Deborah R Gustafson

Summary

Country: Sweden

Publications

  1. ncbi request reprint A 24-year follow-up of body mass index and cerebral atrophy
    D Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 63:1876-81. 2004
  2. ncbi request reprint Mid-life adiposity factors relate to blood-brain barrier integrity in late life
    D R Gustafson
    Department of Psychiatry and Neurochemistry Neuropsychiatric Epidemiology Unit, Institute of Physiology and Neuroscience, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    J Intern Med 262:643-50. 2007
  3. ncbi request reprint An 18-year follow-up of overweight and risk of Alzheimer disease
    Deborah Gustafson
    Department of Nutrition and Food Sciences, Utah State University, Logan, USA
    Arch Intern Med 163:1524-8. 2003
  4. ncbi request reprint Body mass index and white matter lesions in elderly women. An 18-year longitudinal study
    D R Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, USA
    Int Psychogeriatr 16:327-36. 2004
  5. doi request reprint The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEepsilon4, and age of dementia onset
    D R Gustafson
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden
    Neurobiol Aging 31:910-6. 2010
  6. ncbi request reprint Adiposity indices and dementia
    Deborah Gustafson
    Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, SE 413 45, Goteborg, Sweden
    Lancet Neurol 5:713-20. 2006
  7. pmc Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women
    Deborah R Gustafson
    The Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 78:461-4. 2007
  8. doi request reprint A life course of adiposity and dementia
    Deborah Gustafson
    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Sweden
    Eur J Pharmacol 585:163-75. 2008
  9. pmc Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm 117:861-7. 2010
  10. doi request reprint A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Neural Transm 119:833-42. 2012

