Research Topics
Genomes and Genes | Deborah R GustafsonSummaryCountry: Sweden Publications
| Collaborators
|
Detail Information
Publications
A 24-year follow-up of body mass index and cerebral atrophyD Gustafson
Department of Family and Community Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Neurology 63:1876-81. 2004..To investigate the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and cerebral atrophy, a marker of neurodegeneration, in a population-based sample of middle-aged women...- Mid-life adiposity factors relate to blood-brain barrier integrity in late lifeD R Gustafson
Department of Psychiatry and Neurochemistry Neuropsychiatric Epidemiology Unit, Institute of Physiology and Neuroscience, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
J Intern Med 262:643-50. 2007..Adiposity factors included body mass index and blood levels of sex hormone binding globulin (SHBG) and leptin. Design. Retrospective analyses over 24 years within a longitudinal study... - An 18-year follow-up of overweight and risk of Alzheimer diseaseDeborah Gustafson
Department of Nutrition and Food Sciences, Utah State University, Logan, USA
Arch Intern Med 163:1524-8. 2003..Using body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), we examined whether overweight is a risk factor for dementia and AD... - Body mass index and white matter lesions in elderly women. An 18-year longitudinal studyD R Gustafson
Department of Family and Community Medicine, Medical College of Wisconsin, USA
Int Psychogeriatr 16:327-36. 2004..We investigated the longitudinal relationship between body mass index (BMI), a major vascular risk factor, and white matter lesions (WMLs) in older women... 
The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEepsilon4, and age of dementia onsetD R Gustafson
Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden
Neurobiol Aging 31:910-6. 2010..Variations among reports on the relationship between the ACE ID polymorphism and dementia may be due to lack of consideration for gene-gene and gene-phenotype associations...- Adiposity indices and dementiaDeborah Gustafson
Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, SE 413 45, Goteborg, Sweden
Lancet Neurol 5:713-20. 2006..Understanding the life course of adiposity by use of common surrogate measures, such as BMI, among those who do and do not develop dementia is relevant for understanding the causes of dementia and for shaping possible treatment options... 
Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older womenDeborah R Gustafson
The Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
J Neurol Neurosurg Psychiatry 78:461-4. 2007..It is not known, however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy older people...- A life course of adiposity and dementiaDeborah Gustafson
Institute of Neuroscience and Physiology, Section for Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Sweden
Eur J Pharmacol 585:163-75. 2008..Characterizing the life course of adiposity among those who do and do not become demented enhances understanding of biological underpinnings relevant for understanding the etiologies of both dementia and obesity and their co-existence... - Association of the RAGE G82S polymorphism with Alzheimer's diseaseJonny Daborg
Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
J Neural Transm 117:861-7. 2010..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD... - A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's diseaseSara Landgren
Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
J Neural Transm 119:833-42. 2012..However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed... - Kinesin light chain 1 gene haplotypes in three conformational diseasesMalin von Otter
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Neuromolecular Med 12:229-36. 2010..Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract... - Midlife psychological distress associated with late-life brain atrophy and white matter lesions: a 32-year population study of womenLena Johansson
Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
Psychosom Med 74:120-5. 2012..The present study examines the relationship between midlife psychological distress and late-life brain atrophy and white matter lesions (WMLs), which are common findings on neuroimaging in elderly subjects... - Leptin and dementia over 32 years-The Prospective Population Study of WomenDeborah R Gustafson
Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Sweden
Alzheimers Dement 8:272-7. 2012..We explored the relationship between serum leptin in mid-life and dementia, which is a late-life outcome... - No association of LOXL1 gene polymorphisms with Alzheimer's diseaseAlexandra Abramsson
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Neuromolecular Med 13:160-6. 2011..No evidence for associations of these polymorphisms with risk for AD or any of the studied CSF biomarkers measured was found. These results do not support LOXL1 as being a major risk gene for AD... - 37 years of body mass index and dementia: observations from the prospective population study of women in Gothenburg, SwedenDeborah R Gustafson
