S Enerback

Summary

Country: Sweden

Publications

  1. pmc The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function
    Martin E Lidell
    Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Diabetes 60:427-35. 2011
  2. pmc The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis
    Hilmar Vidarsson
    Center of Medical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    PLoS ONE 4:e4471. 2009
  3. pmc Therapeutic prospects of metabolically active brown adipose tissue in humans
    Matthias J Betz
    Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Göteborg Göteborg, Sweden
    Front Endocrinol (Lausanne) 2:86. 2011
  4. ncbi request reprint An enzymatic chromatin switch that directs formation of active brown fat
    Sven Enerback
    Department of Medical and Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Medicinaregatan 9A, P O Box 440, 405 30 Goteborg, Sweden Electronic address
    Cell Metab 19:3-4. 2014
  5. doi request reprint Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature
    Matthias Johannes Betz
    MD, PhD, Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 9A, Box 440, SE 40530 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:4097-104. 2013
  6. doi request reprint Adipose tissue metabolism in 2012: Adipose tissue plasticity and new therapeutic targets
    Sven Enerback
    University of Gothenburg, Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Sweden
    Nat Rev Endocrinol 9:69-70. 2013
  7. pmc Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to rosiglitazone
    Joakim Håkansson
    Department of Medical and Clinical Genetics, Institute of Biomedicine University of Gothenburg, Goteborg, Sweden
    Diabetol Metab Syndr 3:32. 2011
  8. doi request reprint Human brown adipose tissue
    Sven Enerback
    Department of Medical and Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Medicinaregatan 9A, P O Box 440, SE 40530 Goteborg, Sweden
    Cell Metab 11:248-52. 2010
  9. doi request reprint Brown adipose tissue in humans
    S Enerback
    Department of Medical and Clinical Genetics, Goteborg University, Goteborg, Sweden
    Int J Obes (Lond) 34:S43-6. 2010
  10. ncbi request reprint FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
    A Cederberg
    Medical Genetics, Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30, Goteborg, Sweden
    Cell 106:563-73. 2001

Collaborators

  • W Wurst
  • Mary Ellen Harper
  • Sylvie Breton
  • Markku Laakso
  • S Sjoberg
  • K Tasken
  • B Ahren
  • Ulf Smith
  • Martin E Lidell
  • M Mahlapuu
  • P Carlsson
  • Mikael Heglind
  • Rickard Westergren
  • Anna Cederberg
  • Matthias Johannes Betz
  • A Blixt
  • Daniel Nilsson
  • Joakim Håkansson
  • Matthias J Betz
  • Zahra Arani
  • Hilmar Vidarsson
  • M Hellqvist
  • A Cederberg
  • Xiaolin Yang
  • Urs Daniel Lichtenauer
  • Brigitte Mauracher
  • Thomas Mussack
  • Felix Beuschlein
  • Andrea Osswald
  • Marc Slawik
  • M Hulander
  • Julia Fernandez-Rodriguez
  • Simonetta Wallin
  • Valentina Sukonina
  • Xiao Rong Peng
  • Erin L Seifert
  • Fredrik Westberg
  • Paula Itkonen
  • Bjorn Eliasson
  • Tommy Nilsson
  • Adrienne Gowing
  • Mats Grände
  • Sandra Rodrigo Blomqvist
  • M Pelto-Huikko
  • M Aitola
  • S Pierrou
  • S Ernstsson
  • L M Grønning
  • M Ormestad
  • L Samuelsson
  • T Johannesson
  • C Bjursell
  • C Darnfors

