Genomes and Genes
- Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous systemHolger Gerhardt
Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
Dev Dyn 231:503-9. 2004..These observations suggest that Nrp-1 plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain...
- VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodiaHolger Gerhardt
Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
J Cell Biol 161:1163-77. 2003..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
- Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wallPer Lindblom
Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
Genes Dev 17:1835-40. 2003..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
- Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in miceChrister Betsholtz
Department of Medical Biochemistry, University of Goteborg, Sweden
Curr Opin Nephrol Hypertens 13:45-52. 2004....
- A new method for large scale isolation of kidney glomeruli from miceMinoru Takemoto
Department of Medical Biochemistry, Goteborg University, Sweden
Am J Pathol 161:799-805. 2002..This method makes feasible transcript profiling and proteomic analysis of the developing, healthy and diseased mouse glomerulus...
- Endothelial-pericyte interactions in angiogenesisHolger Gerhardt
Department of Medical Biochemistry, , Medicinaregatan 9A, PO Box 440, SE 405 30, , Sweden
Cell Tissue Res 314:15-23. 2003..Genetic data demonstrate the critical importance of pericytes for vascular morphogenesis and function, and imply specific roles for the cell type in various aspects of angiogenesis...
- N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathyJoakim Håkansson
Department of Medical Biochemistry, Sahlgrenska Academy at Gothenburg University, Goteborg, Sweden
PLoS ONE 6:e26026. 2011..Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis...
- Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathyMaria Enge
Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
EMBO J 21:4307-16. 2002..Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy...
- Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signalingJody J Haigh
Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Canada
Dev Biol 262:225-41. 2003..VEGF-A dosage is therefore a critical parameter regulating the density of the vascular plexus in the developing CNS that is in turn a key determinant in the development and architectural organization of the nervous system...
- Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migrationMariona Graupera
Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
Nature 453:662-6. 2008..These results provide the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis...
- Pericytes: gatekeepers in tumour cell metastasis?Holger Gerhardt
Vascular Biology Laboratory, London Research Institute Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
J Mol Med (Berl) 86:135-44. 2008..In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis...
- Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular developmentAlexandra Abramsson
Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Genes Dev 21:316-31. 2007....
- Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrinsJoseph H McCarty
Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Cell Biol 22:7667-77. 2002..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
- Pericytes limit tumor cell metastasisXiaojie Xian
Stem Cell Center, Lund University, Lund, Sweden
J Clin Invest 116:642-51. 2006..These data support a new model for how tumor cells trigger metastasis by perturbing pericyte-endothelial cell-cell interactions...
- Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesisChristiana Ruhrberg
Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
Genes Dev 16:2684-98. 2002..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
- Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeabilityChristopher A Jones
Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
Nat Med 14:448-53. 2008....
- Wnt/beta-catenin signaling controls development of the blood-brain barrierStefan Liebner
Institute of Neurology Edinger Institute, Johann Wolfgang Goethe University, 60325 Frankfurt, Germany
J Cell Biol 183:409-17. 2008..These findings may open new therapeutic avenues to modulate endothelial barrier function and to limit the devastating effects of BBB breakdown...
- Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivoAlan G F Worsley
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
Eur J Immunol 38:1043-9. 2008..These data suggest that, although involved in Th2 direction in vitro, jagged2 is not fundamentally required for Th2 induction by SEA-activated dendritic cells in vivo...
- Growth factor gradients in vascular patterningAndrea Lundkvist
Vascular Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Novartis Found Symp 283:194-201; discussion 201-6, 238-41. 2007..Disruption of VEGF-A gradients provides a novel concept for the mechanism underlying pathological patterning in ocular disease...
- Agent-based simulation of notch-mediated tip cell selection in angiogenic sprout initialisationKatie Bentley
Biomolecular Modelling Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
J Theor Biol 250:25-36. 2008....
- Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivoTetyana Levchenko
Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institute, SE 17176, Stockholm, Sweden
FASEB J 22:880-9. 2008..These findings provide a rationale for using angiomotin antibodies for specifically targeting endothelial migration in angiogenesis-dependent diseases...
- Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesisMats Hellstrom
AngioGenetics Sweden AB, Scheeles vag 2, SE 171 77 Stockholm, Sweden
Nature 445:776-80. 2007....
- Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lensChristopher A Mitchell
Department of Obstetrics and Gynaecology, University of Nottingham, City Hospital, Hucknall Rd, Nottingham, NG5 1PB, UK
Angiogenesis 9:209-24. 2006..The results of this study indicate that individual isoforms of VEGFA induce distinct vascular phenotypes in the eye during embryonic development and that their relative doses provide instructive cues for vascular patterning...