Holger Gerhardt

Summary

Country: Sweden

Publications

  1. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
  2. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
  3. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
  4. ncbi Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Curr Opin Nephrol Hypertens 13:45-52. 2004
  5. pmc A new method for large scale isolation of kidney glomeruli from mice
    Minoru Takemoto
    Department of Medical Biochemistry, Goteborg University, Sweden
    Am J Pathol 161:799-805. 2002
  6. ncbi Endothelial-pericyte interactions in angiogenesis
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, PO Box 440, SE 405 30, Goteborg, Sweden
    Cell Tissue Res 314:15-23. 2003
  7. pmc N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy
    Joakim Håkansson
    Department of Medical Biochemistry, Sahlgrenska Academy at Gothenburg University, Goteborg, Sweden
    PLoS ONE 6:e26026. 2011
  8. pmc Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    Maria Enge
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    EMBO J 21:4307-16. 2002
  9. ncbi Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
    Jody J Haigh
    Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Canada
    Dev Biol 262:225-41. 2003
  10. doi Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
    Mariona Graupera
    Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nature 453:662-6. 2008

Collaborators

Detail Information

Publications23

  1. ncbi Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..These observations suggest that Nrp-1 plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain...
  2. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
    ..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
  3. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
    ..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
  4. ncbi Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice
    Christer Betsholtz
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Curr Opin Nephrol Hypertens 13:45-52. 2004
    ....
  5. pmc A new method for large scale isolation of kidney glomeruli from mice
    Minoru Takemoto
    Department of Medical Biochemistry, Goteborg University, Sweden
    Am J Pathol 161:799-805. 2002
    ..This method makes feasible transcript profiling and proteomic analysis of the developing, healthy and diseased mouse glomerulus...
  6. ncbi Endothelial-pericyte interactions in angiogenesis
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, PO Box 440, SE 405 30, Goteborg, Sweden
    Cell Tissue Res 314:15-23. 2003
    ..Genetic data demonstrate the critical importance of pericytes for vascular morphogenesis and function, and imply specific roles for the cell type in various aspects of angiogenesis...
  7. pmc N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy
    Joakim Håkansson
    Department of Medical Biochemistry, Sahlgrenska Academy at Gothenburg University, Goteborg, Sweden
    PLoS ONE 6:e26026. 2011
    ..Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis...
  8. pmc Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    Maria Enge
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    EMBO J 21:4307-16. 2002
    ..Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy...
  9. ncbi Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
    Jody J Haigh
    Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Canada
    Dev Biol 262:225-41. 2003
    ..VEGF-A dosage is therefore a critical parameter regulating the density of the vascular plexus in the developing CNS that is in turn a key determinant in the development and architectural organization of the nervous system...
  10. doi Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
    Mariona Graupera
    Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nature 453:662-6. 2008
    ..These results provide the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis...
  11. ncbi Pericytes: gatekeepers in tumour cell metastasis?
    Holger Gerhardt
    Vascular Biology Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    J Mol Med (Berl) 86:135-44. 2008
    ..In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis...
  12. pmc Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
    Alexandra Abramsson
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genes Dev 21:316-31. 2007
    ....
  13. pmc Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins
    Joseph H McCarty
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:7667-77. 2002
    ..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
  14. pmc Pericytes limit tumor cell metastasis
    Xiaojie Xian
    Stem Cell Center, Lund University, Lund, Sweden
    J Clin Invest 116:642-51. 2006
    ..These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions...
  15. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    ..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
  16. pmc Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
    Christopher A Jones
    Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Nat Med 14:448-53. 2008
    ....
  17. pmc Wnt/beta-catenin signaling controls development of the blood-brain barrier
    Stefan Liebner
    Institute of Neurology Edinger Institute, Johann Wolfgang Goethe University, 60325 Frankfurt, Germany
    J Cell Biol 183:409-17. 2008
    ..These findings may open new therapeutic avenues to modulate endothelial barrier function and to limit the devastating effects of BBB breakdown...
  18. doi Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo
    Alan G F Worsley
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 38:1043-9. 2008
    ..These data suggest that, although involved in Th2 direction in vitro, jagged2 is not fundamentally required for Th2 induction by SEA-activated dendritic cells in vivo...
  19. ncbi Growth factor gradients in vascular patterning
    Andrea Lundkvist
    Vascular Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Novartis Found Symp 283:194-201; discussion 201-6, 238-41. 2007
    ..Disruption of VEGF-A gradients provides a novel concept for the mechanism underlying pathological patterning in ocular disease...
  20. ncbi Agent-based simulation of notch-mediated tip cell selection in angiogenic sprout initialisation
    Katie Bentley
    Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    J Theor Biol 250:25-36. 2008
    ....
  21. ncbi Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivo
    Tetyana Levchenko
    Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institute, SE 17176, Stockholm, Sweden
    FASEB J 22:880-9. 2008
    ..These findings provide a rationale for using angiomotin antibodies for specifically targeting endothelial migration in angiogenesis-dependent diseases...
  22. ncbi Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    Mats Hellstrom
    AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 445:776-80. 2007
    ....
  23. ncbi Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lens
    Christopher A Mitchell
    Department of Obstetrics and Gynaecology, University of Nottingham, City Hospital, Hucknall Rd, Nottingham, NG5 1PB, UK
    Angiogenesis 9:209-24. 2006
    ..The results of this study indicate that individual isoforms of VEGFA induce distinct vascular phenotypes in the eye during embryonic development and that their relative doses provide instructive cues for vascular patterning...