F Elinder

Summary

Country: Sweden

Publications

  1. pmc A tyrosine substitution in the cavity wall of a k channel induces an inverted inactivation
    Göran Klement
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biophys J 94:3014-22. 2008
  2. doi request reprint Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action
    Xiang ping Xu
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, SE 581 85 Linkoping, Sweden
    Epilepsy Res 80:57-66. 2008
  3. doi request reprint Large-scale movement within the voltage-sensor paddle of a potassium channel-support for a helical-screw motion
    Amir Broomand
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, SE 58185 Linkoping, Sweden
    Neuron 59:770-7. 2008
  4. pmc Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties
    Roope Mannikko
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    J Gen Physiol 125:305-26. 2005
  5. ncbi request reprint On the opening of voltage-gated ion channels
    Fredrik Elinder
    Karolinska Institutet, Department of Neuroscience, The Nobel Institute for Neurophysiology, Stockholm, Sweden
    Physiol Behav 92:1-7. 2007
  6. pmc Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels
    Fredrik Elinder
    Department of Biomedicine and Surgery, Division of Cell Biology, Linkopings Universitet, SE 581 85 Linkoping, Sweden
    J Physiol 575:417-31. 2006
  7. ncbi request reprint Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli
    F Elinder
    Department of Biomedicine and Surgery, Division of Cell Biology, Linkopings Universitet, Linkoping SE 581 85, Sweden
    Cell Death Differ 12:1134-40. 2005
  8. ncbi request reprint A conserved glutamate is important for slow inactivation in K+ channels
    H P Larsson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuron 27:573-83. 2000
  9. pmc Localization of the extracellular end of the voltage sensor S4 in a potassium channel
    F Elinder
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Biophys J 80:1802-9. 2001
  10. ncbi request reprint Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages
    Roope Mannikko
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 419:837-41. 2002

