U T Brunk

Summary

Affiliation: Division of Pathology II
Country: Sweden

Publications

  1. ncbi The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis
    Ulf T Brunk
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Eur J Biochem 269:1996-2002. 2002
  2. ncbi Novel cellular defenses against iron and oxidation: ferritin and autophagocytosis preserve lysosomal stability in airway epithelium
    H L Persson
    Division of Pathology II, Faculty of Health Sciences, , Sweden
    Redox Rep 6:57-63. 2001
  3. ncbi Autophagy, organelles and ageing
    A Terman
    Division of Geriatric Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Pathol 211:134-43. 2007
  4. ncbi Lipofuscin: mechanisms of age-related accumulation and influence on cell function
    Ulf T Brunk
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Free Radic Biol Med 33:611-9. 2002
  5. ncbi Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak
    U T Brunk
    Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Sweden
    Redox Rep 4:3-11. 1999
  6. ncbi The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage
    X M Yuan
    Department of Internal Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Atherosclerosis 133:153-61. 1997
  7. ncbi Starvation-induced autophagocytosis paradoxically decreases the susceptibility to oxidative stress of the extremely oxidative stress-sensitive NIT insulinoma cells
    B T Olejnicka
    Department of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Redox Rep 3:311-8. 1997
  8. ncbi OxLDL-induced macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal redox-active iron
    W Li
    Department of Neurobiology and Locomotion, and Clinical Research Centre, Faculty of Health Sciences, Linkoping University, Sweden
    Free Radic Res 29:389-98. 1998
  9. ncbi Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis
    M Zhao
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    FEBS Lett 509:405-12. 2001
  10. ncbi Beta-cells, oxidative stress, lysosomal stability, and apoptotic/necrotic cell death
    B T Olejnicka
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Antioxid Redox Signal 1:305-15. 1999