Detail Information

Publications25

  1. pmc The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function
    Martin E Lidell
    Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Diabetes 60:427-35. 2011
    ..These findings prompted us to further investigate the role of Foxc2 in the regulation of genes of fundamental importance for metabolism and mitochondrial function...
  2. pmc The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis
    Hilmar Vidarsson
    Center of Medical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    PLoS ONE 4:e4471. 2009
    ....
  3. pmc Therapeutic prospects of metabolically active brown adipose tissue in humans
    Matthias J Betz
    Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Göteborg Göteborg, Sweden
    Front Endocrinol (Lausanne) 2:86. 2011
    ....
  4. ncbi request reprint An enzymatic chromatin switch that directs formation of active brown fat
    Sven Enerback
    Department of Medical and Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Medicinaregatan 9A, P O Box 440, 405 30 Goteborg, Sweden Electronic address
    Cell Metab 19:3-4. 2014
    ....
  5. doi request reprint Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature
    Matthias Johannes Betz
    MD, PhD, Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 9A, Box 440, SE 40530 Gothenburg, Sweden
    J Clin Endocrinol Metab 98:4097-104. 2013
    ..Recently its presence in the cervical adipose tissue of human adults and its association with a favorable metabolic phenotype have been reported...
  6. doi request reprint Adipose tissue metabolism in 2012: Adipose tissue plasticity and new therapeutic targets
    Sven Enerback
    University of Gothenburg, Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, Sweden
    Nat Rev Endocrinol 9:69-70. 2013
    ..A bipotential adipocyte progenitor giving rise to both brown and white adipocytes has also been identified...
  7. pmc Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to rosiglitazone
    Joakim Håkansson
    Department of Medical and Clinical Genetics, Institute of Biomedicine University of Gothenburg, Goteborg, Sweden
    Diabetol Metab Syndr 3:32. 2011
    ..abstract:..
  8. doi request reprint Human brown adipose tissue
    Sven Enerback
    Department of Medical and Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Medicinaregatan 9A, P O Box 440, SE 40530 Goteborg, Sweden
    Cell Metab 11:248-52. 2010
    ..The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy--a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health...
  9. doi request reprint Brown adipose tissue in humans
    S Enerback
    Department of Medical and Clinical Genetics, Goteborg University, Goteborg, Sweden
    Int J Obes (Lond) 34:S43-6. 2010
    ..Ectopic triglyceride storage at these locations is associated with initiation of insulin resistance and, ultimately, development of type 2 diabetes...
  10. ncbi request reprint FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
    A Cederberg
    Medical Genetics, Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30, Goteborg, Sweden
    Cell 106:563-73. 2001
    ....
  11. ncbi request reprint Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2
    M Hellqvist
    Department of Molecular Biology, The Lundberg Laboratory, Goteborg University, Medicinaregatan 9C, S 413 90 Göteborg, Sweden
    J Biol Chem 271:4482-90. 1996
    ..Efficient activation of CC10 by FREAC-1 is shown to be specific for a lung cell line with Clara cell characteristics (H441) and to involve a region of the FREAC-1 protein unable to activate in other cell types...
  12. ncbi request reprint Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations
    M Mahlapuu
    Department of Molecular Biology, Goteborg University, The Lundberg Laboratory, Box 462, SE 405 30 Goteborg, Sweden
    Development 128:2397-406. 2001
    ..Fibroblast growth factor (FGF) 10 and FGF7 both decrease Foxf1 expression and we speculate that this is mediated by transcriptional activation of epithelial Bmp4 (in the case of FGF10) and by inhibition of Shh expression for FGF7...
  13. ncbi request reprint The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm
    M Mahlapuu
    Department of Molecular Biology, Goteborg University, The Lundberg Laboratory, Medicinaregatan 9C, Box 462, S 405 30 Goteborg, Sweden
    Development 128:155-66. 2001
    ....
  14. ncbi request reprint The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB
    M Hellqvist
    Department of Molecular Biology, Goteborg University, Medicinaregatan 9C, Box 462, S 405 30 Goteborg, Sweden
    J Biol Chem 273:23335-43. 1998
