T Tot

Summary

Affiliation: Falun Hospital
Country: Sweden

Publications

  1. ncbi request reprint DCIS, cytokeratins, and the theory of the sick lobe
    Tibor Tot
    Department of Pathology, Central Hospital, 791 82, Falun, Sweden
    Virchows Arch 447:1-8. 2005
  2. ncbi request reprint The theory of the sick breast lobe and the possible consequences
    Tibor Tot
    Department of Pathology, Central Hospital, S 791 82 Falun, Sweden
    Int J Surg Pathol 15:369-75. 2007
  3. ncbi request reprint Metastatic chordoma of the breast: an extremely rare lesion mimicking mucinous cancer
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    APMIS 114:726-9. 2006
  4. pmc Molecular phenotypes of unifocal, multifocal, and diffuse invasive breast carcinomas
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, S 791 82 Falun, Sweden
    Patholog Res Int 2011:480960. 2010
  5. pmc The role of large-format histopathology in assessing subgross morphological prognostic parameters: a single institution report of 1000 consecutive breast cancer cases
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, 791 82, Falun, Sweden
    Int J Breast Cancer 2012:395415. 2012
  6. pmc Comparison of the subgross distribution of the lesions in invasive ductal and lobular carcinomas of the breast: a large-format histology study
    Syster Hofmeyer
    Department of Pathology and Clinical Cytology, Central Hospital Falun, 79182 Falun, Sweden
    Int J Breast Cancer 2012:436141. 2012
  7. pmc Subgross morphology, the sick lobe hypothesis, and the success of breast conservation
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, 79182 Falun, Sweden
    Int J Breast Cancer 2011:634021. 2011
  8. pmc Metaplastic carcinoma of the breast with neuroectodermal stromal component
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, S 791 82 Falun, Sweden
    Patholog Res Int 2011:191274. 2011
  9. doi request reprint Axillary lymph node status in unifocal, multifocal, and diffuse breast carcinomas: differences are related to macrometastatic disease
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden
    Ann Surg Oncol 19:3395-401. 2012
  10. doi request reprint The distribution of lesions in 1-14-mm invasive breast carcinomas and its relation to metastatic potential
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden
    Virchows Arch 455:109-15. 2009

