Helena Edlund

Summary

Country: Sweden

Publications

  1. ncbi Developmental biology of the pancreas
    H Edlund
    Department of Microbiology, University of Umea, Sweden
    Diabetes 50:S5-9. 2001
  2. ncbi Pancreas: how to get there from the gut?
    H Edlund
    Department of Microbiology, University of Umea, Umea, SE 901 87, Sweden
    Curr Opin Cell Biol 11:663-8. 1999
  3. ncbi Transcribing pancreas
    H Edlund
    Department of Microbiology, University of Umea, Sweden
    Diabetes 47:1817-23. 1998
  4. ncbi Factors controlling pancreatic cell differentiation and function
    H Edlund
    Umeå Centre for Molecular Medicine and Dept of Molecular Biology, University of Umea, Sweden
    Diabetologia 44:1071-9. 2001
  5. ncbi Pancreatic organogenesis--developmental mechanisms and implications for therapy
    Helena Edlund
    Umeå Centre for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Genet 3:524-32. 2002
  6. ncbi Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function
    Stella Papadopoulou
    Umeå Centre for Molecular Medicine, University of Umea, S 901 87 Umea, Sweden
    Diabetes 54:2844-51. 2005
  7. ncbi Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells
    Maria Oström
    Umeå Centre for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 3:e2841. 2008
  8. ncbi Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells
    Per Svensson
    Umeå Center for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    BMC Dev Biol 7:129. 2007
  9. ncbi The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity
    Marie Josée Boucher
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    Endocrinology 150:87-97. 2009
  10. ncbi Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
    Sara Edfalk
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Diabetes 57:2280-7. 2008

Collaborators

  • H Li
  • T Edlund
  • Per Svensson
  • Kelly A Loffler
  • Joakim Lundeberg
  • Cecilia Williams
  • Camillo Ricordi
  • Michael D Walker
  • Yuji Mishina
  • L Sommer
  • P L Brubaker
  • Stanley Misler
  • D J Drucker
  • Lars Selander
  • Marie Josée Boucher
  • Sara Edfalk
  • U Ahlgren
  • Pär Steneberg
  • Stella Papadopoulou
  • A Apelqvist
  • Maria Oström
  • Ulf Dahl
  • Joan Goulley
  • J Jonsson
  • Yazhou Li
  • Stefan Norlin
  • Juan Dominguez-Bendala
  • Anastasia Mavropoulos
  • Judy S Crabtree
  • Alan Hart
  • Jean Sebastien Annicotte
  • James D Johnson
  • Jan Sandström
  • A W Hart
  • Mélanie Simoneau
  • Jongmin Jeon
  • Juan Diez
  • Mayrin Correa-Medina
  • Nathalie Baeza
  • Lennart Carlsson
  • Li Xin Li
  • Nir Rubins
  • Luca Inverardi
  • Reut Bartoov-Shifman
  • Li-Xin Li
  • Ricardo Pastori
  • Elisabetta Zecchin
  • Nathalie Devos
  • Melina Ribeiro
  • Dagmar Klein
  • Joseph A Martial
  • Patrick Motte
  • Bernard Peers
  • Frederic Biemar
  • Ulf Ahlgren
  • Xiemin Cao
  • Francesco Argenton
  • Tatsuhiko Kodama
  • Dan S Luciani
  • Settara C Chandrasekharappa
  • Johan Auwerx
  • Francis S Collins
  • Sara R McNally
  • Jeffrey H Hager
  • Thomas Ried
  • Allen M Spiegel
  • Noreen T Ahmed
  • Stephen J Marx
  • Zhiqiang Han
  • Douglas Hanahan
  • Lisa Garrett-Beal
  • Mark A Magnuson
  • A Lee Burns
  • Peter C Scacheri
  • Kristina Schoonjans
  • Elisabeth Fayard
  • Hung Tran
  • Cristina Montagna
  • Gary P Swain
  • Toshiya Tanaka
  • Galvin H Swift
  • Jerrold M Ward
  • Kenneth S Polonsky
  • Jun Fujita
  • Lena M Jonsson
  • Stefan L Marklund
  • Dan Holmberg
  • N Baeza
  • D J Anderson
  • P Beatus

