Per Aspenberg

Summary

Affiliation: Faculty of Health Sciences
Country: Sweden

Publications

  1. ncbi request reprint Doxycycline impairs tendon repair in rats
    Björn Pasternak
    Division of Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop Belg 72:756-60. 2006
  2. pmc Fluid pressure and flow as a cause of bone resorption
    Anna Fahlgren
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 81:508-16. 2010
  3. doi request reprint Sol-gel derived titania coating with immobilized bisphosphonate enhances screw fixation in rat tibia
    Paula Linderbäck
    Department of Physics, Chemistry and Biology, Laboratory of Applied Physics, Linkoping University, SE 581 83 Linkoping, Sweden
    J Biomed Mater Res A 94:389-95. 2010
  4. pmc Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats
    Fredrik Agholme
    Orthopaedics Division, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Sweden
    Acta Orthop 82:628-32. 2011
  5. doi request reprint Early Achilles tendon healing in sheep
    Olena Virchenko
    Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Science, Linkoping, Sweden
    Arch Orthop Trauma Surg 128:1001-6. 2008
  6. pmc Mechanical load and BMP signaling during tendon repair: a role for follistatin?
    Pernilla Eliasson
    The Section for Orthopaedics and Sports Medicine, IKE, Faculty of Health Sciences, Linkoping University, SE 581 85, Linkoping, Sweden
    Clin Orthop Relat Res 466:1592-7. 2008
  7. doi request reprint Rat Achilles tendon healing: mechanical loading and gene expression
    Pernilla Eliasson
    Linkoping University, Orthopedics, AIM IKE, Faculty of Health Sciences, SE 581 83 Linkoping, Sweden
    J Appl Physiol (1985) 107:399-407. 2009
  8. doi request reprint Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants
    Therese Andersson
    Experimental Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, 58183 Linkoping, Sweden
    J Mater Sci Mater Med 21:3029-37. 2010
  9. doi request reprint Weak effect of strontium on early implant fixation in rat tibia
    Paula Linderbäck
    Laboratory of Applied Physics, Department of Physics, Chemistry and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    Bone 50:350-6. 2012
  10. ncbi request reprint Doxycycline-coated sutures improve the suture-holding capacity of the rat Achilles tendon
    Björn Pasternak
    Orthopaedics Section, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 78:680-6. 2007

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Doxycycline impairs tendon repair in rats
    Björn Pasternak
    Division of Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop Belg 72:756-60. 2006
    ..0) microg/ml. In conclusion, tendon healing can be affected by doxycycline at clinically relevant serum concentrations. This observation might be of relevance to further studies exploring effects of MMP-inhibitors on tendon tissue...
  2. pmc Fluid pressure and flow as a cause of bone resorption
    Anna Fahlgren
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 81:508-16. 2010
    ..This is seen around loose screws, for example, but may also contribute to prosthetic loosening. Previous animal studies have shown that such zones can be induced by fluctuations in fluid pressure or flow, caused by implant instability...
  3. doi request reprint Sol-gel derived titania coating with immobilized bisphosphonate enhances screw fixation in rat tibia
    Paula Linderbäck
    Department of Physics, Chemistry and Biology, Laboratory of Applied Physics, Linkoping University, SE 581 83 Linkoping, Sweden
    J Biomed Mater Res A 94:389-95. 2010
    ..Also, locally delivered, that is, surface immobilized alendronate showed a better fixation than systemically delivered. Using sol-gel derived TiO(2) as a platform, it is possible to administer controllable amounts of a variety of BPs...
  4. pmc Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats
    Fredrik Agholme
    Orthopaedics Division, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Sweden
    Acta Orthop 82:628-32. 2011
    ..Sclerostin expression is upregulated in unloaded bone and is downregulated by loading. We wanted to determine whether an anti-sclerostin antibody would stimulate metaphyseal healing in unloaded bone in a rat model...
