- Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytesMats Grände
Institute of Anatomy and Cell Biology, Goteborg University, Goteborg, Sweden
J Cell Sci 115:4227-36. 2002..The observations indicate that concomitant growth factor-induced MEK activation is necessary for TGF-beta1 to convert normal thyroid epithelial cells to a mesenchymal phenotype...
- Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouseHenrik Fagman
Institute of Anatomy and Cell Biology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Am J Pathol 164:1865-72. 2004..This study provides clues to the molecular mechanisms that might be dysregulated in thyroid hemiagenesis and development of ectopic thyroid tissue outside the thyroglossal duct...
- In vitro differentiated adipocytes from a Foxc2 reporter knock-in mouse as screening toolAnna Cederberg
Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Goteborg University, Box 440, 405 30 Goteborg, Sweden
Transgenic Res 18:889-97. 2009..In a cell-based screen using such methodology we demonstrate efficacy by identifying NKH477 as a Foxc2 activating compound...