Detail Information

Publications34

  1. ncbi Developmental biology of the pancreas
    H Edlund
    Department of Microbiology, University of Umea, Sweden
    Diabetes 50:S5-9. 2001
    ..Interestingly, four of the hitherto defined five different maturity-onset diabetes of the young (MODY) genes correspond to transcription factors, and, in addition, several transcription factors have also been linked to type 2 diabetes...
  2. ncbi Pancreas: how to get there from the gut?
    H Edlund
    Department of Microbiology, University of Umea, Umea, SE 901 87, Sweden
    Curr Opin Cell Biol 11:663-8. 1999
    ..With such information, the prospect of using pancreatic stem and/or progenitor cells as a therapeutic approach towards curing diabetic disorders will be within reach...
  3. ncbi Transcribing pancreas
    H Edlund
    Department of Microbiology, University of Umea, Sweden
    Diabetes 47:1817-23. 1998
    ..This review discusses our current knowledge of the mechanisms by which the various pancreatic cell types are generated...
  4. ncbi Factors controlling pancreatic cell differentiation and function
    H Edlund
    Umeå Centre for Molecular Medicine and Dept of Molecular Biology, University of Umea, Sweden
    Diabetologia 44:1071-9. 2001
    ..Nevertheless, key questions regarding the control of proliferation and differentiation of pancreatic progenitor cells into fully functional beta cells remain to be solved...
  5. ncbi Pancreatic organogenesis--developmental mechanisms and implications for therapy
    Helena Edlund
    Umeå Centre for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    Nat Rev Genet 3:524-32. 2002
    ..This information is also pivotal for any attempt to generate functional insulin-producing beta-cells that are suitable for transplantation...
  6. ncbi Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function
    Stella Papadopoulou
    Umeå Centre for Molecular Medicine, University of Umea, S 901 87 Umea, Sweden
    Diabetes 54:2844-51. 2005
    ..Collectively, our data provide evidence that Wnt signaling is required for pancreatic growth but not adult beta-cell function...
  7. ncbi Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells
    Maria Oström
    Umeå Centre for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 3:e2841. 2008
    ....
  8. ncbi Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells
    Per Svensson
    Umeå Center for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    BMC Dev Biol 7:129. 2007
    ..Although several putative target genes have been linked to the beta-cell function of Ipf1/Pdx1, relatively little is known with respect to genes regulated by IPF1/PDX1 in early pancreatic progenitor cells...
  9. ncbi The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity
    Marie Josée Boucher
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    Endocrinology 150:87-97. 2009
    ..Taken together, our data provide evidence for a new mechanism by which IPF1/PDX1 transcriptional activity, and thus possibly pancreas development and/or beta-cell function, is regulated...
  10. ncbi Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
    Sara Edfalk
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Diabetes 57:2280-7. 2008
    ..Here, we addressed whether 1) Gpr40 is expressed in the intestine and 2) Ipf1/Pdx1 function is required for Gpr40 expression...
  11. ncbi BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion
    Joan Goulley
    Umeå Center for Molecular Medicine, University of Umea, SE 901 87 Umea, Sweden
    Cell Metab 5:207-19. 2007
    ..Thus, BMP4-BMPR1A signaling in beta cells plays a key role in GSIS...
  12. ncbi MFng is dispensable for mouse pancreas development and function
    Per Svensson
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    Mol Cell Biol 29:2129-38. 2009
    ....
  13. ncbi Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
    Alan Hart
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Dev Dyn 228:185-93. 2003
    ..Together, our data suggest a role for FGF10/FGFR2b signalling in regulation of pancreatic cell proliferation and differentiation and that FGF10/FGFR2b signalling affects the Notch-mediated lateral inhibition pathway...
  14. ncbi Attenuation of FGF signalling in mouse beta-cells leads to diabetes
    A W Hart
    Department of Microbiology and ULMM, Umea University, Sweden
    Nature 408:864-8. 2000
    ....
  15. ncbi Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
    H Li
    Department of Microbiology, University of Umea, S 901 87 Umea, Sweden
    Nat Genet 23:67-70. 1999
    ..Thus, dorsally Hlxb9 is required for specifying the gut epithelium to a pancreatic fate and ventrally for ensuring proper endocrine cell differentiation...
  16. ncbi Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development
    H Li
    Umeå Center for Molecular Medicine, Umea University, Umea, SE 901 87, Sweden
    Dev Biol 240:247-53. 2001
    ..Thus, a total loss of Hlxb9 expression results in a block of the initiation of the dorsal pancreatic program, while a temporally extended expression of Hlxb9 results in a complete impairment of pancreatic development...
  17. ncbi Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    A Apelqvist
    Department of Microbiology, University of Umea, Sweden
    Curr Biol 7:801-4. 1997
    ..These results provide evidence that the differential expression of endodermally derived Shh controls the fate of adjacent mesoderm at different regions of the gut tube...
  18. ncbi IPF1, a homeodomain protein with a dual function in pancreas development
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Int J Dev Biol 39:789-98. 1995
    ....