  5. doi request reprint Early Achilles tendon healing in sheep
    Olena Virchenko
    Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Science, Linkoping, Sweden
    Arch Orthop Trauma Surg 128:1001-6. 2008
    ..This is the first description of early tendon healing in sheep Achilles tendons...
  6. pmc Mechanical load and BMP signaling during tendon repair: a role for follistatin?
    Pernilla Eliasson
    The Section for Orthopaedics and Sports Medicine, IKE, Faculty of Health Sciences, Linkoping University, SE 581 85, Linkoping, Sweden
    Clin Orthop Relat Res 466:1592-7. 2008
    ..Loading strongly decreased the expression of follistatin, which could lead to increased signaling. The BMP system appears involved in tendon maintenance and healing, and may respond to mechanical loading...
  7. doi request reprint Rat Achilles tendon healing: mechanical loading and gene expression
    Pernilla Eliasson
    Linkoping University, Orthopedics, AIM IKE, Faculty of Health Sciences, SE 581 83 Linkoping, Sweden
    J Appl Physiol (1985) 107:399-407. 2009
    ..In the late phase of healing, tendon-specific genes (scleraxis and tenomodulin) were upregulated with loading, and the healing tissue might to some extent represent a regenerate rather than a scar...
  8. doi request reprint Surface immobilized zoledronate improves screw fixation in rat bone: a new method for the coating of metal implants
    Therese Andersson
    Experimental Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, 58183 Linkoping, Sweden
    J Mater Sci Mater Med 21:3029-37. 2010
    ..No pronounced increase was seen around the pamidronate coated screws. Together, the results demonstrate the possibility of obtaining a significant local therapeutic effect with minute amounts of surface immobilized zoledronate...
  9. doi request reprint Weak effect of strontium on early implant fixation in rat tibia
    Paula Linderbäck
    Laboratory of Applied Physics, Department of Physics, Chemistry and Biology, Linkoping University, SE 581 83 Linkoping, Sweden
    Bone 50:350-6. 2012
    ..Strontium is known to improve bone density, but it appears that this effect is weak in conjunction with metaphyseal bone repair and early implant fixation...
  10. ncbi request reprint Doxycycline-coated sutures improve the suture-holding capacity of the rat Achilles tendon
    Björn Pasternak
    Orthopaedics Section, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 78:680-6. 2007
    ..We therefore hypothesized that treatment with the MMP inhibitor doxycycline would improve the sutureholding capacity of tendon...
  11. doi request reprint Tissue memory in healing tendons: short loading episodes stimulate healing
    Therese Andersson
    Orthopedics and Sports Medicine, AIR IKE, Faculty of Health Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    J Appl Physiol (1985) 107:417-21. 2009
    ..This suggests that patients might be allowed early short loading episodes following, e.g., an Achilles tendon rupture for a better outcome...
  12. ncbi request reprint Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses
    Björn Pasternak
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Int J Colorectal Dis 23:271-6. 2008
    ..Several experimental studies show that MMP inhibitors administered systemically alleviate postoperative weakening of intestinal anastomoses. We hypothesised that local delivery of MMP inhibitors would achieve a similar effect...
  13. doi request reprint Autologous platelets have no effect on the healing of human achilles tendon ruptures: a randomized single-blind study
    Thorsten Schepull
    Department of Clinical and Experimental Medicine, IKE, Linkoping University, Sweden
    Am J Sports Med 39:38-47. 2011
    ..Animal studies have shown that local application of platelet-rich plasma (PRP) stimulates tendon repair. Preliminary results from a retrospective case series have shown faster return to sports...
  14. doi request reprint Low-level mechanical stimulation is sufficient to improve tendon healing in rats
    Therese Andersson
    Experimental Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    J Appl Physiol (1985) 113:1398-402. 2012
    ..This stimulation appears to affect mainly tissue quality, whereas stronger stimulation also increases callus size...
