O Ljungqvist

Summary

Affiliation: Ersta Hospital
Country: Sweden

Publications

  1. ncbi request reprint Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchanged
    Jonas Nygren
    Centre for Gastrointestinal Disease, Ersta Hospital, Box 4622, Karolinska Institute, 116 91 Stockholm, Sweden
    Clin Sci (Lond) 102:457-64. 2002
  2. ncbi request reprint Preoperative fasting
    O Ljungqvist
    Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Br J Surg 90:400-6. 2003
  3. ncbi request reprint To fast or not to fast before surgical stress
    Olle Ljungqvist
    Nutrition 21:885-6. 2005
  4. ncbi request reprint Twelve months' follow-up after treatment with the EndoCinch endoscopic technique for gastro-oesophageal reflux disease: a randomized, placebo-controlled study
    Madeleine Montgomery
    Division of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Scand J Gastroenterol 41:1382-9. 2006
  5. ncbi request reprint Why metabolism matters in elective orthopedic surgery: a review
    Olle Ljungqvist
    Karolinska Institutet, CLINTEC, Huddinge, Sweden
    Acta Orthop 78:610-5. 2007
  6. ncbi request reprint Metabolic perioperative management: novel concepts
    Olle Ljungqvist
    Department of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital, Huddinge Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Curr Opin Crit Care 11:295-9. 2005
  7. ncbi request reprint Modulation of post-operative insulin resistance by pre-operative carbohydrate loading
    Olle Ljungqvist
    Karolinska Institutet at Centre of Gastrointestinal Disease, Ersta Hospital and Dept of Surgery, Huddinge University Hospital, Stockholm, Sweden
    Proc Nutr Soc 61:329-36. 2002
  8. ncbi request reprint The hyperinsulinaemic-euglycaemic glucose clamp: reproducibility and metabolic effects of prolonged insulin infusion in healthy subjects
    M Soop
    Department of Surgery, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Clin Sci (Lond) 98:367-74. 2000
  9. ncbi request reprint Postoperative induction of insulin-like growth factor binding protein-3 proteolytic activity: relation to insulin and insulin sensitivity
    P Bang
    Department of Woman and Child Health, Karolinska Institute and Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 83:2509-15. 1998
  10. ncbi request reprint Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance
    M Soop
    Department of Surgery, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 280:E576-83. 2001

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchanged
    Jonas Nygren
    Centre for Gastrointestinal Disease, Ersta Hospital, Box 4622, Karolinska Institute, 116 91 Stockholm, Sweden
    Clin Sci (Lond) 102:457-64. 2002
    ..The nitrogen retention accompanying GH treatment seems to be due largely to improved nitrogen balance in non-muscle tissue...
  2. ncbi request reprint Preoperative fasting
    O Ljungqvist
    Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Br J Surg 90:400-6. 2003
    ..Several anaesthesia societies now recommend a 2-h preoperative fast for clear fluids and a 6-h fast for solids in most elective patients. The literature supporting such fasting recommendations was reviewed...
  3. ncbi request reprint To fast or not to fast before surgical stress
    Olle Ljungqvist
    Nutrition 21:885-6. 2005
  4. ncbi request reprint Twelve months' follow-up after treatment with the EndoCinch endoscopic technique for gastro-oesophageal reflux disease: a randomized, placebo-controlled study
    Madeleine Montgomery
    Division of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Scand J Gastroenterol 41:1382-9. 2006
    ..However, no placebo-controlled studies have been published as yet. The purpose of this study was to evaluate the effects of the EndoCinch plication technique in a randomized, placebo-controlled setting...
  5. ncbi request reprint Why metabolism matters in elective orthopedic surgery: a review
    Olle Ljungqvist
    Karolinska Institutet, CLINTEC, Huddinge, Sweden
    Acta Orthop 78:610-5. 2007
  6. ncbi request reprint Metabolic perioperative management: novel concepts
    Olle Ljungqvist
    Department of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital, Huddinge Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Curr Opin Crit Care 11:295-9. 2005
    ..This review summarizes novel information regarding the role of metabolic control in the perioperative period...
