H Gronberg

Summary

Country: Sweden

Publications

  1. ncbi request reprint BRCA2 mutation in a family with hereditary prostate cancer
    H Gronberg
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Genes Chromosomes Cancer 30:299-301. 2001
  2. ncbi request reprint Prostate cancer epidemiology
    Henrik Gronberg
    Department of Radiation Sciences Oncology, Umea University, 901 85, Umea, Sweden
    Lancet 361:859-64. 2003
  3. pmc In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer
    H Gronberg
    Department of Oncology, Umea University, 901 85 Umea, Sweden
    Am J Hum Genet 65:134-40. 1999
  4. ncbi request reprint Cancer risk in families with hereditary prostate carcinoma
    H Gronberg
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer 89:1315-21. 2000
  5. ncbi request reprint Genetic variation in the COX-2 gene and the association with prostate cancer risk
    K Shahedi
    Department of Radiation Sciences, Oncology, University of Umea, Umea Sweden
    Int J Cancer 119:668-72. 2006
  6. ncbi request reprint A population based cohort study of patients with multiple colon and endometrial cancer: correlation of microsatellite instability (MSI) status, age at diagnosis and cancer risk
    K Cederquist
    Unit of Medical Genetics, Department of Medical Biosciences, Umea University, S 901 87, Umea, Sweden
    Int J Cancer 91:486-91. 2001
  7. ncbi request reprint Microsatellite instability, PTEN and p53 germline mutations in glioma families
    B Malmer
    Department of Radiation Science, Oncology, Umea University Hospital, Sweden
    Acta Oncol 40:633-7. 2001
  8. pmc No link between viral findings in the prostate and subsequent cancer development
    J Bergh
    Department of Medical Biosciences Pathology, Umea University, Umeå S 90185, Sweden
    Br J Cancer 96:137-9. 2007
  9. ncbi request reprint Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 120:539-42. 2007
  10. ncbi request reprint Primary brain tumours as second primary: a novel association between meningioma and colorectal cancer
    B Malmer
    Department of Oncology, Umea University, Umea, Sweden
    Int J Cancer 85:78-81. 2000