  15. pmc Etanercept does not impair healing in rat models of tendon or metaphyseal bone injury
    Olof Sandberg
    Orthopedics Division, Department of Clinical and Experimental Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Acta Orthop 83:305-10. 2012
    ..We therefore investigated whether blocking of TNF-α with etanercept influences the healing process in established rat models of injury of tendons and metaphyseal bone...
  16. doi request reprint Additive effects of PTH and bisphosphonates on the bone healing response to metaphyseal implants in rats
    Per Aspenberg
    Section of Orthopedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 79:111-5. 2008
    ..Thus, we hypothesized that in contrast to the case in osteoporosis treatment, PTH and bisphosphonates have an additive effect in situations involving bone regeneration...
  17. doi request reprint The effects of Dickkopf-1 antibody on metaphyseal bone and implant fixation under different loading conditions
    Fredrik Agholme
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Bone 48:988-96. 2011
    ..It also seems that Dkk1 is up-regulated both after metaphyseal trauma and after unloading, and that Dkk1 is involved in mechano-transduction...
  18. doi request reprint Primary gene response to mechanical loading in healing rat Achilles tendons
    Pernilla Eliasson
    Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    J Appl Physiol (1985) 114:1519-26. 2013
    ..The five regulated genes appear to constitute a general activation machinery. The further development of gene regulation might depend on the tissue context...
  19. doi request reprint Influence of a single loading episode on gene expression in healing rat Achilles tendons
    Pernilla Eliasson
    Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    J Appl Physiol (1985) 112:279-88. 2012
    ..In conclusion, the fact that there were hardly any regulated genes 24 h after loading suggests that optimal stimulation of healing requires a mechanical loading stimulus every day...
  20. ncbi request reprint How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation
    Olena Virchenko
    Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Linkoping University, Linkoping, SE 581 85, Sweden
    Acta Orthop 77:806-12. 2006
    ..In a rat Achilles tendon transection model, 1 postoperative injection resulted in increased strength after 4 weeks. Considering the short half-lives of factors released by platelets, this very late effect calls for an explanation...
  21. doi request reprint Sclerostin antibody treatment enhances metaphyseal bone healing in rats
    Fredrik Agholme
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Linkoping, Sweden
    J Bone Miner Res 25:2412-8. 2010
    ..Thus, as measured by the amount of bone and its mechanical resistance, the sclerostin antibody increased bone formation during metaphyseal repair but also in untraumatized bone...
  22. doi request reprint Myostatin in tendon maintenance and repair
    Pernilla Eliasson
    Division of Orthopaedics, AIM IKE, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Growth Factors 27:247-54. 2009
    ..However, no effect on further development towards connective tissue formation was found...
  23. ncbi request reprint Independent and additive stimulation of tendon repair by thrombin and platelets
    Olena Virchenko
    Department of Neuroscience and Locomotion, Faculty of Health Science, Orthopaedics and Sports Medicine, Linkoping, Sweden
    Acta Orthop 77:960-6. 2006
    ..Upon tissue injury, platelets are activated by thrombin, which has many biological properties in common with growth factors. We wanted to differentiate the effect of platelets from that of thrombin...
  24. ncbi request reprint Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks
    Karin Wermelin
    Division of Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    J Biomed Mater Res A 86:220-7. 2008
    ..We conclude that the fixation of titanium implants in bone can be improved by fibrinogen matrix-bound bisphosphonates...
  25. pmc Distal radial fractures heal by direct woven bone formation
    Per Aspenberg
    Department of Orthopedics, Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:297-300. 2013
    ..In reality, most fractures occur in metaphyseal cancellous bone. Apart from a study of vertebral fractures, we have not found any histological description of cancellous bone healing in humans...