  7. ncbi request reprint Modulation of post-operative insulin resistance by pre-operative carbohydrate loading
    Olle Ljungqvist
    Karolinska Institutet at Centre of Gastrointestinal Disease, Ersta Hospital and Dept of Surgery, Huddinge University Hospital, Stockholm, Sweden
    Proc Nutr Soc 61:329-36. 2002
    ..In summary, preventing or treating insulin resistance in surgical stress influences outcome. Fasting overnight is not an optimal way to prepare patients for elective surgery. Instead, pre-operative carbohydrates have clinical benefits...
  8. ncbi request reprint The hyperinsulinaemic-euglycaemic glucose clamp: reproducibility and metabolic effects of prolonged insulin infusion in healthy subjects
    M Soop
    Department of Surgery, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Clin Sci (Lond) 98:367-74. 2000
    ..The findings underline the importance of selecting age-matched controls in studies of insulin resistance...
  9. ncbi request reprint Postoperative induction of insulin-like growth factor binding protein-3 proteolytic activity: relation to insulin and insulin sensitivity
    P Bang
    Department of Woman and Child Health, Karolinska Institute and Hospital, Stockholm, Sweden
    J Clin Endocrinol Metab 83:2509-15. 1998
    ..We propose that IGF bioavailability may be increased by the induction of IGFBP-3-PA in insulin-resistant subjects, and that insulin regulates IGFBP-3-PA in this state...
  10. ncbi request reprint Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance
    M Soop
    Department of Surgery, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 280:E576-83. 2001
    ..The better preservation of insulin sensitivity in the treatment group was attributable to a less reduced glucose disposal in peripheral tissues and increased glucose oxidation rates...
  11. doi request reprint Pre-operative carbohydrate loading may be used in type 2 diabetes patients
    U O Gustafsson
    Department of Clinical Science, Intervention and Technology, Centre for Gastrointestinal Disease, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    Acta Anaesthesiol Scand 52:946-51. 2008
    ..Insulin-resistant diabetic patients have not been given CHO because the effects on pre-operative glycaemia and gastric emptying are unknown...
  12. ncbi request reprint A carbohydrate-rich drink reduces preoperative discomfort in elective surgery patients
    J Hausel
    Center of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Anesth Analg 93:1344-50. 2001
    ..Visual analog scales can provide useful information about preoperative discomfort in elective surgery patients...
  13. doi request reprint Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS(®)) Society Recommendations
    U O Gustafsson
    Department of Surgery, Ersta Hospital, Stockholm, Sweden
    World J Surg 37:259-84. 2013
    ..This review aims to present a consensus for optimal perioperative care in colonic surgery and to provide graded recommendations for items for an evidenced-based enhanced perioperative protocol...
  14. ncbi request reprint Preoperative oral carbohydrate nutrition: an update
    J Nygren
    Centre of Gastrointestinal Disease, Karolinska Institutet at Ersta Hospital and Huddinge University Hospital, Stockholm, Sweden
    Curr Opin Clin Nutr Metab Care 4:255-9. 2001
    ....
  15. doi request reprint Guidelines for Perioperative Care in Elective Rectal/Pelvic Surgery: Enhanced Recovery After Surgery (ERAS(®)) Society Recommendations
    J Nygren
    Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    World J Surg 37:285-305. 2013
    ..This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol...
  16. doi request reprint Haemoglobin A1c as a predictor of postoperative hyperglycaemia and complications after major colorectal surgery
    U O Gustafsson
    Centre for Gastrointestinal Disease, Ersta Hospital, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden
    Br J Surg 96:1358-64. 2009
    ..It is not known whether preoperative haemoglobin (Hb) A1c could predict hyperglycaemia and/or adverse outcome after colorectal surgery...
  17. ncbi request reprint Insulin infusion increases levels of free IGF-I and IGFBP-3 proteolytic activity in patients after surgery
    J Nygren
    Center of Gastrointestinal Disease, Ersta Hospital and Karolinska Institute, Karolinska Hospital, Stockholm, Sweden
    Am J Physiol Endocrinol Metab 281:E736-41. 2001
    ....
