- The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrineMagnus Grenegård
Department of Medicine and Health, Division of Drug Research, Division of Clinical Chemistry, Cardiovascular Inflammation Research Center, Linkoping University, Linköping SE 581 85 Sweden
J Biol Chem 283:18493-504. 2008..These results suggest a new mechanism that has ATP as a key element and circumvents the action of aspirin on epinephrine-facilitated PAR4-mediated platelet activation...
- Characterisation of GEA 3175 on human platelets; comparison with S-nitroso-N-acetyl-D,L-penicillamineAnna K Asplund Persson
Department of Medicine and Care, Division of Pharmacology, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
Eur J Pharmacol 496:1-9. 2004..Consequently, this inhibition depends solely on the increase in cGMP. In summary, differences between GEA 3175 and SNAP were observed in NO releasing, cGMP elevating and Ca2+ suppressive properties...
- Chlamydia pneumoniae induces nitric oxide synthase and lipoxygenase-dependent production of reactive oxygen species in platelets. Effects on oxidation of low density lipoproteinsHanna Kälvegren
Department of Medicine and Care, Division of Pharmacology, Faculty of Health Sciences, Linkoping University, Sweden
Thromb Haemost 94:327-35. 2005..pneumoniae or platelets. In conclusion, C. pneumoniae interaction with platelets leading to aggregation, ROS-production and oxidative damage on LDL, may play a crucial role in the development of atherosclerotic cardiovascular disease...
- Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitorsHanna Kälvegren
Division of Pharmacology, Department of Medicine and Care, Cardiovascular Inflammation Research Centre, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
Eur J Pharmacol 566:20-7. 2007..The findings in this study showing that platelets stimulated by C. pneumoniae are unaffected by COX inhibitors but sensitive to 12-LOX inhibitors, may thus be of importance in future management of atherosclerosis and thrombosis...
- The acute-phase protein alpha 1-acid glycoprotein (AGP) induces rises in cytosolic Ca2+ in neutrophil granulocytes via sialic acid binding immunoglobulin-like lectins (siglecs)Peter Gunnarsson
Division of Pharmacology, Department of Medicine and Care, Linkoping University, S 581 85 Linkoping, Sweden
FASEB J 21:4059-69. 2007..Our report provides the first evidence for a signaling capacity by AGP through a defined receptor. Pre-engagement of L-selectin significantly enhanced this signaling capacity...
- alpha(1)-acid glycoprotein (AGP)-induced platelet shape change involves the Rho/Rho kinase signalling pathwayPeter Gunnarsson
Division of Drug Research, Department of Medical and Health Sciences, Linkoping University, S 581 85 Linkoping, Sweden
Thromb Haemost 102:694-703. 2009..Hence, the present study indicates that AGP directly contributes to platelet activation, which in turn might have an impact in physiological haemostasis and/or pathological thrombosis...
- Sialic acid residues play a pivotal role in alpha(1)-acid glycoprotein (AGP)-induced generation of reactive oxygen species in chemotactic peptide pre-activated neutrophil granulocytesPeter Gunnarsson
Division of Drug Research, Department of Medical and Health Sciences, Linkoping University, 581 85 Linkoping, Sweden
Inflamm Res 59:89-95. 2010..The aim of the present study was to establish the importance of sialic acid residues on AGP in modulating human neutrophil functions, with emphasis on the generation of reactive oxygen species (ROS)...