L Groc

Summary

Country: Sweden

Publications

  1. ncbi request reprint In vivo evidence for an activity-independent maturation of AMPA/NMDA signaling in the developing hippocampus
    L Groc
    Department of Physiology, Goteborg University, Box 432, Medicinaregatan 11, 405 30 Goteborg, Sweden
    Neuroscience 121:65-72. 2003
  2. ncbi request reprint Bax, Bcl-2, and cyclin expression and apoptosis in rat substantia nigra during development
    L Groc
    William T Gossett Neurology Laboratories, Henry Ford Hospital, 1 Ford Place 4D, Detroit, MI 48202, USA
    Neurosci Lett 306:198-202. 2001
  3. ncbi request reprint Spontaneous unitary synaptic activity in CA1 pyramidal neurons during early postnatal development: constant contribution of AMPA and NMDA receptors
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 22:5552-62. 2002
  4. ncbi request reprint Nitric oxide synthase inhibition during development: effect on apoptotic death of dopamine neurons
    Laurent Groc
    William T Gossett Neurology Laboratories, Henry Ford Hospital, Detroit, MI, USA
    Brain Res Dev Brain Res 138:147-53. 2002
  5. ncbi request reprint In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
    Eur J Neurosci 16:1931-8. 2002
  6. ncbi request reprint Early establishment of multiple release site connectivity between interneurons and pyramidal neurons in the developing hippocampus
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Box 432, Medicinaregatan 11, Goteborg University, 40530 Goteborg, Sweden
    Eur J Neurosci 17:1873-80. 2003
  7. ncbi request reprint Evidence of deprenyl-insensitive apoptosis of nigral dopamine neurons during development
    L Groc
    William T Gossett Neurology Laboratories, Henry Ford Hospital, Detroit, MI, USA
    Brain Res Dev Brain Res 120:95-8. 2000
  8. ncbi request reprint Lipid peroxidation-mediated oxidative stress and dopamine neuronal apoptosis in the substantia nigra during development
    L Groc
    William T. Gossett Neurology Laboratories, Henry Ford Hospital, 1 Ford Place, 4D, Detroit, MI 48202, USA
    Neurochem Int 39:127-33. 2001
  9. pmc Surface mobility of postsynaptic AMPARs tunes synaptic transmission
    Martin Heine
    CNRS, UMR 5091, Universite Bordeaux, Bordeaux, France
    Science 320:201-5. 2008
  10. ncbi request reprint NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin
    Laurent Groc
    Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5091, 33077 Bordeaux, France
    J Neurosci 27:10165-75. 2007