  26. pmc Stimulation of tendon repair: mechanical loading, GDFs and platelets. A mini-review
    Per Aspenberg
    Section for Orthopaedics, Inst for Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, 581 85, Linkoping, Sweden
    Int Orthop 31:783-9. 2007
    ..This suggests that the mechanical microenvironment might be favourable for the clinical use of growth factors or platelets for this indication. New methods to quantitate human Achilles tendon repair have been developed...
  27. pmc Locally applied Simvastatin improves fracture healing in mice
    Bjorn Skoglund
    Division of Orthopedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    BMC Musculoskelet Disord 8:98. 2007
    ..In this study, simvastatin was administered either subcutaneously or directly to the fracture area, with the goal of stimulating fracture repair at acceptable doses...
  28. doi request reprint Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone
    Brandon R Macias
    Orthopedics, Department of Clinical and Experimental Medicine, Linkoping University, SE 58185, Linkoping, Sweden
    Bone 53:515-9. 2013
    ..This proposes a more complex expression pattern for Sost in response to unloading. Therapeutics that target Sclerostin during altered loading conditions may result in local bone mass changes that are difficult to predict...
  29. doi request reprint Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone
    Jahan Abtahi
    Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Linkoping, Sweden
    J Oral Pathol Med 41:494-9. 2012
    ..We tested the hypothesis that primary osteocyte death is not necessary for the development of jaw osteonecrosis...
  30. ncbi request reprint Unloaded rat Achilles tendons continue to grow, but lose viscoelasticity
    Pernilla Eliasson
    Division of Orthopaedics, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Appl Physiol 103:459-63. 2007
    ..No effect of doxycycline was observed. The results suggest that in growing animals, the tendons continue to grow regardless of mechanical loading history, whereas maintenance of damping properties requires mechanical stimulation...
  31. doi request reprint Bisphosphonate use and atypical fractures of the femoral shaft
    Jörg Schilcher
    Department of Experimental and Clinical Medicine, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    N Engl J Med 364:1728-37. 2011
    ..Studies show conflicting results regarding the possible excess risk of atypical fractures of the femoral shaft associated with bisphosphonate use...
  32. pmc Wnt signaling and orthopedics, an overview
    Fredrik Agholme
    Department of Clinical and Experimental Medicine, IKE, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 82:125-30. 2011
    ..Animal studies have also suggested that these drugs can accelerate fracture healing and implant fixation. This brief overview focuses on currently available information on the effects of manipulations of Wnt signaling on bone healing...
  33. pmc Mechanical properties during healing of Achilles tendon ruptures to predict final outcome: a pilot Roentgen stereophotogrammetric analysis in 10 patients
    Thorsten Schepull
    Section for Orthopaedics and Sports Medicine, Department of Neurosciences and Locomotion, Faculty of Health Sciences, SE 581 85 Linkoping, Sweden
    BMC Musculoskelet Disord 8:116. 2007
    ..We tested if Roentgen stereophotogrammetric analysis (RSA) can be used to follow the restoration of mechanical properties during healing of ruptured Achilles tendons, and if early measurements can predict clinical results...
  34. pmc Celecoxib does not appear to affect prosthesis fixation in total knee replacement: A randomized study using radiostereometry in 50 patients
    Andreas Meunier
    Division of Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 80:46-50. 2009
    ..This could tamper prosthesis fixation. We investigated whether celecoxib, a selective Cox-2 inhibitor, increases prosthesis migration in total knee replacement (TKR)...
  35. pmc Teriparatide improves early callus formation in distal radial fractures
    Per Aspenberg
    Division of Orthopaedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 81:234-6. 2010
    ..As radiographic cortical continuity appears late in the healing process, perhaps too late for clinical relevance, we studied the qualitative appearance of the callus 5 weeks after fracture...
  36. doi request reprint Atypical femoral fractures are a separate entity, characterized by highly specific radiographic features. A comparison of 59 cases and 218 controls
    Jörg Schilcher
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkoping University, Sweden
    Bone 52:389-92. 2013
    ..A possible explanation for these discrepancies could be different definitions of atypical fractures. We aimed to identify specific radiographic fracture characteristics associated with bisphosphonate use...