Collaborators

Detail Information

Publications40

  1. ncbi request reprint BRCA2 mutation in a family with hereditary prostate cancer
    H Gronberg
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Genes Chromosomes Cancer 30:299-301. 2001
    ..Although BRCA2 is probably responsible only for a very small fraction of hereditary prostate cancers, this finding supports previous reports of an increased risk of prostate cancer in BRCA2 mutation carriers...
  2. ncbi request reprint Prostate cancer epidemiology
    Henrik Gronberg
    Department of Radiation Sciences Oncology, Umea University, 901 85, Umea, Sweden
    Lancet 361:859-64. 2003
    ..Several important issues could help in our understanding of this disease-the variation in incidence of prostate cancer between ethnic populations and the factors leading to familial clustering of the diseases...
  3. pmc In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer
    H Gronberg
    Department of Oncology, Umea University, 901 85 Umea, Sweden
    Am J Hum Genet 65:134-40. 1999
    ..These results are consistent with the hypothesis of linkage to HPC1 in a subset of families with prostate cancer, particularly those with an early age at diagnosis...
  4. ncbi request reprint Cancer risk in families with hereditary prostate carcinoma
    H Gronberg
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer 89:1315-21. 2000
    ..The aim of this study was to investigate whether tumors other than prostate carcinoma aggregate in families with HPC or whether this disease can be considered site specific...
  5. ncbi request reprint Genetic variation in the COX-2 gene and the association with prostate cancer risk
    K Shahedi
    Department of Radiation Sciences, Oncology, University of Umea, Umea Sweden
    Int J Cancer 119:668-72. 2006
    ..036, global simulated p-value=0.046). This study supports the hypothesis that inflammation is involved in prostate carcinogenesis and that sequence variation within the COX-2 gene influence the risk of prostate cancer...
  6. ncbi request reprint A population based cohort study of patients with multiple colon and endometrial cancer: correlation of microsatellite instability (MSI) status, age at diagnosis and cancer risk
    K Cederquist
    Unit of Medical Genetics, Department of Medical Biosciences, Umea University, S 901 87, Umea, Sweden
    Int J Cancer 91:486-91. 2001
    ..Mutations in mismatch repair genes can explain some of the increased risk in these families, but mutations in MSI negative families are probably due to other colon cancer susceptibility genes not yet described...
  7. ncbi request reprint Microsatellite instability, PTEN and p53 germline mutations in glioma families
    B Malmer
    Department of Radiation Science, Oncology, Umea University Hospital, Sweden
    Acta Oncol 40:633-7. 2001
    ..Apparently, mutation in the tested tumour suppressor genes or DNA mismatch repair genes does not explain the familial glioma observed in these families...
  8. pmc No link between viral findings in the prostate and subsequent cancer development
    J Bergh
    Department of Medical Biosciences Pathology, Umea University, Umeå S 90185, Sweden
    Br J Cancer 96:137-9. 2007
    ....
  9. ncbi request reprint Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 120:539-42. 2007
    ..Further studies on genetic variations in the IGF1 gene in relation to prostate cancer risk as well as to circulating levels of IGF1 are needed to confirm this novel finding...
  10. ncbi request reprint Primary brain tumours as second primary: a novel association between meningioma and colorectal cancer
    B Malmer
    Department of Oncology, Umea University, Umea, Sweden
    Int J Cancer 85:78-81. 2000
    ..A novel association between meningioma and colorectal cancer, particularly in females, was observed, which justifies further studies to evaluate common aetiological factors...
  11. ncbi request reprint -160C/A polymorphism in the E-cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer
    Björn Anders Jonsson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 109:348-52. 2004
    ..6; 95% CI = 1.4-4.9). Our data indicate that the -160 single nucleotide polymorphism in CDH1 is a low-penetrant prostate cancer susceptibility gene that might explain a proportion of familial and notably hereditary prostate cancer...
  12. ncbi request reprint Familial prostate cancer and possible associated malignancies: nation-wide register cohort study in Sweden
    L Damber
    Department of Oncology, Umea University, Sweden
    Int J Cancer 78:293-7. 1998
    ..Since no other malignancy was significantly associated with prostate cancer, it is most likely that familial prostate cancer is "site-specific"...
  13. ncbi request reprint Estrogen receptor beta polymorphism is associated with prostate cancer risk
    Camilla Thellenberg-Karlsson
    Department of Radiation Sciences Oncology, University of Umea, Umea, Sweden
    Clin Cancer Res 12:1936-41. 2006
    ..ERbeta is thought to exert an antiproliferative and proapoptotic effect. We examined whether sequence variants in the ERbeta gene are associated with prostate cancer risk...