    ..Overexpression of TFIIB potentiates activation by FREAC-2 in a manner dependent on the FREAC-2 activation domains. Nuclear localization of FREAC-2 was found to depend on sequences from both ends of the forkhead domain...
  15. ncbi request reprint FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces
    M Mahlapuu
    Department of Molecular Biology, Goteborg University, Goteborg, S 405 30, Sweden
    Dev Biol 202:183-95. 1998
    ....
  16. ncbi request reprint The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3
    A Blixt
    Department of Molecular Biology, Goteborg University, Goteborg, Medicinaregatan 9C, S 413 90, Sweden
    Genomics 53:387-90. 1998
    ..Fluorescence in situ hybridization was used to localize the human FREAC-2 gene to chromosomal position 6p24-p25, and the localization was further refined by radiation hybrid mapping to 6p25.3...
  17. ncbi request reprint Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53
    S Ernstsson
    Department of Molecular Biology, The Lundberg Laboratory, Goteborg University, Medicinaregatan 9C, S 413 90 Göteborg, Sweden
    J Biol Chem 271:21094-9. 1996
    ..A 5'-promoter deletion series delimits a DNA fragment necessary for WT-1 inducibility in cotransfection experiments. This fragment is shown to contain at least one cis-element that is capable of interacting with recombinant WT-1...
  18. pmc A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle
    A Blixt
    Department of Molecular Biology, Goteborg University, The Lundberg Laboratory, Medicinaregatan 9C, Box 462, S 405 30 Goteborg, Sweden
    Genes Dev 14:245-54. 2000
    ..This implies that FoxE3 is essential for closure of the lens vesicle and is a factor that promotes survival and proliferation, while preventing differentiation, in the lens epithelium...
  19. ncbi request reprint The winged helix transcription factor Fkh10 is required for normal development of the inner ear
    M Hulander
    Department of Molecular Biology, The Lundberg Laboratory, Goteborg University, Sweden
    Nat Genet 20:374-6. 1998
    ..These findings implicate Fkh10 as an early regulator necessary for development of both cochlea and vestibulum and identify its human homologue FKHL10 as a previously unknown candidate deafness gene at 5q34...
  20. ncbi request reprint Insulin resistance and type 2 diabetes--an adipocentric view
    Anna Cederberg
    Medical Genetics, Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Curr Mol Med 3:107-25. 2003
    ..This review sets out to discuss the adipocyte and its role in metabolism as well as the consequences of a metabolic situation, in which the adipocyte has lost its fat storing monopoly...
  21. doi request reprint Brown adipose tissue--a new role in humans?
    Martin E Lidell
    Department of Medical and Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Box 440, SE 40530 Gothenburg, Sweden
    Nat Rev Endocrinol 6:319-25. 2010
    ..Whether or not brown adipose tissue will be useful in the battle against obesity remains to be seen. However, this possibility is certainly well worth exploring...
  22. ncbi request reprint Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance
    Xiaolin Yang
    The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 11:1182-91. 2003
    ..The relation between the expression of brown adipogenic genes and the genes involved in progenitor cell commitment, adipose cell size, and insulin sensitivity in vivo was analyzed...
  23. pmc Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
    S Pierrou
    Department of Molecular Biology, Goteborg University, Sweden
    EMBO J 13:5002-12. 1994
    ..Applying a circular permutation assay, we show that binding of FREAC proteins to their cognate sites results in bending of the DNA at an angle of 80-90 degrees...
  24. ncbi request reprint A compact, flexible and cheap system for acquiring sequence data from autoradiograms with a digitizer and transferring it to an arbitrary host computer
    S Sjoberg
    Department of Medical Biochemistry, University of Gothenburg, Sweden
    Comput Appl Biosci 5:41-6. 1989
    ..The gel reading algorithm described is fast, accurate and simple and the file transfer relies on the safe and well-known Kermit programs...
  25. doi request reprint Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo
    Rickard Westergren
    Dept of Medical and Clinical Genetics, Institute of Biomedicine, Univ of Göteborg, Sweden
    Am J Physiol Endocrinol Metab 298:E548-54. 2010
    ..Foxf2 and its downstream target genes can provide new insights with regard to identification of novel therapeutic targets...