Jonas Nygren

Summary

Affiliation: Ersta Hospital
Country: Sweden

Publications

  1. pmc Patterns in current perioperative practice: survey of colorectal surgeons in five northern European countries
    Kristoffer Lassen
    Department of Gastrointestinal Surgery, University Hospital of Northern Norway, 9038 Tromsø, Norway
    BMJ 330:1420-1. 2005
  2. ncbi Are there any benefits from minimizing fasting and optimization of nutrition and fluid management for patients undergoing day surgery?
    Jonas Nygren
    Centre of Gastrointestinal Disease, Ersta Hospital, and Karolinska Institutet and CLINTEC, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Opin Anaesthesiol 20:540-4. 2007
  3. doi Guidelines for Perioperative Care in Elective Rectal/Pelvic Surgery: Enhanced Recovery After Surgery (ERAS(®)) Society Recommendations
    J Nygren
    Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    World J Surg 37:285-305. 2013
  4. doi Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations
    J Nygren
    Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Nutr 31:801-16. 2012
  5. ncbi The metabolic effects of fasting and surgery
    Jonas Nygren
    Centre of Gastrointestinal Disease, Ersta Hospital and Karolinska Institutet, P O Box 4622, 116 91 Stockholm, Sweden
    Best Pract Res Clin Anaesthesiol 20:429-38. 2006
  6. doi An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patients
    Jonas Nygren
    Center of Gastrointestinal Disease, Ersta Hospital and Karolinska Institutet, Institution of Clinical Sciences at Danderyds Hospital, Stockholm, Sweden
    Dis Colon Rectum 52:978-85. 2009
  7. ncbi Postoperative parenteral nutrition while proactively minimizing insulin resistance
    Monika Svanfeldt
    Division of Surgery, Department for Clinical Science Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nutrition 22:457-64. 2006
  8. ncbi Effect of "preoperative" oral carbohydrate treatment on insulin action--a randomised cross-over unblinded study in healthy subjects
    Monika Svanfeldt
    Division of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge and Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Clin Nutr 24:815-21. 2005
  9. ncbi Preoperative oral carbohydrate treatment attenuates endogenous glucose release 3 days after surgery
    Mattias Soop
    Karolinska Institutet, Centre for Surgical Sciences at Centre for Gastrointestinal Disease at Ersta Hospital, PO Box 4622, SE 11691 Stockholm, Sweden
    Clin Nutr 23:733-41. 2004
  10. doi Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery
    Ulf O Gustafsson
    Department of Surgery, Ersta Hospital, 116 91 Stockholm, Sweden
    Arch Surg 146:571-7. 2011