  14. ncbi request reprint H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences Oncology, Umea University, Umea, Sweden
    J Natl Cancer Inst 96:1248-54. 2004
    ..We examined whether sequence variants in the MIC-1 gene are associated with the risk of prostate cancer...
  15. ncbi request reprint Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 59:132-40. 2004
    ..Here, we further elucidate the role of MSR1 in both Swedish families with HPC and in a cohort of unselected prostate cancer...
  16. ncbi request reprint Prostate cancer in northern Sweden. Incidence, survival and mortality in relation to tumour grade
    H Gronberg
    Department of Oncology, University of Umea, Sweden
    Acta Oncol 33:359-63. 1994
    ..We believe that the most likely explanation for these changes in incidence, survival and mortality is enhanced detection of tumours with more favourable histology as a result of a more frequent use of the diagnostic tools available...
  17. ncbi request reprint Association between the presence of bacterial 16S RNA in prostate specimens taken during transurethral resection of prostate and subsequent risk of prostate cancer (Sweden)
    O Alexeyev
    Department of Medical Biosciences Pathology, Umea University, S 90185, Umea, Sweden
    Cancer Causes Control 17:1127-33. 2006
    ....
  18. ncbi request reprint Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer
    Björn Anders Jonsson
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Int J Cancer 98:838-43. 2002
    ..In a family with hereditary gastric cancer of the diffuse type, we identified the first truncating germline mutation in a Scandinavian family...
  19. ncbi request reprint Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome
    K Cederquist
    Medical and Clinical Genetics, Department of Medical Biosciences, Umea University, Sweden
    Clin Genet 68:533-41. 2005
    ..The several occurrences of breast cancer are not due to the MSH6 mutations. These findings are of great importance for counselling, management and surveillance of families with MSH6 mutations...
  20. ncbi request reprint Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer Res 66:11077-83. 2006
    ..Carriers of five high-risk alleles in the AR, CYP17, and SRD5A2 genes are at approximately 2-fold excess risk to develop prostate cancer...
  21. ncbi request reprint Linkage analysis of prostate cancer susceptibility: confirmation of linkage at 8p22-23
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, University of Umea, 901 87 Umea, Sweden
    Hum Genet 112:414-8. 2003
    ..Thus, we have confirmed evidence for prostate cancer linkage at 8p22-23. Follow-up studies to evaluate the possible association between prostate cancer and genes in this region, especially the MSR1 gene, are warranted...
  22. ncbi request reprint Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, 901 87, Umea, Sweden
    Hum Genet 118:339-47. 2005
    ..Due to the difficulties in replication of genetic association studies, this finding is unusual and novel...
  23. ncbi request reprint Inherited variation in hormone-regulating genes and prostate cancer survival
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Clin Cancer Res 13:5156-61. 2007
    ..However, little is known about genetic determinants of disease progression and prostate cancer-specific death...
  24. ncbi request reprint Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, and Medical Biosciences, Pathology, University of Umea, Umea, Sweden
    Clin Cancer Res 10:7150-6. 2004
    ..To additionally evaluate the possible role of RNASEL in susceptibility to prostate cancer risk, we performed a comprehensive genetic analysis of sequence variants in RNASEL in the Swedish population...
  25. ncbi request reprint Familial brain tumours-genetics or environment? A nationwide cohort study of cancer risk in spouses and first-degree relatives of brain tumour patients
    Beatrice Malmer
    Department of Radiation Sciences, Oncology, Umea University Hospital, Umea, Sweden
    Int J Cancer 106:260-3. 2003
    ..Spouses of PBT patients had an increased risk of skin cancer. We conclude that FDR, not spouses, have a significantly increased risk, which indicates a genetic origin of the familial aggregation of brain tumours...
  26. ncbi request reprint The MTHFR 677C --> T polymorphism and risk of prostate cancer: results from the CAPS study
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea 901 85, Sweden
    Cancer Causes Control 18:1169-74. 2007
    ..In conclusion, our results do not provide strong support for the hypothesis that the MTHFR 677C-->T polymorphism is related to prostate cancer risk...
  27. ncbi request reprint Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Umea University Hospital, 901 85 Umea, Sweden
    J Clin Endocrinol Metab 92:4820-6. 2007
    ..We recently found a haplotype in the 3' region of the IGF-I gene associated with increased risk of prostate cancer, and we hypothesized that the observed association is mediated by circulating IGF-I...