Department of Neurochemistry and Psychiatry, Neuropsychiatric Epidemiology Unit, at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
J Alzheimers Dis 28:163-71. 2012..BMI may be a potential marker of dementia-related neuropathologies in the brain. Dementia is related to a common risk factor, BMI, from mid-to late-life... - Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataractMalin von Otter
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
Mech Ageing Dev 131:105-10. 2010..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset... - Association of complement factor H Y402H gene polymorphism with Alzheimer's diseaseMadeleine Zetterberg
Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD... - Adiposity and cognitive decline: underlying mechanismsDeborah R Gustafson
Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
J Alzheimers Dis 30:S97-112. 2012..This review will illustrate that adipose tissue is a quintessential, multifunctional tissue of the human body... - Prodromal cognitive signs of dementia in 85-year-olds using four sources of informationS Sacuiu
Psychiatry Section, Institute of Clinical Neuroscience, Sahlgrenska Academy, Goteborg University, Sweden
Neurology 65:1894-900. 2005..To evaluate the utility of assessing four cognitive domains obtained from four information sources to identify individuals at risk for developing dementia, Alzheimer disease (AD), and vascular dementia (VaD)... - A population-based study on the influence of brain atrophy on 20-year survival after age 85P J Olesen
Neuropsychiatric Epidemiology Unit, Wallinsgatan 6, 43141 Mölndal, Sweden
Neurology 76:879-86. 2011..To understand the biology behind increasing longevity, it is important to examine factors related to survival in this age group. The relationship between brain atrophy and survival after age 85 remains unclear... - Secular changes in cognitive predictors of dementia and mortality in 70-year-oldsS Sacuiu
Department of Psychiatry and Neurochemistry, Unit of Psychiatric Epidemiology, University of Gothenburg and Sahlgrenska University Hospital, Institute of Neuroscience and Physiology, Wallinsgatan 6, 431 41 Mölndal, Sweden
Neurology 75:779-85. 2010..Successive elderly birth cohorts improved in cognitive performance during the 20th century. It is not clear whether this influences cognitive predictors of dementia and mortality... - Psychotic and behavioural symptoms in a population-based sample of the very elderly subjectsS Ostling
Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
Acta Psychiatr Scand 120:147-52. 2009..The aim was to elucidate the relationship between psychotic and behavioural symptoms in the elderly... - Body mass index, cognition, disability, APOE genotype, and mortality: the "Treviso Longeva" StudyDeborah R Gustafson
Institute for Neuroscience and Physiology, Neuropsychiatric Epidemiology Unit, University of Gothenburg, Wallinsgatan 6, 431 41 Gothenburg, Sweden
Am J Geriatr Psychiatry 20:594-602. 2012..We explored these measures in relation to 7-year mortality in long-lived Italian elderly... - Adiposity hormones and dementiaDeborah R Gustafson
Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy, University of Gothenburg, Sweden
J Neurol Sci 299:30-4. 2010..Understanding the role of adipose tissue in health of the brain is pivotal to a deeper understanding of dementia processes... - Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in GoteborgK Mehlig
Department of Public Health and Community Medicine Primary Health Care, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Am J Epidemiol 167:684-91. 2008..Because a protective effect was not seen for the other beverages, at least part of the association for wine may be explained by components other than ethanol... - Temporal lobe atrophy and white matter lesions are related to major depression over 5 years in the elderlyPernille J Olesen
Neuropsychiatric Epidemiology Unit, Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
Neuropsychopharmacology 35:2638-45. 2010..This may have implications for prevention, as both neurodegeneration and cerebrovascular disease have been related to preventable factors... - The prognosis and incidence of social phobia in an elderly population. A 5-year follow-upB Karlsson
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
Acta Psychiatr Scand 122:4-10. 2010..To examine the prognosis and incidence of social fears and phobia in an elderly population sample followed for 5 years... - GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer riskWei Zheng
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
Breast Cancer Res Treat 74:9-16. 2002..3, 95% CI = 0.4-4.1). This study suggests that certain null GST genotypes may be associated with an elevated risk of breast cancer and the association may be modified by charred meat intake and cigarette smoking...