Detail Information

Publications28

  1. ncbi request reprint A 24-year follow-up of body mass index and cerebral atrophy
    D Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
    Neurology 63:1876-81. 2004
    ..To investigate the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and cerebral atrophy, a marker of neurodegeneration, in a population-based sample of middle-aged women...
  2. ncbi request reprint Mid-life adiposity factors relate to blood-brain barrier integrity in late life
    D R Gustafson
    Department of Psychiatry and Neurochemistry Neuropsychiatric Epidemiology Unit, Institute of Physiology and Neuroscience, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    J Intern Med 262:643-50. 2007
    ..Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study...
  3. ncbi request reprint An 18-year follow-up of overweight and risk of Alzheimer disease
    Deborah Gustafson
    Department of Nutrition and Food Sciences, Utah State University, Logan, USA
    Arch Intern Med 163:1524-8. 2003
    ..Using body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), we examined whether overweight is a risk factor for dementia and AD...
  4. ncbi request reprint Body mass index and white matter lesions in elderly women. An 18-year longitudinal study
    D R Gustafson
    Department of Family and Community Medicine, Medical College of Wisconsin, USA
    Int Psychogeriatr 16:327-36. 2004
    ..We investigated the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and white matter lesions (WMLs) in older women...
  5. doi request reprint The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEepsilon4, and age of dementia onset
    D R Gustafson
    Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden
    Neurobiol Aging 31:910-6. 2010
    ..Variations among reports on the relationship between the ACE ID polymorphism and dementia may be due to lack of consideration for gene-gene and gene-phenotype associations...
  6. ncbi request reprint Adiposity indices and dementia
    Deborah Gustafson
    Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, SE 413 45, Goteborg, Sweden
    Lancet Neurol 5:713-20. 2006
    ..Understanding the life course of adiposity by use of common surrogate measures, such as BMI, among those who do and do not develop dementia is relevant for understanding the causes of dementia and for shaping possible treatment options...
  7. pmc Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women
    Deborah R Gustafson
    The Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 78:461-4. 2007
    ..It is not known, however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy older people...
  8. doi request reprint A life course of adiposity and dementia
    Deborah Gustafson
    Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Sweden
    Eur J Pharmacol 585:163-75. 2008
    ..Characterizing the life course of adiposity among those who do and do not become demented enhances understanding of biological underpinnings relevant for understanding the etiologies of both dementia and obesity and their co-existence...
  9. pmc Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm 117:861-7. 2010
    ..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD...
  10. doi request reprint A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Neural Transm 119:833-42. 2012
    ..However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed...
  11. doi request reprint Kinesin light chain 1 gene haplotypes in three conformational diseases
    Malin von Otter
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 12:229-36. 2010
    ..Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract...
  12. doi request reprint Midlife psychological distress associated with late-life brain atrophy and white matter lesions: a 32-year population study of women
    Lena Johansson
    Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Psychosom Med 74:120-5. 2012
    ..The present study examines the relationship between midlife psychological distress and late-life brain atrophy and white matter lesions (WMLs), which are common findings on neuroimaging in elderly subjects...
  13. doi request reprint Leptin and dementia over 32 years-The Prospective Population Study of Women
    Deborah R Gustafson
    Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Sweden
    Alzheimers Dement 8:272-7. 2012
    ..We explored the relationship between serum leptin in mid-life and dementia, which is a late-life outcome...
  14. doi request reprint No association of LOXL1 gene polymorphisms with Alzheimer's disease
    Alexandra Abramsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 13:160-6. 2011
    ..No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD...
  15. doi request reprint 37 years of body mass index and dementia: observations from the prospective population study of women in Gothenburg, Sweden
    Deborah R Gustafson
    Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 28:163-71. 2012
    ..BMI may be a potential marker of dementia-related neuropathologies in the brain. Dementia is related to a common risk factor, BMI, from mid-to late-life...
  16. doi request reprint Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset...
  17. doi request reprint Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
    Madeleine Zetterberg
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008
    ..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD...
  18. doi request reprint Adiposity and cognitive decline: underlying mechanisms
    Deborah R Gustafson
    Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 30:S97-112. 2012
    ..This review will illustrate that adipose tissue is a quintessential, multifunctional tissue of the human body...
  19. ncbi request reprint Prodromal cognitive signs of dementia in 85-year-olds using four sources of information
    S Sacuiu
    Psychiatry Section, Institute of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
    Neurology 65:1894-900. 2005
    ..To evaluate the utility of assessing four cognitive domains obtained from four information sources to identify individuals at risk for developing dementia, Alzheimer disease (AD), and vascular dementia (VaD)...
  20. pmc A population-based study on the influence of brain atrophy on 20-year survival after age 85
    P J Olesen
    Neuropsychiatric Epidemiology Unit, Wallinsgatan 6, 43141 Mölndal, Sweden
    Neurology 76:879-86. 2011
    ..To understand the biology behind increasing longevity, it is important to examine factors related to survival in this age group. The relationship between brain atrophy and survival after age 85 remains unclear...
  21. pmc Secular changes in cognitive predictors of dementia and mortality in 70-year-olds
    S Sacuiu
    Department of Psychiatry and Neurochemistry, Unit of Psychiatric Epidemiology, University of Gothenburg and Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, Wallinsgatan 6, 431 41 Mölndal, Sweden
    Neurology 75:779-85. 2010
    ..Successive elderly birth cohorts improved in cognitive performance during the 20th century. It is not clear whether this influences cognitive predictors of dementia and mortality...
  22. doi request reprint Psychotic and behavioural symptoms in a population-based sample of the very elderly subjects
    S Ostling
    Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    Acta Psychiatr Scand 120:147-52. 2009
    ..The aim was to elucidate the relationship between psychotic and behavioural symptoms in the elderly...
  23. doi request reprint Body mass index, cognition, disability, APOE genotype, and mortality: the "Treviso Longeva" Study
    Deborah R Gustafson
    Institute for Neuroscience and Physiology, Neuropsychiatric Epidemiology Unit, University of Gothenburg, Wallinsgatan 6, 431 41 Gothenburg, Sweden
    Am J Geriatr Psychiatry 20:594-602. 2012
    ..We explored these measures in relation to 7-year mortality in long-lived Italian elderly...
  24. doi request reprint Adiposity hormones and dementia
    Deborah R Gustafson
    Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Sweden
    J Neurol Sci 299:30-4. 2010
    ..Understanding the role of adipose tissue in health of the brain is pivotal to a deeper understanding of dementia processes...
  25. doi request reprint Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Goteborg
    K Mehlig
    Department of Public Health and Community Medicine Primary Health Care, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Epidemiol 167:684-91. 2008
    ..Because a protective effect was not seen for the other beverages, at least part of the association for wine may be explained by components other than ethanol...
  26. pmc Temporal lobe atrophy and white matter lesions are related to major depression over 5 years in the elderly
    Pernille J Olesen
    Neuropsychiatric Epidemiology Unit, Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Neuropsychopharmacology 35:2638-45. 2010
    ..This may have implications for prevention, as both neurodegeneration and cerebrovascular disease have been related to preventable factors...
  27. doi request reprint The prognosis and incidence of social phobia in an elderly population. A 5-year follow-up
    B Karlsson
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    Acta Psychiatr Scand 122:4-10. 2010
    ..To examine the prognosis and incidence of social fears and phobia in an elderly population sample followed for 5 years...
  28. ncbi request reprint GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer risk
    Wei Zheng
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    Breast Cancer Res Treat 74:9-16. 2002
    ..3, 95% CI = 0.4-4.1). This study suggests that certain null GST genotypes may be associated with an elevated risk of breast cancer and the association may be modified by charred meat intake and cigarette smoking...