Collaborators

Detail Information

Publications23

  1. pmc A tyrosine substitution in the cavity wall of a k channel induces an inverted inactivation
    Göran Klement
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biophys J 94:3014-22. 2008
    ..The experimental findings can be explained by a simple branched kinetic model with two inactivation pathways from the open state...
  2. doi request reprint Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action
    Xiang ping Xu
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, SE 581 85 Linkoping, Sweden
    Epilepsy Res 80:57-66. 2008
    ..This diet increases the concentrations of ketone bodies and polyunsaturated fatty acids (PUFAs) in cerebrospinal fluid (CSF) and plasma. However, its anticonvulsant mechanism is not known...
  3. doi request reprint Large-scale movement within the voltage-sensor paddle of a potassium channel-support for a helical-screw motion
    Amir Broomand
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, SE 58185 Linkoping, Sweden
    Neuron 59:770-7. 2008
    ..A disulfide bond between 325 and 360 was formed in the closed state, while a bond between 325 and 366 was formed in the open state. These data are not compatible with the voltage-sensor paddle model, but support the helical-screw model...
  4. pmc Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties
    Roope Mannikko
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    J Gen Physiol 125:305-26. 2005
    ..Computer simulations suggest that voltage hysteresis in HCN channels decreases the risk of arrhythmia in pacemaker cells...
  5. ncbi request reprint On the opening of voltage-gated ion channels
    Fredrik Elinder
    Karolinska Institutet, Department of Neuroscience, The Nobel Institute for Neurophysiology, Stockholm, Sweden
    Physiol Behav 92:1-7. 2007
    ..This model opens up for understanding how lipophilic drugs and toxins directly affect the voltage sensor...
  6. pmc Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels
    Fredrik Elinder
    Department of Biomedicine and Surgery, Division of Cell Biology, Linkopings Universitet, SE 581 85 Linkoping, Sweden
    J Physiol 575:417-31. 2006
    ..We conclude that although all HCN channels appear to undergo mode shifts - and thus may serve to prevent arrhythmic firing - it is mainly observable in ionic currents from HCN channels with faster kinetics...
  7. ncbi request reprint Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli
    F Elinder
    Department of Biomedicine and Surgery, Division of Cell Biology, Linkopings Universitet, Linkoping SE 581 85, Sweden
    Cell Death Differ 12:1134-40. 2005
    ..Hence, it appears that there might be a dual role for this protein in the plasma membrane: (1) maintenance of redox homeostasis in normal cells and (2) promotion of anion efflux in apoptotic cells...
  8. ncbi request reprint A conserved glutamate is important for slow inactivation in K+ channels
    H P Larsson
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuron 27:573-83. 2000
    ..Breaking these bonds allows the P-S6 loop to rotate, which closes the slow inactivation gate. Our results also suggest a mechanism of how the movement of the voltage sensor can induce slow inactivation by destabilizing these bonds...
  9. pmc Localization of the extracellular end of the voltage sensor S4 in a potassium channel
    F Elinder
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Biophys J 80:1802-9. 2001
    ..We also present a three-dimensional model for all transmembrane segments. Knowledge of this structure is essential for the attempts to understand how voltage opens these channels...
  10. ncbi request reprint Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages
    Roope Mannikko
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 419:837-41. 2002
    ....
  11. pmc S4 charges move close to residues in the pore domain during activation in a K channel
    F Elinder
    The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    J Gen Physiol 118:1-10. 2001
    ..This refutes previous models for slow inactivation with an electrostatic S4-to-gate coupling. Instead, we propose a model with an allosteric mechanism for the S4-to-gate coupling...
  12. pmc Oxaliplatin neurotoxicity--no general ion channel surface-charge effect
    Amir Broomand
    Department of Oncology Pathology, Karolinska Institutet and Karolinska Pharmacy, Karolinska University Hospital, Solna, Stockholm, Sweden
    J Negat Results Biomed 8:2. 2009
    ..The recordings were made with the two-electrode and the cut-open oocyte voltage clamp techniques...
  13. pmc Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids
    Sara I Börjesson
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, Linkoping, Sweden
    Biophys J 95:2242-53. 2008
    ..We believe this provides a new approach for pharmacological treatment that is voltage sensor pharmacology...
  14. pmc Electrostatic tuning of cellular excitability
    Sara I Börjesson
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, Linkoping, Sweden
    Biophys J 98:396-403. 2010
    ..We suggest that electrostatic tuning of ion channel activity constitutes a novel and powerful pharmacological approach with which to affect cellular excitability...
  15. pmc Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics
    Johanna Nilsson
    Department of Neuroscience, Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden
    Biophys J 95:5138-52. 2008
    ..The relevance of these results for understanding the action of local anesthetics on Na channels is discussed...
  16. pmc Biophysical properties of the apoptosis-inducing plasma membrane voltage-dependent anion channel
    Nesar Akanda
    Department of Biomedicine and Surgery, Division of Cell Biology, Linkopings Universitet, SE 581 85 Linkoping, Sweden
    Biophys J 90:4405-17. 2006
    ..These channel properties are similar to those of VDACmt and other VDACpls and are discussed in relation to apoptosis...
  17. pmc Molecular movement of the voltage sensor in a K channel
    Amir Broomand
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Gen Physiol 122:741-8. 2003
    ..Our data suggest that S4 is located close to the pore domain in a neighboring subunit. Our data also place constraints on possible models for S4 movement and are not compatible with a recently proposed KvAP model...
  18. doi request reprint Structure, function, and modification of the voltage sensor in voltage-gated ion channels
    Sara I Börjesson
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, SE 581 85, Linkoping, Sweden
    Cell Biochem Biophys 52:149-74. 2008
    ..Small effects on voltage-sensitivity can have profound effects on excitability. Therefore, medical drugs designed to alter the voltage dependence offer an interesting way to regulate excitability...
  19. ncbi request reprint Non-stationary fluctuation analysis of the Na current in myelinated nerve fibers of Xenopus laevis: experiments and stochastic simulations
    F Elinder
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, SE-171 77 Stockholm, Sweden
    Biosystems 62:13-28. 2001
    ..Features that distinguished this model from the other tested ones were a slower deactivation rate, and an inactivation transition directly from a closed state...
  20. ncbi request reprint Metal ion effects on ion channel gating
    Fredrik Elinder
    Department of Neuroscience, The Nobel Institute for Neurophysiology, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Q Rev Biophys 36:373-427. 2003
    ..With the exception of the ether-à-go-go-like channels, most channel types show remarkably similar ion-specific sensitivities...
  21. ncbi request reprint Voltage-dependent anion channels (VDAC) in the plasma membrane play a critical role in apoptosis in differentiated hippocampal neurons but not in neural stem cells
    Nesar Akanda
    Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkoping University, Linkoping, Sweden
    Cell Cycle 7:3225-34. 2008
    ..Thus, it appears that activation of pl-VDAC during apoptosis is a critical event in differentiated neurons, but not in NSCs...
  22. pmc Electrostatic domino effect in the Shaker K channel turret
    Amir Broomand
    Department of Biomedicine and Surgery, Division of Cell Biology, Linkopings Universitet, Linkoping, Sweden
    Biophys J 93:2307-14. 2007
    ..Residue 425, located at some distance away from the voltage sensor, was shown to electrostatically affect residue K427, which in turn affects the voltage sensor S4-thus, an electrostatic domino effect...
  23. pmc Kinetic relationship between the voltage sensor and the activation gate in spHCN channels
    Andrew Bruening-Wright
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Gen Physiol 130:71-81. 2007
    ..Instead, our data and modeling suggest that spHCN channels open after only two S4s have moved and that S4 motion is rate limiting during voltage activation of spHCN channels...