  19. ncbi The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
    Pär Steneberg
    Umeå Center for Molecular Medicine, University of Umea, SE 901 87 Umea, Sweden
    Cell Metab 1:245-58. 2005
    ..These results suggest that GPR40 plays an important role in the chain of events linking obesity and type 2 diabetes...
  20. ncbi Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms
    Marie Josée Boucher
    Umeå Center for Molecular Medicine, University of Umea, SE 901 87 Umea, Sweden
    J Biol Chem 281:6395-403. 2006
    ..Thus, this current study uncovers a new mechanism that might contribute to diminished levels of IPF1/PDX1 protein and beta-cell dysfunction during the progression of diabetes...
  21. ncbi beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    U Ahlgren
    Department of Microbiology, University of Umea, S 901 87 Umea, Sweden
    Genes Dev 12:1763-8. 1998
    ....
  22. ncbi The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    U Ahlgren
    Department of Microbiology, University of Umea, Sweden
    Development 122:1409-16. 1996
    ..Together these data provide evidence that PDX-1 acts cell autonomously and that the lack of a pancreas in the pdx1-/- mice is due to a defect in the pancreatic epithelium...
  23. ncbi Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
    U Ahlgren
    Department of Microbiology, University of Umea, Sweden
    Nature 385:257-60. 1997
    ....
  24. ncbi Insulin-promoter-factor 1 is required for pancreas development in mice
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Nature 371:606-9. 1994
    ..These findings show that IPF1 is needed for the formation of the pancreas and suggest that it acts to determine the fate of common pancreatic precursor cells and/or to regulate their propagation...
  25. ncbi Overexpression of extracellular-SOD in islets of nonobese diabetic mice and development of diabetes
    Jan Sandström
    Department of Biomedical Sciences, Clinical Chemistry, Umea University, Umea, Sweden
    Free Radic Biol Med 33:71-5. 2002
    ..The results suggest that superoxide radicals secreted to the extracellular space do not contribute to the beta cell destruction in the nonobese diabetic mouse model...
  26. ncbi Notch signalling controls pancreatic cell differentiation
    A Apelqvist
    Department of Microbiology, University of Umea, Sweden
    Nature 400:877-81. 1999
    ..These data provide evidence that ngn3 acts as proendocrine gene and that Notch signalling is critical for the decision between the endocrine and progenitor/exocrine fates in the developing pancreas...
  27. ncbi Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas
    Lars Selander
    Department of Molecular Biology, Umeå Center for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    Mech Dev 113:189-92. 2002
    ..The data presented demonstrate that nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas...
  28. ncbi TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro
    Juan Dominguez-Bendala
    Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Ave, Miami, FL 33136, USA
    Diabetes 54:720-6. 2005
    ..Our results raise the possibility of sequentially specifying stem/progenitor cells toward the beta-cell lineage, by using the appropriate sequence and combination of TAT-fused transcription factors...
  29. ncbi Of mice and MEN1: Insulinomas in a conditional mouse knockout
    Judy S Crabtree
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 23:6075-85. 2003
    ..Comparative genomic hybridization of beta cell tumor DNA from these mice reveals duplication of chromosome 11, potentially revealing regions of interest with respect to tumorigenesis...
  30. ncbi Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development
    Jean Sebastien Annicotte
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP 67404, Illkirch, France
    Mol Cell Biol 23:6713-24. 2003
    ..Taken together, our data indicate that PDX-1 controls LRH-1 expression and identify LRH-1 as a novel downstream target in the PDX-1 regulatory cascade governing pancreatic development, differentiation, and function...
  31. ncbi Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion
    Stefan Norlin
    , University of Ume, S-901 87 Ume, Sweden
    Diabetes 54:125-32. 2005
    ..Thus, NF-kappaB appears to be part of a positive regulatory circuit that maintains GSIS in pancreatic beta-cells...
  32. ncbi sox4b is a key player of pancreatic alpha cell differentiation in zebrafish
    Anastasia Mavropoulos
    Laboratoire de Biologie Moléculaire et de Génie Génétique, Center of Biomedical Integrative Genoproteomics CBIG, Universite de Liege, Institut de Chimie, Batiment B6, 4000 Liege Sart Tilman, Belgium
    Dev Biol 285:211-23. 2005
    ..Taken together, these data demonstrate that, in zebrafish, sox4b is expressed transiently during endocrine cell differentiation and plays a crucial role in the generation of alpha endocrine cells...
  33. ncbi beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
    Yazhou Li
    Department of Medicine, University of Toronto, Banting and Best Diabetes Centre, Toronto General Hospital, 200 Elizabeth St, MBRW 4R402 2, Toronto, Canada M5G 2C4
    Diabetes 54:482-91. 2005
    ..These findings demonstrate that Pdx1 expression is essential for integrating GLP-1R-dependent signals regulating alpha-cell glucagon secretion and for the growth, differentiated function, and survival of islet beta-cells...
  34. ncbi Increased islet apoptosis in Pdx1+/- mice
    James D Johnson
    Renal Division, Department of Internal Medicine, Washington University School of Medicine Barnes Jewish Hospital, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Clin Invest 111:1147-60. 2003
    ....