Collaborators

Detail Information

Publications30

  1. pmc Patterns in current perioperative practice: survey of colorectal surgeons in five northern European countries
    Kristoffer Lassen
    Department of Gastrointestinal Surgery, University Hospital of Northern Norway, 9038 Tromsø, Norway
    BMJ 330:1420-1. 2005
  2. ncbi Are there any benefits from minimizing fasting and optimization of nutrition and fluid management for patients undergoing day surgery?
    Jonas Nygren
    Centre of Gastrointestinal Disease, Ersta Hospital, and Karolinska Institutet and CLINTEC, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Opin Anaesthesiol 20:540-4. 2007
    ..The evidence that preoperative fasting and dehydration not only reduces preoperative well being, but may also affect postoperative recovery is currently being reviewed...
  3. doi Guidelines for Perioperative Care in Elective Rectal/Pelvic Surgery: Enhanced Recovery After Surgery (ERAS(®)) Society Recommendations
    J Nygren
    Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    World J Surg 37:285-305. 2013
    ..This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol...
  4. doi Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations
    J Nygren
    Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Nutr 31:801-16. 2012
    ..This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol...
  5. ncbi The metabolic effects of fasting and surgery
    Jonas Nygren
    Centre of Gastrointestinal Disease, Ersta Hospital and Karolinska Institutet, P O Box 4622, 116 91 Stockholm, Sweden
    Best Pract Res Clin Anaesthesiol 20:429-38. 2006
    ....
  6. doi An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patients
    Jonas Nygren
    Center of Gastrointestinal Disease, Ersta Hospital and Karolinska Institutet, Institution of Clinical Sciences at Danderyds Hospital, Stockholm, Sweden
    Dis Colon Rectum 52:978-85. 2009
    ..This study was designed to investigate the clinical outcome and recovery before and immediately after implementation of the enhanced recovery after surgery enhanced recovery after surgery protocol in colonic and rectal resection...
  7. ncbi Postoperative parenteral nutrition while proactively minimizing insulin resistance
    Monika Svanfeldt
    Division of Surgery, Department for Clinical Science Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nutrition 22:457-64. 2006
    ....
  8. ncbi Effect of "preoperative" oral carbohydrate treatment on insulin action--a randomised cross-over unblinded study in healthy subjects
    Monika Svanfeldt
    Division of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge and Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Clin Nutr 24:815-21. 2005
    ..In this study, we evaluated whether this could be related to increased insulin sensitivity at the onset of surgery. Furthermore, we aimed to establish the optimal dose-regimen...
  9. ncbi Preoperative oral carbohydrate treatment attenuates endogenous glucose release 3 days after surgery
    Mattias Soop
    Karolinska Institutet, Centre for Surgical Sciences at Centre for Gastrointestinal Disease at Ersta Hospital, PO Box 4622, SE 11691 Stockholm, Sweden
    Clin Nutr 23:733-41. 2004
    ..We hypothesised that preoperative oral carbohydrate treatment attenuates insulin resistance and improves whole-body nitrogen balance 3 days after surgery...
  10. doi Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery
    Ulf O Gustafsson
    Department of Surgery, Ersta Hospital, 116 91 Stockholm, Sweden
    Arch Surg 146:571-7. 2011
    ..To study the impact of different adherence levels to the enhanced recovery after surgery (ERAS) protocol and the effect of various ERAS elements on outcomes following major surgery...
  11. ncbi Modulation of post-operative insulin resistance by pre-operative carbohydrate loading
    Olle Ljungqvist
    Karolinska Institutet at Centre of Gastrointestinal Disease, Ersta Hospital and Dept of Surgery, Huddinge University Hospital, Stockholm, Sweden
    Proc Nutr Soc 61:329-36. 2002
    ..In summary, preventing or treating insulin resistance in surgical stress influences outcome. Fasting overnight is not an optimal way to prepare patients for elective surgery. Instead, pre-operative carbohydrates have clinical benefits...
  12. doi Expression of inflammatory and insulin signaling genes in adipose tissue in response to elective surgery
    Anna Witasp
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Centre for Molecular Medicine, L8 00 Karolinska University Hospital, 171 76 Stockholm, Sweden
    J Clin Endocrinol Metab 95:3460-9. 2010
    ..The mechanisms behind postoperative insulin resistance and impaired glucose utilization are not fully understood...
  13. ncbi Metabolic perioperative management: novel concepts
    Olle Ljungqvist
    Department of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital, Huddinge Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Curr Opin Crit Care 11:295-9. 2005
    ..This review summarizes novel information regarding the role of metabolic control in the perioperative period...
  14. ncbi Functional and physiologic assessment of the colonic reservoir or side-to-end anastomosis after low anterior resection for rectal cancer: a two-year follow-up
    Mikael Machado
    Centre of Gastrointestinal Disease, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    Dis Colon Rectum 48:29-36. 2005
    ..This study was designed to compare functional and physiologic outcome after low anterior resection and total mesorectal excision with a colonic J-pouch or a side-to-end anastomosis...
  15. ncbi Intensive insulin treatment in critically ill trauma patients normalizes glucose by reducing endogenous glucose production
    Anders Thorell
    Karolinska Institutet Centre of Surgical Sciences at Centre of Gatrointestinal Diseases, Huddinge University Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 89:5382-6. 2004
    ..In contrast to controls, normalization of glucose concentration during TPN needs high insulin infusion rates and is accounted for by a reduction in EGP, whereas WGD is not increased...
  16. ncbi A comparison in five European Centres of case mix, clinical management and outcomes following either conventional or fast-track perioperative care in colorectal surgery
    Jonas Nygren
