Research Topics
Genomes and GenesSpecies | Jonas NygrenSummaryAffiliation: Ersta Hospital Country: Sweden Publications
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Detail Information
Publications
Patterns in current perioperative practice: survey of colorectal surgeons in five northern European countriesKristoffer Lassen
Department of Gastrointestinal Surgery, University Hospital of Northern Norway, 9038 Troms, Norway
BMJ 330:1420-1. 2005
Are there any benefits from minimizing fasting and optimization of nutrition and fluid management for patients undergoing day surgery?Jonas Nygren
Centre of Gastrointestinal Disease, Ersta Hospital, and Karolinska Institutet and CLINTEC, Karolinska University Hospital Huddinge, Stockholm, Sweden
Curr Opin Anaesthesiol 20:540-4. 2007..The evidence that preoperative fasting and dehydration not only reduces preoperative well being, but may also affect postoperative recovery is currently being reviewed...
Guidelines for Perioperative Care in Elective Rectal/Pelvic Surgery: Enhanced Recovery After Surgery (ERAS(®)) Society RecommendationsJ Nygren
Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
World J Surg 37:285-305. 2013..This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol...- Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendationsJ Nygren
Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
Clin Nutr 31:801-16. 2012..This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol... - The metabolic effects of fasting and surgeryJonas Nygren
Centre of Gastrointestinal Disease, Ersta Hospital and Karolinska Institutet, P O Box 4622, 116 91 Stockholm, Sweden
Best Pract Res Clin Anaesthesiol 20:429-38. 2006.... - An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patientsJonas Nygren
Center of Gastrointestinal Disease, Ersta Hospital and Karolinska Institutet, Institution of Clinical Sciences at Danderyds Hospital, Stockholm, Sweden
Dis Colon Rectum 52:978-85. 2009..This study was designed to investigate the clinical outcome and recovery before and immediately after implementation of the enhanced recovery after surgery enhanced recovery after surgery protocol in colonic and rectal resection... - Postoperative parenteral nutrition while proactively minimizing insulin resistanceMonika Svanfeldt
Division of Surgery, Department for Clinical Science Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Nutrition 22:457-64. 2006..Hypocaloric nutrition results in changes in substrate utilization and nitrogen balance resembling starvation, whereas TPN attenuates these changes... - Effect of "preoperative" oral carbohydrate treatment on insulin action--a randomised cross-over unblinded study in healthy subjectsMonika Svanfeldt
Division of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge and Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
Clin Nutr 24:815-21. 2005..Enhanced insulin action to normal postprandial day-time level at the time of onset of anaesthesia or surgery is likely to, at least partly, explain the effects on postoperative insulin resistance... - Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgeryUlf O Gustafsson
Department of Surgery, Ersta Hospital, 116 91 Stockholm, Sweden
Arch Surg 146:571-7. 2011..To study the impact of different adherence levels to the enhanced recovery after surgery (ERAS) protocol and the effect of various ERAS elements on outcomes following major surgery... - Preoperative oral carbohydrate treatment attenuates endogenous glucose release 3 days after surgeryMattias Soop
Karolinska Institutet, Centre for Surgical Sciences at Centre for Gastrointestinal Disease at Ersta Hospital, PO Box 4622, SE 11691 Stockholm, Sweden
Clin Nutr 23:733-41. 2004..Preoperative carbohydrate treatment attenuated endogenous glucose release on the third postoperative day... - Modulation of post-operative insulin resistance by pre-operative carbohydrate loadingOlle Ljungqvist
Karolinska Institutet at Centre of Gastrointestinal Disease, Ersta Hospital and Dept of Surgery, Huddinge University Hospital, Stockholm, Sweden
Proc Nutr Soc 61:329-36. 2002..In summary, preventing or treating insulin resistance in surgical stress influences outcome. Fasting overnight is not an optimal way to prepare patients for elective surgery. Instead, pre-operative carbohydrates have clinical benefits... - Expression of inflammatory and insulin signaling genes in adipose tissue in response to elective surgeryAnna Witasp
Department of Molecular Medicine and Surgery, Karolinska Institutet, Centre for Molecular Medicine, L8 00 Karolinska University Hospital, 171 76 Stockholm, Sweden
J Clin Endocrinol Metab 95:3460-9. 2010..The mechanisms behind postoperative insulin resistance and impaired glucose utilization are not fully understood... - Metabolic perioperative management: novel conceptsOlle Ljungqvist
Department of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital, Huddinge Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
Curr Opin Crit Care 11:295-9. 2005..This review summarizes novel information regarding the role of metabolic control in the perioperative period... - Functional and physiologic assessment of the colonic reservoir or side-to-end anastomosis after low anterior resection for rectal cancer: a two-year follow-upMikael Machado
Centre of Gastrointestinal Disease, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
Dis Colon Rectum 48:29-36. 2005..This study was designed to compare functional and physiologic outcome after low anterior resection and total mesorectal excision with a colonic J-pouch or a side-to-end anastomosis... - Intensive insulin treatment in critically ill trauma patients normalizes glucose by reducing endogenous glucose productionAnders Thorell
