Aleksander Giwercman

Summary

Country: Sweden

Publications

  1. pmc Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build, 2C, DK 8000 Aarhus C, Denmark
    Environ Health 4:26. 2005
  2. pmc Xenoestrogenic activity in blood of European and Inuit populations
    Eva C Bonefeld-Jorgensen
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build, 1260, University of Aarhus, DK 8000 Aarhus, Denmark
    Environ Health 5:12. 2006
  3. ncbi Preserved male fertility despite decreased androgen sensitivity caused by a mutation in the ligand-binding domain of the androgen receptor gene
    A Giwercman
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 85:2253-9. 2000
  4. ncbi Correlation between sperm motility and sperm chromatin structure assay parameters
    Aleksander Giwercman
    Fertility Centre and Department of Urology, Scanian Andrology Center, Malmo University Hospital, Malmo, Sweden
    Fertil Steril 80:1404-12. 2003
  5. ncbi Linkage between androgen receptor gene CAG trinucleotide repeat length and testicular germ cell cancer histological type and clinical stage
    Aleksander Giwercman
    Fertility Centre, Scanian Andrology Centre, Malmo University Hospital, SE 205 02, Sweden
    Eur J Cancer 40:2152-8. 2004
  6. ncbi Ethnic differences in occurrence of TDS-- genetics and/or environment?
    Aleksander Giwercman
    Fertility Centre and Department of Urology, Scanian Andrology Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Int J Androl 29:291-7; discussion 304-6. 2006
  7. ncbi Reduced risk of prostate cancer in men who are childless as compared to those who have fathered a child: a population based case-control study
    Aleksander Giwercman
    Fertility Centre, Scanian Andrology Centre, Malmo University Hospital, Malmo, Sweden
    Int J Cancer 115:994-7. 2005
  8. ncbi Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: multicentre study in Inuit and European populations
    Saad Elzanaty
    Scanian Andrology Centre, Fertility Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Reprod Toxicol 22:765-73. 2006
  9. ncbi Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics
    Aleksander Giwercman
    Molecular Reproductive Medicine Research Unit, Department of Clinical Sciences, Reproductive Medicine Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Pharmacogenet Genomics 17:391-401. 2007
  10. ncbi Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study
    Yasir Ruhayel
    CRC, Department of Clinical Sciences, Lund University, Malmo University Hospital, Malmo, Sweden
    Clin Endocrinol (Oxf) 67:85-92. 2007

Detail Information

Publications81

  1. pmc Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Build, 2C, DK 8000 Aarhus C, Denmark
    Environ Health 4:26. 2005
    ..Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited...
  2. pmc Xenoestrogenic activity in blood of European and Inuit populations
    Eva C Bonefeld-Jorgensen
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build, 1260, University of Aarhus, DK 8000 Aarhus, Denmark
    Environ Health 5:12. 2006
    ....
  3. ncbi Preserved male fertility despite decreased androgen sensitivity caused by a mutation in the ligand-binding domain of the androgen receptor gene
    A Giwercman
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 85:2253-9. 2000
    ..The patients inherited the mutation from their grandfathers through their mothers, and one of the young men possessing the mutation has fathered a daughter...
  4. ncbi Correlation between sperm motility and sperm chromatin structure assay parameters
    Aleksander Giwercman
    Fertility Centre and Department of Urology, Scanian Andrology Center, Malmo University Hospital, Malmo, Sweden
    Fertil Steril 80:1404-12. 2003
    ..To evaluate the association between chromatin structure and sperm motility...
  5. ncbi Linkage between androgen receptor gene CAG trinucleotide repeat length and testicular germ cell cancer histological type and clinical stage
    Aleksander Giwercman
    Fertility Centre, Scanian Andrology Centre, Malmo University Hospital, SE 205 02, Sweden
    Eur J Cancer 40:2152-8. 2004
    ..The median CAG length was higher if the tumour was metastasing at diagnosis. This is the first study showing an association between the AR polymorphism and histological type as well as the progression rate of TGCC...
  6. ncbi Ethnic differences in occurrence of TDS-- genetics and/or environment?