Detail Information

Publications43

  1. ncbi request reprint DCIS, cytokeratins, and the theory of the sick lobe
    Tibor Tot
    Department of Pathology, Central Hospital, 791 82, Falun, Sweden
    Virchows Arch 447:1-8. 2005
    ....
  2. ncbi request reprint The theory of the sick breast lobe and the possible consequences
    Tibor Tot
    Department of Pathology, Central Hospital, S 791 82 Falun, Sweden
    Int J Surg Pathol 15:369-75. 2007
    ....
  3. ncbi request reprint Metastatic chordoma of the breast: an extremely rare lesion mimicking mucinous cancer
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    APMIS 114:726-9. 2006
    ..Discriminating metastases of mucin-producing tumors in the breast from primary mucinous carcinomas is important with regard to the striking difference in prognosis of these lesions...
  4. pmc Molecular phenotypes of unifocal, multifocal, and diffuse invasive breast carcinomas
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, S 791 82 Falun, Sweden
    Patholog Res Int 2011:480960. 2010
    ..Histological multifocality and diffuse distribution of the invasive tumor component seem to be negative morphologic prognostic parameters in breast carcinomas, independent of the molecular phenotype...
  5. pmc The role of large-format histopathology in assessing subgross morphological prognostic parameters: a single institution report of 1000 consecutive breast cancer cases
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, 791 82, Falun, Sweden
    Int J Breast Cancer 2012:395415. 2012
    ..Noncalcified, low-grade in situ foci, and invasive tumor foci <5 mm were the most frequent causes of discrepant findings...
  6. pmc Comparison of the subgross distribution of the lesions in invasive ductal and lobular carcinomas of the breast: a large-format histology study
    Syster Hofmeyer
    Department of Pathology and Clinical Cytology, Central Hospital Falun, 79182 Falun, Sweden
    Int J Breast Cancer 2012:436141. 2012
    ....
  7. pmc Subgross morphology, the sick lobe hypothesis, and the success of breast conservation
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, 79182 Falun, Sweden
    Int J Breast Cancer 2011:634021. 2011
    ....
  8. pmc Metaplastic carcinoma of the breast with neuroectodermal stromal component
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, S 791 82 Falun, Sweden
    Patholog Res Int 2011:191274. 2011
    ..The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed...
  9. doi request reprint Axillary lymph node status in unifocal, multifocal, and diffuse breast carcinomas: differences are related to macrometastatic disease
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden
    Ann Surg Oncol 19:3395-401. 2012
    ..However, it is not clear whether this propensity manifests in the form of macrometastases or as presumably less-significant low-volume metastatic disease...
  10. doi request reprint The distribution of lesions in 1-14-mm invasive breast carcinomas and its relation to metastatic potential
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden
    Virchows Arch 455:109-15. 2009
    ..These findings indicate that lesion distribution has prognostic relevance for 1-14-mm invasive breast carcinomas and underline the importance of using special techniques in breast pathology for proper assessment of this parameter...
  11. doi request reprint Radiological-pathological correlation in diagnosing breast carcinoma: the role of pathology in the multimodality era
    Tibor Tot
    Department of Pathology, Central Hospital, Falun, Sweden
    Pathol Oncol Res 14:173-8. 2008
    ....
  12. doi request reprint Early and more advanced unifocal and multifocal breast carcinomas and their molecular phenotypes
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden
    Clin Breast Cancer 11:258-63. 2011
    ..I examined the relationship between the recently established prognostic parameter, molecular tumor phenotype and tumor size, lesion distribution (unifocal, multifocal, diffuse growth), and lymph node status...
  13. ncbi request reprint The origins of early breast carcinoma
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden
    Semin Diagn Pathol 27:62-8. 2010
    ....
  14. ncbi request reprint Cost-benefit analysis of using large-format histology sections in routine diagnostic breast care
    Tibor Tot
    Department of Pathology and Clinical Cytology, Uppsala University, Central Hospital, Falun, Sweden
    Breast 19:284-8. 2010
    ..Thus, large-format histopathology is the only cost-effective histotechnology method that meets the needs of modern multidisciplinary diagnostic breast care...
  15. doi request reprint The role of radiological-pathological correlation in diagnosing early breast cancer: the pathologist's perspective
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, 79182, Falun, Sweden
    Virchows Arch 458:125-31. 2011
    ..Interdisciplinary diagnosis is inevitably becoming the new gold standard in the diagnosis and management of early breast carcinomas...
  16. doi request reprint Multifocality in "basal-like" breast carcinomas and its influence on lymph node status
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun, Sweden
    Ann Surg Oncol 18:1671-7. 2011
    ....
  17. doi request reprint Breast cancer multifocality, disease extent, and survival
    Tibor Tot