Collaborators

Detail Information

Publications28

  1. ncbi request reprint In vivo evidence for an activity-independent maturation of AMPA/NMDA signaling in the developing hippocampus
    L Groc
    Department of Physiology, Goteborg University, Box 432, Medicinaregatan 11, 405 30 Goteborg, Sweden
    Neuroscience 121:65-72. 2003
    ..Thus, although critical for certain aspects of neuronal development, correlated neural activity in the neonatal hippocampus does not seem to promote incorporation of AMPA receptors at pure NMDA synapses...
  2. ncbi request reprint Bax, Bcl-2, and cyclin expression and apoptosis in rat substantia nigra during development
    L Groc
    William T Gossett Neurology Laboratories, Henry Ford Hospital, 1 Ford Place 4D, Detroit, MI 48202, USA
    Neurosci Lett 306:198-202. 2001
    ..These novel findings suggest that nigral dopamine neurons undergo developmental apoptotic death through a Bax:Bcl-2-sensitive pathway that does not involve cyclin mediation...
  3. ncbi request reprint Spontaneous unitary synaptic activity in CA1 pyramidal neurons during early postnatal development: constant contribution of AMPA and NMDA receptors
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 22:5552-62. 2002
    ..These findings suggest that the vast majority of nascent glutamatergic synapses express both functional AMPA and NMDA receptors in the neonatal hippocampus...
  4. ncbi request reprint Nitric oxide synthase inhibition during development: effect on apoptotic death of dopamine neurons
    Laurent Groc
    William T Gossett Neurology Laboratories, Henry Ford Hospital, Detroit, MI, USA
    Brain Res Dev Brain Res 138:147-53. 2002
    ..However, those treatments did not rescue dopamine neurons from developmental death, suggesting that NO is not involved in vivo in developmental death of these neurons or in the overall development of the SNc...
  5. ncbi request reprint In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
    Eur J Neurosci 16:1931-8. 2002
    ..The apical dendrite, the axons, or the soma grew normally during activity deprivation. Thus, the in vivo neural activity in the neonate hippocampus seems to promote neuronal growth by initiating novel branches...
  6. ncbi request reprint Early establishment of multiple release site connectivity between interneurons and pyramidal neurons in the developing hippocampus
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Box 432, Medicinaregatan 11, Goteborg University, 40530 Goteborg, Sweden
    Eur J Neurosci 17:1873-80. 2003
    ..The present result thus suggests different mechanisms to govern the maturation of excitatory and inhibitory synaptic transmissions...
  7. ncbi request reprint Evidence of deprenyl-insensitive apoptosis of nigral dopamine neurons during development
    L Groc
    William T Gossett Neurology Laboratories, Henry Ford Hospital, Detroit, MI, USA
    Brain Res Dev Brain Res 120:95-8. 2000
    ..Determining the pathway(s) leading to deprenyl-insensitive apoptosis of nigral dopamine neurons in development may shed light on mechanisms underlying the premature death of dopamine neurons in neurodegenerative disorders...
  8. ncbi request reprint Lipid peroxidation-mediated oxidative stress and dopamine neuronal apoptosis in the substantia nigra during development
    L Groc
    William T. Gossett Neurology Laboratories, Henry Ford Hospital, 1 Ford Place, 4D, Detroit, MI 48202, USA
    Neurochem Int 39:127-33. 2001
    ..These results do not support the hypothesis that lipid peroxidation-mediated oxidative stress is the major mediator of nigral dopamine neuronal apoptosis during the perinatal period...
  9. pmc Surface mobility of postsynaptic AMPARs tunes synaptic transmission
    Martin Heine
    CNRS, UMR 5091, Universite Bordeaux, Bordeaux, France
    Science 320:201-5. 2008
    ..Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses...
  10. ncbi request reprint NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin
    Laurent Groc
    Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5091, 33077 Bordeaux, France
    J Neurosci 27:10165-75. 2007
    ..Our data reveal a new mode of control of synaptic NMDAR assembly at postnatal hippocampal synapses and an unprecedented role of ECM proteins in regulating glutamate receptor surface diffusion...
  11. pmc Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
    Michael D Ehlers
    Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 54:447-60. 2007
    ..Thus, local activity restricts GluR1 mobility on a submicron scale, defining an input-specific mechanism for regulating AMPA receptor composition and abundance...
  12. ncbi request reprint The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
    Cecile Bats
    Physiologie Cellulaire de la Synapse, UMR 5091 CNRS Institut François Magendie, Universite Bordeaux, Bordeaux 33077, France
    Neuron 53:719-34. 2007
    ..These results propose a model in which the Stargazin-PSD-95 interaction plays a key role to trap and transiently stabilize diffusing AMPARs in the postsynaptic density...
  13. ncbi request reprint AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapse
    Laurent Groc
    UMR 5091 CNRS Université de Bordeaux 2 Physiologie Cellulaire de la Synapse, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Cell Tissue Res 326:423-38. 2006
    ..We focus on new findings that shed light on the regulation of receptor cycling events and surface trafficking and the way that this might reshape our thinking about the specific regulation of receptor accumulation at synapses...
  14. ncbi request reprint AMPA signalling in nascent glutamatergic synapses: there and not there!
    Laurent Groc