    Aleksander Giwercman
    Fertility Centre and Department of Urology, Scanian Andrology Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Int J Androl 29:291-7; discussion 304-6. 2006
    ..Such 'susceptibility genes' need to be identified, those involved in the synthesis, action and metabolism of sex steroids being strong candidates...
  7. ncbi Reduced risk of prostate cancer in men who are childless as compared to those who have fathered a child: a population based case-control study
    Aleksander Giwercman
    Fertility Centre, Scanian Andrology Centre, Malmo University Hospital, Malmo, Sweden
    Int J Cancer 115:994-7. 2005
    ..The risk for prostate cancer is reduced among childless men. A dysfunctioning reproductive apparatus fueling to a lesser extent prostatic growth, could be a plausible mechanism of this association...
  8. ncbi Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: multicentre study in Inuit and European populations
    Saad Elzanaty
    Scanian Andrology Centre, Fertility Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Reprod Toxicol 22:765-73. 2006
    ..In conclusion, the negative effects of POP on sperm motility, observed in the same study population might partly be caused by post-testicular mechanisms, involving a decreased epididymal function...
  9. ncbi Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics
    Aleksander Giwercman
    Molecular Reproductive Medicine Research Unit, Department of Clinical Sciences, Reproductive Medicine Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Pharmacogenet Genomics 17:391-401. 2007
    ..We aimed to investigate whether the CAG and GGN polymorphisms in the androgen receptor gene modify the effect of persistent organohalogen pollutant exposure on human sperm characteristics...
  10. ncbi Seasonal variation in serum concentrations of reproductive hormones and urinary excretion of 6-sulfatoxymelatonin in men living north and south of the Arctic Circle: a longitudinal study
    Yasir Ruhayel
    CRC, Department of Clinical Sciences, Lund University, Malmo University Hospital, Malmo, Sweden
    Clin Endocrinol (Oxf) 67:85-92. 2007
    ....
  11. ncbi The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population
    Yvonne L Giwercman
    Department of Urology, Malmo University Hospital, Lund University, Wallenberg Laboratory, Entrance 46, SE 205 02 Malmo, Sweden
    Eur Urol 48:679-85. 2005
    ..To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5alpha-reductase II (SRD5A2) gene...
  12. ncbi Polymorphisms in genes regulating androgen activity among prostate cancer low-risk Inuit men and high-risk Scandinavians
    Charlotte Giwercman
    Fertility Centre, Scanian Andrology Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Int J Androl 31:25-30. 2008
    ....
  13. doi Emotional disorders in testicular cancer survivors in relation to hypogonadism, androgen receptor polymorphism and treatment modality
    Jakob Eberhard
    Department of Oncology, Lund University Hospital, Lund University, SE 221 85 Lund, Sweden
    J Affect Disord 122:260-6. 2010
    ..Hence, the aim of the present study was to investigate whether EMD is related to the presence of hypogonadism, androgen receptor (AR) polymorphism and/or treatment intensity...
  14. doi Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer
    Leon J S Brokken
    Department of Clinical Sciences, Molecular Reproductive Medicine, Lund University, Sweden
    Mol Cell Endocrinol 351:279-85. 2012
    ..The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis...
  15. doi Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland
    Linus Kvist
    Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Malmo, Sweden
    Reprod Toxicol 34:644-50. 2012
    ..002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men...
  16. doi Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men
    Carl Linnér
    Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Malmo, Sweden
    Aging Male 16:52-7. 2013
    ..025 and p = 0.018, respectively). Lower concentrations of E2 did not seem to increase the risk of being diagnosed with diabetes. In conclusion, in hypogonadal men, the rs2207396 variant in ESR1 predicts the risk of type 2 diabetes...
  17. ncbi Frequent finding of the androgen receptor A645D variant in normal population
    Kristina B Lundin
    Department of Clinical Sciences, Fertility Centre, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    J Clin Endocrinol Metab 91:3228-31. 2006
    ..The androgen receptor A645D mutation has been described in one patient with ambiguous genitalia and one boy with normal phenotype...
  18. ncbi Association between tobacco exposure and reproductive parameters in adolescent males
    Jonas Richthoff
    Centre of Reproductive Medicine, Scanian Andrology Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Int J Androl 31:31-9. 2008
    ..Smoking seems to impair sperm production and epididymal as well as accessory sex gland function and could be one of the factors contributing to regional differences in sperm parameters...