    Central Hospital Falun, Department of Pathology and Clinical Cytology, S 79182 Falun, Sweden
    Hum Pathol 42:1761-9. 2011
    ..96 (95%; 1.11-3.48; P = .02) after controlling for the same factors. Lesion distribution and disease extent represent important independent survival-related prognostic parameters in breast carcinoma...
  18. ncbi request reprint Clinical relevance of the distribution of the lesions in 500 consecutive breast cancer cases documented in large-format histologic sections
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    Cancer 110:2551-60. 2007
    ..The aim of the study was to identify breast carcinoma growth patterns indicating increased metastatic potential of the tumor and a need for more aggressive therapy...
  19. ncbi request reprint The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract
    T Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    APMIS 108:467-72. 2000
    ..ER identified 31/34 of breast cancer metastases. By combining the results of CK20 and ER staining all the metastases could be properly classified as the CK20+/ER- pattern identified all the gastrointestinal tumors...
  20. ncbi request reprint The pressing need for better histologic-mammographic correlation of the many variations in normal breast anatomy
    T Tot
    Department of Pathology, Falun Central Hospital, Sweden
    Virchows Arch 437:338-44. 2000
    ..These improvements in communication between the members of the diagnostic team will serve to optimize the sensitivity and specificity of breast cancer diagnosis...
  21. ncbi request reprint The value of cytokeratins 20 and 7 in discriminating metastatic adenocarcinomas from pleural mesotheliomas
    T Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    Cancer 92:2727-32. 2001
    ..In the current study, the value of these CKs in differential diagnosis of malignant pleural lesions was examined...
  22. ncbi request reprint Cytokeratins 20 and 7 as biomarkers: usefulness in discriminating primary from metastatic adenocarcinoma
    T Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, S 791 82, Sweden
    Eur J Cancer 38:758-63. 2002
    ..CK20/7 phenotyping of adenocarcinomas is a useful diagnostic tool if based on algorithmic and probabilistic approaches and a detailed database...
  23. ncbi request reprint The diffuse type of invasive lobular carcinoma of the breast: morphology and prognosis
    Tibor Tot
    Department of Pathology, Falun Central Hospital, 79182 Falun, Sweden
    Virchows Arch 443:718-24. 2003
    ..We propose to delineate the diffuse group of the ILCs as a separate diagnostic category with distinct morphological and radiological features and with unfavorable prognosis...
  24. ncbi request reprint The clinical relevance of cytokeratin phenotyping in needle biopsy of liver metastasis
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    APMIS 111:1075-82. 2003
    ..The results in the CK20- subgroups of the liver metastases are disappointing and cannot substantially help the clinical investigation...
  25. ncbi request reprint Identifying colorectal metastases in liver biopsies: the novel CDX2 antibody is less specific than the cytokeratin 20+/7- phenotype
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    Med Sci Monit 10:BR139-43. 2004
    ..In the present study we compared the sensitivity and specificity of CDX2 expression and the CK20+/CK7- phenotype in predicting the colorectal origin of liver metastases...
  26. ncbi request reprint Correlating the ground truth of mammographic histology with the success or failure of imaging
    Tibor Tot
    Department of Pathology, Central Hospital, S 791 82 Falun, Sweden
    Technol Cancer Res Treat 4:23-8. 2005
    ..Regular mammographic-pathologic correlation may increase the specificity and sensitivity of mammographic diagnosis. This correlation is essential for establishing the proper pre- and postoperative histological diagnosis, too...
  27. ncbi request reprint Eccrine ductal and acrosyringeal differentiation of the breast epithelium--a lesion associated with some metaplastic breast carcinomas
    Tibor Tot
    Department of Pathology, Central Hospital, 79182 Falun, Sweden
    Virchows Arch 449:565-71. 2006
    ..These previously unrecognized metaplastic changes of the breast epithelium may represent precursor lesions of certain types of metaplastic breast carcinomas...
  28. ncbi request reprint The limited prognostic value of measuring and grading small invasive breast carcinomas: the whole sick lobe versus the details within it
    Tibor Tot
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    Med Sci Monit 12:RA170-5. 2006
    ....
  29. ncbi request reprint Unclassified sex cord/gonadal stromal testis tumor with predominance of spindle cells
    M Tarján
    Deaprtment of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    APMIS 114:465-9. 2006
    ..We describe a single case of this rare tumor type and discuss the differential diagnostics options based on a review of the related literature. The problem of the lack of reliable morphological prognostic factors is also addressed...
  30. ncbi request reprint Differences in expression of tumor markers between pre- and postmenopausal women with invasive cervical cancer
    Dan Hellberg
    Center for Clinical Research, Falun, Sweden
    Anticancer Res 28:1793-5. 2008
