Pia Davidsson

Summary

Country: Sweden

Publications

  1. ncbi request reprint Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease
    P Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, S 431 80, Molndal, Sweden
    Neurosci Lett 300:157-60. 2001
  2. ncbi request reprint Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease
    P Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Molndal, Sweden
    Dement Geriatr Cogn Disord 12:243-50. 2001
  3. ncbi request reprint Studies of the pathophysiological mechanisms in frontotemporal dementia by proteome analysis of CSF proteins
    Pia Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Brain Res Mol Brain Res 109:128-33. 2002
  4. ncbi request reprint Identification of proteins in human cerebrospinal fluid using liquid-phase isoelectric focusing as a prefractionation step followed by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionisation mass spectrometry
    P Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital Molndal, Sweden
    Rapid Commun Mass Spectrom 16:2083-8. 2002
  5. ncbi request reprint Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
    Annika Olsson
    Institute of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Exp Neurol 183:74-80. 2003
  6. ncbi request reprint The use of proteomics in biomarker discovery in neurodegenerative diseases
    Pia Davidsson
    Discovery Medicine Molecular Sciences, AstraZeneca R and D, Molndal, Sweden
    Dis Markers 21:81-92. 2005
  7. ncbi request reprint Comparative proteome analysis of thalamus in MK-801-treated rats
    Linda Paulson
    Departament of Clinical Neuroscience, Goteborg University, Sweden
    Proteomics 4:819-25. 2004
  8. ncbi request reprint Comparative genome- and proteome analysis of cerebral cortex from MK-801-treated rats
    Linda Paulson
    Department of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurosci Res 71:526-33. 2003
  9. ncbi request reprint Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia
    Anders Wallin
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 16:200-7. 2003
  10. ncbi request reprint Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients
    Pia Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80, Sweden
    Neuroreport 13:611-5. 2002