  18. ncbi request reprint Randomized clinical trial of the effects of immediate enteral nutrition on metabolic responses to major colorectal surgery in an enhanced recovery protocol
    M Soop
    Centre for Surgical Sciences, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden
    Br J Surg 91:1138-45. 2004
    ..The effects of immediate postoperative enteral nutrition on postoperative nitrogen balance and insulin resistance were studied in patients subjected to an enhanced-recovery protocol...
  19. ncbi request reprint Randomized clinical trial of the effects of oral preoperative carbohydrates on postoperative nausea and vomiting after laparoscopic cholecystectomy
    J Hausel
    Centre of Gastrointestinal Disease, Ersta Hospital and Karolinska Institutet, SE 116 91 Stockholm, Sweden
    Br J Surg 92:415-21. 2005
    ..A carbohydrate-rich drink (CHO) has been shown to reduce preoperative discomfort. It was hypothesized that it may also reduce postoperative nausea and vomiting (PONV)...
  20. doi request reprint Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations
    J Nygren
    Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Nutr 31:801-16. 2012
    ..This review aims to present a consensus for optimal perioperative care in rectal/pelvic surgery, and to provide graded recommendations for items for an evidenced-based enhanced recovery protocol...
  21. doi request reprint Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations
    U O Gustafsson
    Department of Surgery, Ersta Hospital, Stockholm, Sweden
    Clin Nutr 31:783-800. 2012
    ..This review aims to present a consensus for optimal perioperative care in colonic surgery and to provide graded recommendations for items for an evidenced-based enhanced perioperative protocol...
  22. ncbi request reprint Radiological findings do not support lateral residual tumour as a major cause of local recurrence of rectal cancer
    E Syk
    Department of Surgery, Ersta Hospital, Stockholm, Sweden
    Br J Surg 93:113-9. 2006
    ..The aim of this study was to determine the sites of local recurrence following radical (R0) total mesorectal excision (TME) for rectal cancer in an effort to elucidate the reasons for recurrence...
  23. ncbi request reprint Effects of 3 days of "postoperative" low caloric feeding with or without bed rest on insulin sensitivity in healthy subjects
    M Svanfeldt
    Department of Surgery at Gastrocentrum, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
    Clin Nutr 22:31-8. 2003
    ..The purpose of this study was to evaluate the effect of traditional postsurgical low caloric feeding and bed rest on insulin sensitivity and substrate utilization, in younger and older healthy subjects...
  24. ncbi request reprint Minimal effect on energy intake by additional evening meal for frail elderly service flat residents--a pilot study
    A Odlund Olin
    Department of Nursing Development, Karolinska University Hospital, Stockholm, Sweden
    J Nutr Health Aging 12:295-301. 2008
    ..Nutritional problems are common in frail elderly individuals receiving municipal care...
  25. ncbi request reprint Food deprivation increases bacterial translocation after non-lethal haemorrhage in rats
    T Bark
    Department of Surgery, Karolinska Hospital and Institute, Stockholm, Sweden
    Eur J Surg 161:67-71. 1995
    ..To investigate whether brief fasting before the induction of hypotension by non-lethal haemorrhage may induce translocation of enteric bacteria to mesenteric lymph nodes or blood in rats...
  26. ncbi request reprint Insulin stimulated glucose disposal in peripheral tissues studied with microdialysis and stable isotope tracers
    Olav Rooyackers
    Department of Anesthesiology and Intensive Care, Institute for Surgical Sciences, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden
    Clin Nutr 23:743-52. 2004
    ..Here we investigate whether the loss (fractional extraction) of 2H7-glucose infused via a microdialysis catheter can be used to study glucose disposal in skeletal muscle and subcutaneous adipose tissue...
  27. ncbi request reprint Metabolism and catabolism in hip fracture patients: nutritional and anabolic intervention--a review
    Margareta Hedstrom
    Division of Orthopedics, Karolinska University Hospital, Huddinge, Sweden
    Acta Orthop 77:741-7. 2006
    ..Studies of higher scientific quality are needed, and enteral feeding, anabolic treatment and multimodal approaches need to be evaluated in greater depth...