  19. pmc Risk of birth abnormalities in the offspring of men with a history of cancer: a cohort study using Danish and Swedish national registries
    Olof Ståhl
    Department of Clinical Sciences, Molecular Reproductive Medicine Research Unit, Lund University, Malmo, Sweden
    J Natl Cancer Inst 103:398-406. 2011
    ..The potential mutagenic effects of cancer therapies and the growing number of young male cancer survivors have given rise to concern about the health of their offspring...
  20. doi Sperm DNA integrity in men treated for childhood cancer
    Patrik Romerius
    Department of Pediatrics, Lund University and Skåne University Hospital, Malmo, Sweden
    Clin Cancer Res 16:3843-50. 2010
    ..The aim of this study is to assess DNA fragmentation index (DFI) as an indicator of sperm DNA integrity in childhood cancer survivors (CCS), with treatment regimen taken into account...
  21. pmc Impact of PCB and p,p'-DDE contaminants on human sperm Y:X chromosome ratio: studies in three European populations and the Inuit population in Greenland
    Tarmo Tiido
    Molecular Reproductive Medicine Research Unit, Department of Clinical Sciences, Fertility Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Environ Health Perspect 114:718-24. 2006
    ..Our aim in the present study was to investigate whether exposure to 2,2 ,4,4 ,5,5 -hexachlorobiphenyl (PCB-153) and dichlorodiphenyldichloroethene (p,p -DDE) affects sperm Y:X chromosome distribution...
  22. doi Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study
    Aleksander Giwercman
    Reproductive Medicine Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    Int J Androl 33:e221-7. 2010
    ..2-60). We conclude that SCSA DFI adds to the value of semen analysis in prediction of the chance of natural conception...
  23. doi Estrogen receptor α single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors
    Patrik Romerius
    Department of Pediatrics, Skane University Hospital, Lund University, Lund, Sweden
    Pharmacogenet Genomics 21:263-9. 2011
    ..Identification of genetic markers for the risk of azoospermia in childhood cancer survivors may help in identifying boys to whom testicular cryopreservation should be offered...
  24. ncbi Androgen receptor gene GGN and CAG polymorphisms among severely oligozoospermic and azoospermic Swedish men
    Yasir Ruhayel
    Fertility Centre, Scanian Andrology Centre, Malmo, Sweden
    Hum Reprod 19:2076-83. 2004
    ..We investigated the androgen receptor gene GGN polymorphism and its relation to male infertility and receptor function...
  25. doi Risk factors for post-treatment hypogonadism in testicular cancer patients
    Jakob Eberhard
    Department of Oncology, Lund University Hospital, Lund University, SE 22185 Lund, Sweden
    Eur J Endocrinol 158:561-70. 2008
    ..Testicular germ-cell cancer (TGCC) patients are at risk of developing hypogonadism but no risk factors have yet been defined...
  26. doi Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations
    Christian H Lindh
    Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, 221 85 Lund, Sweden
    Chemosphere 88:1269-75. 2012
    ..For the other populations no strong determinants were found...
  27. doi Determination of serum amyloid P component in seminal plasma and correlations with serum hormone levels in young, healthy men
    Annika Sonesson
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malmo, Sweden
    Scand J Clin Lab Invest 71:569-75. 2011
    ..It seems that hormonal regulation is not the major pathway regulating seminal plasma SAP, and seminal plasma SAP and serum SAP are not co-regulated...
  28. pmc Single semen analysis as a predictor of semen quality: clinical and epidemiological implications
    Lars Rylander
    Reproductive Medicine Centre, Malmo University Hospital, Lund University, Malmö SE 20502, Sweden
    Asian J Androl 11:723-30. 2009
    ..In a clinical situation, when the question is whether the semen quality is normal or not, the first ejaculate will, in at least 85% of cases, give a correct overall conclusion...
  29. doi Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure
    Mona Bungum
    Reproductive Medicine Centre, Malmo University Hospital, Malmo, Sweden
    Fertil Steril 93:277-9. 2010
    ..9% vs. 0)...