  28. ncbi request reprint Genome-wide scan of Swedish families with hereditary prostate cancer: suggestive evidence of linkage at 5q11.2 and 19p13.3
    Fredrik Wiklund
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 57:290-7. 2003
    ..Prostate cancer (CaP) is a common disorder with multiple genetic and environmental factors contributing to the disease. CaP susceptibility loci can be identified through genome-wide scans of high-risk families...
  29. ncbi request reprint Second primary cancers in men with prostate cancer: an increased risk of male breast cancer
    Camilla Thellenberg
    Department of Radiation Sciences, Oncology, Umea University, Sweden
    J Urol 169:1345-8. 2003
    ..However, risk of bladder cancer and kidney cancer increases. We examine the risk of common and rare second primary cancers following prostate cancer in a large population based cohort to identify possible common etiological factors...
  30. ncbi request reprint Genetic variation in p53 and ATM haplotypes and risk of glioma and meningioma
    Beatrice Susanne Malmer
    Department of Radiation Sciences, Oncology, Umea University Hospital, 901 85, Umea, Sweden
    J Neurooncol 82:229-37. 2007
    ..Therefore, we tested the hypothesis that polymorphisms and haplotypes in p53 and ATM could be associated with glioma and meningioma risk...
  31. pmc Interleukin-1 receptor antagonist haplotype associated with prostate cancer risk
    F Lindmark
    Department of Radiation Sciences Oncology, Umea University, Sweden
    Br J Cancer 93:493-7. 2005
    ....
  32. doi request reprint Dietary supplement use patterns in men with prostate cancer: the Cancer Prostate Sweden study
    A Westerlund
    Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Ann Oncol 22:967-72. 2011
    ..In a European setting, we know little about the use of dietary supplements among men with prostate cancer (PCa) and to what extent lifestyle, disease or other factors influence such use...
  33. pmc Genetic variation in the upstream region of ERG and prostate cancer
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, Umea University, Umea, Sweden
    Cancer Causes Control 20:1173-80. 2009
    ..Here, we investigated if inherited genetic variation upstream of ERG alters prostate cancer risk and survival...
  34. ncbi request reprint A systematic overview of radiation therapy effects in rectal cancer
    Bengt Glimelius
    Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala, Sweden
    Acta Oncol 42:476-92. 2003
    ..The literature is inconclusive with respect to how frequently this occurs. Radiotherapy frequently produces symptom relief in patients with rectal cancer not amendable to surgery...
  35. ncbi request reprint Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden
    Kristina Cederquist
    Unit of Medical and Clinical Genetics, Department of Medical Biosciences, Umea University, Sweden
    Int J Cancer 109:370-6. 2004
    ....
  36. ncbi request reprint Systematic replication study of reported genetic associations in prostate cancer: Strong support for genetic variation in the androgen pathway
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 66:1729-43. 2006
    ..Despite considerable efforts and initial promising findings, the field of prostate cancer genetics is characterized by inconclusive reports and no prostate cancer gene has yet been established...
  37. ncbi request reprint Different aetiology of familial low-grade and high-grade glioma? A nationwide cohort study of familial glioma
    Beatrice Malmer
    Department of Radiation Sciences, Oncology, Umea University Hospital, Umea, Sweden
    Neuroepidemiology 21:279-86. 2002
    ..LGG families apparently have features manifesting a distinct pedigree pattern with sibpairs affected at a young age. These families could provide new insights into the aetiology of glioma...
  38. ncbi request reprint Breast cancer as a second primary in patients with prostate cancer--estrogen treatment or association with family history of cancer?
    Camilla Thellenberg Karlsson
    Department of Radiation Sciences, Oncology, University of Umea, Sweden
    J Urol 176:538-43. 2006
    ..In the current study we performed a comprehensive investigation of whether treatment for prostate cancer and/or family history is responsible for the excess risk...
  39. ncbi request reprint Adjuvant chemotherapy in colorectal cancer: a joint analysis of randomised trials by the Nordic Gastrointestinal Tumour Adjuvant Therapy Group
    Bengt Glimelius
    Department of Oncology, Radiology and Clinical Immunology, University Hospital, Uppsala, Sweden
    Acta Oncol 44:904-12. 2005
    ..15), favouring chemotherapy, was seen. The present analyses corroborate a small but clinically meaningful survival gain from adjuvant chemotherapy in colon cancer stage III, but not in the other presentations...
  40. ncbi request reprint Does a low frequency of P53 and Pgp expression in familial glioma compared to sporadic controls indicate biological differences?
    Beatrice Malmer
    Department of Radiation Sciences, Oncology, Umea University, 90187 Umea, Sweden
    Anticancer Res 22:3949-54. 2002
    ....