352:1535-42 pubmed publisher
    ..Thus, senGCs guard and protect the colonic crypt from bacterial intruders that have penetrated the inner mucus layer. ..
  4. Bergström J, Birchenough G, Katona G, Schroeder B, Schütte A, Ermund A, et al. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc Natl Acad Sci U S A. 2016;113:13833-13838 pubmed
    ..Viable bacteria were found in spleen and were associated with increased abdominal fat pad mass in Zg16-/- animals. The function of ZG16 reveals a mechanism for keeping bacteria further away from the host colon epithelium. ..
  5. Birchenough G, Hansson G. Bacteria Tell Us How to Protect Our Intestine. Cell Host Microbe. 2017;22:3-4 pubmed publisher
    ..In this issue of Cell Host & Microbe, Wlodarska et al. (2017) demonstrate that the mucin-utilizing Peptostreptococcus russellii protects the host from inflammatory disease via metabolite signals. ..
  6. Ermund A, Meiss L, Rodríguez Piñeiro A, Bähr A, Nilsson H, Trillo Muyo S, et al. The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem Biophys Res Commun. 2017;492:331-337 pubmed publisher
    ..Normal clearance of the respiratory tree of pigs and humans, both rich in submucosal glands, is performed by thick and long mucus bundles. ..
  7. Holmén Larsson J, Thomsson K, Rodríguez Piñeiro A, Karlsson H, Hansson G. Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution. Am J Physiol Gastrointest Liver Physiol. 2013;305:G357-63 pubmed publisher
    ..Many fucosylated glycans were found in both the proximal and distal colon. Thus the mucin O-glycans vary along the mouse gastrointestinal tract. ..
  8. Lang T, Hansson G, Samuelsson T. An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. BMC Genomics. 2006;7:197 pubmed
    ..Finally, our finding that the chicken Muc13 is distributed between multiple exons raises the interesting possibility that the length of the PTS domain could be controlled by alternative splicing. ..