    Physiologie Cellulaire de la Synapse, CNRS UMR 5091, Universite Bordeaux 2, 33077 Bordeaux, France
    Trends Neurosci 29:132-9. 2006
    ..Thus, the AMPA receptor silence of nascent glutamatergic synapses depends on the synaptic activation history rather than on the nascent state itself...
  15. doi request reprint The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
    Laurent Groc
    Physiologie Cellulaire de Synapse, UMR 5091 CNRS, Universite Bordeaux 2, Bordeaux 33077, France
    Nat Neurosci 11:868-70. 2008
    ..Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking...
  16. ncbi request reprint Kainic acid lesion-induced nigral neuronal death
    Jane A Foster
    William T Gossett Neurology Laboratories, Henry Ford Health System, 1 Ford Place, 4D, Detroit, MI 48202, USA
    J Chem Neuroanat 26:65-73. 2003
    ..This experimental procedure is useful for studying mechanisms underlying protracted death of nigral DA neurons and may provide valuable mechanistic information relevant to understanding the etiology of PD...
  17. ncbi request reprint Compensatory dendritic growth of CA1 pyramidal cells following growth impairment in the neonatal period
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
    Eur J Neurosci 18:1332-6. 2003
    ..These results suggest that the early hippocampal activity controls the growth rate but is not necessary for the generation of an adult normal basal dendritic tree...
  18. ncbi request reprint Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
    Laurent Groc
    UMR 5091 CNRS Université Bordeaux 2, Bordeaux 33077, France
    Nat Neurosci 7:695-6. 2004
    ..Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes...
  19. ncbi request reprint Behavioral and neurochemical repercussions of hippocampal network activity blockade during the neonatal period
    Henrik Ponten
    Department of Pharmacology, Goteborg University, Sweden
    Brain Res Dev Brain Res 155:81-6. 2005
    ..We found no significant differences in either behavioral or biochemical pattern, indicating that an early neonate neural activity blockade does not induce behavioral alterations in pre- and post-puberty rats...
  20. pmc NMDA receptor surface mobility depends on NR2A-2B subunits
    Laurent Groc
    Physiologie Cellulaire de la Synapse, Unité Mixte de Recherche UMR 5091, Centre National de la Recherche Scientifique CNRS, Universite Bordeaux 2, 33077 Bordeaux, France
    Proc Natl Acad Sci U S A 103:18769-74. 2006
    ..This suggests that the switch in synaptic NMDAR subtypes depends on the regulation of the receptor surface trafficking...
  21. ncbi request reprint Pathological apoptosis in the developing brain
    Klas Blomgren
    Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Apoptosis 12:993-1010. 2007
    ..Here we review our current knowledge of the mechanisms involved, with special focus on the potential for therapeutic intervention tailored to the needs of the developing brain...
  22. pmc Single nanoparticle photothermal tracking (SNaPT) of 5-nm gold beads in live cells
    David Lasne
    Centre de Physique Moleculaire Optique et Hertzienne, CNRS UMR 5798 and Université Bordeaux 1, Talence Cedex, France
    Biophys J 91:4598-604. 2006
    ..Single Nanoparticle Photothermal Tracking has the unique potential to record arbitrary long trajectory of membrane proteins using nonfluorescent nanometer-sized labels...
  23. ncbi request reprint [Optical control of neuronal network activity]
    Laurent Groc
    Unité Physiologie Cellulaire de la Synapse, UMR 5091 CNRS, Universite Bordeaux 2, Bordeaux 33077, France
    Med Sci (Paris) 23:585-7. 2007
  24. ncbi request reprint Roles of Ras-Erk in apoptosis of PC12 cells induced by trophic factor withdrawal or oxidative stress
    Hao Jiang
    William T Gossett Neurology Laboratories, Henry Ford Health System, Detroit, MI 48202 USA
    J Mol Neurosci 25:133-40. 2005
    ..These results suggest that the Ras-Erk pathway is critical in mediating protection against apoptotic cell death induced by either trophic factor withdrawal or increased oxidative stress...
  25. ncbi request reprint Surface trafficking of neurotransmitter receptor: comparison between single-molecule/quantum dot strategies
    Laurent Groc
    Physiologie Cellulaire de la Synapse, Unité Mixte de Recherche 5091, Centre National de la Recherche Scientifique, Universite Bordeaux 2, 33077 Bordeaux, France
    J Neurosci 27:12433-7. 2007
  26. ncbi request reprint Multiple routes for glutamate receptor trafficking: surface diffusion and membrane traffic cooperate to bring receptors to synapses
    Laurent Cognet
    Centre de Physique Moleculaire Optique et Hertzienne, CNRS UMR 5798 and Université Bordeaux 1, 351 Cours de la Liberation, 33405 Talence Cedex, France
    Sci STKE 2006:pe13. 2006
    ..Together, these approaches have demonstrated that glutamate receptors diffuse at high rates in the neuronal membrane and suggest a key role for surface diffusion in the regulation of receptor numbers at synapses...
  27. doi request reprint Probing the dynamics of protein-protein interactions at neuronal contacts by optical imaging
    Olivier Thoumine
    CNRS UMR 5091, Institut Magendie, Universite Bordeaux 2, 33077 Bordeaux, France
    Chem Rev 108:1565-87. 2008
  28. ncbi request reprint Resveratrol-induced apoptotic death in human U251 glioma cells
    Hao Jiang
    William T Gossett Neurology Laboratories, Henry Ford Health System, Detroit, Michigan 48202, USA
    Mol Cancer Ther 4:554-61. 2005
    ..These results suggest that multiple signaling pathways may underlie the apoptotic death of U251 glioma induced by resveratrol, which warrants further exploration as an anticancer agent in human glioma...