  28. ncbi request reprint New developments facilitating nutritional intake after gastrointestinal surgery
    Jonas Nygren
    Centre of Gastrointestinal Disease, Ersta Hospital, PO Box 4622, SE 116 91 Stockholm, Sweden
    Curr Opin Clin Nutr Metab Care 6:593-7. 2003
    ..Thus, developing routines and treatments that promote sufficient early oral intake after surgery and maintain adequate energy intake in the postoperative period are probably of great importance for the outcome from surgery...
  29. ncbi request reprint Stress-induced insulin resistance: recent developments
    Mattias Soop
    Karolinska Institute, CLINTEC, Karolinska University Hospital, Huddinge, Sweden
    Curr Opin Clin Nutr Metab Care 10:181-6. 2007
    ..Interest in stress-induced insulin resistance has increased during the past 5 years. Relevant clinical and mechanistic investigations during the past year will be reviewed...
  30. ncbi request reprint Are there any benefits from minimizing fasting and optimization of nutrition and fluid management for patients undergoing day surgery?
    Jonas Nygren
    Centre of Gastrointestinal Disease, Ersta Hospital, and Karolinska Institutet and CLINTEC, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Curr Opin Anaesthesiol 20:540-4. 2007
    ..The evidence that preoperative fasting and dehydration not only reduces preoperative well being, but may also affect postoperative recovery is currently being reviewed...
  31. pmc Similar outcome after colonic pouch and side-to-end anastomosis in low anterior resection for rectal cancer: a prospective randomized trial
    Mikael Machado
    Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Ann Surg 238:214-20. 2003
    ..To compare a colonic J-pouch or a side-to-end anastomosis after low-anterior resection for rectal cancer with regard to functional and surgical outcome...
  32. ncbi request reprint A comparison in five European Centres of case mix, clinical management and outcomes following either conventional or fast-track perioperative care in colorectal surgery
    Jonas Nygren
    Centre for Surgical Sciences, Division of Surgery, Karolinska Institutet and Centre of Gastrointestinal Disease, Ersta Hospital, PO Box 4622, 11691 Stockholm, Sweden
    Clin Nutr 24:455-61. 2005
    ..This study reviewed the case mix, clinical management, and clinical outcomes of patients undergoing colorectal resection in five European centres performing different forms of conventional or 'fast-track' perioperative care...
  33. ncbi request reprint [Is fasting after gastrointestinal surgery necessary? Meta-analysis of early enteral nutrition versus traditional nutritional therapy]
    Anders Thorell
    Mag tarmcentrum, Ersta sjukhus, Stockholm
    Lakartidningen 99:1786-90. 2002
  34. ncbi request reprint Prognostic significance of Cyclin A in epidermoid anal cancer
    Per J Nilsson
    Centre of Gastrointestinal Disease, Ersta Hospital, SE 116 91 Stockholm, Sweden
    Oncol Rep 16:443-9. 2006
    ..05) but no impact on survival was found. For p53 and CD31 no significant correlations were obtained. Cyclin A may be an indicator of radiosensitivity and a valuable prognostic marker in epidermoid anal cancer...
  35. pmc Preoperative fasting
    Eldar Søreide
    Can J Surg 49:218-9; author reply 219. 2006
  36. ncbi request reprint Modern preoperative fasting guidelines: a summary of the present recommendations and remaining questions
    Eldar Søreide
    Department of Anaesthesia, Division of Acute Care Medicine, Stavanger University Hospital, Stavanger, Norway
    Best Pract Res Clin Anaesthesiol 20:483-91. 2006
    ..Active implementation of new evidence is also needed. To improve perioperative care, anaesthesiologists, surgeons and the nursing staff must work together...
  37. ncbi request reprint Epidermoid anal cancer: a review of a population-based series of 308 consecutive patients treated according to prospective protocols
    Per J Nilsson
    Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Int J Radiat Oncol Biol Phys 61:92-102. 2005
    ..The use of neoadjuvant chemotherapy has been infrequently reported in the literature. This study presents results from a large population-based series and provides comparisons between different treatments...