  30. doi Environmental factors and testicular function
    Aleksander Giwercman
    Reproductive Medicine Centre, Skåne University Hospital Malmö, Lund University, SE 205 02 Malmo, Sweden
    Best Pract Res Clin Endocrinol Metab 25:391-402. 2011
    ....
  31. doi Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease
    Åke Västermark
    Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Lund, Sweden
    Eur J Cancer 47:413-9. 2011
    ..Future studies should focus on the impact of sex hormones on foetal germ cell development and the interaction between environmental factors and androgen receptor variants in relation to the risk of testicular malignancy...
  32. ncbi Androgen receptor CAG repeat length correlates with semen PSA levels in adolescence
    Yvonne Lundberg Giwercman
    Department of Urology, Malmo University Hospital, Lund University, Malmo, Sweden
    Prostate 59:227-33. 2004
    ..Our aim was to investigate whether CAG repeat number might have an impact on prostate function in adolescence...
  33. doi Association between follicle-stimulating hormone receptor polymorphisms and reproductive parameters in young men from the general population
    Ida Lindgren
    Molecular Genetic Reproductive Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmo, Sweden
    Pharmacogenet Genomics 22:667-72. 2012
    ..The aim of the present study was therefore to examine whether these genetic variants of the FSHR influence reproductive parameters in men from the general population...
  34. doi Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro
    Christel Björk
    Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund University, Malmo, Sweden
    Reprod Toxicol 32:293-7. 2011
    ..Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity...
  35. doi Constitutive expression of the antibacterial CXC chemokine GCP-2/CXCL6 by epithelial cells of the male reproductive tract
    Mattias Collin
    Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    J Reprod Immunol 79:37-43. 2008
    ..GCP-2/CXCL6 in seminal plasma may play roles in both host defense of the male urogenital tract and during fertilization...
  36. doi Male infertility and prostate cancer risk: a nested case-control study
    Yasir Ruhayel
    Department of Urology, Malmo University Hospital, Malmo, Sweden
    Cancer Causes Control 21:1635-43. 2010
    ....
  37. pmc A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation
    Marlene D Dalgaard
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Med Genet 49:58-65. 2012
    ..The incidence of these disorders has increased over the last few decades, and testicular cancer now affects 1% of the Danish and Norwegian male population...
  38. doi Beta-microseminoprotein in serum correlates with the levels in seminal plasma of young, healthy males
    Camilla Valtonen-Andre
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    J Androl 29:330-7. 2008
    ..This suggests that MSP in serum can be used as a marker of prostate secretion, despite the contribution from extra prostatic tissues...
  39. pmc Serum levels of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in relation to markers of reproductive function in young males from the general Swedish population
    Jonas Richthoff
    Fertility Centre, Malmo University Hospital, Malmo, Sweden
    Environ Health Perspect 111:409-13. 2003
    ....
  40. ncbi Exposure to persistent organochlorine pollutants associates with human sperm Y:X chromosome ratio
    Tarmo Tiido
    Fertility Centre, Scanian Andrology Centre, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Reprod 20:1903-9. 2005
    ..During the last decades, there has been concern that exposure to endocrine disruptors, such as persistent organochlorine pollutants (POPs), may contribute to sex ratio changes in offspring of exposed populations...
  41. ncbi Remarkably low incidence of hypospadias in Greenland despite high exposure to endocrine disrupters; possible protective effect of androgen receptor genotype
    Yvonne L Giwercman
    Department of Clinical Sciences, Wallenberg Laboratory, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Pharmacogenet Genomics 16:375-7. 2006
    ..This finding indicates that AR genotype could contribute to a genetic predisposition in Greenlanders, who despite one of the worlds highest body burden of POPs, seem to be protected from hypospadias...
  42. doi Very high correlations between fresh weight and lipid-adjusted PCB-153 serum concentrations: irrespective of fasting status, age, body mass index, gender, or exposure distributions
    Lars Rylander
    Division of Occupational and Environmental Medicine, Lund University, SE 221 85 Lund, Sweden
    Chemosphere 88:828-31. 2012
    ..This raises the question of the necessity of lipid adjustment. The aim of the present study was to evaluate the correlation between fresh weight and lipid adjusted concentrations...