  37. doi request reprint Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures
    Per Aspenberg
    Orthopaedics, Linkoping University, Linkoping, Sweden
    J Bone Miner Res 25:404-14. 2010
    ..The shortened time to healing for teriparatide 20 microg compared with placebo still may suggest that fracture repair can be accelerated by teriparatide, but this result should be interpreted with caution and warrants further study...
  38. doi request reprint Fluid-induced osteolysis: modelling and experiments
    Lars Johansson
    Department of Management and Engineering, Linkoping University, Linkoping, Sweden
    Comput Methods Biomech Biomed Engin 14:305-18. 2011
    ....
  39. pmc Annotation: parathyroid hormone and fracture healing
    Per Aspenberg
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:4-6. 2013
    ..Although both are encouraging and appear to show acceleration of normal fracture healing, they have methodological shortcomings that preclude definitive conclusions...
  40. pmc Elevated plasma levels of TIMP-1 in patients with rotator cuff tear
    Hanna C Björnsson Hallgren
    Institution for Clinical and Experimental Medicine and Sports Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Acta Orthop 83:523-8. 2012
    ..We measured the plasma levels of MMPs and their tissue inhibitors (TIMPs) in patients with rotator cuff tears and related changes in the pattern of MMP and TIMP levels to the extent of the rotator cuff tear...
  41. pmc Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics
    Björn Pasternak
    Orthopaedics and Sports Medicine, IKE, Linkoping University, Linkoping, Sweden
    Acta Orthop 80:693-703. 2009
    ..This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice...
  42. ncbi request reprint Parecoxib impairs early metaphyseal bone healing in rats
    Andreas Meunier
    Division of Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, SE, 581 85 Linkoping, Sweden
    Arch Orthop Trauma Surg 126:433-6. 2006
    ..Cox2 inhibitors decrease prostaglandin production and therefore influence bone healing especially in unstable long bone models. It is unclear to what extent implant fixation in stable metaphyseal bone is impaired...
  43. doi request reprint Efficacy of a sclerostin antibody compared to a low dose of PTH on metaphyseal bone healing
    Fredrik Agholme
    Orthopaedics, Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    J Orthop Res 32:471-6. 2014
    ..2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:471-476, 2014. ..
  44. pmc Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate
    Jörg Schilcher
    Department of Orthopedics, AIM IKE, Faculty of Health Science, Linkoping University, Linkoping, Sweden
    Acta Orthop 80:413-5. 2009
    ..Recent case reports have identified an association between long-term bisphosphonate treatment and stress fractures of the femoral shaft. The risk of such fractures in bisphosphonate users has not been determined...
  45. doi request reprint Bone resorption induced by fluid flow
    Lars Johansson
    Department of Management and Engineering, Linkoping University, Linkoping, Sweden
    J Biomech Eng 131:094505. 2009
    ....
  46. ncbi request reprint Parecoxib impairs early tendon repair but improves later remodeling
    Olena Virchenko
    Section for Orthopaedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping, Sweden
    Am J Sports Med 32:1743-7. 2004
    ..Cyclooxygenase-2 inhibitors inhibit bone repair...
  47. doi request reprint Early controlled tension improves the material properties of healing human achilles tendons after ruptures: a randomized trial
    Thorsten Schepull
    Thorsten Schepull, Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Am J Sports Med 41:2550-7. 2013
    ..The aim of this study was to examine if tensional loading leads to an improvement in the mechanical properties of the healing Achilles tendon...
  48. pmc Dichotomous location of 160 atypical femoral fractures
    Veronika A Koeppen
    Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 84:561-4. 2013
    ..We determined whether there is a dichotomy in this respect...
  49. doi request reprint A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants
    Jahan Abtahi
    Department of Oral and Maxillofacial Surgery, Linkoping University Hospital, Sweden
    Bone 50:1148-51. 2012
    ..012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants...