Karolinska Institutet Centre of Surgical Sciences at Centre of Gatrointestinal Diseases, Huddinge University Hospital, Stockholm, Sweden
J Clin Endocrinol Metab 89:5382-6. 2004..In contrast to controls, normalization of glucose concentration during TPN needs high insulin infusion rates and is accounted for by a reduction in EGP, whereas WGD is not increased... - A comparison in five European Centres of case mix, clinical management and outcomes following either conventional or fast-track perioperative care in colorectal surgeryJonas Nygren
Centre for Surgical Sciences, Division of Surgery, Karolinska Institutet and Centre of Gastrointestinal Disease, Ersta Hospital, PO Box 4622, 11691 Stockholm, Sweden
Clin Nutr 24:455-61. 2005..Morbidity and mortality appears to be similar with either approach. Prospective evaluation of the potential benefits of the fast-track approach in different European centres is merited... - Optimizing perioperative management of patients undergoing colorectal surgery: what is new?Mattias Soop
Karolinska Institute, CLINTEC, Karolinska University Hospital Huddinge and Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
Curr Opin Crit Care 12:166-70. 2006..This review highlights recent developments in individual perioperative interventions in colorectal surgery, and progress in so-called fast-track or enhanced-recovery programmes... - Combined treatment with exercise training and acarbose improves metabolic control and cardiovascular risk factor profile in subjects with mild type 2 diabetesHenrik Wagner
Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76 Stockholm, Sweden
Diabetes Care 29:1471-7. 2006..The effect of exercise training and acarbose on glycemic control, insulin sensitivity, and phenotype was investigated in mild type 2 diabetes... - New developments facilitating nutritional intake after gastrointestinal surgeryJonas Nygren
Centre of Gastrointestinal Disease, Ersta Hospital, PO Box 4622, SE 116 91 Stockholm, Sweden
Curr Opin Clin Nutr Metab Care 6:593-7. 2003..Thus, developing routines and treatments that promote sufficient early oral intake after surgery and maintain adequate energy intake in the postoperative period are probably of great importance for the outcome from surgery... - Increased expression of inflammatory pathway genes in skeletal muscle during surgeryAnna Witasp
Karolinska Institutet, Department of Molecular Medicine and Surgery, Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
Clin Nutr 28:291-8. 2009..As increasing data suggests a link between inflammation and insulin resistance, we aimed to evaluate if the expression of inflammatory and insulin signaling genes is regulated in skeletal muscle during surgery... - [Ways to safer perioperative routines in colonic resections. ERAS--a North European project for better surgical treatment]Olle Ljungqvist
CLINTEC, Karolinska Institutet
Lakartidningen 103:1708-10. 2006 - Microdialysis methods for measuring human metabolismOlav Rooyackers
Centre for Surgical Sciences, Karolinska Institutet, Department of Anesthesiology and Intensive Care, Karolinska University Hospital, 141 86 Huddinge, Sweden
Curr Opin Clin Nutr Metab Care 7:515-21. 2004..To discuss the advantages and limitations of the microdialysis technique as a diagnostic and research tool using recent findings on human metabolism... - Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchangedJonas Nygren
Centre for Gastrointestinal Disease, Ersta Hospital, Box 4622, Karolinska Institute, 116 91 Stockholm, Sweden
Clin Sci (Lond) 102:457-64. 2002..The nitrogen retention accompanying GH treatment seems to be due largely to improved nitrogen balance in non-muscle tissue... - Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscleJeanette E Kuhl
Dept of Molecular Medicine and Surgery, Karolinska Institutet, S 171 76 Stockholm, Sweden
Am J Physiol Endocrinol Metab 290:E1296-303. 2006..These changes persist after the increases in AMPK activity and whole body insulin sensitivity and fatty acid oxidation, typically caused by an acute bout of exercise in healthy individuals, have dissipated... - Similar outcome after colonic pouch and side-to-end anastomosis in low anterior resection for rectal cancer: a prospective randomized trialMikael Machado
Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
Ann Surg 238:214-20. 2003.... - Stress-induced insulin resistance: recent developmentsMattias Soop
Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge, Sweden
Curr Opin Clin Nutr Metab Care 10:181-6. 2007..Interest in stress-induced insulin resistance has increased during the past 5 years. Relevant clinical and mechanistic investigations during the past year will be reviewed... - Nutritional support and oral intake after gastric resection in five northern European countriesKristoffer Lassen
Department of Gastrointestinal Surgery, University Hospital of Northern Norway, Tromsø, Norway
Dig Surg 22:346-52; discussion 352. 2005..We describe postoperative practice after gastric resections in five northern European countries. METHOD AND SETTING: Questionnaire survey in all major digestive surgical centres in Scotland, the Netherlands, Denmark, Sweden and Norway... - [Is fasting after gastrointestinal surgery necessary? Meta-analysis of early enteral nutrition versus traditional nutritional therapy]Anders Thorell
Mag tarmcentrum, Ersta sjukhus, Stockholm
Lakartidningen 99:1786-90. 2002