  43. doi Estrogens and phytoestrogens in male infertility
    Aleksander Giwercman
    Reproductive Medicine Centre, Skane University Hospital, Lund University, Malmo, Sweden
    Curr Opin Urol 21:519-26. 2011
    ....
  44. ncbi Duration of sexual abstinence: epididymal and accessory sex gland secretions and their relationship to sperm motility
    Saad Elzanaty
    Fertility Center and Department of Clinical Chemistry, Scanian Andrology Center, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Hum Reprod 20:221-5. 2005
    ..The data on the association between the abstinence period and sperm motility are conflicting...
  45. pmc The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins
    Anneli M L Edström
    Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
    J Immunol 181:3413-21. 2008
    ..These data provide novel roles for the resolution of seminal clots and for the high zinc concentration in human seminal plasma...
  46. pmc Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility
    Mona Bungum
    Reproductive Medicine Centre RMC, Skane University Hospital, Malmo, Sweden
    Asian J Androl 13:69-75. 2011
    ..More conflicting data exist regarding the role of sperm DNA fragmentation in relation to fertilization, pre-embryo development and pregnancy outcome in in vitro fertilization and intracytoplasmic sperm injection (ICSI)...
  47. ncbi Sperm chromatin structure assay parameters measured after density gradient centrifugation are not predictive for the outcome of ART
    Mona Bungum
    Centre of Reproductive Medicine, Malmo University Hospital, 205 02 Malmo, Sweden
    Hum Reprod 23:4-10. 2008
    ..The aim of this study is to assess whether SCSA analysis of sperm prepared by density gradient centrifugation (DGC) could add more information in regard to the prediction of treatment outcome...
  48. ncbi Reproductive function during summer and winter in Norwegian men living north and south of the Arctic circle
    Gunilla Malm
    Fertility Center, Scanian Andrology Centre, Malmo University Hospital, SE 205 02, Malmo, Sweden
    J Clin Endocrinol Metab 89:4397-402. 2004
    ..223 ng/liter). The length of the daylight period may have a slight impact on hormonal markers of spermatogenesis but does not cause substantial changes in spermatozoa numbers and motility...
  49. ncbi A novel mutation in the D-box of the androgen receptor gene (S597R) in two unrelated individuals Is associated with both normal phenotype and severe PAIS
    Yvonne L Giwercman
    Department of Urology, Malmo University Hospital, Lund University, Malmo, Sweden
    Horm Res 61:58-62. 2004
    ..Therefore, we routinely perform sequencing of the AR gene in all cases with suspected androgen insensitivity...
  50. ncbi Influence of endocrine disruptors on human male fertility
    Aleksander Giwercman
    Reproductive Medicine Centre and Molecular Reproductive Research Group, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Reprod Biomed Online 15:633-42. 2007
    ..Future studies will reveal whether prenatal exposure does more strongly affect male fertility and whether genetic predisposition regulates the susceptibility of an individual to the adverse effects of endocrine disruptors...
  51. pmc Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study
    Johannes Bobjer
    Reproductive Medicine Centre, Skåne University Hospital Malmö, Malmo, Sweden
    PLoS ONE 8:e61466. 2013
    ..We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases...
  52. doi 47,XXY Klinefelter syndrome: clinical characteristics and age-specific recommendations for medical management
    Lise Aksglaede
    Department of Growth and Reproduction GR, Rigshospitalet, Blegdamsvej, Copenhagen Ø, Denmark
    Am J Med Genet C Semin Med Genet 163:55-63. 2013
    ..The aim of this review is to present the clinical aspects of XXY and the age-specific recommendations for medical management. © 2013 Wiley Periodicals, Inc...
  53. ncbi Blood levels of free-PSA but not complex-PSA significantly correlates to prostate release of PSA in semen in young men, while blood levels of complex-PSA, but not free-PSA increase with age
    Charlotta Sävblom
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, Malmo University Hospital, Malmo, Sweden
    Prostate 65:66-72. 2005
    ..We also compared age-related changes of PSA-forms in blood from young versus older men...
  54. ncbi The impact of testicular carcinoma and its treatment on sperm DNA integrity
    Olof Ståhl
    Department of Oncology, Lund University Hospital, Lund, Sweden
    Cancer 100:1137-44. 2004
    ..The aim of the current study was to evaluate the impact of chemotherapy and irradiation on sperm DNA integrity...
