Genomes and Genes
Gunnar C Hansson
- SchÃ¼tte A, Ermund A, Becker Pauly C, Johansson M, Rodríguez Piñeiro A, BÃ¤ckhed F, et al. Microbial-induced meprin Î² cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus. Proc Natl Acad Sci U S A. 2014;111:12396-401 pubmed publisher..This process regulates mucus properties, can be triggered by bacterial contact, and is nonfunctional in CF due to poor mucin unfolding. ..
- Rodríguez Piñeiro A, Bergström J, Ermund A, Gustafsson J, Schütte A, Johansson M, et al. Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins. Am J Physiol Gastrointest Liver Physiol. 2013;305:G348-56 pubmed publisher..g., Clca1, Zg16, Klk1). This study provides a deeper knowledge of the gastrointestinal mucus proteome that will be important in further understanding this poorly studied mucosal protection system. ..
- Birchenough G, Nyström E, Johansson M, Hansson G. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science. 2016;352:1535-42 pubmed publisher..Thus, senGCs guard and protect the colonic crypt from bacterial intruders that have penetrated the inner mucus layer. ..
- BergstrÃ¶m J, Birchenough G, Katona G, Schroeder B, SchÃ¼tte A, Ermund A, et al. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc Natl Acad Sci U S A. 2016;113:13833-13838 pubmed..Viable bacteria were found in spleen and were associated with increased abdominal fat pad mass in Zg16-/- animals. The function of ZG16 reveals a mechanism for keeping bacteria further away from the host colon epithelium. ..
- Birchenough G, Hansson G. Bacteria Tell Us How to Protect Our Intestine. Cell Host Microbe. 2017;22:3-4 pubmed publisher..In this issue of Cell Host & Microbe, Wlodarska etÂ al. (2017) demonstrate that the mucin-utilizing Peptostreptococcus russellii protects the host from inflammatory disease via metabolite signals. ..
- Ermund A, Meiss L, Rodríguez Piñeiro A, Bähr A, Nilsson H, Trillo Muyo S, et al. The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem Biophys Res Commun. 2017;492:331-337 pubmed publisher..Normal clearance of the respiratory tree of pigs and humans, both rich in submucosal glands, is performed by thick and long mucus bundles. ..
- Holmén Larsson J, Thomsson K, Rodríguez Piñeiro A, Karlsson H, Hansson G. Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution. Am J Physiol Gastrointest Liver Physiol. 2013;305:G357-63 pubmed publisher..Many fucosylated glycans were found in both the proximal and distal colon. Thus the mucin O-glycans vary along the mouse gastrointestinal tract. ..
- Lang T, Hansson G, Samuelsson T. An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. BMC Genomics. 2006;7:197 pubmed..Finally, our finding that the chicken Muc13 is distributed between multiple exons raises the interesting possibility that the length of the PTS domain could be controlled by alternative splicing. ..