Detail Information

Publications32

  1. ncbi request reprint Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease
    P Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, S 431 80, Molndal, Sweden
    Neurosci Lett 300:157-60. 2001
    ..These data suggest that CSF biomarkers are capable not only of identifying a biochemical effect of drugs, but also of differentiating between different compounds in a dose-dependent manner...
  2. ncbi request reprint Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease
    P Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Molndal, Sweden
    Dement Geriatr Cogn Disord 12:243-50. 2001
    ..Due to the similarity of the expression of APP, PS-1 and rab3a, it is tempting to speculate whether there is a functional relationship between these proteins...
  3. ncbi request reprint Studies of the pathophysiological mechanisms in frontotemporal dementia by proteome analysis of CSF proteins
    Pia Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Brain Res Mol Brain Res 109:128-33. 2002
    ....
  4. ncbi request reprint Identification of proteins in human cerebrospinal fluid using liquid-phase isoelectric focusing as a prefractionation step followed by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionisation mass spectrometry
    P Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital Molndal, Sweden
    Rapid Commun Mass Spectrom 16:2083-8. 2002
    ..Liquid-phase IEF, as a prefractionation step prior to 2-DE, reduce sample complexity, facilitate detection of less abundant protein components, increases the protein loads and the protein amount in each gel spot for MALDI-MS analysis...
  5. ncbi request reprint Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
    Annika Olsson
    Institute of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Exp Neurol 183:74-80. 2003
    ..Neither the levels of CSF-beta-sAPP nor CSF-Abeta(42) differed when comparing ApoE4 allele-positive with allele-negative individuals...
  6. ncbi request reprint The use of proteomics in biomarker discovery in neurodegenerative diseases
    Pia Davidsson
    Discovery Medicine Molecular Sciences, AstraZeneca R and D, Molndal, Sweden
    Dis Markers 21:81-92. 2005
    ....
  7. ncbi request reprint Comparative proteome analysis of thalamus in MK-801-treated rats
    Linda Paulson
    Departament of Clinical Neuroscience, Goteborg University, Sweden
    Proteomics 4:819-25. 2004
    ..Our results show the high potential of using proteomic methods for the validation of animal models of schizophrenia and to identify new proteins involved in the pathophysiological mechanisms of schizophrenia...
  8. ncbi request reprint Comparative genome- and proteome analysis of cerebral cortex from MK-801-treated rats
    Linda Paulson
    Department of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    J Neurosci Res 71:526-33. 2003
    ..Overall, these results with a combined approach of genomics and proteomics add to the validity of subchronic N-methyl-D-aspartate (NMDA)-receptor antagonist treatment as an animal model of schizophrenia...
  9. ncbi request reprint Decreased cerebrospinal fluid acetylcholinesterase in patients with subcortical ischemic vascular dementia
    Anders Wallin
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 16:200-7. 2003
    ..01) and FTD groups (p < 0.05). No influence of ApoE epsilon4 allele possession on CSF-AChE activity was found. It is suggested that abnormal CSF-AChE activity in patients with SVD reflects a disturbance in the cholinergic system...
  10. ncbi request reprint Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients
    Pia Davidsson
    Department of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80, Sweden
    Neuroreport 13:611-5. 2002
    ..The most prominently altered proteins were the apolipoproteins, especially proapolipoprotein...
  11. ncbi request reprint Effects on rat thalamic proteome by acute and subchronic MK-801-treatment
    Linda Paulson
    Department of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Mölndal SE 431 80 Mölndal, Sweden
    Eur J Pharmacol 505:103-9. 2004
    ..Our results show that different treatment times of MK-801 to rats give different biochemical results. Therefore, it is important to use the same treatment time in studies that will be compared...
  12. doi request reprint Proteomics of apolipoproteins and associated proteins from plasma high-density lipoproteins
    Pia Davidsson
    AstraZeneca Cardiovascular R and D, Molndal, Sweden
    Arterioscler Thromb Vasc Biol 30:156-63. 2010
    ..This, combined with controlled purification steps of HDL and its subclasses should provide further information about proteins involved in the particles postulated spectrum of functions, including those believed to be atheroprotective...
  13. ncbi request reprint Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease
    Maja Puchades
    Unit of Experimental Neuroscience, Department of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, S 431 80 Molndal, Goteborg, Sweden
    Brain Res Mol Brain Res 118:140-6. 2003
    ..The levels of 37 proteins spots were altered in AD patients. One of the identified proteins, alpha-2-HS glycoprotein, has not previously been linked to AD. Our study shows that several glycoproteins are altered in AD...
  14. ncbi request reprint Proteome studies of CSF in AD patients
    Pia Davidsson
    Discovery Medicine Molecular Pharmacology, AstraZeneca R and D, Molndal, SE 431 83 Molndal, Sweden
    Mech Ageing Dev 127:133-7. 2006
    ..Several studies show that the use of a panel of biomarkers derived from proteomic analysis is an advantageous way to distinguish AD from normal, and other dementia subjects...
  15. ncbi request reprint Unaltered plasma levels of beta-amyloid(1-40) and beta-amyloid(1-42) upon stimulation of human platelets
    Annika Olsson
    Institute of Clinical Neuroscience, Experimental Neuroscience Section, Goteborg University, Sahlgrenska University Hospital Molndal, Molndal, Sweden
    Dement Geriatr Cogn Disord 16:93-7. 2003
    ..We found that the levels of Abeta(40/42) in plasma were not related to platelet activation, suggesting that sampling techniques affecting platelet activation do not confound measurement of Abeta(40/42 )in plasma...
  16. ncbi request reprint Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms
    A M Nilselid
    Institute of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
    Neurochem Int 48:718-28. 2006
    ..However, the individual clusterin levels overlap between the two groups, and thus cerebrospinal fluid clusterin measurement is not suitable as a biochemical marker in the diagnosis of Alzheimer's disease...