  38. ncbi request reprint Functional and physiologic assessment of the colonic reservoir or side-to-end anastomosis after low anterior resection for rectal cancer: a two-year follow-up
    Mikael Machado
    Centre of Gastrointestinal Disease, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden
    Dis Colon Rectum 48:29-36. 2005
    ..This study was designed to compare functional and physiologic outcome after low anterior resection and total mesorectal excision with a colonic J-pouch or a side-to-end anastomosis...
  39. ncbi request reprint Preoperative oral carbohydrate treatment attenuates endogenous glucose release 3 days after surgery
    Mattias Soop
    Karolinska Institutet, Centre for Surgical Sciences at Centre for Gastrointestinal Disease at Ersta Hospital, PO Box 4622, SE 11691 Stockholm, Sweden
    Clin Nutr 23:733-41. 2004
    ..We hypothesised that preoperative oral carbohydrate treatment attenuates insulin resistance and improves whole-body nitrogen balance 3 days after surgery...
  40. ncbi request reprint Effect of "preoperative" oral carbohydrate treatment on insulin action--a randomised cross-over unblinded study in healthy subjects
    Monika Svanfeldt
    Division of Surgery, CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge and Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Clin Nutr 24:815-21. 2005
    ..In this study, we evaluated whether this could be related to increased insulin sensitivity at the onset of surgery. Furthermore, we aimed to establish the optimal dose-regimen...
  41. ncbi request reprint 'Failure' of early oral feeding in traditional care
    Olle Ljungqvist
    Karolinska Institutet Centre for Surgical Sciences, Division of Surgery, Karolinska University Hospital, Huddinge, Sweden
    ANZ J Surg 74:295-6. 2004
  42. ncbi request reprint Nutritional support and oral intake after gastric resection in five northern European countries
    Kristoffer Lassen
    Department of Gastrointestinal Surgery, University Hospital of Northern Norway, Tromsø, Norway
    Dig Surg 22:346-52; discussion 352. 2005
    ..We describe postoperative practice after gastric resections in five northern European countries. METHOD AND SETTING: Questionnaire survey in all major digestive surgical centres in Scotland, the Netherlands, Denmark, Sweden and Norway...
  43. ncbi request reprint Postoperative parenteral nutrition while proactively minimizing insulin resistance
    Monika Svanfeldt
    Division of Surgery, Department for Clinical Science Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Nutrition 22:457-64. 2006
    ....
  44. ncbi request reprint Microdialysis methods for measuring human metabolism
    Olav Rooyackers
    Centre for Surgical Sciences, Karolinska Institutet, Department of Anesthesiology and Intensive Care, Karolinska University Hospital, 141 86 Huddinge, Sweden
    Curr Opin Clin Nutr Metab Care 7:515-21. 2004
    ..To discuss the advantages and limitations of the microdialysis technique as a diagnostic and research tool using recent findings on human metabolism...
  45. doi request reprint Inspired by the pioneers: the lesson of the Judy Taylor story
    Olle Ljungqvist
    Clin Nutr 27:319-20. 2008
  46. ncbi request reprint Orally inoculated Escherichia coli strains colonize the gut and increase bacterial translocation after stress in rats
    Carl Gustaf Nettelbladt
    Department of Surgery, Karolinska Hospital, S 17176 Stockholm, Sweden
    Shock 20:251-6. 2003
    ..The composition of the gut flora seems to be an underestimated factor in the pathophysiology of bacterial translocation...
  47. ncbi request reprint Nutritional care in hospitals
    Olle Ljungqvist
    Clin Nutr 21:449. 2002
  48. ncbi request reprint Optimizing perioperative management of patients undergoing colorectal surgery: what is new?
    Mattias Soop
    Karolinska Institute, CLINTEC, Karolinska University Hospital Huddinge and Centre for Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden
    Curr Opin Crit Care 12:166-70. 2006
    ..This review highlights recent developments in individual perioperative interventions in colorectal surgery, and progress in so-called fast-track or enhanced-recovery programmes...
  49. ncbi request reprint [Ways to safer perioperative routines in colonic resections. ERAS--a North European project for better surgical treatment]
    Olle Ljungqvist
    CLINTEC, Karolinska Institutet
    Lakartidningen 103:1708-10. 2006