  50. doi request reprint Fixed or loose? Dichotomy in RSA data for cemented cups
    Per Aspenberg
    Department of Orthopaedics, IKE, Faculty of Health Sciences, Linkoping, Sweden
    Acta Orthop 79:467-73. 2008
    ..We present an exploratory evaluation of such a dichotomy using a mixture distribution algorithm...
  51. ncbi request reprint Platelet concentrate injection improves Achilles tendon repair in rats
    Per Aspenberg
    Orthopedics and Sports Medicine, Department of Neuroscience and Locomotion, Faculty of Health Science, SE 581 85 Linkoping, Sweden
    Acta Orthop Scand 75:93-9. 2004
    ..Blood platelets release a cocktail of growth factors when activated, some of which are thought to initiate and stimulate repair...
  52. ncbi request reprint Surface-bound bisphosphonates enhance screw fixation in rats--increasing effect up to 8 weeks after insertion
    Karin Wermelin
    Orthopedics Section, Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Acta Orthop 78:385-92. 2007
    ..A bisphosphonate coating improves screw fixation 2 weeks after implantation in cancellous bone. This study on rats examined further development of fixation over time for screws inserted in cancellous and cortical bone...
  53. ncbi request reprint Drugs and fracture repair
    Per Aspenberg
    Department of Neuroscience and Locomotion, Faculty of Health Science, Orthopaedics and Sports Medicine, Linkoping, SE 581 85, Sweden
    Acta Orthop 76:741-8. 2005
  54. ncbi request reprint Improved healing of transected rabbit Achilles tendon after a single injection of cartilage-derived morphogenetic protein-2
    Carina Forslund
    Department of Orthopedics, Lund University Hospital, Lund, Sweden
    Am J Sports Med 31:555-9. 2003
    ..Achilles tendon ruptures in humans might be treated more efficiently with the help of a growth factor. Cartilage-derived morphogenetic protein-2 has been shown to induce formation of tendon-like tissue...
  55. ncbi request reprint A comparative dose-response study of cartilage-derived morphogenetic protein (CDMP)-1, -2 and -3 for tendon healing in rats
    Carina Forslund
    Department of Orthopedics, Lund University Hospital, Lund, Sweden
    J Orthop Res 21:617-21. 2003
    ..Only the CDMP-2 group and the controls contained significantly less calcium than the OP-1 group.In conclusion, the three CDMPs appeared similar as regards improvement of tendon repair and osteogenicity in this setting...
  56. ncbi request reprint CDMP-2 induces bone or tendon-like tissue depending on mechanical stimulation
    Carina Forslund
    Department of Orthopaedics, Lund University Hospital, 22185 Lund, Sweden
    J Orthop Res 20:1170-4. 2002
    ..This study suggests that the response to CDMP-2 is dependent on the mechanical situation at the site where it is applied...
  57. ncbi request reprint Indomethacin and celecoxib improve tendon healing in rats
    Carina Forslund
    Orthopedic Department, Lund University Hospital, Lund, Sweden
    Acta Orthop Scand 74:465-9. 2003
    ..Because of the reduction in cross-sectional area without an effect on failure load, the use of Cox-inhibitors may be beneficial in clinical situations where thickening of a healing tendon is a problem--e.g., in the hand or shoulder...
  58. ncbi request reprint [Promising outcome with thrombocyte concentrate against tendinosis. Ongoing randomized controlled trials--important to await results]
    Per Aspenberg
    Linkopings Universitet
    Lakartidningen 105:906-8. 2008
  59. ncbi request reprint Improved healing of ligament to bone with point fixation in rabbits
    Shwan Khoschnau
    Department of Orthopedics, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 77:967-72. 2006
    ..This healing can be achieved either by pressing the tissue against the bone (press fixation) or by suturing the soft tissue to the bone (point fixation)...