  55. pmc The circadian variation in Anti-Müllerian hormone in patients with polycystic ovary syndrome differs significantly from normally ovulating women
    Leif Bungum
    Reproductive Medicine Center, Skane University Hospital, Lund University, Malmo, Sweden
    PLoS ONE 8:e68223. 2013
    ....
  56. doi Circadian variation in concentration of anti-Müllerian hormone in regularly menstruating females: relation to age, gonadotrophin and sex steroid levels
    Leif Bungum
    Reproductive Medicine Center, Skane University Hospital, Lund University, Entrance 74, Malmo 20502, Sweden
    Hum Reprod 26:678-84. 2011
    ..The aim of the study is to assess the circadian variation in AMH, and to evaluate its clinical relevance and biological aspects as an effect of age and other endocrine mechanisms involved in the regulation of AMH secretion...
  57. doi The antibacterial chemokine MIG/CXCL9 is constitutively expressed in epithelial cells of the male urogenital tract and is present in seminal plasma
    Helena M Linge
    Section for Infection, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    J Interferon Cytokine Res 28:191-6. 2008
    ..The relatively high levels of MIG/CXCL9 in seminal plasma point to roles for this chemokine in both host defense of the male urogenital tract and during fertilization...
  58. ncbi Effect of graded testicular doses of radiotherapy in patients treated for carcinoma-in-situ in the testis
    Peter Meidahl Petersen
    Department of Growth and Reproduction, Finsencenter, Copenhagen University Hospital, Rigshospitalet, Copenhagen
    J Clin Oncol 20:1537-43. 2002
    ..To determine the effect of radiotherapy in doses 14 to 20 Gy on eradication of carcinoma-in-situ (CIS) testis and on the Leydig cell function...
  59. ncbi A frequent allele codes for a truncated variant of semenogelin I, the major protein component of human semen coagulum
    Ake Lundwall
    Department of Laboratory Medicine, Lund University, University Hospital, Malmo, Sweden
    Mol Hum Reprod 9:345-50. 2003
    ....
  60. ncbi Sperm concentration in Latvian military conscripts as compared with other countries in the Nordic-Baltic area
    Igor Tsarev
    Latvian University Biomedicine Centre, Ratsupites 1, Riga LV 1067, Latvia
    Int J Androl 28:208-14. 2005
    ..Sperm concentration was significantly higher in men with both parents born in Latvia (77 +/- 60 x 10(6)/mL), compared with men with both parents born outside Latvia (55 +/- 45 x 10(6)/mL, p = 0.03)...
  61. ncbi Reproductive effects of male psychologic stress
    Niels Henrik I Hjollund
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Epidemiology 15:21-7. 2004
    ..Male psychologic stress can affect semen quality and couple fecundability...
  62. pmc Semen quality in relation to xenohormone and dioxin-like serum activity among Inuits and three European populations
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Environ Health Perspect 115:15-20. 2007
    ..Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds...
  63. ncbi The RsaI polymorphism in the estrogen receptor-beta gene is associated with male infertility
    Elin L Aschim
    Department of Gynecology and Obstetrics, Rikshopitalet University Hospital, Oslo, Norway
    J Clin Endocrinol Metab 90:5343-8. 2005
    ..Estrogens and estrogen receptors (ERs) play a role in regulating testicular function. ERbeta contains two silent polymorphisms, RsaI (G1082A) and AluI (G1730A)...
  64. ncbi Urinary phthalate metabolites and biomarkers of reproductive function in young men
    Bo A G Jonsson
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, Lund, Sweden
    Epidemiology 16:487-93. 2005
    ..A recent study in humans reported dose-response relations between low phthalate levels in urine and human semen parameters, which raises the question whether humans are more sensitive to phthalate exposure than animals...
  65. ncbi Quality control workshops in standardization of sperm concentration and motility assessment in multicentre studies
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Int J Androl 28:144-9. 2005
    ..72). This study indicates that training and subsequent follow-up workshops can assure minimum variability among centres in assessments of sperm concentration and motility...