    ..THE AIM of the present study was to investigate the differences in the expression of tumor markers in squamous cell and in adenomatous carcinomas in pre- and postmenopausal women, respectively...
  31. doi request reprint Pitfalls in immunohistochemical validation of tumor marker expression--exemplified in invasive cancer of the uterine cervix
    Dan Hellberg
    Center for Clinical Research, Falun, Sweden
    Gynecol Oncol 112:235-40. 2009
    ..To study if immunohistochemical expression of tumor markers as prognostic predictors is influenced by clinical stage, adjustments for expression of other tumor markers and histological type in cervical cancer...
  32. ncbi request reprint Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia
    Raghad Samir
    Department of Obstetrics and Gynecology, Falun Hospital, Falun, Sweden
    Anticancer Res 30:1217-22. 2010
    ..The aim of this study was to To investigate correlations between serum progesterone and serum estradiol levels and expression of tissue tumor markers in cervical intraepithelial neoplasia (CIN) and normal epithelium...
  33. ncbi request reprint Mammographic tumor features can predict long-term outcomes reliably in women with 1-14-mm invasive breast carcinoma
    Laszlo Tabar
    Mammography Department, Central Hospital, Falun, Sweden
    Cancer 101:1745-59. 2004
    ..The radiologic images of 1-14-mm invasive breast carcinomas can be classified into 5 separate categories. The use of these mammographic indicators to predict patient outcome has important prognostic and therapeutic implications...
  34. pmc Primary adenocarcinoma of the seminal vesicle
    M Tarján
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    Indian J Urol 25:143-5. 2009
    ..We demonstrate a case of SVC and discuss the problems related to diagnosis in this tumor...
  35. ncbi request reprint Prediction of extracapsular extension of prostate cancer based on systematic core biopsies
    M Tarján
    Department of Pathology and Clinical Cytology, Central Hospital, Falun, Sweden
    Scand J Urol Nephrol 40:459-64. 2006
    ..To evaluate the clinical utility of transrectal ultrasound-guided systematic sextant or octant biopsies for the prediction of extracapsular extension (ECE) at radical prostatectomy...
  36. doi request reprint The metastatic capacity of multifocal breast carcinomas: extensive tumors versus tumors of limited extent
    Tibor Tot
    Department of Pathology, Central Hospital, S 791 82 Falun, Sweden
    Hum Pathol 40:199-205. 2009
    ..These results confirm that the extent and distribution of lesions in breast carcinomas are important biological prognostic factors and indicate a need for special histopathologic techniques for adequate assessment of these parameters...
  37. doi request reprint Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium
    Raghad Samir
    Department of Obstetrics and Gynecology, Falun Hospital, Falun, Sweden
    Am J Obstet Gynecol 202:579.e1-7. 2010
    ..The purpose of this study was to investigate correlations between smoking and serum cotinine, respectively, and tumor marker expression in cervical intraepithelial neoplasia (CIN) and normal epithelium...
  38. ncbi request reprint Predicting the outcome of squamous cell carcinoma of the uterine cervix using combinations of individual tumor marker expressions
    Annika K Lindström
    Ventrum Clinic, Bjursås, Sweden
    Anticancer Res 27:1609-15. 2007
    ..To evaluate if combining the individual expression patterns of biomarkers targeting different molecular alterations in tumor development will improve prognosis prediction in invasive squamous cell carcinoma of the uterine cervix...
  39. ncbi request reprint Lobular intraepithelial neoplasia [lobular carcinoma in situ] with comedo-type necrosis: A clinicopathologic study of 18 cases
    Oluwole Fadare
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Am J Surg Pathol 30:1445-53. 2006
    ..However, because classic LIN with necrosis is apparently rare in its pure form, reexcision is recommended when this lesion is detected in isolation in a core biopsy...
  40. ncbi request reprint Immunohistochemical study of androgen receptors in breast carcinoma. Evidence of their frequent expression in lobular carcinoma
    Cristina Riva
    Department of Human Morphology, Section of Pathology, University of Insubria, Varese, Italy
    Virchows Arch 447:695-700. 2005
    ..In addition, AR positive carcinomas are frequently characterized by a low or intermediate grade, a low proliferative index and ER and/or PR co-expression...
  41. ncbi request reprint Invasive breast cancer: correlation of dynamic MR features with prognostic factors
    Botond K Szabó
    Division of Diagnostic Radiology, Center for Surgical Sciences, Karolinska Institute, Huddinge University Hospital, 14186, Stockholm, Sweden
    Eur Radiol 13:2425-35. 2003
    ..Our results suggest that these MR signs are not only important in differentiating benign from malignant lesions, but may also be useful to noninvasively identify highly aggressive breast carcinomas...
  42. ncbi request reprint Associations between ten biological tumor markers in squamous cell cervical cancer and serum estradiol, serum progesterone and smoking
    Annika K Lindström
    Ventrum Clinic, Bjursås, Sweden
    Anticancer Res 27:1401-6. 2007
    ..To study possible associations between selected tumor markers and co-factors in squamous cell cervical cancer...