  17. ncbi request reprint Proteomics and lipids of lipoproteins isolated at low salt concentrations in D2O/sucrose or in KBr
    Marcus Ståhlman
    AstraZeneca R and D, Molndal, Sweden
    J Lipid Res 49:481-90. 2008
    ..However, significant differences were found in the profiles of LDL and HDL, indicating that the D(2)O/sucrose method allowed a more complete characterization of its exchangeable apolipoproteins and proteins...
  18. ncbi request reprint Proteome analysis of conditioned medium from cultured adult hippocampal progenitors
    Annika Dahl
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital Molndal, Goteborg University, 431 80 Mölndal, Sweden
    Rapid Commun Mass Spectrom 17:2195-202. 2003
    ..Identification of bioactive proteins in vitro is of potential importance for the understanding of the regulatory mechanisms of the cells in vivo...
  19. ncbi request reprint Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, SE 431 80 Molndal, Sweden
    Dement Geriatr Cogn Disord 16:25-30. 2003
    ..The ADAS-cog score was slightly increased (p < 0.05). The results suggest that simvastatin acts directly on the processing of APP by inhibiting both the alpha- and the beta-secretase pathways...
  20. ncbi request reprint Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease
    Henrik Ryberg
    Institute of Clinical Neuroscience, Sahlgren University Hospital, University of Goteborg, 413 45 Goteborg, Sweden
    Neurochem Int 45:57-62. 2004
    ..The majority of the patients with AD or ALS had free 3-NT levels in the same range as seen in the control individuals and only a few patients showed increased levels of free 3-NT...
  21. ncbi request reprint Decreased CSF-beta-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of beta-amyloid induced by disparate mechanisms
    Magnus Sjogren
    Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, Molndal, Sweden
    Dement Geriatr Cogn Disord 13:112-8. 2002
    ..Furthermore, decreased CSF-Abeta42 levels may be common in neurodegenerative disorders possibly reflecting changes in the metabolism of beta-amyloid or axonal degeneration...
  22. doi request reprint Evaluation of the combination of bead technology with SELDI-TOF-MS and 2-D DIGE for detection of plasma proteins
    Carina Sihlbom
    AstraZeneca R and D Molndal, Molndal, Sweden
    J Proteome Res 7:4191-8. 2008
    ..Our data suggest that integration of the bead technology with our current proteomic technologies will enhance the possibility to deliver new peptide/protein biomarker candidates in our projects...
  23. ncbi request reprint A proteomic study of the apolipoproteins in LDL subclasses in patients with the metabolic syndrome and type 2 diabetes
    Pia Davidsson
    AstraZeneca R and D Molndal, Molndal, Sweden
    J Lipid Res 46:1999-2006. 2005
    ....
  24. ncbi request reprint Comparison of preparative and analytical two-dimensional electrophoresis for isolation and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometric analysis of transthyretin in cerebrospinal fluid
    Ann Westman-Brinkmalm
    Department of Clinical Neuroscience, Goteborg University, Molndal, Sweden
    Anal Biochem 301:161-7. 2002
    ....
  25. ncbi request reprint Reduction of the synaptophysin level but normal levels of glycerophospholipids in the gyrus cinguli in schizophrenia
    Mikael Landen
    Section of Psychiatry, Institute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden
    Schizophr Res 55:83-8. 2002
    ..This also lends further support to the notion that a synaptic disturbance or loss is of importance in the pathogenesis of schizophrenia...
  26. doi request reprint Myocardial release of FKBP12 and increased production of FKBP12.6 in ischemia and reperfusion experimental models
    Karin Astrom-Olsson
    Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Biochem Biophys Res Commun 390:1299-304. 2009
    ..6 in this model and in cell cultures...
  27. ncbi request reprint Prefractionation of cerebrospinal fluid to enhance glycoprotein concentration prior to structural determination with FT-ICR mass spectrometry
    Carina Sihlbom
    Institute of Medical Biochemistry, Goteborg University, Sweden
    J Proteome Res 4:2294-301. 2005
    ..The albumin depletion method is the most suitable as prefractionation method of CSF prior to 2-DE for structural determination of glycoproteins in the study of neurodegenerative disorders...
  28. ncbi request reprint Cerebrospinal fluid levels of total-tau, phospho-tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment
    Niels Andreasen
    Neurotec, Department of Geriatric Medicine, B84, Huddinge University Hospital, Stockholm, Sweden
    Acta Neurol Scand Suppl 179:47-51. 2003
    ..CSF diagnostic markers will be especially important when drugs with potential effects on the progression of AD (e.g. gamma-secretase inhibitors) will reach the clinical phase...
  29. ncbi request reprint Increased [(3)H]tiagabine binding to GAT-1 in the cingulate cortex in schizophrenia
    Ingrid Sundman-Eriksson
    Department of Clinical Sciences, Division of Psychiatry, Umea University, Umea, Sweden
    Neuropsychobiology 45:7-11. 2002
    ..The increase in GAT-1 in schizophrenia could be explained by a modulatory upregulation in the cingulate cortex...
  30. ncbi request reprint Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples
    Karin Björhall
    AstraZeneca R and D Molndal, Department of Discovery Medicine Molecular Sciences, 43183 Molndal, Sweden
    Proteomics 5:307-17. 2005
    ..Our study provides a comprehensive investigation of commercially available depletion columns and will be of high importance for future proteomic studies on serum samples...
  31. ncbi request reprint Structural analysis of 2D-gel-separated glycoproteins from human cerebrospinal fluid by tandem high-resolution mass spectrometry
    Kristina Hakansson
    Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310 3706, USA
    J Proteome Res 2:581-8. 2003
    ..IRMPD obviates the need for glycan release, which prevents sample dispersal, and allows the assignment of glycan structures to specific sites of N-glycosylation...
  32. doi request reprint Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer's disease patients and healthy individuals
    Carina Sihlbom
    Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at Goteborg University, 440, SE 405 30 Goteborg, Sweden
    Neurochem Res 33:1332-40. 2008
    ..Protein expression levels of alpha1-antitrypsin were decreased, while the protein levels of apolipoprotein E and clusterin were increased in AD. No specific glycoform could be specifically assigned to AD...