  66. pmc Exposure to PCBs and p,p'-DDE and human sperm chromatin integrity
    Anna Rignell-Hydbom
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Environ Health Perspect 113:175-9. 2005
    ..These results suggest that POP exposure may have a slight negative impact on human sperm chromatin integrity...
  67. ncbi Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene
    Elin L Aschim
    Andrology Laboratory, Department of Gynaecology and Obstetrics, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Clin Endocrinol Metab 89:5105-9. 2004
    ..Our findings indicate an association between GGN length and the risk of cryptorchidism and penile hypospadias, both conditions considered consequences of low androgenicity...
  68. pmc Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and
    Bo A G Jonsson
    Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Environ Health 4:27. 2005
    ....
  69. ncbi Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone
    Pierre Marc G Bouloux
    Department of Endocrinology, The Royal Free Hospital, London, United Kingdom
    J Androl 24:604-11. 2003
    ..In conclusion, a weekly dose of 450 IU (3 x 150 IU or 2 x 225 IU) recFSH, in addition to hCG, was able to induce spermatogenesis in many hypogonadotropic azoospermic men who failed to respond to treatment with hCG alone...
  70. pmc Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines
    Jens Peter Bonde
    Department of Occupational Medicine, Aarhus University Hospital, Arhus, Denmark
    Environ Health Perspect 116:269-77. 2008
    ..We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function...
  71. doi Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 93:2737-45. 2008
    ..The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear...
  72. pmc Xenoandrogenic activity in serum differs across European and Inuit populations
    Tanja Krüger
    Department of Environmental and Occupational Medicine, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Environ Health Perspect 115:21-7. 2007
    ....
  73. ncbi Editorial comment on: noninvasive detection of testicular carcinoma in situ in semen using OCT3/4
    Aleksander Giwercman
    Eur Urol 54:159. 2008
  74. ncbi Semen quality and exposure to persistent organochlorine pollutants
    Gunnar Toft
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Epidemiology 17:450-8. 2006
    ..The majority of studies have been conducted among selected populations of infertility clients or among occupational cohorts including a limited number of participants...
  75. pmc Dioxin-like activities in serum across European and Inuit populations
    Manhai Long
    Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, University of Aarhus, Vennelyst Boulevard 6, DK 8000 Aarhus C, Denmark
    Environ Health 5:14. 2006
    ....
  76. ncbi Oxidative DNA damage in human sperm influences time to pregnancy
    Steffen Loft
    Institute of Public Health, University of Copenhagen, Department of Growth and Reproduction, The National University Hospital, Denmark
    Hum Reprod 18:1265-72. 2003
    ..Oxidative stress and related DNA damage in human sperm may be important for fecundity and pregnancy outcome...
  77. doi Sperm DNA damage in men from infertile couples
    Juris Erenpreiss
    Andrology Laboratory, Riga Stradins University, LV 1007 Riga, Latvia
    Asian J Androl 10:786-90. 2008
    ..To investigate the prevalence of high levels of sperm DNA damage among men from infertile couples with both normal and abnormal standard semen parameters...
  78. ncbi Job strain and male fertility
    Niels Henrik I Hjollund
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Epidemiology 15:114-7. 2004
    ..We collected prospective data on job strain among men, and describe the associations with semen quality and probability of conceiving a clinical pregnancy during a menstrual cycle...
  79. doi Assessment of sexual health in aging men in Europe: development and validation of the European Male Ageing Study sexual function questionnaire
    Daryl B O'Connor
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    J Sex Med 5:1374-85. 2008
    ..Assessment of male sexual dysfunction has been the focus of substantial scientific effort. Less research has focused on the development of instruments for the measurement of sexual functioning in aging men...
  80. ncbi Gonadotoxic cancer treatment in males--a reason for andrological counselling?
    Aleksander Giwercman
    Radiother Oncol 68:213-5. 2003
  81. ncbi Alcohol consumption at the time of conception and spontaneous abortion
    Tine Brink Henriksen
    Perinatal Epidemiological Research Unit, Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus, Denmark
    Am J Epidemiol 160:661-7. 2004
    ..Only the adjusted relative risks for 10 or more drinks/week compared with no intake were statistically significant. Both male and female alcohol intakes during the week of conception increased the risk of early pregnancy loss...