Detail Information

Publications24

  1. ncbi The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis
    Ulf T Brunk
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Eur J Biochem 269:1996-2002. 2002
    ..This interrelated mitochondrial and lysosomal damage irreversibly leads to functional decay and death of postmitotic cells...
  2. ncbi Novel cellular defenses against iron and oxidation: ferritin and autophagocytosis preserve lysosomal stability in airway epithelium
    H L Persson
    Division of Pathology II, Faculty of Health Sciences, , Sweden
    Redox Rep 6:57-63. 2001
    ....
  3. ncbi Autophagy, organelles and ageing
    A Terman
    Division of Geriatric Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Pathol 211:134-43. 2007
    ..Increased oxidative stress, in turn, further enhances damage to both mitochondria and lysosomes, thus diminishing adaptability, triggering mitochondrial and lysosomal pro-apoptotic pathways, and culminating in cell death...
  4. ncbi Lipofuscin: mechanisms of age-related accumulation and influence on cell function
    Ulf T Brunk
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Free Radic Biol Med 33:611-9. 2002
    ..Lipofuscin, thus, may be much more directly related to cellular degeneration at old age than was hitherto believed...
  5. ncbi Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak
    U T Brunk
    Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Sweden
    Redox Rep 4:3-11. 1999
    ..Regardless of the precise mechanism, these observations suggest that partial rupture of the acidic vacuolar compartment may be one of the final pathways in apoptosis...
  6. ncbi The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage
    X M Yuan
    Department of Internal Medicine, Faculty of Health Sciences, Linkoping University, Sweden
    Atherosclerosis 133:153-61. 1997
    ....
  7. ncbi Starvation-induced autophagocytosis paradoxically decreases the susceptibility to oxidative stress of the extremely oxidative stress-sensitive NIT insulinoma cells
    B T Olejnicka
    Department of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Redox Rep 3:311-8. 1997
    ..The insulin-producing beta cell may belong to this type of cells...
  8. ncbi OxLDL-induced macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal redox-active iron
    W Li
    Department of Neurobiology and Locomotion, and Clinical Research Centre, Faculty of Health Sciences, Linkoping University, Sweden
    Free Radic Res 29:389-98. 1998
    ....
  9. ncbi Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis
    M Zhao
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    FEBS Lett 509:405-12. 2001
    ..Additional results suggest that, perhaps as a consequence of lysosomal stabilization, Bcl-2 may prevent activation of phospholipase A2, an event potentially important in the ultimate initiation of apoptosis...
  10. ncbi Beta-cells, oxidative stress, lysosomal stability, and apoptotic/necrotic cell death
    B T Olejnicka
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Antioxid Redox Signal 1:305-15. 1999
    ..The stress that was applied in this study may be comparable to what occurs within the vicinity of activated macrophages during autoimmune insulitis...
  11. ncbi Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
    A Terman
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Exp Gerontol 34:755-70. 1999
    ....
  12. ncbi Delayed oxidant-induced cell death involves activation of phospholipase A2
    M Zhao
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    FEBS Lett 509:399-404. 2001
    ..This supports a causal association between PLA2 activation and delayed oxidant-induced cell death and suggests that Bcl-2 may suppress apoptosis by preventing PLA2 activation...
  13. ncbi Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation
    W Li
    Department of Pathology II, Clinical Research Centre, Faculty of Health Sciences, University of Linkoping, Sweden
    Arterioscler Thromb Vasc Biol 18:177-84. 1998
    ..Exposure to AcLDL resulted in its uptake with enlargement of the lysosomal apparatus, but the stability of the lysosomal membranes was not changed...
  14. ncbi Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis
    A Terman
    Department of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Mech Ageing Dev 104:277-91. 1998
    ..The results suggest that (i) ceroid/lipofuscin forms within secondary lysosomes due to peroxidative damage of autophagocytosed material, and (ii) it is not substantially eliminated from non-dividing cells by degradation or exocytosis...
  15. ncbi Sphingosine-induced apoptosis is dependent on lysosomal proteases
    K Kågedal
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Biochem J 359:335-43. 2001
    ..We conclude that cathepsin D and one or more cysteine proteases, such as cathepsins B or L, are important mediators of sphingosine-induced apoptosis, working upstream of the caspase cascade and mitochondrial membrane-potential changes...
  16. ncbi Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis
    H L Persson
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Redox Rep 6:327-34. 2001
    ..Therefore, the antioxidant actions of LA and LM may arise from intralysosomal iron chelation, with LM being more effective in this regard...
  17. ncbi Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation
    A Terman
    Department of Neuroscience and Locomotion, Faculty of Health Sciences, Linkoping University, Sweden
    Exp Gerontol 34:943-57. 1999
    ....
  18. ncbi Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content
    S P Sundelin
    Divisions of Division of Ophthalmology, Department of Neuroscience and Locomotion, Linkoping University, Linkoping, Sweden
    Free Radic Biol Med 30:74-81. 2001
    ..These results suggest that melanin acts as an efficient antioxidant, perhaps by interacting with transition metals...
  19. ncbi On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes
    A Terman
    Department of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Mech Ageing Dev 100:145-56. 1998
    ....
  20. ncbi Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products
    X M Yuan
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Sweden
    Free Radic Biol Med 28:208-18. 2000
    ..The early disruption of lysosomes induced by ChOx, with resultant autophagocytosis may be a critical event in apoptosis and/or necrosis of macrophages/foam cells during the development of atherosclerotic lesions...
  21. ncbi Lysosomal labilization
    A Terman
    Division of Geriatric Medicine, Faculty of Health Sciences, , , Sweden
    IUBMB Life 58:531-9. 2006
    ..Consequently, factors influencing the stability of lysosomes, for instance their content of labile and redox-active iron, seem to be essential for the survival of cells...
  22. ncbi Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic activity
    J Neuzil
    Division of Pathology II, University Hospital, Linkoping, Sweden
    Apoptosis 7:179-87. 2002
    ..Here we review the evidence that particular analogs of vitamin E may act as both antiatherogenic and anti-cancer agents, and discuss the possible molecular bases for these actions...
  23. ncbi Bismuth-induced lysosomal rupture in J774 cells
    M Stoltenberg
    Department of Neurobiology, Institute of Anatomy, University of Aarhus, Denmark
    APMIS 110:396-402. 2002
    ..Such accumulations resulted in lysosomal rupture - assayed by the acridine orange uptake technique and flow cytofluorometry - and ensuing apoptotic cell death...
  24. ncbi The comparative biology of neuromelanin and lipofuscin in the human brain
    K L Double
    Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW, Australia
    Cell Mol Life Sci 65:1669-82. 2008
    ..This review presents comparative aspects of the biology of neuromelanin and lipofuscin, as well as a discussion of their hypothesized functions in brain and their possible roles in aging and neurodegenerative disease...