    Centre for Surgical Sciences, Division of Surgery, Karolinska Institutet and Centre of Gastrointestinal Disease, Ersta Hospital, PO Box 4622, 11691 Stockholm, Sweden
    Clin Nutr 24:455-61. 2005
    ..This study reviewed the case mix, clinical management, and clinical outcomes of patients undergoing colorectal resection in five European centres performing different forms of conventional or 'fast-track' perioperative care...
  17. ncbi Optimizing perioperative management of patients undergoing colorectal surgery: what is new?
    Mattias Soop
    Karolinska Institute, CLINTEC, Karolinska University Hospital Huddinge and Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Curr Opin Crit Care 12:166-70. 2006
    ..This review highlights recent developments in individual perioperative interventions in colorectal surgery, and progress in so-called fast-track or enhanced-recovery programmes...
  18. ncbi Combined treatment with exercise training and acarbose improves metabolic control and cardiovascular risk factor profile in subjects with mild type 2 diabetes
    Henrik Wagner
    Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Diabetes Care 29:1471-7. 2006
    ..The effect of exercise training and acarbose on glycemic control, insulin sensitivity, and phenotype was investigated in mild type 2 diabetes...
  19. doi Increased expression of inflammatory pathway genes in skeletal muscle during surgery
    Anna Witasp
    Karolinska Institutet, Department of Molecular Medicine and Surgery, Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Clin Nutr 28:291-8. 2009
    ..As increasing data suggests a link between inflammation and insulin resistance, we aimed to evaluate if the expression of inflammatory and insulin signaling genes is regulated in skeletal muscle during surgery...
  20. ncbi New developments facilitating nutritional intake after gastrointestinal surgery
    Jonas Nygren
    Centre of Gastrointestinal Disease, Ersta Hospital, PO Box 4622, SE 116 91 Stockholm, Sweden
    Curr Opin Clin Nutr Metab Care 6:593-7. 2003
    ..Thus, developing routines and treatments that promote sufficient early oral intake after surgery and maintain adequate energy intake in the postoperative period are probably of great importance for the outcome from surgery...
  21. ncbi [Ways to safer perioperative routines in colonic resections. ERAS--a North European project for better surgical treatment]
    Olle Ljungqvist
    CLINTEC, Karolinska Institutet
    Lakartidningen 103:1708-10. 2006
  22. ncbi Can nutritional supplements and rectal enema be used as bowel cleansing for colonoscopy?--Results of a randomized controlled pilot study
    Ulf O Gustafsson
    Department of Surgery, Ersta Hospital and Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 49:485-91. 2014
    ..Currently available preparations for colonoscopy have low tolerability and may cause fluid and electrolyte shifts. An alternative method of bowel cleansing is required...
  23. ncbi Microdialysis methods for measuring human metabolism
    Olav Rooyackers
    Centre for Surgical Sciences, Karolinska Institutet, Department of Anesthesiology and Intensive Care, Karolinska University Hospital, 141 86 Huddinge, Sweden
    Curr Opin Clin Nutr Metab Care 7:515-21. 2004
    ..To discuss the advantages and limitations of the microdialysis technique as a diagnostic and research tool using recent findings on human metabolism...
  24. ncbi Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchanged
    Jonas Nygren
    Centre for Gastrointestinal Disease, Ersta Hospital, Box 4622, Karolinska Institute, 116 91 Stockholm, Sweden
    Clin Sci (Lond) 102:457-64. 2002
    ..The nitrogen retention accompanying GH treatment seems to be due largely to improved nitrogen balance in non-muscle tissue...
  25. doi Relationship between preoperative symptoms and improvement of quality of life in patients undergoing elective inguinal herniorrhaphy
    Jesper Magnusson
    Karolinska Institutet, Department of Clinical Sciences, Danderyds Hospital and Department of Surgery, Ersta Hospital, Stockholm, Sweden Electronic address
    Surgery 155:106-13. 2014
    ..Improvement of quality of life (QoL) is the ultimate goal for inguinal hernia repair. Data on QoL before surgery are scarce, and it is not known whether postoperative improvement of QoL relates to preoperative symptoms...
  26. ncbi Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle
    Jeanette E Kuhl
    Dept of Molecular Medicine and Surgery, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 290:E1296-303. 2006
    ..These changes persist after the increases in AMPK activity and whole body insulin sensitivity and fatty acid oxidation, typically caused by an acute bout of exercise in healthy individuals, have dissipated...
  27. pmc Similar outcome after colonic pouch and side-to-end anastomosis in low anterior resection for rectal cancer: a prospective randomized trial
    Mikael Machado
    Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Ann Surg 238:214-20. 2003
    ..To compare a colonic J-pouch or a side-to-end anastomosis after low-anterior resection for rectal cancer with regard to functional and surgical outcome...
  28. ncbi Stress-induced insulin resistance: recent developments
    Mattias Soop
    Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge, Sweden
    Curr Opin Clin Nutr Metab Care 10:181-6. 2007
    ..Interest in stress-induced insulin resistance has increased during the past 5 years. Relevant clinical and mechanistic investigations during the past year will be reviewed...
  29. ncbi Nutritional support and oral intake after gastric resection in five northern European countries
    Kristoffer Lassen
    Department of Gastrointestinal Surgery, University Hospital of Northern Norway, Tromsø, Norway
    Dig Surg 22:346-52; discussion 352. 2005
    ..We describe postoperative practice after gastric resections in five northern European countries. METHOD AND SETTING: Questionnaire survey in all major digestive surgical centres in Scotland, the Netherlands, Denmark, Sweden and Norway...
  30. ncbi [Is fasting after gastrointestinal surgery necessary? Meta-analysis of early enteral nutrition versus traditional nutritional therapy]
    Anders Thorell
    Mag tarmcentrum, Ersta sjukhus, Stockholm
    Lakartidningen 99:1786-90. 2002